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The Brain-Gut Connection And How Your Brain Is Under Attack 24/7 By Dr. Lindsey Berkson 3 Human Brains: 1. One: inside your head 2. Two: Enteric Nervous System inside Your Gut

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Page 1: The Brain-Gut Connection - Dr. Lindsey Berkson · 3. Three: Your Microbiome (microbial life—viral, fungal and bacteria) inside your gut but actually also live throughout your body

TheBrain-GutConnectionAndHowYourBrainIsUnderAttack24/7ByDr.LindseyBerkson

3HumanBrains:

1. One:insideyourhead2. Two:EntericNervousSysteminsideYourGut

Page 2: The Brain-Gut Connection - Dr. Lindsey Berkson · 3. Three: Your Microbiome (microbial life—viral, fungal and bacteria) inside your gut but actually also live throughout your body

3. Three:YourMicrobiome(microbiallife—viral,fungalandbacteria)insideyourgutbutactuallyalsolivethroughoutyourbodyinbiomes

GutandBrain:samestart.

• NeuralCrestinthewombsplitsinhalf.• Halfgoestobrain• Otherhalftothegut.• Sametissue.• Withsemipermeablesurroundingbarrier.

It’snowthoughtthatthemicrobiomeisrunningtheshow.Letmetellyouwhy.Insidethehumanbody:

• Thereare1%genesofhumancells.• But99%genesofmicrobialcells.

Begsthequestion:Who’shostingwhom?

• Microbiota-gut-brainaxisisreal.• CurrNeurolNeurosciRep.2017Oct17;17(12):94.Microbiota-Brain-GutAxis

andNeurodegenerativeDiseases.

• Researchhasincriminatedadisturbedgutmicrobiotainanumberofcentralnervoussystemdisorders,includingParkinson'sdisease.

• Healthyseniorshaveyoungmicrobiota.• CellMolLifeSci.2017Oct14.Gutmicrobiotachangesintheextreme

decadesofhumanlife:afocusoncentenarians.

• Unhealthygutandmicrobiotaincreaseriskofdepressionandanxietyandstressworsensguthealthoverall.

• JNeuroendocrinol.2017Oct12.Steroids,Stress,andtheGutMicrobiome-BrainAxis.

Gutaffectsglobalhealth.

• Accumulatingdatasuggestthatalteredcommunicationbetweengutmicrobiotaandhostsystemscouldparticipateindisorderssuchasobesity,diabetesmellitus,andautoimmunedisordersaswellasneuropsychiatricdisorders,includingautism,anxiety,andmajordepressivedisorders.

Yourgutandbrainaxisis“bi”andhasconstantcross-talk.

• Complexandbi-directionalnetworksbetweengastrointestinalmicrobiotaandtheirhost.

Page 3: The Brain-Gut Connection - Dr. Lindsey Berkson · 3. Three: Your Microbiome (microbial life—viral, fungal and bacteria) inside your gut but actually also live throughout your body

• Communicationpathwaysbetweengutmicrobiotaandthecentralnervoussystemcouldincludeautonomic,neuroendocrine,enteric,andimmunesystems,withpathologyresultingindisruptiontoneurotransmitterbalance,increasesinchronicinflammation,orexacerbatedhypothalamic-pituitary-adrenalaxisactivitywhichisreallyhowadrenalfatiguestartsorevenis.

Fixingthegutmightbepartoftheansweroffixingyourmoods.

• BiolPsychiatry.2017Aug30.pii:S0006-3223(17)31902-9.HarnessingGutMicrobesforMentalHealth:GettingFromHeretoThere.

5ConnectorsofGut-BrainAxis

1. Vagusnerve(oxytocin,otherhormones,soy,rhubarb,dandelionroot,pintobeans,pomegranate,magnesium,zinc)

• GutsendsmoremessagestothebrainviatheVagusnervethanthebraindoes

• tothegut.

