nhp002 [5.5 ± 1.24%]

1
C) NHP002 [5.5 ± 1.24%] NHP003 [2.2 ± 0.47%] A) NHP001 [2.2 ± 0.37%] B) x200 x200 x200 x200 x200 x200 NHP001 w/o IS NHP002 with IS NHP003 with IS Immunosuppression period weeks 6 8 10 12 14 16 18 0 5 10 15 20 25 Hepatic PBGD activity (pmol URO/mg prot/h) *** * Normal range 0 non injecte d (n=4) NHP 001 NHP 002 NHP 003 ** * 0 5 10 15 20 25 PBGD expression mRNA (arbitrary units) **

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A). Immunosuppression period. ***. 18. 16. *. 14. Hepatic PBGD activity (pmol URO/mg prot/h). 12. Normal range. 10. 8. 6. weeks. 0. 5. 10. 15. 20. 25. NHP001 w/o IS. NHP002 with IS. NHP003 with IS. **. 25. 20. PBGD expression mRNA (arbitrary units). 15. **. 10. *. - PowerPoint PPT Presentation

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Page 1: NHP002 [5.5 ± 1.24%]

C)

NHP002[5.5 ± 1.24%]

NHP003[2.2 ± 0.47%]

A)

NHP001[2.2 ± 0.37%]

B)

x200 x200 x200 x200x200 x200

NHP001 w/o IS

NHP002 with IS

NHP003 with IS

Immunosuppression period

weeks6

8

10

12

14

16

18

0 5 10 15 20 25

He

pa

tic

PB

GD

ac

tiv

ity

(pm

ol

UR

O/m

g p

rot/

h) ***

*

Normal range

0

noninjected

(n=4)

NHP001

NHP002

NHP003

**

*

0

5

10

15

20

25

PB

GD

exp

ress

ion

mR

NA

(ar

bit

rary

un

its)

**