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1dr. Noza Hilbertina, M.Biomed, SpPA
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Tumor : pembengkakan yg abnormal Kedokteran
modern
Neoplasma
2dr. Noza Hilbertina, M.Biomed, SpPA
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Neoplasia = neoplasma = pertumbuhan baru
an abnormal mass of tissue the growth of which exceeds and is
uncoordinated with that of the normal tissues
persists in the same excessive manner after cessation of the stimuli which evoked the change (Willis : British oncologist)
3dr. Noza Hilbertina, M.Biomed, SpPA
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Oncology : oncos (yunani) = tumor ilmu yang mempelajari ttg tumor
Kanker : istilah umum untuk tumor ganas Crab (latin)
Tumor berasal dari transformasi neoplastik dari sel yang berinti di dlm tubuh
Sel neoplastik = sel-sel yang telah bertransformasi
4dr. Noza Hilbertina, M.Biomed, SpPA
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Transformasi melibatkan serangkaian perubahan genetik lolos dari mekanisme pengaturan pertumbuhan normal secara permanen
Proliferasi sel yang berlebihan dan tidak teratur
OTONOM5dr. Noza Hilbertina, M.Biomed, SpPA
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Perangai tumor : jinak, ganas Histogenetik : sel asal tumor
PENTING UNTUK MERENCANAKAN PENATALAKSANAAN
6dr. Noza Hilbertina, M.Biomed, SpPA
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Non invasif dan tetap terlokalisir Pertumbuhan lambat Kemiripan histologi dengan jaringan
asal
7dr. Noza Hilbertina, M.Biomed, SpPA
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Invasif shg dpt menyebar secara langsung atau mlli metastasis
Pertumbuhan relatif cepat Gambaran histologis lebih bervariasi
dibandingkan dengan jaringan asal
8dr. Noza Hilbertina, M.Biomed, SpPA
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Tumor borderline : histologi intermediet antara jinak dan ganas
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Karakteristik Jinak GanasDiferensiasi /anaplasia
Diferensiasi baik/typical
Kurangnya diferensiasi/atypical
Derajat pertumbuhan
Progresif, lambat, menetap atau regresi, mitosis jarang
Lambat-cepat, byk mitosis
Invasi lokal Kohesif, ekspansif, batas tegas, tdk menginfiltrasi/invasi jar sktr
Invasif lokal, infiltrasi jar sktr
Metastasis Absen Sering terjadidr. Noza Hilbertina, M.Biomed, SpPA 10
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Berdasarkan sel asal Ditentukan secara histologi Dapat di grade kan bdsrkan kemiripan
histologi dg jar asal Grade histologi berkorelasi dg perangai
klinis tumor
11dr. Noza Hilbertina, M.Biomed, SpPA
KLASIFIKASI WHO
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Kelenjar normal
Adenoma
Adenokarsinoma grade II
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Sel epitel : sel skuamosa, sel transisional, sel basal, sel galndular
Jaringan penyambung : otot polos, otot lurik, jar lemak, p. darah, tulang, kartilago, mesothel, synovium
Organ limfoid dan hematopoitik
13dr. Noza Hilbertina, M.Biomed, SpPA
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Masing-masing nama tumor menunjukkan karakteristik tersendiri (term of cause, appearance and behaviour)
Diagnosis dan penamaan yang akurat sgt penting tatalaksana optimal
14dr. Noza Hilbertina, M.Biomed, SpPA
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-----OMA Tumor epitel jinak : ---- papilloma,
adenoma Tumor jar penyambung jinak : prefix = sel
asal tumor---oma Tumor epitel ganas : karsinoma Tumor jar penyambung ganas : sarkoma Sel darah : ----Aemia (Leukaemia) kecuali anemia ; bukan neoplastik
15dr. Noza Hilbertina, M.Biomed, SpPA
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TIPE JINAK GANASEPITELIALSquamous cell Squamous cell
papillomaSqumous cell carcinoma
TransisionalBasal cellGlandular Adenoma Adenocarcinoma MESENCHYMALSmooth muscle leiomyoma Leiomyosarcoma Striated muscleAdipose tissueBlood vessel Angioma Bone Osteosarcoma CartilageMesotheliumSynovium Synovioma
16dr. Noza Hilbertina, M.Biomed, SpPA
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Feature Carcinoma SarcomaAsal Epitelial Jar
PenyambungPerangai Ganas GanasFrekuensi Sering JarangRute Metastasis tersering
Limfe Darah
Fase in-situ (+) (-)Kelompok Usia
Biasanya > 50 thn
Biasanya < 50 thndr. Noza Hilbertina, M.Biomed, SpPA 17
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Berdasarkan org yg pertama kali mengenali atau
menjelaskan deskripsi tumor ttt. Burkitt’s lymphoma Ewing’s sarcoma Grawitz tumour Wilm’s tumour
18dr. Noza Hilbertina, M.Biomed, SpPA
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Melanoma : tumor ganas melanosit Lymphoma : tumor ganas sel limfoid Myeloma ; tumor ganas sel plasma
MALIGNANT ------------------------
19dr. Noza Hilbertina, M.Biomed, SpPA
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Granuloma Tuberkuloma Atheroma Mycetoma
20dr. Noza Hilbertina, M.Biomed, SpPA
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TERATOMA : neoplasma yg dibentuk oleh sel yang menunjukkan ketiga lapis sel germinal : ectoderm, mesoderm, endoderm
TUMOR EMBRYONAL (---blastoma) : retinoblastoma, neuroblastoma, hepatoblastoma.
TUMOR CAMPUR : kombinasi tipe sel spt pleomorfik adenoma, fibroadenoma, carsinosarcoma
21dr. Noza Hilbertina, M.Biomed, SpPA
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APUDomas DAN TUMOR KARSINOID APUD = Amine content and/or Precursor
Uptake and Decarboxylation) sel dari sistim endokrin diffusa spt sel C dari kelj tiroid, sel islet langerhans.
HAMARTOMAS : tumour-like lesion, selalu jinak, tdr dr dua atau lebih tipe sel matur yg secara normal ditemukan di organ tempat lesi tsb berasal
22dr. Noza Hilbertina, M.Biomed, SpPA
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KISTA : ruang terisi cairan dan di lapisi oleh epitel
Tipe-tipe kista :- Kongenital : kista branchial, thyroglossal- Neoplastik : cystadenoma, cystadenocarcinoma- Parasitik : kista hydatid ec Echinococcus
granulosus- Retensi : kista epidermoid, kista pilar- Implantasi : akibat pembedahan atau
implantasi accidental dr epidermis23dr. Noza Hilbertina, M.Biomed, SpPA
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General And Systematic Pathology : Edited JCE Underwood, Churchill Livingstone, Toronto, 2004
Robbins and Cotran Pathologic Basis of Disease : Kumar, Abbas, Fausto, Elseviers Saunders, 2009
Pathology Illustrated : Peter S Macfarlene, Churchill Livingstone, Toronto, 2000
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