Eevropis respiraciuli sazogadoebis XX yovelwliuri kongresi

179 monozigoturi da 85 dizigoturi wyvili iqna gamokvleuli

F filtvebis disfunqciasa da sisxlZarRvebis

elastiurobis daqveiTebas Soris inaxa mWidro genetikuri urTierTkavSiri

aTerosklerozsa da sasunTqi gzebis daavadebebs aqvT genetikuri korelacia.

The International Twin Study 2009, (Hungary, Italy, and the United States)

TST-is aqvs axal testebze meti an toli sensitiuroba T-SPOT-is gamoyenebisas meti pozitiuri Sedegi iqna

miRebuli, vidre Quantiferon-TB GOLD-s dros specifiuroba orive axali testisa gacilebiT maRalia, vidre TST-is specifiuroba Quantiferon-TB GOLD-isa T-SPOT-TB-is BCG-

vaqcinirebul pirebSi erTnairia Sualeduri(ganusazRvreli) Sedegebi erTnairia CD4+-is donem ar moaxdina raime gavlena testebis Sedegze

(461,29±307,49)(I. Latorre, X. Martinez-Lacasa, R. Font, A. Lacoma, J. Puig, C. Tural, E. Cuchi, J. Lite, C. Prat, M. Perez, V. Ausina, J. Dominguez (Terrassa, Badalona, Spain)

CD4+ and CD8+ T-ujredebisadmi PPD-specifiuroba mcirdeba dabali incidentobis qveynebSi, SedarebiT maRali incidentobis qveynebisa (20% vs 64,1%) (C. Giehl (Saarbrucken, Germany))

TST-is, Quantiferon-TB GOLD-isa T-SPOT-TB-is SedarebiTi

daxasiaTeba

upiratesoba mieniWos mantus tests (TST) maRali incidentobis qveynebSi

IFG-assay aqtiurad gamoiyenos latenturi DA tuberkulozis diagnostirebisTvis dabali incidentobis qveynebSi

ERS/ATS-is rekomendacia

gama-interferonis producirebuli proteini (Interferon gamma-induced protein 10 kDa (IP-10). miekuTvneba CXC jgufis citokinebs

sekretirdeba IFN-γsapasuxod monocitebis, endoTeliaruli ujredebisa da fibroblastebis mier

misi done momatebulia virusuli “C” hepatitis dros

IP-10-is donis 150 pg/mL-ze nakleboba aiv-inficirebul pirebSi arT-Terapiis dawyebamde iTvleba keTilsaimedo niSnad

Kkvlevebma aCvenes, rom IP-10aseve avlens specifiur pasuxs tuberkulozuri mikobaqteriis mimarT

A aiv-inficirebul pirebSi IP-10 iyo markeri M. tuberculosis–is sapasuxod,

damoukideblad CD4+T ujredebis donisa (D. Goletti, A. Raja, B. Syed Ahamed Kabeer, C. Rodrigues, A. Sodha, O. Butera, S. Carrara, G. Vernet, C. Longuet, S. Tangara, M. Leportier, E. Girardi, P. Lagrange (Roma, Italy; Chennai, Mumbai, India; Lyon, Marcy L'Etoile, Paris, France)

IP-10

dafuZnebulia ESAT6/CFP10),

- inovaciuri kanSida diagnostikuri testi- dafuZnebulia or rekombinantul cilaze: ESAT6/CFP10, romelnic ar moipovebian - BCG vaqcinaSi- keTdeba da ikiTxeba zustad im teqnologiiT, rogorc mantus testi

ESAT6/CFP10 miRebulia Escherichia coli-is genetikurad modificirebuli kulturidan.

amflifikacia SemdgomSi moxda M. tuberculosis -is dnm-ze

Seqmnilia seCenovis sax. moskovis samedicino akademiis molekuluri medicinis samecniero-kvleviT institutSi

gavlili aqvs aprobacia moskovis, sanqt-peterburgis, samaris da riazanis tub. dawesebulebebSi

Diaskintest

axasiaTebs usafrTxoebis maRali profili

maRali specifiuroba 90-100% (p<0,05)

maRali mgrZnobeloba 98-100% (p<0,05)

hiperergiuli reaqcia (vezikulut-nekrotuli forma, limfangiti, limfangoiti) - 2-14% (p<0,05)

mniSvnelovani imunosupresiis dros testi SeiZleba iyos uaryofiTi

saSualebas iZleva vimsjeloT procesis aqtivobaze da SevafasoT antituberkulozuri Terepiis efeqturoba (gankurnebulebSi testi uaryofiTia)

Diaskintest

gacilebiT iafia

ar saWiroebs maRalteqnologiebs (ELISA, T-SPOT)

ar saWiroebs maRalkvalificiur laboratoriul personals

IFG-assay-Tan SedarebiT Diaskintest: