Sports commentatorBoomer Esiason withWCBS2 News anchorChris Wragge at the 30thincarnation of the RealEstate industry’s EmpireBall in NYC.

> Article on page 19

DRIfocusJoin us on social media!

Diabetes Research Institute Foundation Summer 2014/ Volume 41 / Issue 2

In 2013, the Diabetes Research Institute and Foundation announced thenext step in our approach to discover a biological cure by developing a DRIBioHub – a bioengineered “mini organ” that mimics the native pancreas,containing real insulin-producing cells that sense blood sugar and releasethe precise amount of insulin needed, in real time, together with criticalcomponents that keep the cells safe, healthy and functioning long term.

The BioHub is a platform approach that builds upon decades of progressin clinical islet transplantation and holds the promise of achieving a prac-tical cure by restoring natural insulin production in millions of childrenand adults living with diabetes.

Over the last year, DRI Director Dr.Camillo Ricordi and his team have beeninvestigating an optimal location within the body to house a BioHub. Cur-rently, islets are transplanted into the liver, but that site is not an idealhome for the cells. One area of focus is the omentum, an apron-like lininginside the abdomen. DRI researchers believe that the omentum may be anideal location for a BioHub.

“The omentum is a very vascularized tissue that is easily accessed surgically, and most importantly, has the same blood supply anddrainage characteristics of the pancreas,” said Dr. Ricordi.

Encouraging preliminary data in experimental and preclinical modelshas shown that islets in the omentum can engraft and improve bloodglucose control.

“We have observedlong term survivaland function of theislets in this site,”said Dr. DoraBerman-Wein -berg, a member ofthe DRI’s CellTransplant Center,who conductedthese experiments with Dr. Antonello Pileggi, director of PreclinicalCell Processing and Translational Models, and their respective teams.

"We were able to establish and optimize a protocol for implantingislets onto the surface of the omentum. Preliminary islet transplan-tation studies in experimental models of diabetes confirmed the feasibility of the approach," said Dr. Pileggi.

This exciting research is now moving to patient trials. The DRI has receivedapproval from the Food and Drug Administration to proceed with a PhaseI/II clinical trial that will test the omentum as a possible transplant sitefor a DRI BioHub. In this pilot trial, researchers will transplant insulin-producing islet cells within a “biodegradable scaffold,” one of the approaches considered for a BioHub platform.

Continued on Page 9

PILOT CLINICAL TRIAL WILL TEST A NEW SITE IN THE BODY FOR A DRI BIOHUB PLATFORM

Music legend Barry Gibbperformed an exclusiveconcert for a sold-outcrowd at the 40th Anniversary Love andHope Ball.

> Article on page 18

Celebrating 40 years 30 Years of Support

Disney star Dylan RileySnyder of the TV showKickin’ It with WillaBesner at the NortheastRegion’s Kids’ Carnival for a Cure.

> Article on page 17

Kickin’ It at Kids’ Carnival

Shannon and Ray Allenof the Miami HEAT, withDr. Camillo Ricordi, before their events, co-chaired by Andria and Javier Holtz and presented by Hublot.

> Article on page 16

Ray of Hope

Lesley Carey, president ofThe Biggest Loser Resorts,and Bobby Saleem, finalistfrom NBC’s The BiggestLoser, at the DRI Walkpresented by Walgreens.

> Articles on pages 14 & 15

The Biggest Loser

Dear Friends,

As we close this fiscal year and head into summer, we do so poised to begina pilot clinical trial that will test a new transplant site in the body to housea DRI BioHub. We have been eagerly anticipating this trial and are pleasedto share this news with you.

DRI researchers will transplant islets within a biodegradable scaffold, oneof the approaches considered for a BioHub platform. This promising researchis being translated to patients with T1D after demonstrating encouragingresults in experimental models. In addition to the information contained inthe cover story, more details about the biodegradable scaffold can be viewedin our BioHub video, DiabetesResearch.org/BioHub.

While this clinical trial is certainly a highlight of what has been a very busyyear, there is other good news to share.

In our last issue, we introduced the DRI Foundation’s new president and CEOJoshua Rednik. Josh, whose message appears below, has spent the last sixmonths familiarizing himself with our organization, donors, and volunteers,as well as countless D-families. He has taken the helm of the DRIF at a mostexciting time and I, together with my board colleagues, have the highestconfidence in his ability to lead with distinction and integrity.

Speaking of leadership, in this issue we acknowledge a number of individualswho exhibit that trait through their service to the DRI. No one has exempli-fied that role more than Sonja Zuckerman, who served as Life Chairman ofLove and Hope for 40 years. Sonja, who was also a member of our NationalBoard of Directors, has spent her life helping the DRI fulfill its mission to curediabetes and we are exceedingly grateful for everything she has done for us.

A history of commitment also defines our relationship with North America’s Building Trades Unions, which have demonstrated that strong

leadership can organize a force of millions to rally for our cause. Their dedication to the DRI remains strong, as so many union members are personally affected by diabetes.

New York Times best-selling author Brenda Novak celebrated the 10th year of her Online Auction for Diabetes Research, which resulted in a record-level of funds raised.

In our Florida Region, board members like Crystal Blaylock Sanchez and Rick Tonkinson are leading by example. So is Greg Besner, who we recentlywelcomed to our Northeast Board.

Earlier this year, the Allen and Holtz families joined forces to lead two successful events, the Ray Allen Golf Classic and Ray of Hope Luncheon, bothheld the same day.

And while he is only 13, Jonathan Berman is already undertaking his secondfundraising initiative for the DRI with his Power of One program.

Around the country, our Diabetes Diplomats are leading projects that arepersonally meaningful to them as they raise critical funds for research.

These individuals, together with the donors, committee members, and other volunteers featured in this issue, are taking the concept ofleadership to new heights. Suffice it to say that we will all benefit fromtheir – and all of our – collective efforts to provide the DRI with the resources needed to cure this disease. Thank you again for your supportand continued generosity. Best wishes for an enjoyable summer!

Sincerely,

Harold G. Doran, Jr., Chairman of the Board

Dear Friends,

As I sat down to draft this letter, I marked the six month anniversary ofjoining the DRI Foundation as president and CEO. Needless to say, thatperiod of time has passed quickly. Such is life when you are learning somuch that is new and exciting.

Of the many things that I have witnessed in my tenure thus far, twostand out.

First, as someone who did not have a close personal connection to diabetes prior to joining the DRIF, I have quickly come to understandhow the disease impacts everyone who lives with it daily, as well as thepeople who love and support them. It is an insidious and immenselychallenging illness to live with, and while we celebrate advances in management when they come, such improvements are not a cure.

Second, the DRI is unique. I have no doubt that we are the most comprehensive diabetes research center in the world, uniting a team ofresearchers with an array of expertise so that they together then canfocus solely on discovering a biological cure. The fact that we collaboratewith other leading research centers around the world only cements ourdistinct place in the diabetes community.

I am keenly aware of the challenges thatlie ahead in continuing to pursue that bio-logical cure. Of course, chief among themis the need to ensure that our researchersat the DRI have the resources they need topursue their work in earnest, with dedica-tion and focus. This is work we cannot doalone. Your assistance – your donations insupport of our research, your sponsorshipof our events, your serving as ambassadors to those you know within andoutside of the diabetes community, and more – is nothing short of critical.

To say that I have been touched and inspired by what I have experiencedduring my tenure thus far would be an understatement. I am convincedthat our work has the capacity to change the world, for people with dia-betes and beyond. I am grateful for the warm welcome I have receivedand I look forward to your feedback, questions, and support. Thank you.

Sincerely,

Joshua Rednik, President and CEO

A Messagefrom the Chairman

PRESIDENT’S MESSAGE

The Diabetes Research Institute Foundation is pleased to announce the appointment of Greg Besner of Short Hills, NJ, to its Northeast Board of Directors.

Greg has been the founder and CEO of several successful technology and consumer product companies. He mostrecently launched a new software company called CultureIQ, Inc., to help companies use data to manage, measureand improve their corporate culture. He is also an adjunct professor of entrepreneurship at New York University,teaching a class called, “Ready, Fire, Aim.”

Prior to becoming an entrepreneur, Greg served in the capacity of president, COO and CFO for several other successfulcompanies and had a prosperous career on Wall Street working at Goldman Sachs and then Merrill Lynch. Prior tolaunching CultureIQ, Greg was the CFO of New York-based SecondMarket Holdings, Inc. Before SecondMarket,Greg led a group of private investors in the Series B funding of House Party, Inc., a growth stage digital media company,where he served as COO from 2009-2010. Prior to joining House Party, Greg was the founder and CEO of Computer-share Executive Services, a SaaS fin-tech company formally known as Restricted Stock Systems, Inc. (“RSS”), from2000 until 2009. In 2007, Greg sold RSS to Computershare Limited, a public company based in Australia, and he remained as president until January of 2009. During his tenure as CEO of RSS, Greg was named the Ernst & Young 2003 Entrepreneur of the Year in New Jersey.

