Curriculum Vitae

of

NICHOLAS KALAVREZOS

Head & Neck and Reconstructive Surgeon

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BIOGRAPHY

Nicholas Kalavrezos is a Consultant in Oral and Maxillofacial Surgery at

University College London Hospitals with a sub-specialty interest in

oral oncology and microvascular reconstruction. His clinical practice

also includes surgical treatment of salivary gland neoplasms, as well

as thyroid surgery.

Nicholas was born in October 1962 in Athens, Greece to a medical

family. His father was an obstetrician – gynaecologist in Athens – and

Nicholas was brought up visiting his father's medical practice

regularly. This influenced him significantly in choosing a surgical

career from a very early stage of his life.

Nicholas started his undergraduate training in dentistry in 1980 at the

University of Athens. Given his desire to follow a surgical career he

continued to study medicine at the University of Patras where he

graduated in 1992. During his medical training Nicholas spent his

summer holidays visiting eminent Maxillofacial Units in Europe. One of

these observerships included time spent with Professor Hermann

Sailer, Professor of Maxillofacial Surgery at the University Hospital of

Zurich in Switzerland. Professor Sailer was impressed by Nicholas’s

enthusiasm and, indeed, offered him a full resident post in his unit.

He started his maxillofacial career in the University Hospital in Zurich

in 1993 following one year’s training in general surgery. In Zurich he

completed his thesis in the management of craniofacial trauma. After a

four-year residential programme, he moved to the UK where he

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completed his training. The emphasis was on head and neck oncology

and microvascular surgery and therefore Nicholas gained experience in

eminent UK centres such as Liverpool, Mount Vernon, St

Bartholomew’s and the Royal London Hospital.

In early 2002 he was appointed Consultant Maxillofacial Surgeon at

University College London Hospitals with a sub-specialty interest in

oral oncology and microvascular reconstruction. Within the last 5 years

the Head and Neck Unit at the University College Hospital has been

developed into one of the busiest and most successful Head and Neck

Units in the country. The surgical armamentarium of the Centre has

improved vastly- Nicholas carries out one to two microvascular cases

per week with success rates well beyond 95%! His clinical practice also

includes surgical treatment of salivary gland neoplasms as well as

thyroid surgery.

He has set up links with various centres in Europe and he organizes

annual conferences of head & neck oncology and facial reconstruction.

Of particular interest are the links he developed with patients from

Nigeria - coming to London for unique single stage treatment of huge,

face disfiguring tumours such as ameloblastomas.

These patients have been refused treatment elsewhere and indeed,

they come to London for life-changing, single-stage surgical

treatment:

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Kubarat A is an example of this life changing treatment:

Fig. 1: Pre-treatment appearance

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PERSONAL DETAILS

NAME: Nicholas Kalavrezos

DATE OF BIRTH: 19th October 1962, Athens, GR

GMC: 4468996

GDC: 74201

MPS: 318705

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UNIVERSITY EDUCATION

Bachelor of Dental Surgery,

University of Athens (Greece), 1986

Bachelor of Medicine and Bachelor of Surgery,

University of Patras (Greece), 1992

POST-GRADUATE EDUCATION

Dissertation thesis (Dr med),

Medical School of the University of Zurich (Switzerland),

“Bone Scanning for the evaluation of carcinomatous invasion

of the mandible” 1995

Dissertation thesis (Dr med dent),

Dental School of the University of Zurich (Switzerland),

“Long term results after treatment of frontal sinus fractures:

Clinical and radiological aspects” 1998

Fellowship of the Royal College of Surgeons of Edinburgh 1998

Fellowship of the Faculty of Dentistry

Royal College of Surgeons in Ireland 1999

Intercollegiate Fellowship in Oral & Maxillofacial Surgery 2001

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CURRENT POST

Consultant Maxillofacial/Head & Neck Surgeon, University College

London Hospitals.

Honorary Consultant at Great Ormond Street Hospital for Children.

Honorary Consultant at the Whittington Hospital.

