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Prevention of Excessive Anticoagulation from WarfarinSTARTER PACK – WEBINAR #1
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Why is it important to reduce the incidence of excessive INRs?
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What is “Excessive Anticoagulation”?
• No national definition• No CMS PfP standard definition• Some HIIN’s define it as an INR > 5, some INR > 6• Great Lakes defines it as an INR > 6
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Why Excessive INR Reduction?
• Key Statistics– 150,000 hospital acquired excessive INRs annually – At an average of $8,000 per ADE, this equals $1.2B– 2004 study by Bond (2004):
• 26,000 inpatient deaths annually in Medicare population…no pharmacy involvement
Bond and Raehl, Pharmacist-provided anticoagulation management in United States hospitals: death rates, length of stay, Medicare charges, bleeding complications, and transfusions, Pharmacotherapy, 24:953-963, 2004. Retrieved at https://www.ncbi.nlm.nih.gov/pubmed/15338843
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How does an high INR cost money?
• Delayed discharges• Lab costs• Bleeding related costs
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Can we prevent excessive INRs, or… it is just a “cost of doing business”?
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Can It Be Done?
• Large Indiana hospital reduced high INRs by > 50%
• Standard work• Standard labs• Pharmacist-driven monitoring and orders
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Can It Be Done?
• Rural Kentucky hospital reduced high INRs by > 50%
• Standard work• Standard labs• Pharmacist-driven monitoring and orders
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And in 2016…
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• Hospital based pharmacists reported that pharmacy driven warfarin management:– Reduced sub-therapeutic INRs (55% to 39%, RR 29%)– Reduced supra-therapeutic INRs > 5 (3.7% to 2.6%, RR 30%)– Reduced time to achieve therapeutic range by 0.5 days– Did increase supra-therapeutic INRs 3.5 – 4.9 (13% to 19%,
RI 46%)
Downing, Mortimer, and Hiers, Impact of a pharmacist-driven warfarin management protocol on achieving therapeutic International Normalized Ratios. AJHSP, 73(5 Supp 1): S69-S73. Retrieved at http://www.ajhp.org/content/73/5_Supplement_1/S69/tab-e-letters
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Can It Be Done?
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Getting Started
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Project Goal
• HIIN goal: 20% reduction in excessive INR events
• Great Lakes is one of 16 HIINs working to achieve this bold goal!
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First Things First
• Ask:• Are we ready?• Is there urgency?• Is there leadership
support?• Who owns this effort?• What resources are
needed?• What if we are not ready
for full-scale change?• Assess the readiness
before you proceed
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Establishing Your Team
• Successful teams are multi-disciplinary• Who do you need on your team?
• Executive Champion – senior leader who will provide support
• Team Leader – a person with authority to test the change ideas
• Team Members – pharmacists, physicians, nursing, lab specialists, dietary, IT, patient advocate
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Tips for Effective Meetings• Plan ahead
– Set the agenda
– Gather data/materials
– Do pre-work
• Be brief– there is no rule that says a
meeting needs to last an hour!
• Timed Agenda• “Parking Lot”• Take “actionable” minutes• FOLLOW UP
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Best PracticesWHAT WORKS
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Summary of Best Practices
• Engage patients and families• Make it easy to find the data and underlying
themes of failures• Pharmacy management of warfarin dosing• Pharmacy tracks and trends all INRs
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Summary of Best Practices (continued)
• All patients have INR drawn upon admission, even if chronically taking warfarin
• All patients on warfarin get daily INRs drawn• Identify all drug-drug interactions and dietary
preferences• Identify patients not suited for warfarin therapy
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Engage Patients and Families
• Explain risks/benefits/alternative• Listen to, respect, understand and respond to
patient concerns• Identify work or hobby related risk factors• Identify mobility challenges and fall risks• Seek barriers to medication management and
ability to obtain regular INRs once discharged
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Make it easy to find the data and underlying themes of failures• How often do you find a patient has an INR > 6
from anything other than warfarin?• Do you really need to verify each event by
opening the chart?• Open a patient's chart to:
– Validate…Look at 10 in depth and verify that at least 9 patients are/were receiving warfarin
– While looking at those 10….look for themes…what is causing most cases of high INRs in your facility?