Greg is also an active investor and consultant for numerous successful companies and start-ups. Of note, he was an investor and consultant forZappos.com starting in 2005 until Zappos was sold to Amazon in 2009. Greg currently serves on the Board of Directors or the Board of Advisorsfor 10 privately-held companies and also serves on the Board of Directors of the Young Presidents’ Organization (“YPO”) NJ Chapter. He is thefounder and CEO of Leslie Hsu LLC, a fashion accessories company that he and his wife, Leslie Hsu Besner, founded in 2000.

It’s fair to say that Greg is fueled by ambition and the drive to succeed. But to those who know him personally, it’s clear that his true motivationstems from a desire to fulfill the one wish of his eldest daughter, Willa – finding a cure for her type 1 diabetes. Through their family foundation,Willa’s Wish Foundation, Inc., they have made multiple major gifts to advance research being conducted at the Diabetes Research Institute. Theyhost an annual event in NYC, Cocktails for a Cure, to be held September 13, and have sponsored several of the DRI Foundation’s Northeast events.Willa (see photo on cover) appeared in the DRIF’s Future Free from T1D campaign video last year, and her little sister, Lana, has also been involved withtheir fundraising efforts.

Florida Region Board member Crystal Blaylock Sanchez wears many hats — head of a family-owned business and a major, annual fundraising event, plus mother to two boys,Cameron and Matthew. Possibly the most important and challenging job she handles is“backup pancreas” for Matthew, who was diagnosed with type 1 diabetes in 2005 at age 5.

As president of Blaylock Oil and executive director of the Shell Key West Challenge, whichhas raised more than $500,000 for the Diabetes Research Institute (see page 19), Crystalcould easily rest on her laurels and avoid adding anything else to her very full plate. Her

drive, however, to find a cure for her son and millions more is always at the core of every step taken and each decision made.

“Bottom line is I want a cure for Matthew and everyone else who suffers with diabetes, and we believe in the DRI,” she said with conviction, whichis exactly what motivates those around her to support her cause.

Surrounding her personal efforts is an impressive grassroots fundraising circle of friends, colleagues, vendors and other wholesalers who havecontributed additional dollars to the DRI. From programs like Pump for a Cure, Dollars for Dolphins, and Pucker for a Cure to church and restaurantfundraisers, “Cure” ring sales and a Fish Skinz tournament, Crystal has inspired so many others to commit to fundraising projects for the DRI. Furthermore, she always steps to the plate when asked to participate in the DRI Foundation’s campaigns, photo shoots, videos, and special events.

“The support I’ve received from family and friends is very humbling. But it’s because we know that whether its $5 or $500, it goes to research for a cure. No fundraiser is too small or insignificant. Every amount helps, and we can all contribute to the end result that I’m very much looking forward to — a cure.”

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GREG BESNER JOINS THE NORTHEAST BOARD OF DIRECTORS

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BOARD SPOTLIGHT: CRYSTAL BLAYLOCK SANCHEZ

Crystal Blaylock Sanchez with her boys, Cameron and Matthew.

With over 25 years of experience in wealth management, Rick Tonkinson understands planned giving. He is the president of Tonkinson Financial, a family business that provides a common-sense,realistic and encouraging approach to the financial issues of hisclients, who come from middle class families with less than $1 millionin assets. Rick has continued to demonstrate his business savvy, kindness and passion for the Diabetes Research Institute. Recently, he established a $1 million bequest to benefit the DRI. But as Rick says, “You don’t need 25 years of experience to make a planned gift. Virtually anyone can make one.”

Rick learned the value of a dollar delivering newspapers for Newsdayin Long Island at the age of 12. He credits his spirit of community andgiving back to his New York upbringing and his mother as a rolemodel. Rick says his mother was the biggest influence in his life and,although she passed away in 1974, people still remember her kindness.

Determined to live up to the virtues of his mother, Rick joined thePeace Corps after graduating from Pennsylvania State University.While volunteering with the Peace Corps in Colombia he met his wife,Margarita, who was a high-level executive in Colombia’s port author-

ity. In 1981, Rick and Margarita moved to Miami with their son, Steven.Since then, Rick has made a huge impact on the South Florida community.In addition to being a member of the DRI Foundation’s Florida RegionBoard, Rick is a major donor to 30 charities in the local community. Heserves as chairman of the FIU College of Architecture and the Arts Advisory Board as well as a board member at the Arsht PerformingArts Center and trustee to the Cleveland Orchestra. Rick is committedto tithing 10 percent of his gross income to the community.

Although Rick is passionate about all the organizations he supports,the DRI in particular is a top priority for him. “I am convinced that researchers at the DRI will find a cure for diabetes,” he said. “And oncethey get a grip on the source, other related illnesses can also becured.” Rick says the DRI’s transparency and collaborative relationshipswith researchers around the world allow him to sleep well at night,knowing his funds are going to the right place. Recognizing the DRI’sneed for immediate funding, Rick and Margarita also have recentlymade a $150,000 contribution that will elevate them to the DRIF’s Distinguished Humanitarians giving society, which honors thosewhose cumulative contributions range from $250,000 to $499,999.

Rick discovered he had diabetes at 51, just six months after climbingMt. Kilimanjaro with his son,Steven. He thanks Dean Pascal Goldschmidtfor referring him to the DRI when he was tired of the status quo andsearching for an organization with a comprehensive approach to combatting diabetes. Rick’s diabetes was out of control when he firstbegan treatment at the DRI. He credits Dr. Alessia Fornoni for finding alife-saving link between his kidney disease and diabetes, the team of Dr. Bresta Miranda-Palma and Allison Wick for communicating withhim regularly to help him successfully manage his blood glucose levels,and Dr. Juan Dominguez-Bendala for being his health conscience. Ricksays, “We talk a lot about the DRI family, and I truly believe in it. I amwilling to give not only for analytical reasons but for the emotional con-nection I have with everyone involved, including the magnificent staff.”

Motivated by his fellow board members and their long-time commit-ments, Rick pledges to be even more generous as he becomes moreprosperous. He invites everyone to join him in supporting the DRI aswe advance toward a cure. For tips from Rick about making plannedgifts, please see our Q&A with him on page 8.

CERTIFIED FINANCIAL PLANNER™ RICK TONKINSONMAKES A BEQUEST OF HIS OWN

Margarita and Rick Tonkinson receiving a Cycle of Discovery award; see page 6to learn more about this award series.

BE THE HERO… JOIN THE DIABETES DIPLOMATS

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Diabetes Diplomats are a league of students, teachers, parents, grandparents, and other family members and friends who are taking the search for a cure into their own hands. They come from all over the world and serve as advocates, educators, and event fundraisers in their schools, neighbor-hoods, and online. Some have diabetes. Some don’t. But they have all decided to “Be the Hero” by supporting the Diabetes Research Institute in itsmission to cure this disease that affects 29 million children and adults in the U.S. alone. Learn more at DiabetesResearch.org/DiabetesDiplomats.

The fight for a cure took center stage at the Miami Children’s Theater in Miami, FL, on February21 in a special fundraising night during the production of How to Succeed in Business WithoutReally Trying. This was not “children’s theater” as you might imagine it, and the lead actor,Sammy Schechter, was no ordinary talent. He has type 1 diabetes. He and his parents, Rosa andBenno Schechter, were responsible for this evening benefit, where 25 percent of ticket sales plusgenerous donations from the audience were donated to the DRI. After playing the role of “Finch,”Sammy addressed the crowd directly, talking about how diabetes has affected his life and howimportant a cure is to the millions living with this relentless disease.

The Rosenberg family of New Jersey – Greg, Denise, Ally, and twins Jake and Jesse – continues to think of new ways to support the DRI Foundation.  Jesse and his friend Matthew Weksler are forminga club at their high school to raise awareness about type 1 diabetes.  They’ve already held twofundraisers – a school bake sale and the 3rd annual Spin for a Cure (originated by the Rosenberg children) at The Gym in Englewood, NJ.  Jesse’s brother Jake and his friends participated, as did the entire Rosenberg family.  Jesse and Matt are planning a number of events and speakers for the nextschool year.  And a big shout-out goes to dad Greg for nominating the DRI Foundation as a beneficiaryof financial services firm BTIG, LLC’s annual Commissions for Charity Day.  These various events and activities raised more than $8,000 for the DRI Foundation, for which we say, thanks so much, Rosenberg family and friends!

It was a picture perfect birthday celebration for professional photographer Gabriela Bianchini – whoput on a special 30th birthday auction of her work in Delray Beach, FL, to benefit the DRI, on January 24.More than 120 people helped bring in more than $8,000 that evening – which Gabriela held in honor ofher youngest brother, Gianni, who has been living with type 1 diabetes since he was 17 years old.Guests enjoyed fine art, appetizers and cocktails, all while supporting a cause near and dear to Gabriela’sheart. All 31 of her fine art pieces were snatched up – including a big ticket “I Love New York” piece thatauctioned for $800. This helped make it her “best birthday ever.”

