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Weight Management Gene Expression Science
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Advances in Gene Expression Science Allow Scientists to Compare & Contrast
Expression Patterns of two Biological States
Biological State #1 Biological State #2 State
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Comparison of Genetic Profiles of Adipose Tissue in Identical Twins
Pietiläinen et al. PLoS Med. 2008 Mar 11;5(3):e51.
Same DNA
Different Expression of Genes
Normal Weight Twin Overweight Twin
Compared to their normal weight twin, overweight twins exhibited down regulation of gene expression pathways related to:
• Fat Regulation (storage versus utilization)• Muscle Protein Synthesis
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• Nu Skin owns patented technologies to study anti-aging interventions through gene expression science
• Deep understanding of gene expression science
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Identified Gene Expression Pathways Linked toFat Storage and Fat Metabolism
FAT
ST
OR
AG
E
FAT
BU
RN
LifeGen pre-clinical study of Adipose, Gastrocnemius muslce, Hypothalamus
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Ghrelin
LeptinInsulin
References:
Gene Expression relates to the Appetite Control Center of the Brain
• Appetite Control• Eating Behavior• Regulation of energy intake
1. Smeets et al. Proceeding of the Nutrition Society. 2012;71:511-520.
2. Guthoff M, et al. J Clin Endocrinol Metab. 2010;95:748-755.
3. De Silva, et al. Cell Metab. 2011;14:700-706.
4. Malik S, et al. Cell Metab. 2008;7:400-409.
5. Farooqi IS, et al. Science. 2007;317:1355
6. Suzuki K, et al. Experimental Diabetes Research. 2012:1-19.
7. Viquerie N, et al. Diabetologia. 2005;48(1):123-131.
8. Mager et al. European Journal of Endocrinology. 2008;158:
9. Mutch DM, et al. Am J Clin Nutr. 2011;94(6):1399-1409.
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Formulations Based on:• Proprietary gene Expression Research• The latest and most robust nutritional science
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Eating Plan Based on:Protein Science & Nutrition Science
• Supports metabolically-active lean muscle and inhibits fat storage1
Reference: Wycherley TP, et al. AJCN. 2012;96(6):1281-98.
• An eating plan designed to complement the supplements.
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Carbohydrates(260g)
Proteins(90g)
Fats(67g)
Typical Reduced Calorie Diet – 2000 kcalF
at Burning
Foods
Fat
Sto
ring
Foo
ds
Fat S
toring F
oods
Carbohydrates(260 g)
Proteins(90 g)
Fats(67 g)
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Carbohydrates(260g)
Proteins(90g)
Fats(67g)
Typical Reduced Calorie Diet – 2000 kcalF
at Burning
Foods
Fat
Sto
ring
Foo
ds
Fat S
toring F
oods
Carbohydrates(180 g)
– 1200 kcal
Fats(33 g)
Proteins(45 g)
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Carbohydrates(260g)
Fats(67g)
Proteins(90g)
Eating Plan – 1200 kcalF
at Burning
Foods
Fat
Sto
ring
Foo
ds
Fat S
toring F
oodsProteins
(90 g)
Carbohydrates(260 g)
Fats(67 g)
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Carbohydrates(260g)
Proteins(90g)
Fats(67g)
Fat B
urning F
oods
Fat
Sto
ring
Foo
ds
Fat S
toring F
oods
Carbohydrates(120 g)
Fats(40 g)
Eating Plan – 1200 kcal
Proteins(90 g)
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Eating Most of Your Protein with Only One Meal of the Day Limits Duration of Metabolic Burn
FA
T S
TO
RIN
GF
AT
BU
RN
ING
Time in Metabolic Burn Zone = Only 3 hours/day
Adapted from: 1. Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86.2. Layman DL. Nutrition and Metabolism, 2009; 6:12.
Breakfast Lunch Dinner
ZO
NE
S
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Eating Protein with Each Meal Accelerates Metabolic Burn
FA
T S
TO
RIN
GF
AT
BU
RN
ING
Adapted from: 1. Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86.2. Layman DL. Nutrition and Metabolism, 2009; 6:12.
Breakfast Lunch Dinner
Time in Metabolic Burn Zone = 9 hours/day
ZO
NE
S
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Open Label Clinical Study
Participants Reported…- Lower levels of Hunger- Changes in body silhouette- Clothes fit better- Liked this program better than programs
they had tried previously
- 90 Days on ingredients-based program- 45 women and 21 men completed the study
Results of unpublished preliminary study 2013
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ageLOC TR90 Summary• Healthy weight management and Body Shaping program.• Based on gene expression science, addresses key
factors related to weight management: - Healthy Metabolism, - Promotes Lean Muscle Maintenance - Appetite Control
• Studies on TR90 weight management program resulted in significant weight loss, fat loss and changes in gene expression.
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17
SIGNS & SYMPTOMS
NutritionScience
Gene Expression
Science
Antioxidant Science
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LIFEPAK—THE PERFECT COMPANION
• Nutritional foundation is important– LifePak® provides that foundation
• Ensure adequate nutrition during reduced calorie regimen
• Dietary antioxidants for added protection from oxidative stress
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LifePak Off-sets Oxidative Stress During DietingAv
erag
e SC
S fo
r stu
dy
parti
cipa
nts
10,000
20,000
30,000
40,000
36,00030,00029,000
Baseline 6 Weeks 12 Weeks
• Participants took LifePak
• Scanner Scores increase an average of 6,000 per person
Data from My Victory Open-label Study 2007
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AGELOC R2 – The Perfect Companion
• Maintain energy levels
• Assist with cell renewal and cleansing during lipolysis
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TR90 SUPPORT TOOLS
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Create and communicate your personal transformation through a compelling story and transformation number that is completely unique to your ageLOC TR90 experience.
WHAT’S YOUR TRANSFORMATION NUMBER? Ninety nine