short-acting intrathecal opioids fentanyl / sufentanil
DESCRIPTION
Short-Acting Intrathecal Opioids Fentanyl / Sufentanil. Improves intraoperative analgesia 1–4 ↓ Local anesthetic doses → ↓ hypotension 2,4 ↓ Intraoperative nausea and vomiting 3,4 ↓ Shivering RR = 0.26 4 ↑ Pruritus RR = 11.7 4 ; dose-related 3–5 M ay induce subtle acute tolerance 6 - PowerPoint PPT PresentationTRANSCRIPT
Short-Acting Intrathecal Opioids Fentanyl / Sufentanil
• Improves intraoperative analgesia1–4
• ↓ Local anesthetic doses → ↓ hypotension 2,4
• ↓ Intraoperative nausea and vomiting3,4
• ↓ Shivering RR = 0.264
• ↑ Pruritus RR = 11.74; dose-related3–5
May induce subtle acute tolerance6
Optimal fentanyl dose: 10–15 µg3,7
Series1
4%
24%
LA + IT opioids
LA alone1. Dahlgren, Anesth Analg 1997;85:1288-93
2. Ben-David, Reg Anesth Pain Med 2000;25:235-9
3. Dahl, Anesthesiology 1999;91:1919-27
4. Pöpping, Pain 2013;154(8):1383-90
5. Palmer, Reg Anesth 1995;20:389-94
6. Carvalho, Int J Obstet Anesth 2012;21:29-34
7. Hunt, Anesthesiology 1989;71:535-40 Intraoperative Pain (% patients)1,3