It was a record year for the annual Blair County Diabetes Walk/Fun Day in Duncansville, PA, on May 17 withnearly 500 people stepping up for a cure and helping to raise more than $20,000 for the DRI. The event wascreated and is organized yearly by Lisa Treese, whose 10-year-old son, Zach, was diagnosed with type 1 diabetesat age 3. Participants, which included many family teams honoring a loved one with type 1, enjoyed a funfamily day of walking, Zumba warm ups, free medical exams, a kids’ tent with fun baseball-themed activities and more.

For Debra Roberts, life isn’t a race, it’s a marathon. And each year, she makes it a point to run miles for causes shestrongly believes in. This year, Debra decided to honor her father-in-law, Ted, who has lived with diabetes for morethan 30 years, by running California’s San Luis Obispo Marathon in April – and raising funds for the Diabetes Research Institute in the process. Debra not only raised $500 during the marathon with the support of lovedones, but she also reached out via Facebook, letters, and her SLO Marathon Babes team to contribute an additional$2,500-plus. She utilized the Diabetes Diplomats website to collect funds for her efforts. But Debra isn’t slowingher pace any time soon! She will continue raising funds for the DRI through the end of the year.

1) DRIF's Jill Shapiro Miller, Rosa and Sammy Schechter, Theater Operations Director Tim Fath, Director Ron Headerick of How to Succeed In Business Without Really Trying, 2) Jake Rosenberg, Jesse Rosenberg, and Matthew Weksler, 3) Gabriella Bianchini, 4) Team Yay, 5) SLO Marathon Babes

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FOUNDATION DONORS RECOGNIZEDAwards from the DRI Foundation’s Cycle of Discovery series were presented to donors who recently made majorgifts. The award program corresponds with the Foundation’s cumulative giving designations. Awards were presented individually and at Foundation events.

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RECOGNIZING DONORS THROUGH THE CYCLE OF DISCOVERY

As seen in every issue of the DRIFocus newsletter, the Diabetes ResearchInstitute Foundation recognizes donors who have reached various levels of giving with an elegant series of eight crystal sculptures. Eachaward was selected for its visual portrayal of the scientific journeythrough the evolution of an idea, aptly named The Cycle of Discovery.

Although no two pieces are exactly the same, each sculpture is an artisticrepresentation of the endless questioning, the complex investigation,the perpetuation of thought, and the significant accomplishmentsmade by DRI scientists who are committed to finding a cure as quicklyas possible.

“What I really like about this award series is that it sparks a conversation,” stated Josh Rednik, president and CEO of the DRI Foundation.

“If someone sees this beautiful, crystal award displayed at your officeor in your home, it’s an opportunity for you to tell that person why youreceived it and what the Diabetes Research Institute means to you.”

Donors who make a new gift of $25,000 or more, or whose additionalcontributions elevate them to a new giving level, are acknowledgedwith their respective award. Those who have created a legacy by providing for the DRI through their estate plans become members ofthe DRI Heritage Society and receive a plaque. All individuals, organiza-tions, corporations, and foundations that have reached one of these lev-els are permanently recognized on one of the DRI’s distinctive walls ofhonor. DRI Foundation donors at the Founders level and above are alsorecognized by the University of Miami.

Visionaries $10,000,000+ InnovationChairman’s Council $5,000,000+ ValidationLeadership Council $1,000,000+ PerpetuationGovernors’ Society $500,000+ TranslationDistinguished

Humanitarians $250,000+ RealizationGrand Founders $100,000+ ExplorationFounders $50,000+ HypothesisBenefactors $25,000+ Query

DONOR LEVEL AWARD

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PERPETUATIONAWARD: Joan and William Fishlinger (1)

REALIZATIONAWARD: Charlie Guigno for Sportsmen for Charity (2)

EXPLORATION AWARD: Janie and Ron Kupferman (3), Maria and EricReeps (4), Wendy Waller (5)

HYPOTHESIS AWARD: Al Amore of Trinity Real Estate (6), Mercedesand David Carlson (7), Jeanne Fibus and Randi Fibus Caster with DRIF's Josh Rednik (not pictured Ken Fibus) (8), Barbara and NormanShapiro (9), Richard Veltri of United Air Conditioning (10), Rina and Jerrold Weinbrom (not pictured Jerrold) (11)

QUERY AWARD: Fran and Howard Helfant (12)

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1) Query, 2) Hypothesis, 3) Exploration, 4) Realization, 5) Translation, 6) Perpetuation, 7) Validation, 8) Innovation

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Certified financial planner™ Rick Tonkinson, president of Tonkinson Financial and member of the Diabetes Research Institute Foundation’s Florida Region Board, provides answers to these frequently asked questions about planned giving.

1. What is a planned gift?

A planned gift is a gift to be made in the future that immediately satisfiesyour philanthropic goals and might improve your financial situation. Itcan be a bequest in a will or trust, a beneficiary designation of an insurance policy or retirement plan, a transfer on death designation ofa bank or securities account, a charitable trust, or a charitable gift annuity.

2. Who can make a planned gift?

Virtually anyone can make a planned gift at any level. I believe there is a perception problem among people that they can’t make plannedgifts, but these gifts offer tax advantages for all, regardless of age or financial means.

3. Why should I make a planned gift?

The DRI relies on planned gifts to continue its critical work toward a cure. When you establish a planned gift, you leave a lasting legacy thatwill extend the benefits of your generosity far into the future and on amuch broader scale.

4. What is the most popular planned gift?

By far, the most popular planned gift to the Diabetes Research InstituteFoundation (DRIF) is a bequest made through your will. When makinga bequest, you can designate a specific dollar amount, a percent of yourestate, or what is left in your estate after other bequests are fulfilled. Itis simple to establish and, because it is revocable, you can make changesat any time.

5. How do I make a planned gift?

The DRIF can provide detailed information, including draft language, foryour attorney or other advisor regarding any planned gift you are considering. Please contact Jill Shapiro Miller at (800) 321-3437 to arrange for a confidential conversation.

6. If I make a planned gift to the DRIF, must I inform anyone?

It is not necessary for you to inform the DRIF of your plans. However,they are always delighted to welcome a donor to the Heritage Society,which honors those who have demonstrated their commitment to theDRIF with a planned gift (see page 6). As a member of the DRI HeritageSociety, you are setting an example for others to follow. Plus, you will receive a plaque that demonstrates your commitment to the DRI, andyour name will be inscribed on a wall of honor at the Institute.

RICK TONKINSON ANSWERS

YOUR PLANNED GIVING QUESTIONS

Most people can afford to make a planned gift in supportof a cause that’s close to their heart even if they plan toprovide for family members.

SUPPORT OUR WORK WHILE DOING YOURSMany employers encourage employees to support charitable organizationsthrough workplace giving campaigns. These gifts are tax deductibleand can be made through a payroll deduction program. Simply selectthe DRI Foundation from your company’s charitable choices and encourageyour co-workers to do the same. If the Foundation is not already an option, you can further assist by working with us to determine how togo about being included.

For participants in the Combined Federal Campaign (CFC), our numberis #11149. We are also listed under the Health 1st America’s CharitiesFederation. The easiest way to find us is in the alphabetical index at the back of your campaign guide. If your company holds a United Way campaign, you have the opportunity to contribute to the DRI Foundationby utilizing the write-in feature. Please call 1-800-321-3437 or emailinfo@drif.org if you have any questions.

Who could have imagined that in 1974 when Sonja Zuckerman suggested having a ball to benefitthe Diabetes Research Institute, the event would still be going strong 40 years later?

Every charity has its champions, but there is no one more synonymous with the Love and Hopegroup than Sonja. Serving at the helm of this unparalleled fundraising effort as Life Chairman forthe past 40 years, she has helped to raise millions of dollars for the DRI. This year, at the annual ThankYou Luncheon for the Love and Hope committee, Sonja announced that she was stepping downfrom her position.

Though she has no direct connection to diabetes, Sonja has taken on the search for a cure as a personal mission, inspiring countless others to join in her crusade. She served on the DRI Foundation’s National Board of Directors for years and is now an Honorary Board member and aDistinguished Humanitarian of the organization . Her role as Life Chairman of the Love and HopeCommittee utilized her fiery spirit, boundless creativity, and impeccable eye for detail.

Born in Cairo, Egypt, Sonja moved to Israel early on and was educated in French schools. By thetime she came to the United States, more than 50 years ago, she had mastered seven languages,all with the self-assured authority for which she is known. Versatile and determined, she firmlybelieved that it was her obligation to get involved in her community.

Before making Miami her home, Sonja was an active participant in important causes in New York,Chicago, and Detroit, where she became the impetus that launched the longstanding Angel Ball,benefiting the National Council for Jewish Women.

In a moving and heartfelt speech at the Thank You Luncheon, Sonja stressed that although she isstepping down from her active role; she is not going anywhere and is always available when needed.

While she will be deeply missed in the leadership position, she has left behind an incredible legacyof wonderful and generous donors and an active and involved committee.

