Download - Fusion 1 day presentation
The contact lens that The contact lens that thinks its an eye dropthinks its an eye drop
Contact Lens Related Dry Contact Lens Related Dry EyeEye
55% of wearers experience end-of-day discomfortMost common cause of drop-out is
due to discomfort41% due to dryness symptoms
FUSION CONCEPTThe new generation of contact lenses that release a natural tear substitute
Safilens has dedicated years of research and innovation looking for ways to maximise contact lens comfort and optimise ocular hydration. Safilens believes the controlled release of bio-active substances during contact lens wear to be the key to maintaining the delicate relationship between the contact lens and the tear film
Hyaluronic AcidHyaluronic AcidBenefits in EyecareBenefits in Eyecare
Biological polymerHA’s function in nature
is to attract waterextremely effective, even at very low concentrationsAttracts 3000x its own weight in water
Bio-adhesive propertiesNon Newtonian
behaviourProtective effect on
corneal epithelium
Tamarind Seed Tamarind Seed Polysaccharide (TSP)Polysaccharide (TSP)
Similar structure to ocular mucin
Similar structure to ocular mucin
HA + TSPHA + TSPThe interaction between HA and TSP is
cooperative forming a new bi-polymer
Resulting performance > SUM of its 2 partsResulting performance > SUM of its 2 parts
Relative Performance of Relative Performance of tear substitutestear substitutes
Natural Semi-synthetic Synthetic
HA TSP HPMC CMC PVA PVP
Hydration **** **** ** **** **** *
Lubrication
**** **** ** *** *** ***
Muco-adhesive
**** **** * **** * *
Muco-mimetic
**** **** * * * *
Viscoelastic
**** **** * *** * *
Wound healing
*** *** * ** * *
Ref: Current Medical Research and Opinion (2006)
Non Newtonian Fluid at High Viscosity Non Newtonian Fluid at Low Viscosity
Non-Newtonian BehaviourNon-Newtonian Behaviour
How it works…How it works…
Polymer chains become more disorganised with heating increasing its fluiditySheer force from blinking aids flow into
tearsNon-Newtonian behaviour mimics the
natural tearsMore fluid during blink – more viscous between blinks
Fusion Technolog
y
Increased tear film stability for
improved comfort
Prolonged muco-
mimetic activity
Maintains lens
hydration longer
Constant hydration
and lubrication
for excellent VA
Minimal friction
between lens and lid
Ultra-thin lens designHandles wellLens can be pulled quite robustly without breaking
Excellent DK/t: 40 (-3.00 at 35ºC)
More or less same as other hydrogel daily disposables
Lens design Lens design
ParametersParameters
-0.50 to -6.00 (0.25 steps)
-6.50 to -12.00 (0.50 steps)
Filcon IVIncorporating a bipolymer of HA-TSP
At the end of the day, At the end of the day, which would you choose?which would you choose?
[email protected]@safilens.com