C)

NHP002[5.5 ± 1.24%]

NHP003[2.2 ± 0.47%]

A)

NHP001[2.2 ± 0.37%]

B)

x200 x200 x200 x200x200 x200

NHP001 w/o IS

NHP002 with IS

NHP003 with IS

Immunosuppression period

weeks6

8

10

12

14

16

18

0 5 10 15 20 25

He

pa

tic

PB

GD

ac

tiv

ity

(pm

ol

UR

O/m

g p

rot/

h) ***

*

Normal range

0

noninjected

(n=4)

NHP001

NHP002

NHP003

**

*

0

5

10

15

20

25

PB

GD

exp

ress

ion

mR

NA

(ar

bit

rary

un

its)

**