Sonja’s greatest wish is that she will be able to celebrate a cure for diabetes – and to help plan thevictory party! To those that have had the privilege of working with her, Sonja Zuckerman has been and will continue to be an inspiration.

FOR 40 YEARS OF PASSIONATE LEADERSHIP AND LOYAL FRIENDSHIPHONORING SONJA ZUCKERMAN

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The biodegradable scaffold is a combination of a patient's own plasma andthrombin, a commonly used, clinical-grade enzyme. When combined, thesesubstances create a gel-like material that sticks to the omentum andholds the islets in place. This section of the omentum will be folded overand stitched, creating a pouch around the biodegradable scaffold mix-ture. Over time, the body will absorb the gel, leaving the islets intact,while new blood vessels are formed to support their survival and function. This pilot trial will include the immunosuppressive regimencurrently used for clinical islet transplantation studies.

“This is a very important first step in the overall development of the BioHub because this will set the site of implantation and the platformtechnology. We have to show initially that this transplant can functionand be equivalent to the liver as a site of implantation,” explains Dr. Ricordi. “We will then add all the other components that will favornew blood vessel development, oxygen generation, cell protection andother agents that will allow us to reduce and eventually eliminate systemic immunosuppression, which is our goal for a biological cure.”

The DRI also plans to test another BioHub platform – a “bioengineered

scaffold,” a sponge-like disc made of clinical-grade silicone – also utilizing the omentum as a transplant site. Researchers are in discussions with the FDA about additional preclinical testing that theregulatory agency has required before approval of that pilot clinical trialin the U.S. can be granted.

“We will test both the biodegradable scaffold and the bioengineered scaffold to see which approach is better and demonstrates greater benefitsfor patients with diabetes. Both approaches will allow us to add all the components necessary for developing a BioHub mini organ,” adds Dr. Ricordi.

For more information on the pilot trial and to download the Islet Trans-plantation Application form, please visit DiabetesResearch.org/PilotTrial.

The DRI has also made progress in the other strategic areas comprisingthe BioHub, which include methods to protect the insulin-producingcells from the immune system, as well as a means of developing an unlimited supply of cells. You can read more about the DRI’s researchprogress at DiabetesResearch.org/AnnualReport.

PILOT CLINICAL TRIAL (continued from cover)

The DRI has shown that islet cell transplantation can restore naturalinsulin production in those with type 1 diabetes. Almost all patientshave been able to discontinue their use of insulin and maintain normal blood sugar levels, some for more than 10 years.

However, over time, most of these patients have had to resume insulintherapy. Researchers believe that many of the transplanted islet cellsare lost at the time of infusion and in the days following the procedure due to several reasons, among them is a temporary lack of adequate oxygen immediately post-transplant within the infusionsite; the harmful inflammation that occurs at the implant site; andthe use of harsh anti-rejection drugs, among other reasons.

Currently, researchers do not have a means of locating and measuringhow many insulin-producing cells remain alive and functioning in patients who have received islet transplants, or how many cells remainupon clinical diagnosis of type 1 diabetes.

Thanks to new advances in imaging and nanotechnology, DRI researchers are developing and testing a special class of manufacturedmolecules that can “hone in” on specific cell markers, including those that are unique to insulin-producing beta cells. This new “tool” presents a novel way to transport protective agents only to the desired target. These molecules, known as aptamers, are generated in our labs and designed to bind to the beta cells. Incorporating fluorescent“flags” to beta cell-specific aptamers could allow researchers to detect their location and acquire an accurate measurement of thenumber of functioning cells in vivo (within a living organism).

Researchers Luca Inverardi, M.D., Paolo Serafini, Ph.D., and GiacomoLanzoni, Ph.D., are leading the effort. We spoke with Dr. Lanzoni aboutaptamers’ potential to target beta cells – not only for their imagingpotential, but also for their ability to deliver anti-rejection drugs (immunosuppressants) locally, where the islets are placed, like within a DRI BioHub.

Q. What are aptamers?

A. Aptamers are very small molecules that can penetrate deeply into tissues. Think of them as very small programmable drones for delivery: they are revolutionary. We build them in the lab andthey’re designed to target something of interest, such as a specificcomponent of a living cell – and they will bind to that. This uniquecharacteristic makes them very useful for beta cell imaging and targeting. We are testing aptamers designed to visualize functioningbeta cells within the body in order to quantify their numbers and location. In the future, we would like to use these aptamers for thedelivery of protective agents directly to the beta cells themselves. Aptamers are easy and relatively cheap to produce. Plus, the way wemodify them makes them very robust. Moreover, they are non-im-

munogenic – which means they will not cause an immune reaction.That’s very important. We do not want an immune reaction againstthe beta cells.

Q. Why do you consider aptamers to be revolutionary?

A. In addition to the characteristics mentioned above, aptamers canalso be developed with amazing speed. Doing the same thing with antibodies would take several years. For example, we developed aptamers for mouse islets in just a few months, and we are now seeing the binding of these aptamers in vivo in just one year withinthese experimental models. It’s truly remarkable.

Q. How can aptamers be used?

A. We believe we can use them to see beta cells in vivo. As of today,there is no way to visualize insulin-producing cells, nor to know theirnumbers and location, for example, when transplanted into a recipient.If we could see them, we could understand a lot more about what isgoing on during disease progression and after a treatment. We couldalso follow them at various time points after islet transplantation andtreatment.

Currently, the way researchers estimate cell function is to measurethe levels of C-peptide, a by-product of natural insulin release. How-ever, these levels do not indicate the number of cells doing the job. In order to see them, to measure the beta cell mass in vivo, we aretagging the aptamers so they emit light. If they bind to beta cells,we’ll be able to scan the body and see how many and where they are.

Q. How safe are they?

A. Aptamers are already used in the clinical setting for other diseases,so, they have been shown to be safe. But since every single aptamer isdifferent, further research will be needed in order to obtain regulatoryapproval for this purpose.

Q. How do we know they will bind to the correct cells – the oneswe’re targeting?

A. We select beta cell-specific aptamers out of literally millions of“random” aptamers. We identify those aptamers that bind with avery high affinity to beta cells, the cell type we actually want to target. During that same selection process, aptamers that bind toother cells and tissues are eliminated.

Q. What’s the current state of this research?

A. We have developed aptamers that bind to these cells in mice. Inpreliminary studies, we saw the specific binding in the pancreas invivo. We have sequenced these aptamers, which means we know how

WITH DR. GIACOMO LANZONIUNDER THE MICROSCOPE

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Jay S. Skyler, M.D., M.A.C.P., received the Distinction in Endocrinology Award at the American Association of ClinicalEndocrinologists (AACE) 23rd Annual Scientific & Clinical Congress in Las Vegas on May 15, 2014. The award is given toan AACE member in recognition of advancing the under-standing of endocrinology through research and education.

Dr. Skyler has focused his research on immune intervention and beta cell expansion or replacement. He is the chairman of the NIH-sponsored network that conducts clinical trialsinternationally in efforts to prevent type 1 diabetes.

"I am deeply honored to receive this award,” said Dr. Skyler, who is the deputy director for Clinical Research and Academic Programs at the Diabetes Research Institute. “It is particularlygratifying to join the list of distinguished previous recipients."

DRI’S DR. SKYLER PRESENTED DISTINCTION IN ENDOCRINOLOGY AWARD

The ability to stop the immune system from attacking pancreatic islet cells is critical for restoring natural insulin production and reaching a biological cure for diabetes. Thanks to recent grants awarded by The Iacocca Foundation, two of theDRI’s scientists who are making important inroads in this critical area will be ableto continue their innovative research toward this goal.

Dr. Alice Tomei, research assistant professor of surgery and member of the DRI’s bio-engineering team, is investigating ways that cancerous tumors evade destructionby the immune system with the goal of using that “escape mechanism” to protectinsulin-producing cells. Dr. Tomei and her team have published key findings in thejournal Science demonstrating that tumors secrete the molecule CCL21, which isnaturally found in lymph nodes as a mechanism of self protection. Armed with thisimportant information, the team has performed additional studies and has foundthat CCL21 expression in beta cells (the insulin-producing cell component withinislets) completely prevents type 1 diabetes in experimental models. The fundingaward from The Iacocca Foundation will allow Dr. Tomei and her team to build upon this groundbreaking research.

Dr. Peter Buchwald, director of drug discovery, is targeting a recently identified signaling pathway that leads to autoimmune destruction of insulin-producing cells. He and his team have had promising results in experimental models demon-strating that new-onset diabetes can be reversed by blocking this pathway with a protein known as Smad-7. There is also scientific evidence supporting his theorythat the use of Smad-7 not only controls the autoimmune destruction of the isletcells, but can also lead to islet regeneration. With the funding from The IacoccaFoundation, Dr. Buchwald and his team will focus on investigating the possible beta cell-enhancing effects of this treatment with the goal of quickly translatingthis research to clinical therapies.

THE IACOCCA FOUNDATION AWARDS GRANTS TO DRI SCIENTISTSFOR INNOVATIVE RESEARCH

AROUND

THE DRI to build them. Now we can build up largequantities of them, and for a relatively lowprice because of the technique we use.

