ecm cell adhesion molecules
DESCRIPTION
molecular biologyTRANSCRIPT
![Page 1: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/1.jpg)
Interaction of cells with the environment
Unit Outline:
What is outside the cell and how do cells communicate with what’s “out there”?
How do cells interact with their external environment?
How do cells interact with each other?
![Page 2: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/2.jpg)
Extracellular space
![Page 3: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/3.jpg)
Extracellular space
basal surface of ectodermal cell of chick embryo
apical surface of epithelial
cell from intestinal
lining
![Page 4: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/4.jpg)
Extracellular matrix
epidermis pulled away from basement membrane
basement membrane
between blood vessels of
glomerus and renal tubules
collagen
![Page 5: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/5.jpg)
Extracellular matrix
![Page 6: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/6.jpg)
Extracellular matrix
Proteins of ECM - collagen
![Page 7: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/7.jpg)
Extracellular matrix
Proteins of ECM - proteoglycans
![Page 8: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/8.jpg)
Extracellular matrix
Proteins of ECM -
fibronectin
![Page 9: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/9.jpg)
Extracellular matrix
Proteins of ECM - laminin
collagen
laminin
![Page 10: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/10.jpg)
Interaction of cells with ECM
inactive
INTEGRINS
![Page 11: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/11.jpg)
Interaction of cells with ECM
INTEGRINS
functions of outside-in signals
differentiationmotilitygrowth survival
ligands have RGD
motif
![Page 12: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/12.jpg)
Interaction of cells with ECM
FOCAL ADHESIONS
FA
![Page 13: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/13.jpg)
Interaction of cells with ECM
FOCAL ADHESION
S
![Page 14: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/14.jpg)
Interaction of cells with ECM
HEMIDESMOSOMES
![Page 15: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/15.jpg)
Interaction of cells with ECM
![Page 16: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/16.jpg)
Interaction of cells with cells
CELL ADHESION MOLECULES
![Page 17: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/17.jpg)
Interaction of cells with cells
CELL ADHESION MOLECULES
![Page 18: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/18.jpg)
Interaction of cells with cells
CELL ADHESION MOLECULES
![Page 19: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/19.jpg)
Interaction of cells with ECM and other
cells
CELL ADHESION MOLECULES VS
ECM ATTACHMENT MOLECULES
![Page 20: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/20.jpg)
vocabularyextracellular spaceextracellular matrixbasement membraneglycocalyxcollagenfibronectinproteoglycanGAG chainslaminininside-out signalingoutside-in signalingfocal adhesionfocal adhesion kinase (FAK)actin keratin
talinvinculinactininhemidesmosomecell adhesion moleculeselectinlectinImmunoglobulin superfamilycadherintight junctionadherins junctiondesmosomegap junction
![Page 21: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/21.jpg)
Extracellular Matrix Unit Learning Goals:the extracellular space:
a. discuss the concept that the physical interactions between cells and their extracellular environment is highly specific as a result of molecular interactions between molecules on the cell with molecules in the matrix between cells and molecules on neighboring cells
b. describe the molecular components of the extracellular matrix (ECM) and discuss the cellular processes regulated by interactions between cells and their extracellular environment
![Page 22: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/22.jpg)
interaction of cells with ECM:
a. compare the structure, function and signaling activity of integrins and “true” ECM proteins like collagen, laminin, and proteoglycans
b. comapre the structure and functions of molecular structures formed at the site of attachment of cells to an artificial substrate (focal adhesion) and to the basement membrane (hemidesmosome)
![Page 23: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/23.jpg)
interaction of cells with other cells:
a. describe the general class of proteins mediating interactions between cells (cell adhesion molecules) using specific examples
b. compare the functions of cell adhesion molecules and extracellular matrix attachment molecules
c. discuss why insoluble solutes, whch cannot freely diffuse through the plasma membrane, also cannot pass freely between cells of an epithelial layer, and what would happen to tissues of they could
![Page 24: Ecm Cell Adhesion Molecules](https://reader037.vdocument.in/reader037/viewer/2022102904/55cf9967550346d0339d369e/html5/thumbnails/24.jpg)
d. compare tight junctions, adherins junctions, desmosomes, and gap junctions in terms of structure, function and the type of cells in which they are found
e. draw, in cross section, two neighboring epithelial cells and illustrate the relative location and general structure of adherins junctions, desmosomes, tight junctions and gap junctions