Special interest:

Head & Neck Oncology

and

Free Tissue Reconstruction

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PUBLICATIONS

1. Swinson B, Ryan F, Barrett AW, Jerjes W, Landon G, Calonje E, Kalavrezos N. Histiocytoid eccrine sweat gland carcinoma of the eyelid: report of a case. Clin Exp Dermatol. 2006 Nov;31(6):786-9. 2. Norris P, Lewis N, Kalavrezos N. Formation of compartments in the neck to facilitate suction drainage during transfer of free flaps. Br J Oral Maxillofac Surg. 2006 May 17; [Epub ahead of print] 3. Kalavrezos N, Hardee PS, Hutchison IL. Reconstruction of through-and-through osteocutaneous defects of the mouth and face with subscapular system flaps. Ann R Coll Surg Engl. 2005 Jan;87(1):45-52. 4. Baqain ZH, Thakkar C, Kalavrezos N. Superselective embolization for control of facial haemorrhage. Injury. 2004 Apr;35(4):435-8. 5. Kalavrezos N. Current trends in the management of frontal sinus fractures. Injury. 2004 Apr;35(4):340-6. 6. Witherow H, Swinson BD, Amin M, Kalavrezos N, Newman L. Management of oral and maxillofacial infection. Hosp Med. 2004 Jan;65(1):28-33.

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7. Swinson BD, Witherow H, Amin M, Kalavrezos N, Newman L. Principles of management in oral cancer. Hosp Med. 2003 Jul;64(7):404-10. 8. Brown J, Kalavrezos N, D’Souza J, Lowe D, Magennis P, Woolgar J Factors that influence the method of mandibular resection in the management of oral squamous cell carcinoma Br J Oral Maxillofac Surg 40(4): 275-284, 2002 9. Brown JS, Lowe D, Kalavrezos N, D’Souza J, Magennis P, Woolgar J Patterns of invasion and routes of tumor entry into the mandible by oral squamous cell carcinoma Head Neck 24(4), 370-383, 2002 10. Kalavrezos N, Gratz KW, Eyrich GK, Sailer HF Late sequelae after high midface trauma J R Coll Surg Edinb 45, 359-62, 2000 11. Kalavrezos N, Gratz KW, Sailer HF Frontal sinus fractures: Computed Tomography (CT) evaluation of sinus obliteration with lyophilised cartilage J Cranio-Maxillofac Surg 27, 20-24, 1999 12. Sailer HF, Gratz KW, Kalavrezos N Frontal sinus fractures: Principles of treatment and long term results after sinus obliteration with the use of lyophilised cartilage J Cranio-Maxillofac Surg 26, 235-242, 1998

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13. Kalavrezos N, Gratz KW, Oechslin CK, Sailer HF Die Obliteration der Stirnhoehle mit lyophilisiertem Knoerpel bei frontalen Frakturen (The obliteration of the frontal sinus with lyophilised cartilage in frontal bone fractures) Mund-, Kiefer-, und Gesichtschirurgie (Suppl 1) 2, 66-69, 1998 14. Kalavrezos N, Gratz KW, Sailer HF, Stahel WA Correlation of imaging and clinical features in the assessment of mandibular invasion of oral carcinomas Int J Oral Maxillofac Surg 25, 439-445, 1996 ***This paper was included (extended abstract) in the 1998-Year Book of Dentistry (Ed: L.H. Meskin, 175-179, Mosby) 15 . Bochlogyros PN, Kalavrezos N Intestinal adenocarcinoma metastatic to the mandible Proceedings of the 2nd Mediterranean Congress of Oral and Maxillofacial Surgery, Ed: Monduzzi Editore, 213-217, 1994 16. Bochlogyros PN, Panos G, Kalavrezos N The preservation of condylar position in orthognathic surgery Gr J Oral Maxillofac Surg 8, 1-8, 1993 17. Bochlogyros PN, Kalavrezos N Single-point stabilisation of zygomatic fractures Gr J Oral Maxillofac Surg 6, 7-11, 1991

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18. Kalavrezos N, Bochlogyros PN, Panos G Surgical correction of a patient with Goldenhar syndrome Gr J Oral Maxillofac Surg 5, 147-150, 1990 19. Bochlogyros PN, Kalavrezos N A new technique for the reduction of the dislocated mandibular condyle Gr J Oral Maxillofac Surg 5, 99-102, 1990 20. Bochlogyros PN, Kalavrezos N, Panos G, Pappas J, Andreou J The role of three-dimensional computed tomography in the decision of the therapeutic plan in cranio-maxillofacial surgery Gr J Oral Maxillofac Surg 4, 171-76, 1989 21. Spyropoulos N, Diamantopoulos AN, Kalavrezos N A study for the determination of the image discrepancy in occlusal X-rays Odontostomatol Proodos 41, 249-252, 1987 22. Kalavrezos N, Diamantopoulos AN Contemporary aspects on aphthous ulcers Hell Stomatol Chron. 1987 Jul-Sep;31(3):177-82.