We know that rodent islets are different fromhuman islets, so we have to design differentaptamers for humans. We are developingthem right now, and we have already beensuccessful in developing aptamers that bindto human islets in laboratory experiments.

Q. What are the next steps?

A. We have selected aptamers that bind toislets. But islets are clusters of several types of cells. So, now we need to identify which aptamers bind specifically to beta cells (thecells that produce insulin), which aptamersbind specifically to alpha cells (the cells thatproduce glucagon), and so on.

Q. How could this help patients who receiveislet cell transplants?

A. We would be able to see and track thetransplanted cells. Today, we know howmany cells we infuse into a patient, but it’snot possible to see them and follow whathappens to them – where they end up andhow many survive. Currently, we assess onlythe function of islet cell transplants by meas-uring C-peptide levels in blood samples, butwe really do not know if that level is beingproduced by just a few, over-worked cells try-ing to keep up with the glucose demands, orif that measurement reflects many cellsworking efficiently.

Recent studies by groups here at the DRI reported that, despite the use of chronic anti-rejection drugs, autoimmunity can again betriggered, resulting in the return of type 1 dia-betes. So, we believe that this technologywill allow us to assess the number of viablebeta cells in patients, and evaluate changesover time in the same individual. Also, itcould help assess the effectiveness of im-munosuppressive drugs or other methods toprotect these cells.

Approximately 60 people gathered at the Delaire Country Club in Delray Beach, FL, to learnmore about the cure-focused work of the Diabetes Research Institute and the developmentof a DRI BioHub. In a presentation titled, “Reaching the Biological Cure: Resolving the RemainingChallenges,” the DRI’s Dr. Antonello Pileggi reported on protection of cells from harmful immunesystem attack, how to increase the supply of cells for transplant, and stopping the autoimmuneprocess that caused the onset of diabetes. He spoke about how the DRI BioHub, an integratedmini organ that mimics the native pancreas, addresses critical research challenges and holdsthe promise of restoring natural insulin production in millions of children and adults. Uponconclusion, guests asked questions and spoke directly with Dr. Pileggi, who is the director ofPreclinical Cell Processing and Translational Models at the Cell Transplant Center of the DRI.

GATHERING IN DELRAY BEACH

The historical and unparalleled partnership between North America’sBuilding Trades Unions and the Diabetes Research Institute and Foundation continues to reach new heights. Earlier this year, theBuilding Trades held their 2014 Legislative Conference at the Washington Hilton & Towers Hotel in Washington, DC. PresidentSean McGarvey invited DRIF’s Joshua Rednik and Tom Karlya to attend, and they were humbled by the outpouring of support fromthe more than 3,000 representatives there.

“The presentation about the Diabetes Research Institute came rightafter former President Bill Clinton addressed the crowd. You canimagine what it’s like to follow him! But when our DRI video played,featuring several kids with diabetes talking about their fears, theirconcerns and their hope for a cure, you could have heard a pin drop,”said Karlya. “The support of the Building Trades is immeasurable, and Iwas struck by the emotion in the room and the pride each member soobviously felt. They won’t stop until the DRI finds a cure for diabetes.”

Each year, two unions are recognized for their fundraising efforts, aspart of the DAD’s Day campaign (Dollars Against Diabetes). Membersof IBEW Local 26 and the Minneapolis Building and ConstructionTrades Council were recognized for their highly successful golf tournaments and for their dedication to the cause.

The Building Trades' support stems back to 30 years ago when unionrepresentatives met with a handful of parents from the DRI Foundation,all of whom had children living with diabetes. They explained the grand

vision for the Institute – a state-of-the-art center where scientistswould have every tool necessary to conduct their research. Withoutdelay or debate, Blueprint for Cure was born.

The relationship reached a major milestone when the men andwomen of the Building Trades funded – and built – the DRI facility inMiami, which continues to be the most comprehensive diabetes research center of its kind in the world.

Today, the vision for Blueprint for Cure (comprised of DADs Day eventsoccurring around the country and the national organization’s Laborof Love weekend) is a diabetes-free tomorrow. Its mission is to unifythe fundraising efforts of local labor councils and their communitiesaround the country through increased communication and eventsupport. Next up? Look for coverage of the Labor of Love & Softball Slam,which took place June 20-23 in Atlantic City, NJ, in the next issue ofthe DRIfocus newsletter as North America’s Building Trades Unions continue “Moving Towards a Cure.”

BUILDING TRADES’ SUPPORT CONTINUES “MOVING TOWARDS A CURE”

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1) Brent Booker, secretary-treasurer, North America’s Building Trades Unions, TomKarlya, vice president, DRIF, Josh Rednik, president and CEO, DRIF, DanMcConnell,business manager, Minneapolis BCTD, Paul Klesmit, chairman of the Minneapolisevent, Sean McGarvey, president, North America’s Building Trades Unions, ButchRamos, president, IBEW Local 26, Chuck Graham, business manager, IBEW Local 26

2) This is a scene from the DRI video that played at the 2014 Legislative Conferencefeaturing 5-year-old Olivia who has type 1 diabetes. Wearing a hard hat, sheadoringly blows a kiss and thanks the Building Trades for their support.

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“PARENTS EMPOWERING PARENTS” WITH NEWS YOU CAN USE TODAY In May, the Journal of the American Medical Association (JAMA) releasedthe results of a study conducted from 2001-2009, confirming that theincidence of type 1 and type 2 diabetes has drastically increased amongchildren and adolescents. The study found that the prevalence of type 1diabetes increased an alarming 21 percent in youth under the age of 20.This sizeable upsurge adds to the urgency of finding a cure now. Whilescientists at the Diabetes Research Institute work fervently toward thatend, we also know how essential emotional support is now for the familiesliving with diabetes.

Whether you’re a newly diagnosed or an experienced “diabetes family,”the PEP Talk eNewsletter can offer up just the right advice or can be a

needed refresher on something you learned long ago. The PEP Talk distributes biweekly and features news and tips on positive language,effective communication, dealing with feelings and other psycho/social issues. Become a DRInsider and subscribe to PEP Talk: DiabetesResearch.org/Register

Looking for personal connection? There’s always someone to talk to onthe Diabetes Research Institute Foundation’s PEP Squad closed grouppage on Facebook. Whether you have a question after a 3 a.m. BG checkor you need advice on a school issue, you can usually find another parent who can instantly chime in with an anecdote, encouragement,or guidance. Join the group: Facebook.com/groups/PEPsquadDRI

It really is true that it takes a team to care for and support a kid (and afamily) with type 1 diabetes. The responsibilities for some team membersare relatively limited and are clearly attached to their titles, such as "endocrinologist,” “diabetes educator,” “dietician,” “school nurse,” “clergymember,” “therapist,” or even “pet.” This just does not apply to “moms”and “dads.” There is nothing limited or clearly assigned about the avalanche of new responsibilities and obligations that become obviousin the days, weeks, and months after receiving the diagnosis. There isnothing inherent to “mom” or “dad” that gives much direction, so parents must be proactive in defining their roles and working togetheron the team.

How is it for you? In many families, one parent (usually mom) is in the“driver’s seat,” assuming the role of primary caretaker, while the otherparent (usually dad) rides “shotgun.” In other families, some moms anddads both want to “drive.” While more challenging, this too can workwell. In either case, what happens when the parenting partners wantto move at different “speeds” and in different “directions?” What I’mtalking about, of course, is when parents have very different styles of solving diabetes-related challenges, parenting their children, andcoping with the realities of diabetes.

How can parents come together as a team when these differencesthreaten the harmony, stability, and happiness that helps families reachtheir potential? Here are a few ideas:

• Often, there is a very close agreement between parents on the overall goals you both have, but there may be differences about howto achieve them. Find that common ground and come togetheraround that shared purpose.

• Play to your individual strengths. For example, if you are more...

> detail-oriented and organized,order the diabetes care supplies, write upthe treatment guidelines for school staff, or track health care expenses.

> assertive and diplomatic, be an advocate for your child’s needs atschool and elsewhere.

> emotionally “wise” and nurturing, set the tone for helping your childrencope with the many feelings they may experience about the changesthat diabetes brings.

> verbal and good at communicating, be the one to train school staffon care tasks.

> analytical, take the lead on problem solving blood sugar control difficulties.

> athletic, put together exercise guidelines for school, camp, and sports teams.

> business-minded, get involved in fundraising and networking.

> creative, help your children and family express themselves freely.

> funny, find ways to bring lightness and levity to the serious issuesyour family is facing.

• Recognize that different styles and approaches don’t have to conflictwith each other. Explore ways that they can complement each otherand benefit your family. Be sure to acknowledge each other for yourunique contributions.

However you decide to structure your parenting roles after diagnosis, beproactive and look for the strengths you each bring. This will go a longway in helping your family move beyond the diagnosis and get back tothe challenges of raising well-adjusted children, cultivating your relationships, flourishing as families, and leading safe, healthy, and fulfilled lives.

