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Treatment duration and outcomes for male urinary tract infection (UTI)
• Retrospective review of 33,336 patients with index UTI from
Veterans Affairs database (fiscal yr 2009)
• Association between patient/treatment characteristics and outcome
(UTI recurrence and Clostridium difficile infection (CDI) over 12 mo)
for index cases in uni/multivariate analysis
• Antibiotics with highest use:
– Ciprofloxacin 62.7%
– Trimethoprim/sulfamethoxazole 26.8%
Drekonja DM. IDSA 2012 abs.1322
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Treatment duration and outcomes for male urinary tract infection (UTI)
• CDI risk was higher with longer than shorter treatment duration: 0.5% vs 0.3%, P=0.02; OR 1.40; 95% CI 0.96-2.06
Longer antibiotic treatment duration of ≥7 days may be associated with increased late recurrence of UTI and subsequent CDI
Drekonja DM. IDSA 2012 abs.1322
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Relevance of empiric antibiotics for urinary tract infection (UTI) in non-critically ill patients
• Retrospective review of 447 non-critically ill patients with UTI (period June 2010-2011)
• Exclusion: requirement of ICU or inotropes, concurrent other infections• Grouping according to susceptibility of urine cultures to empiric antibiotics
used: comparison for clinical response to antibiotics at day 3-5, in-hospital mortality, length of stay
Lee SY. IDSA 2012 abs.1370
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Relevance of empirical antibiotics for urinary tract infection (UTI) in non-critically ill patients
Since no adverse clinical outcomes are found, choice of antibiotics in non-critically ill patients could be deferred to after culturing results
Lee SY. IDSA 2012 abs.1370
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