Treatment duration and outcomes for male urinary tract infection (UTI)

• Retrospective review of 33,336 patients with index UTI from

Veterans Affairs database (fiscal yr 2009)

• Association between patient/treatment characteristics and outcome

(UTI recurrence and Clostridium difficile infection (CDI) over 12 mo)

for index cases in uni/multivariate analysis

• Antibiotics with highest use:

– Ciprofloxacin 62.7%

– Trimethoprim/sulfamethoxazole 26.8%

Drekonja DM. IDSA 2012 abs.1322

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Treatment duration and outcomes for male urinary tract infection (UTI)

• CDI risk was higher with longer than shorter treatment duration: 0.5% vs 0.3%, P=0.02; OR 1.40; 95% CI 0.96-2.06

Longer antibiotic treatment duration of ≥7 days may be associated with increased late recurrence of UTI and subsequent CDI

Drekonja DM. IDSA 2012 abs.1322

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Relevance of empiric antibiotics for urinary tract infection (UTI) in non-critically ill patients

• Retrospective review of 447 non-critically ill patients with UTI (period June 2010-2011)

• Exclusion: requirement of ICU or inotropes, concurrent other infections• Grouping according to susceptibility of urine cultures to empiric antibiotics

used: comparison for clinical response to antibiotics at day 3-5, in-hospital mortality, length of stay

Lee SY. IDSA 2012 abs.1370

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Relevance of empirical antibiotics for urinary tract infection (UTI) in non-critically ill patients

Since no adverse clinical outcomes are found, choice of antibiotics in non-critically ill patients could be deferred to after culturing results

Lee SY. IDSA 2012 abs.1370

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