By: Dr. Gary Levenston of the PEP Squad

Dr. Gary Levenston is a clinical psychologistliving in South Florida whose family hasbeen impacted by type 1 diabetes.

PARENTING ROLES AFTER DIAGNOSIS

Raising more than $1.5 milliontoward finding a cure for diabetes has been a work oflove, dedication and the fruitof a growing four-year part-nership between Walgreensof South Florida and the Diabetes Research Institute

Foundation. This year, an additional $500,000 was raised throughthe sale of “scannables” in Walgreens stores across South Florida,family teams, raffles, generous contributions from individuals, and corporate sponsors such as Neutrogena, the Miami Dolphins, Sun Life Stadium, PepsiCo, Frito-Lay, NIPRO, Alpina Foods, Red Bull, Coca-Cola, and Florida Ice, to name a few.

March 8th marked the fourth year of the DRI Walk for Diabetes & FamilyFun Day presented by Walgreens, which took place at Sun Life Stadiumin Miami Gardens and Tradition Square in Port St. Lucie. It attractedmore than 8,600 enthusiastic supporters from all over South Floridaand St. Lucie County.

“Walgreens is honored to support the work of the Diabetes ResearchInstitute. We are very grateful to our customers and associates whohave been exceptional in supporting our commitment by participatingin the DRI Walk for Diabetes & Family Fun Day, as well as supportingour in-store fundraising program,” said Roy Ripak, Walgreens marketvice president.

In stores, scannable sales added to the overall efforts by allowing customers at all Walgreens stores from Port St. Lucie down throughthe Florida Keys to support the cause throughout the month by purchasing DRI-branded "scannables" at checkout. Proceeds fromthose sales added $272,000 to the funds raised for the walk – and all directly benefited the DRI.

“Over the many years, Walgreens has been our partner in promoting,supporting and organizing this event. Thank you to Roy Ripak and theentire team of employees at Walgreens, who have dedicated countlesshours to making this event a success,” said DRI Foundation Presidentand CEO Joshua Rednik, during a speech after the walk.

Josh also acknowledged the hard work of family teams who raisethousands of dollars, and assemble their loved ones each year in custom inspirational T-shirts to walk for a cure. This includes thisyear’s top fundraising families, the Perez and Tacher families.

“Seeing all those individuals, familiesand communities that rallied aroundthem was truly inspiring, and we’revery grateful for all the families whohave pulled together to help us raisefunds and bring so many people tosupport such a special event. Youhelped us make this the biggest year of this event yet,” stated Josh.

This year’s event also included participation of the Biggest Loser Resorts– which sponsored The Biggest Loser 5K RunWalk chip-timed 5K and agrand raffle that gave four lucky winners a weeklong stay for two atBiggest Loser Resorts located across the country. Bobby Saleem, thispast season’s finalist from NBC's The Biggest Loser also attendedalongside Biggest Loser Resort trainers and staff – who led the warm-up,cheered on participants as they ran and walked toward the finish line,and gave South Florida a taste of what The Biggest Loser Resorts areall about.

“It was a fantastic experience for all of us to be part of this event and support our friends at the Diabetes Research Institute and theirremarkable work to find a cure for type 1 diabetes,” said Lesley Carey,president of The Biggest Loser Resorts. “We were also thrilled that ittook place in such a vibrant and energetic place like South Florida –which has definitely become one of the potential locations we’relooking into for our next Biggest Loser Resort.”

Along with the walk and Biggest Loser experience, families enjoyed anarray of activities; from a Miami Dolphins Football Fun Skills Course,bounce houses, zip lining, rock climbing, a Walgreens health fair wherepharmacists answered questions and provided health tips about diabetescare, give-a-ways, and vendors, to carnival rides, and live music. Participantsalso got to meet and greet celebrities including Miami Dolphins playersOlivier Vernon and Marcus Thigpen, plus alumnus John Offerdahl,Miami Dolphin Cheerleaders, Footy from the Footy and Mike Showon 560 WQAM, Froggy from the Y-100 Morning Show, and NathalieRodriguez from MIA 93.9 and WIOD Newsradio 610.

WALGREENS, BIGGEST LOSER RESORTS AND THE SOUTHFLORIDA COMMUNITY STEP UP FOR A DIABETES CURE

1) Left to right: Market Vice President of Walgreens Roy Ripak and President andCEO of the DRI Foundation Joshua Rednik receive a proclamation from MiamiDistrict 12 Commissioner Jose “Pepe” Diaz.

2) Walgreens Store Manager and DRI Walgreens Walk Coordinator ClintSmethurst strikes a pose with Miami Dolphins Cheerleaders.

3) A strong show of support for diabetes research from Biggest Loser Resorts Fitness Director and Coach Betty Herberger.

4) Kade Baily (left) supports his friend and classmate, Jace Tacher, who was diagnosed with type 1 diabetes just after his 2nd birthday, as part of Team Jace — the family team with the second highest amount of funds raised.

5) Tyler Perez (right) from Team Tyler, the top fundraising family team of the 2014 walk,  poses with his friend and Miami Dolphins Running Back Marcus Thigpen.

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LET ME COUNT THE WAYS TO GIVE

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1) The Berman family: Jonathan, Mark, Morgan, Lauren, andMichelle, 2) Jonathan with friend and fellow fundraiser, TristanWakefield, at the DRI's Matering Your Diabetes program.

When NBA All-Star Ray Allen isn’t scoring big on the court for his cham-pionship Miami HEAT team, he’s doing so off the court for his 7-year-oldson, Walker, and millions like him. Ray and his wife, Shannon, have beenbig advocates for type 1 diabetes ever since Walker’s diagnosis at just 17months old. From testifying about the importance of research to holdingevents that raise funds for research, the Allens have been taking shotsat diabetes with full force – and they’re not slowing down.

Recently, they joined forces with their friends, longtime Diabetes Research Institute supporters and South Florida philanthropists Andriaand Javier Holtz to host and chair the 2014 Ray Allen Golf Classic andRay of Hope Luncheon presented by Hublot at the exclusive La GorceCountry Club on Miami Beach to benefit the Diabetes Research Institute Foundation and JDRF.

More than 700 family, friends and philanthropists came out to supportthe Allens and Holtzes, including Ray’s fellow HEAT teammates Chris"Birdman" Andersen, Shane Battier, Chris Bosh; LeBron James; andRashard Lewis; former Heat star Alonzo Mourning, and actressGabrielle Union, who is also engaged to Miami HEAT's Dwyane Wade.

Guests bid on exclusive silent and live auction items throughout theevents. During the luncheon's silent auction, more than 100 vintage designer handbags went up for grabs, along with other fashionable items. Later in the day, there was another silent auction forthe golfers, which featured an autographed, blown-up photograph of“The Shot” Ray made that helped the Miami HEAT win its third NBAChampionship, along with other priceless signed sports memorabilia.Three one-piece, limited-edition Hublot watches, the sneakers Ray woreduring the 2013 NBA Finals, and other Ray Allen-signed memorabiliawere among the highly-coveted items claimed at top dollar during thelive auction, for which Ray served as auctioneer with comedian andwriter Chris Spencer, while Ray’s mother, Flora, modeled and displayedthe items.

“We had the opportunity to tour the Diabetes Research Institute lastweek, and we saw what they do first hand. They are the ones that wereally rely on. When we talk about finding a cure, they are the ones whoare in the lab every single day really making it happen,” said Ray during

the awards dinner. “Everything that you guys have done here todayhelps this man [DRI’s Dr. Camillo Ricordi] find a cure for us. And one ofthe great things I learned about him in the lab is that he has people allover the world that are collaborating to eradicate this terrible disease.”

The Allen family, including sons Wystan, Wynn, and Rayray and daughterTierra, is committed to helping support critical research to find a curefor Walker. Likewise, the Holtz family has raised nearly $2 million forthe cure-focused work of the Diabetes Research Institute with their previously held events. Their son, Andrew, now 19, was diagnosed withtype 1 diabetes just after his 7th birthday. His older siblings, Matthewand Nicole, have always been involved in the family's fundraising efforts, and the events are extremely well-supported by their family,friends, and colleagues.

During the program, Andrew addressed the audience with a heartfeltspeech. “The fact that you are all here for me and Walker is really justamazing. And I feel so lucky to have you all in my life,” he said. “I was 7years old when I was diagnosed with diabetes and I had no idea whatit all meant. And Walker is 7 years old, but he's been living with thissince he was a baby and look at him, he's the happiest kid in the room.He reminds me a lot of myself when I was that age. He really is such aninspiration to me, and to all of us.”

