TheBrain-GutConnectionAndHowYourBrainIsUnderAttack24/7ByDr.LindseyBerkson
3HumanBrains:
1. One:insideyourhead2. Two:EntericNervousSysteminsideYourGut
3. Three:YourMicrobiome(microbiallife—viral,fungalandbacteria)insideyourgutbutactuallyalsolivethroughoutyourbodyinbiomes
GutandBrain:samestart.
• NeuralCrestinthewombsplitsinhalf.• Halfgoestobrain• Otherhalftothegut.• Sametissue.• Withsemipermeablesurroundingbarrier.
It’snowthoughtthatthemicrobiomeisrunningtheshow.Letmetellyouwhy.Insidethehumanbody:
• Thereare1%genesofhumancells.• But99%genesofmicrobialcells.
Begsthequestion:Who’shostingwhom?
• Microbiota-gut-brainaxisisreal.• CurrNeurolNeurosciRep.2017Oct17;17(12):94.Microbiota-Brain-GutAxis
andNeurodegenerativeDiseases.
• Researchhasincriminatedadisturbedgutmicrobiotainanumberofcentralnervoussystemdisorders,includingParkinson'sdisease.
• Healthyseniorshaveyoungmicrobiota.• CellMolLifeSci.2017Oct14.Gutmicrobiotachangesintheextreme
decadesofhumanlife:afocusoncentenarians.
• Unhealthygutandmicrobiotaincreaseriskofdepressionandanxietyandstressworsensguthealthoverall.
• JNeuroendocrinol.2017Oct12.Steroids,Stress,andtheGutMicrobiome-BrainAxis.
Gutaffectsglobalhealth.
• Accumulatingdatasuggestthatalteredcommunicationbetweengutmicrobiotaandhostsystemscouldparticipateindisorderssuchasobesity,diabetesmellitus,andautoimmunedisordersaswellasneuropsychiatricdisorders,includingautism,anxiety,andmajordepressivedisorders.
Yourgutandbrainaxisis“bi”andhasconstantcross-talk.
• Complexandbi-directionalnetworksbetweengastrointestinalmicrobiotaandtheirhost.
• Communicationpathwaysbetweengutmicrobiotaandthecentralnervoussystemcouldincludeautonomic,neuroendocrine,enteric,andimmunesystems,withpathologyresultingindisruptiontoneurotransmitterbalance,increasesinchronicinflammation,orexacerbatedhypothalamic-pituitary-adrenalaxisactivitywhichisreallyhowadrenalfatiguestartsorevenis.
Fixingthegutmightbepartoftheansweroffixingyourmoods.
• BiolPsychiatry.2017Aug30.pii:S0006-3223(17)31902-9.HarnessingGutMicrobesforMentalHealth:GettingFromHeretoThere.
5ConnectorsofGut-BrainAxis
1. Vagusnerve(oxytocin,otherhormones,soy,rhubarb,dandelionroot,pintobeans,pomegranate,magnesium,zinc)
• GutsendsmoremessagestothebrainviatheVagusnervethanthebraindoes
• tothegut.
• Gutfeelings.• Gutwallisonesinglecellnexttoneurotransmittersandblood,sowhatfeeds• Gutissueslinkedtomoodissues.Forexample,peoplewithfoodallergies• havemoreanxietyandmoodissuesthanpeoplewithoutmoodissues.
Foodallergiescausemoodchanges:Hepatogastroenterology.1998Sep-Oct;45(23):1559-64.Anxietyanddepression:acommonfeatureofhealthcareseekingpatientswithirritablebowelsyndromeandfoodallergy.
• OxytocinmainhormoneofVagusnerve.• Oxytocincanbedisruptedlikeanyotherhormone.Pitocincreatingan
epidemicofmoreanxiouskids?ADHD?
2. SexsteroidHormones(SEXYBRAIN–runyourbrain,alongwithyour
microbiallife(testosterone,estrogen,progesterone,zinc,magnesium,iodine,Bvitamins,taurine,tryptophan)
3. Nutrients–vitaminA,zinc,glutamine,shortchainfattyacids
4. Neuropeptides–neurotransmitters,guthormones
5. Gatekeepers–gutbarrier,bloodbrainbarrier(hormones,nutrients)MajorBrainEnemies
• Unhealthygut• FoodAllergies• Sugar–reducesbloodcirculationtobrain,reducesvolume• Obesity–cytokinesreducevolume• NSAIDs–blockprogesterone–reducevolume• HormoneAlteringChemicals–blockthesupportivehormones• Stress–increasecortisolblockotherhormones• Sedentarylifestyle–reducecirculationandfitnessevenofbrain• Nutrientdeficiencies–zincforexample,magnesium• Nicotine• ExcessiveAlcohol•
Thebasisofthegut-brainaxiscomprisesanarrayofmulti-traffickingpathways.Microorganisms.2017Oct12;5(4).pii:E66.TheGutMicrobiomeFeelingsoftheBrain:APerspectiveforNon-Microbiologists.
Perturbationsofthegutmicrobialcommunityhavealreadybeenimplicatedinmultiplehostdiseasessuchasobesity,diabetes,andinflammation,whilerecentevidencesuggestsapotentialroleofthemicrobiota-gut-brainaxisinneuropsychiatricdisorders,suchasdepressionandanxiety.BrainBehavImmun.2017Jan25.pii:S0889-1591(17)30016-8.Microbesandmentalhealth:Areview.Chronicpainmaybesecondarytoimbalanceofgut-brain-microbiotahealth.HandbExpPharmacol.2017;239:269-287.TheRoleoftheGastrointestinalMicrobiotainVisceralPain.Bonehealth–microbiomehealthJClinEndocrinolMetab.2017Oct1;102(10):3635-3646.AssociationBetweenGutMicrobiotaandBoneHealth:PotentialMechanismsandProspective.DiseaseMicrobialsignaturesBulimia,Alzheimer’sandmore.JClinDiagnRes.2017Aug;11(8):KC01-KC05.Anti-AlzheimerPropertiesofProbiotic,LactobacillusplantarumMTCC1325inAlzheimer'sDiseaseinducedAlbinoRats.AutismNeuroscience.2016Jun2;324:131-9.Themicrobiota-gut-brainaxisanditspotentialtherapeuticroleinautismspectrumdisorder.
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