Erythropoietin Accelerates Functional Recovery After Peripheral Nerve Injury

by John C. Elfar, Justin A. Jacobson, J. Edward Puzas, Randy N. Rosier, and Michael J. Zuscik

J Bone Joint Surg AmVolume 90(8):1644-1653

August 1, 2008

©2008 by The Journal of Bone and Joint Surgery, Inc.

Representative control footprint demonstrating measurements used to calculate the sciatic function index.

John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644-1653

©2008 by The Journal of Bone and Joint Surgery, Inc.

Effects of sciatic crush injury on the sciatic function index.

John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644-1653

©2008 by The Journal of Bone and Joint Surgery, Inc.

John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644-1653

©2008 by The Journal of Bone and Joint Surgery, Inc.

John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644-1653

©2008 by The Journal of Bone and Joint Surgery, Inc.

Effect of timing of erythropoietin administration (5000 U/kg administered by subcutaneous injection) on the sciatic function index in mice subjected to a sciatic crush injury (for a sixty-

second duration) as described in the Materials and Methods section.

John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644-1653

©2008 by The Journal of Bone and Joint Surgery, Inc.

Immunohistochemical staining of erythropoietin receptors in sciatic nerve tissue harvested from mice subjected to sciatic injury or sham surgery with or without erythropoietin administration.

John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644-1653

©2008 by The Journal of Bone and Joint Surgery, Inc.