![Page 1: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/1.jpg)
![Page 2: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/2.jpg)
Predictors of the outcome of Predictors of the outcome of diabetic foot ulcer at Assiut diabetic foot ulcer at Assiut
university hospitaluniversity hospital ByBy
Walaa Anwar Muhammad KhalifaWalaa Anwar Muhammad Khalifa
M.B.B.CHM.B.B.CHM.ScM.ScFaculty of medicineFaculty of medicine
Assiut UniversityAssiut University
Under supervision ofUnder supervision ofProf. Dr. Lobna Farag EltoonyProf. Dr. Lobna Farag Eltoony
Professor of internal medicine&head of endocrinology unitProfessor of internal medicine&head of endocrinology unitFaculty of medicineFaculty of medicineAssiut UniversityAssiut University
Dr. Mona Muhammad SolimanDr. Mona Muhammad SolimanLecturerLecturer of internal medicine of internal medicine
Faculty of medicineFaculty of medicineAssiut UniversityAssiut University
![Page 3: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/3.jpg)
IntroductionIntroduction Diabetic foot ulcers are a common and much Diabetic foot ulcers are a common and much
feared complication of diabetes, with recent feared complication of diabetes, with recent studies suggesting that the lifetime risk of studies suggesting that the lifetime risk of developing foot ulcer in diabetic patients may be developing foot ulcer in diabetic patients may be as high as 25% (Singh et al.,2005).as high as 25% (Singh et al.,2005).
Up to 50% of older patients with type 2 diabetes Up to 50% of older patients with type 2 diabetes have one or more risk factors for foot ulceration. have one or more risk factors for foot ulceration.
A list of the principal risk factors that might A list of the principal risk factors that might result in foot ulcer development are result in foot ulcer development are demonstrated ( Abbott et al ., 2002.) demonstrated ( Abbott et al ., 2002.)
![Page 4: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/4.jpg)
Risk factors of foot ulcerRisk factors of foot ulcer1-1- Previous amputation.Previous amputation.
2-2- Past history of foot ulceration.Past history of foot ulceration.
3-3- Peripheral neuropathy.Peripheral neuropathy.
4-4- Peripheral vascular disease.Peripheral vascular disease.
5-5- Foot deformityFoot deformity..
6-6- Visual impairment.Visual impairment.
7-7- Diabetic nephropathy.Diabetic nephropathy.
8-8- Poor glycemic controlPoor glycemic control..
9-9- Cigarette smokingCigarette smoking
![Page 5: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/5.jpg)
![Page 6: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/6.jpg)
The most common triad of causes that The most common triad of causes that
interact and result in foot ulceration has interact and result in foot ulceration has
been identified asbeen identified as neuropathy neuropathy,, deformity deformity
and and traumatrauma ( Boulton et al., 2004) ( Boulton et al., 2004)
![Page 7: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/7.jpg)
• The risk of amputation is 15 to 40 times The risk of amputation is 15 to 40 times greater in a person with diabetes than in greater in a person with diabetes than in one who doesn't have the disease one who doesn't have the disease
( Nabuurs et al..2005).( Nabuurs et al..2005).
![Page 8: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/8.jpg)
The population of diabetic patients who The population of diabetic patients who present with foot ulceration are present with foot ulceration are
heterogenous,there are characteristics that heterogenous,there are characteristics that may vary among patients, such as the may vary among patients, such as the presence of peripheral arterial disease presence of peripheral arterial disease
infection,andco-morbidities. infection,andco-morbidities. Peripheral arterial disease is considered Peripheral arterial disease is considered
an important predictor of outcomean important predictor of outcome (Prompers et al., 2007).(Prompers et al., 2007).