Page 4: The Brain-Gut Connection - Dr. Lindsey Berkson · 3. Three: Your Microbiome (microbial life—viral, fungal and bacteria) inside your gut but actually also live throughout your body

• Gutfeelings.• Gutwallisonesinglecellnexttoneurotransmittersandblood,sowhatfeeds• Gutissueslinkedtomoodissues.Forexample,peoplewithfoodallergies• havemoreanxietyandmoodissuesthanpeoplewithoutmoodissues.

Foodallergiescausemoodchanges:Hepatogastroenterology.1998Sep-Oct;45(23):1559-64.Anxietyanddepression:acommonfeatureofhealthcareseekingpatientswithirritablebowelsyndromeandfoodallergy.

• OxytocinmainhormoneofVagusnerve.• Oxytocincanbedisruptedlikeanyotherhormone.Pitocincreatingan

epidemicofmoreanxiouskids?ADHD?

2. SexsteroidHormones(SEXYBRAIN–runyourbrain,alongwithyour

microbiallife(testosterone,estrogen,progesterone,zinc,magnesium,iodine,Bvitamins,taurine,tryptophan)

3. Nutrients–vitaminA,zinc,glutamine,shortchainfattyacids

4. Neuropeptides–neurotransmitters,guthormones

5. Gatekeepers–gutbarrier,bloodbrainbarrier(hormones,nutrients)MajorBrainEnemies

• Unhealthygut• FoodAllergies• Sugar–reducesbloodcirculationtobrain,reducesvolume• Obesity–cytokinesreducevolume• NSAIDs–blockprogesterone–reducevolume• HormoneAlteringChemicals–blockthesupportivehormones• Stress–increasecortisolblockotherhormones• Sedentarylifestyle–reducecirculationandfitnessevenofbrain• Nutrientdeficiencies–zincforexample,magnesium• Nicotine• ExcessiveAlcohol•

Thebasisofthegut-brainaxiscomprisesanarrayofmulti-traffickingpathways.Microorganisms.2017Oct12;5(4).pii:E66.TheGutMicrobiomeFeelingsoftheBrain:APerspectiveforNon-Microbiologists.

Page 5: The Brain-Gut Connection - Dr. Lindsey Berkson · 3. Three: Your Microbiome (microbial life—viral, fungal and bacteria) inside your gut but actually also live throughout your body

Perturbationsofthegutmicrobialcommunityhavealreadybeenimplicatedinmultiplehostdiseasessuchasobesity,diabetes,andinflammation,whilerecentevidencesuggestsapotentialroleofthemicrobiota-gut-brainaxisinneuropsychiatricdisorders,suchasdepressionandanxiety.BrainBehavImmun.2017Jan25.pii:S0889-1591(17)30016-8.Microbesandmentalhealth:Areview.Chronicpainmaybesecondarytoimbalanceofgut-brain-microbiotahealth.HandbExpPharmacol.2017;239:269-287.TheRoleoftheGastrointestinalMicrobiotainVisceralPain.Bonehealth–microbiomehealthJClinEndocrinolMetab.2017Oct1;102(10):3635-3646.AssociationBetweenGutMicrobiotaandBoneHealth:PotentialMechanismsandProspective.DiseaseMicrobialsignaturesBulimia,Alzheimer’sandmore.JClinDiagnRes.2017Aug;11(8):KC01-KC05.Anti-AlzheimerPropertiesofProbiotic,LactobacillusplantarumMTCC1325inAlzheimer'sDiseaseinducedAlbinoRats.AutismNeuroscience.2016Jun2;324:131-9.Themicrobiota-gut-brainaxisanditspotentialtherapeuticroleinautismspectrumdisorder.

DrLindseyBerkson.com512-507-3279

[email protected]%offaconsultwithmeifyousayyouwereinthe

NeurologySummit.Checkout:Dr.Berkson’sBestHealthRadio

Checkoutmylatestbookonhowtoprotectyourbrainandintimacyintoday’stoxicworld:SEXYBRAIN!Goto

sexybrainsystem.comforfreegifts,tobuythebook,andmore.

Page 6: The Brain-Gut Connection - Dr. Lindsey Berkson · 3. Three: Your Microbiome (microbial life—viral, fungal and bacteria) inside your gut but actually also live throughout your body

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