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Page 1: Short-Acting Intrathecal Opioids Fentanyl / Sufentanil

Short-Acting Intrathecal Opioids Fentanyl / Sufentanil

• Improves intraoperative analgesia1–4

• ↓ Local anesthetic doses → ↓ hypotension 2,4

• ↓ Intraoperative nausea and vomiting3,4

• ↓ Shivering RR = 0.264

• ↑ Pruritus RR = 11.74; dose-related3–5

May induce subtle acute tolerance6

Optimal fentanyl dose: 10–15 µg3,7

Series1

4%

24%

LA + IT opioids

LA alone1. Dahlgren, Anesth Analg 1997;85:1288-93

2. Ben-David, Reg Anesth Pain Med 2000;25:235-9

3. Dahl, Anesthesiology 1999;91:1919-27

4. Pöpping, Pain 2013;154(8):1383-90

5. Palmer, Reg Anesth 1995;20:389-94

6. Carvalho, Int J Obstet Anesth 2012;21:29-34

7. Hunt, Anesthesiology 1989;71:535-40 Intraoperative Pain (% patients)1,3

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