![Page 9: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/9.jpg)
Therefore. Outcome data on these patients Therefore. Outcome data on these patients with diabetic foot ulcer are needed such a with diabetic foot ulcer are needed such a requirement is underlined by the fact that requirement is underlined by the fact that although diabetic foot ulcers are usually although diabetic foot ulcers are usually reported and analyzed as one clinical entity reported and analyzed as one clinical entity marked differences in patient, foot and marked differences in patient, foot and ulcer characteristics can exist between ulcer characteristics can exist between patientspatients. . These observations raise the These observations raise the question of wether predictors of outcome in question of wether predictors of outcome in patients may differ (Prompers et al., 2007).patients may differ (Prompers et al., 2007).
![Page 10: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/10.jpg)
The aim of the studyThe aim of the study To assess the potential baseline clinical and To assess the potential baseline clinical and
laboratory characteristics that best predict poor laboratory characteristics that best predict poor outcome (non healing of the foot ulcer).outcome (non healing of the foot ulcer).
The main outcome of the study is complete The main outcome of the study is complete healing of the foot within the maximum follow healing of the foot within the maximum follow up period of 1 year.up period of 1 year.
Healing was defined as healing (intact skin) of Healing was defined as healing (intact skin) of the whole foot at two consecutive visits. the whole foot at two consecutive visits.
![Page 11: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/11.jpg)
Patients & study designPatients & study design It is a prospective study in which 100 It is a prospective study in which 100
patients with diabetic foot ulcer will be patients with diabetic foot ulcer will be followed and managed for 1 year.followed and managed for 1 year.
About 50 patients are still under About 50 patients are still under research.research.
Patients includedPatients included were those presenting were those presenting for the first time with a new foot ulcer for the first time with a new foot ulcer within period of 12 months.within period of 12 months.
![Page 12: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/12.jpg)
Excluded patientsExcluded patients 1- Patients who had been treated for an 1- Patients who had been treated for an
ulcer on the ipsilateral foot during the ulcer on the ipsilateral foot during the previous 12 months. previous 12 months.
2- Patients with sever end organ 2- Patients with sever end organ failure.failure.
3- Patients with gangrenous foot. eg, 3- Patients with gangrenous foot. eg, gas gangrene.gas gangrene.
![Page 13: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/13.jpg)
MethodMethod Data collected prospectively of patients Data collected prospectively of patients
referred to a foot care clinic referred to a foot care clinic recorded recorded Data include. Data include.
Demographics,detailed history and complete Demographics,detailed history and complete physical examinationphysical examination
Data on co- morbidities including ( retinopathy Data on co- morbidities including ( retinopathy nephropathy, hypertension and ischemic heart nephropathy, hypertension and ischemic heart disease) .disease) .
![Page 14: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/14.jpg)
Data on foot examinationData on foot examination include. include.
(foot inspection, Pedal pulse, (foot inspection, Pedal pulse, ABI measurement and joint ABI measurement and joint examination).examination).
Data on ulcer characteristics.Data on ulcer characteristics. ulcers were classified ulcers were classified
according toaccording to1-PEDIS system.1-PEDIS system. ( perfusion, extent, depth, ( perfusion, extent, depth,
infection and sensation ) infection and sensation ) ..
