Transcript
ASDimpaired brain development BehavioralCognitivephysical abnormalitiessocial interaction
Gut distressdysbiosis of the microbiotainflammatory bowel diseaseObesitycardiovascular disease
INTRODUCTION
Mice and humansocial Emotionalanxiety-like behaviorsbrain development and function
EXPERIMENTAL PROCEDURES(maternal immune activation;MIA)Mice
i.p. on E12.5 with saline or 20 mg/kg poly(I:C)
OffspringBacteroides fragilis
every other day for 6 days at weaning
Intestinal Permeability4 kDa FITC-dextran
Behavioral Testing
MIA Offspring Exhibit GI BarrierDefects
DSS:Dextran sulfate sodium S:saline+vehicleP:poly(I:C)+vehicle