wang chung han. asd impaired brain development behavioral cognitive physical abnormalities social...

Wang Chung Han

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Wang Chung Han

ASDimpaired brain development BehavioralCognitivephysical abnormalitiessocial interaction

Gut distressdysbiosis of the microbiotainflammatory bowel diseaseObesitycardiovascular disease

INTRODUCTION

Mice and humansocial Emotionalanxiety-like behaviorsbrain development and function

Page 3: Wang Chung Han. ASD impaired brain development Behavioral Cognitive physical abnormalities social interaction Gut distress dysbiosis of the microbiota

EXPERIMENTAL PROCEDURES(maternal immune activation;MIA)Mice

i.p. on E12.5 with saline or 20 mg/kg poly(I:C)

OffspringBacteroides fragilis

every other day for 6 days at weaning

Intestinal Permeability4 kDa FITC-dextran

Behavioral Testing

Page 4: Wang Chung Han. ASD impaired brain development Behavioral Cognitive physical abnormalities social interaction Gut distress dysbiosis of the microbiota

MIA Offspring Exhibit GI BarrierDefects

DSS:Dextran sulfate sodium S:saline+vehicleP:poly(I:C)+vehicle

Page 5: Wang Chung Han. ASD impaired brain development Behavioral Cognitive physical abnormalities social interaction Gut distress dysbiosis of the microbiota

MIA Offspring Exhibit Abnormal Expression of Cytokines

Adult colon

Adult small intestines

Page 6: Wang Chung Han. ASD impaired brain development Behavioral Cognitive physical abnormalities social interaction Gut distress dysbiosis of the microbiota

Bacteroides fragilis Improves Gut Barrier Integrity in MIA Offspring

Page 7: Wang Chung Han. ASD impaired brain development Behavioral Cognitive physical abnormalities social interaction Gut distress dysbiosis of the microbiota

Bacteroides fragilis Improves Gut abnormal cytokine in MIA Offspring

Page 8: Wang Chung Han. ASD impaired brain development Behavioral Cognitive physical abnormalities social interaction Gut distress dysbiosis of the microbiota

B. fragilis Treatment AmelioratesAutism-Related Behavioral Abnormalities in MIA Offspring

Page 9: Wang Chung Han. ASD impaired brain development Behavioral Cognitive physical abnormalities social interaction Gut distress dysbiosis of the microbiota

B. fragilis Treatment AmelioratesAutism-Related Behavioral Abnormalities in MIA Offspring

Page 10: Wang Chung Han. ASD impaired brain development Behavioral Cognitive physical abnormalities social interaction Gut distress dysbiosis of the microbiota

ASD Behavioral Testing

Gut Barrier Integrity

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