![Page 15: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/15.jpg)
22 - -Meggitt- wagner classification of foot ulcers
Grade0Grade0:Pre- or post- ulcerative lesion :Pre- or post- ulcerative lesion completely epithelializedcompletely epithelialized
Grade1Grade1:Superficial, full thickness:Superficial, full thickness ulcer limited ulcer limited to the dermis, not extending to the subcutisto the dermis, not extending to the subcutis
Grade 2Grade 2:Ulcer of the skin extending through the :Ulcer of the skin extending through the subcutis with exposed tendon or bone and subcutis with exposed tendon or bone and without osteomyelitis or abscesswithout osteomyelitis or abscess
Grade 3Grade 3:Deep ulcers with osteomyelitis or :Deep ulcers with osteomyelitis or abscess formationabscess formation
GradeGrade 44:Localized gangrene of the toes or the :Localized gangrene of the toes or the forefoot forefoot
GradeGrade 55:Foot with extensive gangrene:Foot with extensive gangrene
![Page 16: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/16.jpg)
3- The university of Texas classification 1998
StageStageGradeGrade
00112233
AAPre- or post- Pre- or post- ulcerative ulcerative lesion lesion completely completely epithelailizd epithelailizd
Superficial Superficial wound not wound not involving involving tendon, tendon, capsule or capsule or bone bone
Wound Wound penetrating penetrating to tendon or to tendon or capsule capsule
Wound Wound penetrating penetrating to bone or to bone or joint joint
BBWith With infectioninfection
With With infection infection
With With infectioninfection
With With infectioninfection
CCWith With ischemiaischemia
With With ischemiaischemia
With With ischemiaischemia
With With ischemiaischemia
DDWith With infectioninfectionand and ischemiaischemia
With With infectioninfectionand and ischemiaischemia
With With infectioninfectionand and ischemiaischemia
With With infectioninfectionand ischemiaand ischemia
![Page 17: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/17.jpg)
Laboratory data includeLaboratory data include
Complete blood picture, liver Complete blood picture, liver function, urea and creatinine ,24 function, urea and creatinine ,24 hrs proteins in urine, creatinine hrs proteins in urine, creatinine clearance, lipogram and (Hb A1c)clearance, lipogram and (Hb A1c)
. .
![Page 18: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/18.jpg)
Management of diabetic foot ulcerManagement of diabetic foot ulcer
All Patients were treated According to protocols based All Patients were treated According to protocols based on the international consensus on the diabetic foot on the international consensus on the diabetic foot which include offloading ,diagnosis and treatment of which include offloading ,diagnosis and treatment of infection, assessment of vascular status and regular infection, assessment of vascular status and regular wound debridement . wound debridement .
![Page 19: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/19.jpg)
Results of 50 patients:In 50 patients: 34 (68%) females ,the mean age 50.76 ± 13.35.
![Page 20: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/20.jpg)
Diagram (2) :shows results of patient characteristics
non-smokers
past history of amputation
insulin therapy
neuropathic symptom
s
0
10
20
30
40
50
no.
of c
a ses
![Page 21: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/21.jpg)
Diagram(3):shows results of Diagram(3):shows results of foot inspectionfoot inspection
![Page 22: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/22.jpg)
VariableVariableHealedHealed(n= 31)(n= 31)
UnhealedUnhealed(n= 19)(n= 19)
