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Effects of Gastric Bypass Surgery in Patients With Type 2 Diabetes and Only Mild Obesity
Featured Article:
Ricardo V. Cohen, M.D., Jose C. Pinheiro, M.D., Carlos A. Schiavon, M.D., João E. Salles, M.D., Bernardo L. Wajchenberg, M.D., David E. Cummings,
M.D.
Diabetes Care Volume 35: 1420-1428
July, 2012
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Study Objectives
Cohen R et al. Diabetes Care 2012;35:1420-1428
• Roux-en-Y gastric bypass (RYGB) ameliorates type 2 diabetes in severely obese patients through mechanisms beyond just weight loss, and it may benefit less obese diabetic patients
• Study determined the long-term impact of RYGB on patients with diabetes and only class I obesity (BMI 30–35 kg/m2 )
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Study Design & Methods
• Sixty-six consecutively selected diabetic patients with BMI 30–35 kg/m2 underwent RYGB in a tertiary-care hospital and were prospectively studied for up to 6 years (median 5 years [range 1–6]), with 100% follow-up
• Main outcome measures were safety and the percentage of patients experiencing diabetes remission (HbA1c < 6.5% without diabetes medication)
Cohen R et al. Diabetes Care 2012;35:1420-1428
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Cohen R et al. Diabetes Care 2012;35:1420-1428
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Cohen R et al. Diabetes Care 2012;35:1420-1428
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Cohen R et al. Diabetes Care 2012;35:1420-1428
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Cohen R et al. Diabetes Care 2012;35:1420-1428
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Cohen R et al. Diabetes Care 2012;35:1420-1428
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Conclusions
• Largest, longest-term study to date examining RYGB for diabetic patients without severe obesity
• RYGB safely and effectively ameliorated diabetes and associated comorbidities, reducing cardiovascular risk, in patients with a BMI of only 30–35 kg/m2
Cohen R et al. Diabetes Care 2012;35:1420-1428