Download - disseration presentation
![Page 1: disseration presentation](https://reader036.vdocument.in/reader036/viewer/2022062503/58e58d461a28abdd148b4e95/html5/thumbnails/1.jpg)
Mortality Rates of Cancer Patients
Priya Herian 1011944BSc (Hons) Mathematics
University of Wolverhampton
Supervisor: Ruth FaircloughPrinciple Lecturer Mathematics
Faculty of Science and Engineering
![Page 2: disseration presentation](https://reader036.vdocument.in/reader036/viewer/2022062503/58e58d461a28abdd148b4e95/html5/thumbnails/2.jpg)
AbstractAim
Mortality rates of patients affected by variables Acceptance or Rejection of the null-hypothesis
MethodSPSS SoftwareCox Proportional Hazard ModelKaplan-Meier Analysis
ResultsAmpullary Cancer affected by “resected” and “complications”Pancreatic Cancer affected by “resected” and “less than 69”
ConclusionRejection of null-hypothesisConfirmation using Kaplan-Meier Analysis
![Page 3: disseration presentation](https://reader036.vdocument.in/reader036/viewer/2022062503/58e58d461a28abdd148b4e95/html5/thumbnails/3.jpg)
Overview of Cancer
Genes change
Cells grow excessively and multiple too fast
Over 200 types of cancer
![Page 4: disseration presentation](https://reader036.vdocument.in/reader036/viewer/2022062503/58e58d461a28abdd148b4e95/html5/thumbnails/4.jpg)
Ampullary Cancer Facts
Figure 1.1 Age-standardised incidence rates of Ampulla of Vater cancer per 100’000 European population (ASR(E)) by Gender and Year of diagnosis
![Page 5: disseration presentation](https://reader036.vdocument.in/reader036/viewer/2022062503/58e58d461a28abdd148b4e95/html5/thumbnails/5.jpg)
Pancreatic Cancer Facts
5th most common cause of cancer death in men
4th most common cause of cancer death in women
More common in women than men
Half of all deaths are in 75 years and over
![Page 6: disseration presentation](https://reader036.vdocument.in/reader036/viewer/2022062503/58e58d461a28abdd148b4e95/html5/thumbnails/6.jpg)
Cox Proportional Hazard Model (Cox PH
Model)Various variables upon the time a specified event takes to happen
Estimate of treatment effect on survival
t = time X = predictor variables H0 = null hypothesis
Assumes the time to an event is defined by a hazard function
Creation of baseline hazard function, independent of exponential function
Baseline Hazard defines the shape of hazard function
![Page 7: disseration presentation](https://reader036.vdocument.in/reader036/viewer/2022062503/58e58d461a28abdd148b4e95/html5/thumbnails/7.jpg)
Assumptions & Decisions
SPSSClear Accurate
HypothesisH0 : The mortality rates of cancer patients are not affected by the following variables: resected, less than 69, multiple procedures and complicationsH1 : At least one variable has an impact on the mortality rates of cancer patients
Forward Stepwise Function within SPSS
![Page 8: disseration presentation](https://reader036.vdocument.in/reader036/viewer/2022062503/58e58d461a28abdd148b4e95/html5/thumbnails/8.jpg)
SPSS Cox PH Model Output
![Page 9: disseration presentation](https://reader036.vdocument.in/reader036/viewer/2022062503/58e58d461a28abdd148b4e95/html5/thumbnails/9.jpg)
Kaplan-Meier Analysis
ni number of subjects at riskdi number of subjects who failti time
Product Limit EstimatorNon-parametric statisticEstimate survival function Fraction of patients living over time
![Page 10: disseration presentation](https://reader036.vdocument.in/reader036/viewer/2022062503/58e58d461a28abdd148b4e95/html5/thumbnails/10.jpg)
Kaplan-Meier Assumptions
Ampullary CancerNot Resected with No Complications = 1Not Resected with Complications = 2Resected with No Complications = 3Resected with Complications= 4
Pancreatic CancerNot Resected and being 69 or older = 1Not Resected and being less than 69 = 2Resected and being 69 or older = 3Resected and being less than 69 = 4
![Page 11: disseration presentation](https://reader036.vdocument.in/reader036/viewer/2022062503/58e58d461a28abdd148b4e95/html5/thumbnails/11.jpg)
Kaplan-Meier Analysis Output
![Page 12: disseration presentation](https://reader036.vdocument.in/reader036/viewer/2022062503/58e58d461a28abdd148b4e95/html5/thumbnails/12.jpg)
Conclusion & Critical Evaluation
20.053% differenceAmpullary cancer – higher survival rate
HypothesisNull hypothesis is rejected
No measurable difference between gender and multiple procedures
Further WorkExtending data amountComputer Software PackagesSurvival Analysis MethodsLiterature Review
![Page 13: disseration presentation](https://reader036.vdocument.in/reader036/viewer/2022062503/58e58d461a28abdd148b4e95/html5/thumbnails/13.jpg)