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Journal Club 30/09/05 V Dory
GP treatment decisions for patients with depression: an observational study
Kendrick T, King F, Albertella L, Smith P
Br J Gen Pract 2005;55:280-6
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Journal Club 30/09/05 V Dory
Background
England : Increase in anti-depressant prescriptions- may be inappropriate
Many patients (2/3) with major depression are not receiving recommended treatment
This may be linked to GPs’ beliefs and patients’ beliefs
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Journal Club 30/09/05 V Dory
Research question :Understanding GP behaviour
What influences GP treatment decisions for depression:Severity of depressionPatient demographic factorsAdverse life eventsPast historyPatient attitudes towards antidepressants (as
seen by GPs/ as reported by patients)
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Journal Club 30/09/05 V Dory
Methods
Observational studyPatients:
– HADS (HAD-D severity)
– Socio-demographic factors
– Perceived financial difficulties
– Brief schedule of threatening life events
– Health status
– Attitudes to antidepressants
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Journal Club 30/09/05 V Dory
GPs: Is patient depressed : 0-4
If >= 2:Action takenAdverse life event or difficultiesPatient’s attitude towards antidepressantsPrevious mental health problemsChronic physical health pbsPrevious antidepressant treatmentHow well do you know patientAcknowledgement of diagnosis of depression
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Journal Club 30/09/05 V Dory
Notes checked after 2 months for subsequent diagnosis of / treatment for depression
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Journal Club 30/09/05 V Dory
Methods: Recruitment
Recruitment of GP practices
Phase I: 2 practices 9 GPs (of 9)
Phase II: 6 practices (5 of 7 newly approached + 1 from phase I) 11 GPs (of 18)
No information on selection process
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Journal Club 30/09/05 V Dory
Methods: recruitment
Patients
Inclusion criteria: >18 years old Able to complete screening questionnaire
Exclusion criteria: Currently taking AD/psychiatric treatment Terminal illness
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Journal Club 30/09/05 V Dory
Consent
Ph I : directly approached by researcher
Ph II: approached by receptionist then researcher
Consent slip given to GP before consultation
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Journal Club 30/09/05 V Dory
Patients437 + 257 patients = 694 patients59%- 43% of appts100 depressed
67 HAD-D 8-1033 HAD-D >10
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Journal Club 30/09/05 V Dory
Results
Missing data
GPs completed questionnaires for 97-95% of patients enrolled
Patients all filled in HAD on the spot but sent other questionnaires by post in 73%-72% of cases (no difference in HAD-D score)
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Results: diagnosis of depression
GPs are not very accurate:
Ph I HAD +
HAD -
total
GP + 19 42 61
GP - 38 326 364
total 57 368 425
Prév 13,4%
Se 33%
Sp 89%
PPV 31%
NPV 89%
LR+ 3
LR- 0.75
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Journal Club 30/09/05 V Dory
Results: treatment decisions
Acknowledgement: 49%/35%
AD: 8%/22%
Follow-up/referral: 16%/7%
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Journal Club 30/09/05 V Dory
Results: association between AD offers and GP perceptions
Severity of depressionModerate>mildP = 0.019/0.001
Attitude of patient twds ADP= 0.045/0.004
Absence of adverse life events or difficultiesP=0.03/0.847
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Journal Club 30/09/05 V Dory
Results: GP perceptions of patient’s attitudes
GP ‘pos attitude’ // patient ‘addictiveness’
GP ‘neg attitude’ # patient ‘effectiveness’
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Journal Club 30/09/05 V Dory
Results : changes between ph I and II
More offers of ADNo link between offer of AD and adverse
life events
BUT:
Different population
Insufficient numbers of GPs
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Journal Club 30/09/05 V Dory
Discussion : Main findings
Poor diagnostic accuracy
Management :– Lack of acknowledgement with patients– AD offers linked to severity and perceived
patient attitude to AD
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Journal Club 30/09/05 V Dory
Limitations
Selection of practices???
Relatively small sample size re R/ decisions (101)
2 phases : different practices so no comparison feasable