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COURSES ORGANISED 2007 “Treatment Of The Disfigured Face” UCLH Head & Neck Centre March 2007, London, UK 2005 *Microvascular reconstruction in the Head and Neck: One size fits all? UCLH Head & Neck Centre June 2005, London, UK 1997 “Evolution In Craniofacial Surgery” University Hospital Zurich, September 1997, Zurich, Switzerland

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INVITED LECTURES 21st Conference of the Hellenic Association of Oral and Maxillofacial Surgery, Ioannina, May 2007 Title: Defect characteristics and type of reconstruction

as predictors of speech and swallowing following

surgery for oral and oropharyngeal cancer

37th meeting of the German-Austrian-Swiss Association for Head and Neck Oncology (DOESAK) Bochum University, November 2006 Title: Reconstruction of the oral cavity following

ablative surgery for cancer

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10th International Congress On Oral Cancer, Creece 2005 Chairman of Satellite Symposium PDT: A treatment option for the 21st century Conference of the Hellenic Association of Oral and Maxillofacial Surgery, Greece, November 2001 Title: Surgical management of Oral cancer

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ORAL PRESENTATIONS “A comparison of the anterolateral thigh flap with the radial forearm flap in the reconstruction of intraoral defects” British Association of Oral and Maxillofacial Surgeons June 2007 Mick Gillhooly, Nicholas Kalavrezos, Mike Amin “Current concepts in the management of head & neck sarcomas. A ten year retrospective to evaluate treatment modalities, survival & function” British Association Of Head & Neck Oncologists, April 2007 Amir Ketabchi, Chris Boshoff, Nicholas Kalavrezos, Laurence Newman “Single stage treatment of a giant, neglected ameloblastoma” European Association of Oral and Maxillofacial Surgery September 2006 Nicholas Kalavrezos

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“The pattern of the tumour invasive front in oral squamous cell carcinoma and its effect on recurrence rate” British Association of Oral and Maxillofacial Surgeons June 2005 Colin Liew, M El Maaytah, N Kalavrezos, D Moles, AW Barrett, G Thomas, C Hopper, L Newman International Conference in Oral Cancer, Crete 2005 “100 consecutive subscapular axis flaps in the head and neck” Conference of the International Association of Oral and Maxillofacial Surgeons, September 2005 N Kalavrezos, P. Hardee, I. Hutchison “Positron Emission Tomography (PET) for the monitoring of patients treated for stage IV head & neck cancer” British Association of Head & Neck Oncologists April 2003 H Witherow, N Kalavrezos, L. Newman, L Prvulovitz

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“Reconstruction of composite oro-osseo-cutaneous defects with subscapular axis flaps” British Association of Oral and Maxillofacial Surgeons June 2001 N Kalavrezos, M Cashman, PSGF Hardee, IL Hutchison “Conservative management of the mandible in oral carcinomas: Rationale of a treatment protocol” European Association of Oral and Maxillofacial Surgery September 2000 Nicholas Kalavrezos, JS Brown, D Lowe, J Woolgar “Factors influencing the conservative management of the mandible in oral carcinomas” British Association of Oral and Maxillofacial Surgeons June 2000 N Kalavrezos, JS Brown, D Lowe, J Woolgar

“Postoperative sequelae after naso-orbital-ethmoid (NOE) trauma” European Association of Oral and Maxillofacial Surgery September 1998 Nicholas Kalavrezos, KW Gratz, HF Sailer

