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Erythropoietin Accelerates Functional Recovery After Peripheral Nerve Injury
by John C. Elfar, Justin A. Jacobson, J. Edward Puzas, Randy N. Rosier, and Michael J. Zuscik
J Bone Joint Surg AmVolume 90(8):1644-1653
August 1, 2008
©2008 by The Journal of Bone and Joint Surgery, Inc.
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Representative control footprint demonstrating measurements used to calculate the sciatic function index.
John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644-1653
©2008 by The Journal of Bone and Joint Surgery, Inc.
![Page 3: Erythropoietin Accelerates Functional Recovery After Peripheral Nerve Injury by John C. Elfar, Justin A. Jacobson, J. Edward Puzas, Randy N. Rosier, and](https://reader036.vdocument.in/reader036/viewer/2022082505/56649cea5503460f949b5380/html5/thumbnails/3.jpg)
Effects of sciatic crush injury on the sciatic function index.
John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644-1653
©2008 by The Journal of Bone and Joint Surgery, Inc.
![Page 4: Erythropoietin Accelerates Functional Recovery After Peripheral Nerve Injury by John C. Elfar, Justin A. Jacobson, J. Edward Puzas, Randy N. Rosier, and](https://reader036.vdocument.in/reader036/viewer/2022082505/56649cea5503460f949b5380/html5/thumbnails/4.jpg)
John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644-1653
©2008 by The Journal of Bone and Joint Surgery, Inc.
![Page 5: Erythropoietin Accelerates Functional Recovery After Peripheral Nerve Injury by John C. Elfar, Justin A. Jacobson, J. Edward Puzas, Randy N. Rosier, and](https://reader036.vdocument.in/reader036/viewer/2022082505/56649cea5503460f949b5380/html5/thumbnails/5.jpg)
John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644-1653
©2008 by The Journal of Bone and Joint Surgery, Inc.
![Page 6: Erythropoietin Accelerates Functional Recovery After Peripheral Nerve Injury by John C. Elfar, Justin A. Jacobson, J. Edward Puzas, Randy N. Rosier, and](https://reader036.vdocument.in/reader036/viewer/2022082505/56649cea5503460f949b5380/html5/thumbnails/6.jpg)
Effect of timing of erythropoietin administration (5000 U/kg administered by subcutaneous injection) on the sciatic function index in mice subjected to a sciatic crush injury (for a sixty-
second duration) as described in the Materials and Methods section.
John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644-1653
©2008 by The Journal of Bone and Joint Surgery, Inc.
![Page 7: Erythropoietin Accelerates Functional Recovery After Peripheral Nerve Injury by John C. Elfar, Justin A. Jacobson, J. Edward Puzas, Randy N. Rosier, and](https://reader036.vdocument.in/reader036/viewer/2022082505/56649cea5503460f949b5380/html5/thumbnails/7.jpg)
Immunohistochemical staining of erythropoietin receptors in sciatic nerve tissue harvested from mice subjected to sciatic injury or sham surgery with or without erythropoietin administration.
John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644-1653
©2008 by The Journal of Bone and Joint Surgery, Inc.