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Pharmacy Management of Warfarin Dosing
• Becoming more common• Pharmacy students are learning it• Pharmacists on the job for years are learning it
– ClotCare.org, Anticoagulation Training Programs. Retrieved at: http://clotcare.org/anticoagtrainingprograms.aspx
• Data shows as good and often is better than “best usual care” (physician management)
Key Resources: Wong (2010), Donovan (2006), and Merrens (2008)
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Warfarin Tampering: Process Capability 60%
Adapted from Brent James MD / Courtesy of Larry Staker MD/ Dimitri Lerner, PharmD UCSD
2.5 3.04.1 2.5 3.55.0 4.03.03.3 3.0
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3.0
6
5
4
3
2
1
Warfarin Untampered: Process Capability 94%Adapted from Brent James MD / Courtesy of Larry Staker MD / Dimitri Lerner, PharmD UCSD
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• Infrastructure:– Mandatory order sets: steer providers toward
involving pharmacist• Contains all required elements: indication, goal of tx,
monitoring
– Standardized initiation• Baseline labs• Dosing guidelines/nomograms• Previous warfarin history• Problem list/DDI screen• Bleeding risk assessment
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Warfarin Dosing by Pharmacy
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Initial Dosing: Decision Support
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Warfarin Adjustment
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Pharmacists track and trend all INRs
• If the organization is not yet ready for pharmacist driven warfarin management then:
• Partner with the physicians– Track and trend all INRs– It makes a difference when pharmacists do it
Key Resources: Metersky (2016)
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All patients have INR drawn upon admission, even if chronically taking warfarin• Many things are different when admitted
– Usually ill, often quite ill – Catabolic; low albumin levels– New medications and antibiotics– Different diet
Key Resources: Metersky (2016)
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All patients on warfarin get daily INRs drawn
• And after the patients have been admitted…more happens...– More medications, especially antibitoics– More catabolic; dropping albumin levels– They might not eat their greens! (Or it might be the
first time they’ve been served them in a long time!)– Dosing anomalies– Loading
Key Resources: Metersky (2016)
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Identify all drug-drug interactions and dietary preferences• The DDI interactions you already check for
– Do you use a system?– How many do you identify? How many do you miss?
• Do you know if the patient is eating or not?• Or what the patient is eating…more Vit K, less Vit ?• Some systems (UC San Diego) feed this data to the
pharmacist through the EHR
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The UCSD Warfarin Pharmacy Flowsheet
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The UCSD Warfarin Pharmacy Flowsheet
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Identify patients not suited for warfarin therapy• Significant potential drug-drug interactions • Significant and inconsistent warfarin-diet
interactions• Fall/bleeding risk…is the benefit of any
anticoagulant worth the risk?• Likely barriers to regular INR tests
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Develop Your Learning Loop
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PDSA…PDSA...PDSA...
• Small tests of Change/Rapid Cycle
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Learning Loop Ideas
• Invite champion pharmacists and physicians• Support the training of pharmacists • Co-manage a few patients with the pharmacist
driving the decisions• Look at the results• Compare pharmacist managed “in range” INRs
(test group) with physician managed (control group)
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Keep Learning as You Spread
Few Unit Whole Hospital Outpatients
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Key Resources for More Information
• Anticoagulation Agent Adverse Drug Event Gap Analysis Retrieved at: http://www.mnhospitals.org/Portals/0/Documents/ptsafety/ade/Medication-Safety-Gap-Analysis-Anticoagulation-Agent.pdf
• AHA/HRET HEN 2.0 Adverse Drug Event Change Package Retrieved at: http://www.hret-hen.org/topics/ade/HRETHEN_ChangePackage_ADE.pdf
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Key Resources for Information on Pharmacy Driven Warfarin Management
• Donovan, J., Drake, J., Whittaker, P., et al, Pharmacy-managed anticoagulation: Assessment of in-hospital efficiency and evaluation of financial impact and community acceptance, Journal of Thrombosis and Thrombolysis, 22:23-30, 2006. Retrieved at: http://link.springer.com/article/10.1007/s11239-006-8328-9
• Merrens, E. J., DiPaola, C. A., MacKenzie, T., Effect of an Inpatient Anticoagulation Service on Improving the Safe Use of Warfarin Sodium, Society of Hospital Medicine Annual Meeting, 2008. Retrieved at: http://www.shmabstracts.com/abstract/effect-of-an-inpatient-anticoagulation-service-on-improving-the-safe-use-of-warfarin-sodium/
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Key Resources for Information on Pharmacy Driven Warfarin Management
• Metersky, M. L., Eldridge, N., Wang, Y., et al, Predictors of warfarin-associated adverse events in hospitalizes patients: Opportunities to prevent patient harm, Journal of Hospital Medicine, 11:276-282, 2016. Retrieved at: https://www.ncbi.nlm.nih.gov/pubmed/26662851
• Wong et al, Efficacy and safety of a pharmacist-managed inpatient anticoagulation service for warfarin initiation and titration, J Clinical Pharmacy and Therapeutics, 2010. Retrieved at: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2710.2010.01216.x/full
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Understanding the MeasuresHOW WILL YOU KNOW THAT YOU’RE MAKING A DIFFERENCE?
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ISMP Trigger Alert List
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Gap AnalysisWHAT IT IS AND HOW YOU USE IT
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What is the Current State of Excessive INR Prevention?
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What and How
• A tool that will help you understand what’s currently in place and not in place in your facility
• Check items that are in place
• Prioritize gaps based on learnings
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Excessive INR Reduction Gap Analysis
• Domains– Contact info– Foundation– HIT– Best practices– Help
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Your First/Next StepsGET GOING
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Stop Talking. Start Doing.
• Perform your Gap Analysis• Access the Resources provided
- make notes and ask questions
• View Webinar #2– How to engage and involve
stakeholders– Learn about PDSA and
Small Tests of Change• Decide the next level of HIIN
support– Onsite assistance– Improvement Action
Network– Other
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“The way to get started is to quit talking and begin doing.”
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Where to find the Resources
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