Special thanks are extended to everyone who helped make this eventpossible, including event sponsors: Presenting Sponsor Hublot; GoldSponsor The Holtz Family; Dinner Sponsor Maria & Sheldon Lowe andFamily; Sterling Sponsors Balogh Family Foundation, Wayne and ArleneChaplin, Michel & Lauren Deller, Marquis Bank, Miami HEAT, Dr. BrigittRok and Mr. Alan Potamkin, Ray of Hope Foundation, Wells Fargo Advisors, LLC; Bronze Sponsors Brodson Construction, Hilary and RichardCooper, Inserra Shop-Rite Supermarkets, Morrison Brown Argiz & FarraLLC; FJ Pollak, Tracfone; Stearns Weaver Miller Weissler Alhadeff & Sitterson, P.A.; Diamond Sponsors Micky and Madeleine Arison FamilyFoundation, Lisa and David Desmond, Janie Kupferman; Beverage Sponsor Southern Wine & Spirits; Goody Bag Sponsor Air Jordan; andGolf Shirt Sponsor Perry Ellis.

AGAINST DIABETES

1) From left to right, Back row: Matthew Holtz, Nicole Holtz, Andrew Holtz, JavierHoltz, Andria Holtz, Shannon Allen, Ray Allen, Wystan Allen; Front Row: Wynn,Walker, and Rayray Allen.

2) Miami HEAT’s Chris “Birdman” Andersen and DRI COO Mitra Zehtab.

3) Diabetes Research Institute (DRI) supporters and colleagues: Manager ofDonor Relations Aimee Siegel-Harris, NE Region Board member Lindsey Inserra,National Board member Bonnie Inserra, DRI Foundation CEO Joshua Rednik, Sr.Development Director Gary A. Kleiman, DRI Director Dr. Camillo Ricordi, Na-tional Board member Sheldon L. Singer.

4) Walker Allen poses with Maria Fernanda Alvarez and Tatiana Botero, who allhave type 1 diabetes.

5) LeBron James and Local 10 Anchor Laurie Jennings.

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Holiday cheer was in abundance at the Long Island Holiday Reception, hosted by Roberta (left) andBruce Waller at Muttontown Club on December 12. Among the 70 special guests in attendance wereFran and Howard Helfant, Rina and Jerry Weinbrom, Eric and Maria Reeps, Joan and Bill Fishlinger,and Wendy Waller, who were all presented with Cycle of Discovery Awards for their generous contributions and support of the DRI. Also honored was Allan L. Pashcow, who has been involvedwith the DRI for more than 20 years and recently ended his term of office as chairman of the regionalboard. Pictured are Roberta, Dara Melnick, and Wendy.

Long Island Holiday Reception

The ladies at the Palm Beach Auxiliary raised more than $112,000 for the DRI at their 15th Annual A Giftof Love…A Gift of Hope Luncheon, which was held at the Polo Club of Boca Raton February 10. EventChairwomen (l-r) Gloria Katz, Renee Aronin, and Natalie Olstein welcomed 270 ladies to the sold-outluncheon, where they treated them to an afternoon of private boutique shopping, card games, and raffles.They also heard from 15-year-old speaker Brooke Miller, who has type 1 diabetes, and DRIF COO Deborah Chodrow – who made a special announcement that a portion of the proceeds of the eventwould go toward a critical piece of research equipment to be used at the DRI, in memory of SethAronin, the late son of event co-founder and chairwoman Renee and her husband, Arven Aronin. Seth

had type 1 diabetes. A plaque was placed on the Equipment Wall at the DRI to pay tribute to his memory. To date, the Palm Beach County Auxiliary has raised nearly $600,000 for the DRI since its founding in 1998.

A Gift of Love…A Gift of Hope Luncheon

Hot off the heels of his “Saturday Night Live” cameo and U.S. media tour, music legend Barry Gibbperformed an exclusive concert for a sold-out crowd of nearly 800 people at the 40th Anniversary Loveand Hope Ball, held at the Westin Diplomat Resort & Spa in Hollywood on February 15. The black-tie gala– combined with November’s Preview Party – helped raise nearly $1 million this year, and was held inhonor of Life Chairman Sonja Zuckerman, who has been at the helm of Love and Hope for all 40 years.Executive Chairman Sandra Levy (standing) and DRI Director Dr. Camillo Ricordi were also recognizedfor their unwavering commitment to the DRI. Mistress of Ceremonies Belkys Nerey, Emmy Award-winning journalist and anchor of WSVN News, thanked event honorees: Honorary Chairman ShirleyHarris (seated), Anniversary Honorees Janie and Ronald Kupferman, Love Honorees Barbara and Norman Shapiro, Hope Honorees Mercedes and David Carlson, Ruby Star Honorees Sandy and Senator Paul Steinberg and Gold Star Honoree Sheila Wohl, as well as National Chairman KathySimkins. Event sponsors The GEO Group, Global Trend Alert, Landmark Trust, Neiman Marcus, PerfectVodka, Margarita and Rick Tonkinson, and Saks Fifth Avenue were also recognized.

40th Anniversary Love and Hope Ball

Empire Ball

More than 900 guests gathered for the 30th annual Empire Ball, the signature event of theDRI Foundation’s Real Estate Division, on December 11 at New York's Grand Hyatt Hotel.Guests enjoyed a lavish cocktail reception, followed by a bountiful dinner and an informative,humorous, and poignant program kicked off by Ball Chairman Peter L. DiCapua, chairmanof CodeGreen Solutions. During its 30-year span, more than $32 million has been raised fordiabetes research – with this year’s gala bringing in more than $1.3 million, including anoverwhelmingly generous anonymous gift of $100,000. Pictured with special guest sportscommentator Boomer Esiason (second from left) and DRI Scientific Director Dr. Camillo Ricordi (center) are Honorees Andrew Cooke, Jay Badame, and Joe Dussich.

EVENTS

D.R.E.a.M.S. in the city

The Ninth Annual D.R.E.a.M.S. in the city took place on Tuesday, May 6th, at The Pierre in NYC.Nearly 300 people feted the evening’s honorees, Irene and Sy Cohen and Diane and Robert Cohen,who received the “Dare to Dream” award; and Dr. Jason C. Baker, who received the Humanitarianaward. The festivities raised more than $550,000. Longtime co-chairs and sponsors were Samantha Shanken Baker, Bonnie Inserra, and Meryl Lieberman. The 50-Carat Presenting Sponsorwas The Inserra Family. Platinum Sponsors were the Cohen Family Foundation, Shanken FamilyFoundation, and Stacy Joy Goodman Memorial Foundation. Alan Kalter of Late Show with DavidLetterman served as MC, while the Jay Prince Band played an amazing musical set.

EVENTSOut of the Kitchen

A crowd of 240 tapped into their inner foodies at Out of the Kitchen at the St. Regis Bal Harbour Resorton March 13 – and helped raise more than $155,000. At this unique affair, 20 chefs performed theircraft tableside for tables of 12 diners – which included Miami HEAT’s Ray Allen and his wife, Shannon,CBS Miami Entertainment Reporter Lisa Petrillo, WPLG Local 10 News Anchor Laurie Jennings, and Comedian Chris Spencer, who acted as event MC. The event was co-chaired by (l-r) Steve and TammyKlein, Amy and Scott Greenwald, St. Regis Executive Chef Tom Parlo, Executive Pastry Chef AntonioBachour, and Chef de Cuisine for J & G Grill Brad Kilgore. The list of hot chefs included: Top Chef

Finalist Nina Compton, Timon Ballo, Gabriela Machado, Conor Hanlon, Cesar Zapata, Marc Vidal, Michael Corvino, Giorgio Grapicavoli, Makoto,Dena Marino, Sean Brasel, Andrea Curto-Randazzo, Aaron Brooks, Todd Erickson, Carlos Brescia, Jeremiah Bullfrog, and Dave Hackett.

Cooking for a Cure

It was a sizzling 11th Annual Cooking for a Cure – with more than $9,000 raised. Nassau County Legislator and DRIF Board Member Delia DeRiggi-Whitton (right) led the committee to create another fabulous evening at Page One Restaurant, Glen Cove, on Monday, April 7. This year, the eventhonored Dr. Francesco J. Caputo (second from left) of Caputo Chiropractic. He is a personal trainer/fitness, nutritional counselor and motivational speaker who has authored and published the children’s book Diana the Organic Banana. Also pictured are DRIF’s Northeast Region Director Tony Childs (left) and Chef Jeanine DiMenna.

The Crystal Ball

More than 300 guests, including daytime television royalty Susan Lucci and worldrenowned author Nelson DeMille, helped raise more than $728,000 at the 15th annualCrystal Ball, held May 3 at The Garden City Hotel in Long Island. DRI Foundation NE Region Co-chairman Bruce Siegel served as Master of Ceremonies, Allan L. Pashcowreceived the Gillin Family Humanitarian Award, and Frank Pusinell, RA, EVP of operations,property management and construction, RXR Realty, was honored with the Distinguished Service Award. Formerly referred to as the Crystal Ball Honoree, this year’s

award was renamed the Rowland and Sylvia Schaefer Award, in memory of a couple who helped advance the DRI’s research. The award was presented by the Schaefers' daughter and son-in-law Roberta and Bruce Waller to Dr. Camillo Ricordi via video. Bruce co-chaired the eventalong with his sister, Wendy Waller. (Pictured l-r: Allan and Louise Pashcow, Susan Lucci, Helmut Huber, Sandy and Nelson DeMille).