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“Therapeutisches Konzept, Behandlung und postoperative Sequelae nach frontobasalem Trauma” (therapeutic concept, management and postoperative sequelae after frontobasilar trauma) 38th Workshop of the Austrian Association of Surgery and allied Specialties, Innsbruck May 1997 Nicholas Kalavrezos, KW Gratz, HF Sailer “Positron emission tomography (PET) for the staging of oral cancer?” Mediterranean Congress of Oral and Maxillofacial Surgery, Antalya, Turkey, May 1997 AP Zimmermann, ND Kalavrezos, KW Gratz, HF Sailer “Langzeit-Ergebnisse nach Sinus frontalis Obliteration mit lyophilisierem Knorpel bei ausgedehnten frontobasalen Frakturen” (long term results of frontal sinus obliteration with lyophilised cartilage) Conference of the German Association of Oral and Maxillofacial Surgery, Hamburg, Germany, May 1997 ND Kalavrezos, CK Oechslin, KW Gratz, HF Sailer

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“Analgesie bei Patienten mit terminalen Tumorstadien in Mund- Kiefer- und Gesichtsbereich” (analgesia in patients with tumours of terminal stage in the maxillofacial region) Conference of the German Association for Palliative care, Nurnberg, Germany, February 1997 CK Oechslin, ND Kalavrezos, KW Gratz, AP Zimmermann, HF Sailer “Therapeutic concept and management of complex midface trauma” Congress of the International Association of Maxillofacial Surgeons in Training The Netherlands, September 1995 ND Kalavrezos, CK Oechslin, KW Gratz, HF Sailer “Bone scanning for the evaluation of carcinomatous invasion of the mandible” International Conference on Oral and Maxillofacial Surgery Hungary June 1995 ND Kalavrezos, KW Gratz, HF Sailer

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“Preoperative diagnostic imaging in the assessment of mandibular invasion by oral malignancies” Mediterranean Congress of Oral and Maxillofacial Surgery, Nice, France, June 1995 ND Kalavrezos, KW Gratz, HF Sailer “Intestinal adenocarcinoma metastatic to the mandible” Mediterranean Congress of Oral and Maxillofacial Surgery, Corfu, Greece, June 1993 PN Bochogyros, N Kalavrezos The role of three-dimensional computer tomography in the decision of the therapeutic plan in cranio-maxillofacial surgery Mediterranean Congress of Oral and Maxillofacial Surgery, Athens, Greece, June 1989 PN Bochogyros, N Kalavrezos, G Panos, J Pappas, J Andreou

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Posters “Bone scanning for the evaluation of mandibular tumour invasion” European Association of Oral and Maxillofacial Surgery The Netherlands September 1994 N Kalavrezos, KW Gratz, HF Sailer “Versatility of hydroxyapatite cement (Bone Source) in craniofacial surgery: Illustration of two cases” British Association of Oral and Maxillofacial Surgery Birmingham June 1999 N Kalavrezos, H Thuau, G Bounds

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Academic Distinctions and Awards “Changing trends in the management of road traffic accidents in the county of Pelloponese” Best Oral Presentation in the Audit Day Medical School of University of Patras 1992 “Contemporary aspects on apthous ulcers” 1st prize for student paper in Oral Medicine Dental School of University of Athens 1986 “A study for the determination of the image discrepancy in occlusal x-rays” 1st prize for student paper in Oral Medicine Dental School of University of Athens 1986

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OPERATIVE DEMONSTRATIONS OF MICROSURGICAL TECHNIQUES “microvascular techniques and stepwise flap raising course”

University of Bochum , Germany November 2006 TEACHING EXPERIENCE Lecturer to post-graduate students in oral and maxillofacial surgery, Eastman Dental Hospital, London 2002- present Topic: Surgical management of oral cancer- reconstruction of the oral cavity Lecturer to the junior doctors of A & E and General Surgery at the Homerton General Hospital, London 2000-2001 Topic: Facial injuries Academic lecturer at the Dental School, University Hospital Zurich, Switzerland Topic: Oral Surgery:

I. Introduction to techniques of wound primary closure II. Methods of maxillo-mandibular immobilisation

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Administration and Committees Chairman of the Audit Committee for North London Cancer Network 2006- present Chair of the North-East Thames region for Audit British Association of Oral and Maxillofacial Surgerons 2002-2006 President of the International association of Maxillofacial Surgeons in Training (IAMFST) 1998-2000 President of the Organising Committee, VI IAMFST Congress, Zurich, Switzerland 1997