TotalTotal(n= 50)(n= 50)P-valueP-value
Age:47.39 ± 11.4247.39 ± 11.4256.26 ± 16.7656.26 ± 16.7650.76 ± 13.3550.76 ± 13.350.0210.021
Sex:
0.0140.014 Males n%6(37.5%)6(37.5%)10(62.5%)10(62.5%)1616
Females n%25(73.6%)25(73.6%)9(26.4%)9(26.4%)3434
Smoking (n%)2(20.0%)2(20.0%)8(80.0%)8(80.0%)10100.0070.007
BMI31.64 ± 3.8831.64 ± 3.8829.21 ± 5.6029.21 ± 5.6030.72 ± 4.7130.72 ± 4.71NSNS
Diabetes duration:
0.0010.001 < 10 years22(84.6%)22(84.6%)4(15.4%)4(15.4%)2626
≥ 10years9(37.5%)9(37.5%)15(62.5%)15(62.5%)2424
Insulin use (n%)25(61.0%)25(61.0%)16(39.0%)16(39.0%)4141NSNS
Retinopathy (n%)10(50%)10(50%)10(50%)10(50%)2020NSNS
Hypertension10(47.6%)10(47.6%)11(53.4%)11(53.4%)2121NSNS
Ischemic heart disease6(42.9%)6(42.9%)8(57.1%)8(57.1%)1414NSNS
Nephropathy6(35.3%)6(35.3%)11(64.7%)11(64.7%)17170.0050.005
Table(1)Baseline characteristics of patients with healed and unhealed ulcers
![Page 23: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/23.jpg)
VariableHealed( n=31)Unhealed n=19TotalP-value Sever neuropathy(n %4(30.7%)9(69.3%)130.018ABI0.93±0.050.75±0.090.86±0.80.000Colour change (n%)1(10%)9(90.0%)100.001Superficial infection8(53.3%)7(46.7%)15NSDeep infection2(20%)8(80%)100.007Ulcer site:
For foot10(32.2%)3(15.8%)13NSMid foot4(12.9%)4(21%)8NSHind foot6(19.3%)7(36.8%)13NSToes8(25.8%)4(21%)12NSDorsum3(9.6%)1(5.2%)4NS
Ulcer extent0.009 1-5cm23(76.7%)7(23.3%)30
>5cm8(40.0%)12(60.0%)20Ulcer duration
0.001 <1 week15(88.3%)2(11.7%)171 week-3months13(68.4%)6(31.6%)19>3 months3(21.4%)11(78.6%)14
Table(2)Baseline characteristics of ulcer examination and relation to healing
![Page 24: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/24.jpg)
VariableHealedUnhealed Totalp. value Ulcer depth (n%)
0.005Grade.116(88.9%)2(11.1%)18Grade.213(54.2%)11(45.8%)24Grade.32(25.0%)6(75.0%)8
Texas class. (n%)1A+2A21(84%)4(16%)250.0012D+3D1(10.0%)9(90.0%)100.001
Wagner class. (n%):
0.001Grade 116(88.9%)2(11.1%)18Grade 213(59.1%)9(40.9%)22Grade 32(20%)8(80%)10
Base line characteristics of ulcer examination and relation to healing (cont.)
![Page 25: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/25.jpg)
Table (3) aboratory data and relation to healing VariableUnHealed n=19Healed n=31P-value
Urea mmol/L8.09 ± 2.636.68 ± 1.94NS
S.Creatinine umol/L206.63 ± 165.5093.36 ± 36.600.001
Cr.Clearance ml/min56.25 ± 32.0792.53 ± 27.180.000
24 hr protein in urine mg/l442.42 ± 226.22229.71 ± 149.420.000
WBCS k/ul11.39 ± 3.907.33 ± 2.040.000
Hgb gm/dl10.11 ± 1.7311.62 ± 1.080.004
Platelets k/ul247.00 ± 28.93235.10 ± 27.07NS
Hb A1c H%12.88 ± 2.038.06 ± 0.990.008
Serum albumin g/l26.28 ± 5.8730.69 ± 4.370.004
Bilirubin umol/l11.31 ± 3.0510.97 ± 2.61NS
ALT Iu/l20.31 ± 4.8115.72 ± 6.20NS
AST Iu/l18.03 ± 6.4616.65 ± 5.95NS
S. Cholest mg/dl228.47 ± 67.16189.39 ± 45.350.010
TG mg/dl162.56 ± 40.69139.42 ± 87.640.000
HDLmg/dl37.49 ± 8.0743.15 ± 8.600.000
LDLmg/dl113.42 ± 29.7895.92 ± 16.140.048
![Page 26: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/26.jpg)
Predictor variablePredictor variableOutcome: Outcome: unhealingunhealing
Sig.Sig.OROR95.0%C.I.95.0%C.I.
Duration of diabetes: > 10 yrsDuration of diabetes: > 10 yrs0.008*0.008*2.162.161.02-2.611.02-2.61
Male sexMale sex0.024*0.024*1.111.111.03-2.861.03-2.86
Sever p.neuropathySever p.neuropathy0.012*0.012*1.131.130.89-1.460.89-1.46
Texas grade 2D, 3DTexas grade 2D, 3D0.004*0.004*1.241.241.15-3.241.15-3.24
Wagner grade-3Wagner grade-30.005*0.005*1.181.181.09-2.981.09-2.98
>3 months Ulcer duration>3 months Ulcer duration0.013*0.013*1.121.121.33-2.851.33-2.85
ABI< 0.8ABI< 0.80.006*0.006*1.161.161.05-2.681.05-2.68
Table (4)Multivariate regression analysis of predictor variables towards unhealing.
![Page 27: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/27.jpg)
![Page 28: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/28.jpg)
Case (1)Case (1)
![Page 29: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/29.jpg)
Case (2)Case (2)
![Page 30: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/30.jpg)
Case (3)Case (3)
![Page 31: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/31.jpg)
Case 4
![Page 32: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/32.jpg)
Case 5
![Page 33: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/33.jpg)
Case 6
![Page 34: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/34.jpg)
Unhealed cases Unhealed cases
![Page 35: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/35.jpg)
Conclusion In conclusion, the major findings from this
study are, male sex, duration of diabetes ≥10years, sever pripheral neuropathy, ulcer duration>3month,Wagner grade3,Texas grade2D,3D and limb ischemia as ABI<0.8 independently predict poor outcome (unhealing) of diabetic foot ulcer .
![Page 36: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/36.jpg)
ReferencesReferences1-Abbot CA , Carrington AL Ashe H ,1-Abbot CA , Carrington AL Ashe H , BathsBaths , , every l.c Giriffiths J , HannAW,every l.c Giriffiths J , HannAW, HussainA , JacksonN , Johnson KE . RyderHussainA , JacksonN , Johnson KE . Ryder CH , Tor kingtonR , van Ross ER ,CH , Tor kingtonR , van Ross ER , WALLEY AM , WIDDOWS P , Williamsons , Boulton AJ : WALLEY AM , WIDDOWS P , Williamsons , Boulton AJ :
The north The north –– west diabetes foot care study : inciderce of , and risk factors for new west diabetes foot care study : inciderce of , and risk factors for new diabetic foot ulceration in acommunity . based patient cohort . Diabet Med 2002 , diabetic foot ulceration in acommunity . based patient cohort . Diabet Med 2002 , 19:377-389 .19:377-389 .
2-Boulton AJ , kirsner RS , vileikytel2-Boulton AJ , kirsner RS , vileikytel : clinical practice: neuropathic diabetic foot : clinical practice: neuropathic diabetic foot ulcers . NE ngl J Med 2004 , 351ulcers . NE ngl J Med 2004 , 351:48-55 3-3:48-55 3-3
3-Nabuvrs- Franssen M H, Huijberts MS, Nieuwenhuijzn kruseman A C , 3-Nabuvrs- Franssen M H, Huijberts MS, Nieuwenhuijzn kruseman A C , Willems J, schaper N C ,Willems J, schaper N C , health- related quality of life of diabetic foot ulcer patients health- related quality of life of diabetic foot ulcer patients and their caregivers . Diabefologia 2005 48 : 1906-1910and their caregivers . Diabefologia 2005 48 : 1906-1910
4-prompersl , Huijberts M, Apelqvist J4-prompersl , Huijberts M, Apelqvist J : optimal organization of heath care : optimal organization of heath care indiabetic foot diseaseindiabetic foot disease
introduction to the eurodiale study . intj low extreme wounds 2007 6:11-17introduction to the eurodiale study . intj low extreme wounds 2007 6:11-17
6- Singh N , Armstrong DG , lipsky BA :6- Singh N , Armstrong DG , lipsky BA : preventing foot ulcers in patients with preventing foot ulcers in patients with diabetes JAMA 2005 293 : 217-228diabetes JAMA 2005 293 : 217-228
![Page 37: Predictors of the outcome of diabetic foot ulcer at Assiut university hospital](https://reader035.vdocument.in/reader035/viewer/2022081514/554b31eeb4c905d3088b5091/html5/thumbnails/37.jpg)