Kids’ Carnival for a Cure

Families from all over the tri-state area came together for the annual Kids' Carnival for a Cure, whichtook place at Dave and Buster’s at the Mall at The Source in Westbury, March 16. Leading the eventwere Kids’ Carnival Co-chairs Sheri Donaldson, Lauren and Steven Field, Frankie Lam and Susan Rubinstein – who welcomed the attendees, including special guest, Disney star Dylan Riley Snyder(center), who plays the role of “Milton” on the hit series, Kickin' It. Kids and parents enjoyed a day offood and drinks, goody bags, playing video and arcade games, jumping on inflatables, bowling, play-ing pool and more. There were also raffles and a silent auction, which helped raise more than$128,000. (Pictured l-r: DRIF’s Josh Rednik, Aaron Field, Matthew Donaldson and DRIF’s Tony Childs.

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The 31st Annual Don Strock Diabetes Golf Classic presented by the Miami Seaquarium drovein nearly $125,000 on May 14 – crossing the $2.5 million mark in overall funds raised to date. Tournament Host Don Strock (far right) and Chairman Bruce Fishbein (second from left) ofThe Produce Connection, saw another strong show of support from more than 140 celebrityand amateur golfers, which included alumni, NFL pros, and radio personalities, such as John“Footy” Kross, Scott “Froggy” Langley,Charles Bennett, Eddie Hill,Kerry Glenn, Stephen Potter,Roy Barker, Pat Dennis, John Harris, and Quadtrine Hill. They played an 18-hole tournament,

followed by a cocktail hour and an awards dinner, live and silent auctions and a moving speech by Arianna Lamosa, who was joined onstageby her 6-year-old daughter, Olivia, who has type 1 diabetes. Also pictured with Strock and Fishbein are Fishbein’s grandson Isaiah (right) andArthur Hertz (center) of Miami Seaquarium with characters from the family attraction.

Don Strock Diabetes Golf Classic

It was a record year for the Brenda Novak Online Auction for Diabetes Research, with more than $370,000 in fundsraised through auction items and a special edition A Sweet Life Boxed Set sales. Created by New York Times and USAToday Bestselling Author Brenda Novak 10 years ago in honor of her 17-year-old son, Thad, who has type 1 diabetes,the auction has raised a whopping $2 million plus for diabetes research. This year, exclusive items included CelineDion “meet and greet” and concert tickets, signed books by fellow bestselling authors, and hundreds more. But thehot item of the auction was the A Sweet Life anthology – which Novak created with the help of 13 fellow authorsand sold exclusively to benefit the auction.

Brenda Novak’s Online Auction for Diabetes Research

Nearly $500,000 was raised at the 25th Annual Shell Key West Fishing Challenge thisyear thanks to the participation of hundreds of fishermen, Shell employees, wholesalersand corporate sponsors. DRI COO Dr. Mitra Zehtab was one of the guest speakers at thethree-day, deep-sea fishing competition – which took place April 24-27 on the beautifulwaters surrounding Key West. The event, started by Jo andHayden Blaylock, founder andCEO of Blaylock Oil Company, and continued today by daughter Crystal Blaylock Sanchez,began benefiting the DRI after Crystal’s son, Matthew Sanchez (center), was diagnosedwith T1D. Also pictured with the Blaylocks are event sponsor (l-r) Paul Stanifer, Motiva En-terprises general manager of fuel sales and marketing; Dan Romasko, Motiva Enterprises.

Shell Key West Challenge

Vince Wilfork Draft Fundraiser

Vince Wilfork (right), defensive tackle for the New England Patriots, held his 11th annual draft nightfundraiser at Pinz Entertainment in Milford, MA, this past May. The event that he and his wife, Bianca(center), organize each year was well attended and raised funds for the DRI and Joslin Diabetes Center inBoston. His efforts are in memory of his father who passed away from diabetes-related complications. Pictured with the Wilforks is DRIF VP Tom Karlya.

Sportsmen for Charity saw yet another successful sold-out year at the picturesque Pawling Mountain Club inPawling, NY, on April 25. Participants enjoyed delectable food, practice rounds, a friendly sportsmen competitionand cocktail hour with the stunning Appalachian Trail National Park as the backdrop. Pictured are DRI FoundationNortheast Region Director Tony Childs (l) presenting Event Chair Charles Guigno (r) with a Realization Award forhis dedication to the DRI every year.

Sportsmen for Charity

CALENDARFishing for a CureAugust 2014 / MICHIGANThis local fishing tournament, held onKent Lake in Kensington Metropark ofLivingston County, MI, raises diabetesawareness and funds for the DRI.

The Rod Gilbert DRI Golf ClassicAugust 11, 2014 / LONG ISLANDTo be held at the beautiful Pine HollowCountry Club, this event will feature afun day of golf, followed by an awardsdinner and silent auction.

Haute TeaSeptember 12, 2014 / FLORIDAThe Young Society of Love and Hope will host the third annual event, featuring lunch, champagne, silentauction and prizes for the finest hats.

Cocktails for a Cure September 13, 2014 / NEW YORK

The Besner family and Willa's WishFoundation host an evening of cocktails,hors d'oeuvres and dancing at the Hudson Terrace Salon.

Gold Coast Concours/Bimmerstock September 14, 2014 / LONG ISLANDHundreds of exotic cars and BMWs willbe showcased throughout the day atthis magnificent exhibit, to be held atthe City of Glen Cove’s downtown.

Phil Peterson’s Key West Poker Run September 19 - 22, 2014 / FLORIDAPhil Peterson will host his annual motorcycle run, which starts in Miamiand finishes in Key West for SouthFlorida’s biggest biker party weekendof the year.

The Donaldson Organization Golf Outing October 6, 2014 / NEW YORKThe Donaldson Organization will host

a golf outing at Winged Foot GolfCourse in Mamaroneck, NY. Enjoy afull day of golf, plus a hearty breakfastand lunch, followed by a cocktail reception and dinner.

All In for a CureNovember 4, 2014 / NEW YORKTo be held at the Grand Havana Room,the seventh annual Texas Hold’em tournament will feature a silent auction,fine wines and spirits, exclusive cigars,hors d’oeuvres and a dinner buffet.

Fall Into Fashion November 6, 2014 / LONG ISLANDTo be held at the Garden City Hotel,this event will highlight the upcomingseason’s best fashions during a splendidlunch with a “chance” auction and more.

Love and Hope Preview Party November 7, 2014 / FLORIDAKick off the celebration with us at the

event long-ago dubbed the "heart ofLove and Hope." To be held at the St.Regis Bal Harbour Resort, the eveningwill begin with a fabulous cocktail reception and continue in the ballroomwith dinner and dancing.

Empire Ball December 10 2014 / NEW YORKA veritable Who’s Who of New York’sreal estate giants, this annual black-tiedinner dance is the industry’s socialevent of the season, to be held at theGrand Hyatt Hotel.

Champions for Charity December 2014 / LONG ISLANDThis annual holiday shopping benefit isdesigned to raise funds for not-for-profitorganizations. Twenty five percent ofsales will be donated to the DRI whensupporters use a Champions for CharityCard. Shop, shop, shop!

For information on the events or to make reservations, visitDiabetesResearch.org or call one of the DRI Foundation officeslisted below.

Diabetes Research Institute Foundation National Office200 South Park RoadSuite 100Hollywood, FL 33021

address service requested

Non-Profit Org.US Postage

PAIDDiabetes ResearchInstitute Foundation

DRIfocus

DRIfocus

The Diabetes Research Institute Foundation supports the Diabetes Research Institute at the University of Miami Leonard M. MillerSchool of Medicine, whose mission is to develop and rapidly apply the most promising research to treat and cure those now livingwith diabetes. To obtain additional information or request copies of DRIfocus, please call (800) 321-3437 or e-mail lweintraub@drif.org, or visit DiabetesResearch.org.

Marketing & Communications Dept.Lori Weintraub, APRLauren SchreierJoelle ParraLaurie Cummings

ContributorsGary KleimanGlenn Kleiman Melissa PenaJill SalterAimee Siegel-HarrisMitra Zehtab, M.D.

is a publication of the Diabe tes Research Institute Foundation.Summer 2014/ Volume 41 / Issue 2

DIABETES RESEARCH INSTITUTE FOUNDATION

PhotographyDRI / DRIF staff and volunteersGabriela BianchiniMarc S. Levine PhotographyJoe Marzo PhotographyAndrew Milne PhotographyDonna Victor

DesignFranz Franc Design Group Inc.

National Office / Florida Region200 South Park Road, Suite 100 Hollywood, FL 33021 Phone: (954) 964-4040 Fax: (954) 964-7036 info@drif.org

Northeast Region / Manhattan Office381 Park Avenue South, Suite 1118New York, NY 10016 Phone: (212) 888-2217 Fax: (212) 888-2219neregion@drif.org

Northeast Region / Jericho Office410 Jericho Turnpike, Suite 201Jericho, NY 11753Phone: (516) 822-1700 Fax: (516) 822-3570 neregion@drif.org