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MAKE A KWL CHART ABOUT CANCER (WRITE ON 1 SIDE OF
THE BLANK PAPER)
What I already know
about cancer
What I want to know
about cancer
What I learned about
cancer
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CELL CYCLE• Introduction Video
• http://www.dnalc.org/view/15536-Cell-division-tumor-growth-and-metastasis-3D-animation-with-basic-narration.html
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OBJECTIVES• Explain the major stages of the cell cycle and cellular
division
• Describe specific events occurring in each of the phases of cellular division including cytokinesis
• Explain how cellular division functions to form new cells and maintain complex organisms
• Describe the role of mitosis in asexual reproduction and explain how it maintains the chromosome number, and how it may contribute to limiting genetic variation
• Explain how a mutation might cause the cell cycle to be altered to allow for uncontrolled cell growth
• Relate the development of cancer (uncontrolled growth) to mutations that affect the proteins that regulate the cell cycle
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ESSENTIAL QUESTION
• What can you infer about how cell division in a normal cell compares to cell division in a cancer cell?
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THE CELL CYCLE
5
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CELL CYCLE – WRITE THIS DOWN!
6
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GAP 1 (G1)
Cell growth
Normal FunctionsReplications of organelles
7
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SYNTHESIS (S)
Copies DNA
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GAP 2 (G2)
Additional growth and carrying out normal functions
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MITOSIS
Cell Division
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1. Prophase
2. Metaphase
3. Anaphase
4. Telophase
5. Cytokinesis
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TWO MAIN PHASES IN THE CELL CYCLE
Mitosis
Interphase
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CHROMOSOME STRUCTURE
• One long continuous thread of DNA
• DNA wraps around proteins called histones
• DNA and histones form chromatin, which looks like spaghetti, during interphase
• Chromosomes condense tightly for mitosis. Because they are duplicated, they look like an X
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1. INTERPHASE
• Copies DNA, grows, and duplicates organelles
nucleus
cell
DNA
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2. PROPHASE
• Chromosomes condense, nuclear envelope breaks down, spindle fibers form
nucleus
cell
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3. METAPHASE
• Spindle fibers align chromosomes along the cell equator (middle of cell)
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4. ANAPHASE
• Chromatids separate to opposite sides of cell
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5. TELOPHASE• Nuclear membranes start to form around
the chromosomes, chromosomes begin to uncoil, spindle fibers fall apart
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6. CYTOKINESIS• Divides the cytoplasm between two
daughter cells
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NEW “DAUGHTER” CELLS
• Get 2 exact copies of original cells
• same DNA
• “clones”
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MITOSIS IN PLANT CELL
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onion root tip
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MITOSIS• In the cell cycle
•Animals have cleavage furrow that bends in to divide
•Plants have cell plate that divides
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BINARY FISSION• Asexual reproduction of a single-
celled organism by division into two equal parts
• Takes place in Prokaryotes
• Ex. bacteria
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WHAT ARE SOME ADVANTAGES AND/OR DISADVANTAGES TO
ASEXUAL REPRODUCTION?
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CELLS DIVIDE AT DIFFERENT RATES
• Rates of cell division vary widely and are linked to the body’s need
• The length of G1 varies most widely among cell types
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CELL SIZE IS LIMITED
• If cells were too small, they could not contain all the organelles necessary for life.
• If cells were too large, they could not move enough materials across the membrane surface.
• To maintain a suitable size, cell growth and division must be coordinated.
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REGULATION OF CELL CYCLE
What would happen if the cell cycle was not regulated (i.e. something to control how often it divides)?
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INTERNAL FACTORS
• Checkpoints are located during the G1, G2, and M phase of the cell cycle
• If something is not right, the cell will not continue in the cycle and will wait until the issue is fixed
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EXTERNAL FACTORS
•Cell to cell contact and chemical signals/growth factors can both influence a cell to divide
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CARCINOGENS
•Substances that produce or promote the development of cancer
•Examples: tobacco smoke, air pollutants, radiation, and viruses
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CANCER CELLS
•characterized by uncontrolled cell division;
•continue to grow despite cell-cell contact or lack of growth factors
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TUMORS
• Disorganized clumps of cancer cells that do not carry out specialized functions needed by the body
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APOPTOSIS
• Programmed cell death
• Plays a role in normal development
• Rids the body of unhealthy cells
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COOKIE ACTIVITY
• Grab 3 cookies
• Take them apart, try to get icing on both sides of the oreos
• Grab 16 pieces of little papers
• Create chromosomes from the papers
• Demonstrate prophase, metaphase, anaphase and telophase using the cookies as the cells and cutouts as the chromosomes