E l e c t r o n i c s A n y w h e r e

Conformal Electronics for Natural Integration with the Human Body

Ben Schlatka VP of Business Development, co-founder

bschlatka@mc10inc.com

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•  Company Overview

•  Technology Overview

•  Case Study 1 –  Balloon Catheter

•  Case Study 2 –  Wearable “Skin Mounted” Electronics

Agenda

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Overview

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Summary •  Based in Cambridge, MA, USA

•  Backed by North Bridge, Osage Partners

•  Extensive advisory board spanning semiconductor, materials, optics, and life science industries

Management Team & Key People David A. Icke, CEO Advanced Electron Beams, Teradyne, KLA-Tencor, Cypress Semiconductor. BS Stanford; MBA Harvard

Jeffrey Carbeck, PhD, CTO Arsenal Medical, Nanoterra Asst. Prof. Chemical Engineering, Princeton BS Michigan, PhD MIT, Post Doc Harvard

Kevin Dowling, PhD, VP of R&D Philips/Color Kinetics, PRI Automation, Robotics Institute BS, MS, PhD Carnegie Mellon

Ben Schlatka, VP of Business Development IBM Microelectronics, Nantero BBA UMass, Amherst; MBA Harvard

John A. Rogers, PhD, Co-Founder University of Illinois Urbana Champaign, Depts. of Materials Science & Engineering, Electrical & Computer Engineering, and Chemistry Founded: Active Impulse Systems

George M. Whitesides, PhD, Co-Founder Harvard University, Dept. of Chemistry & Chemical Biology. Founded: Genzyme, Geltex, Surface Logix, Nanoterra

Carmichael S. Roberts, PhD, Chairman North Bridge Venture Partners, Partner. Founded: Arsenal Biomedical, Surface Logix, Inc

John M Deutch, PhD Institute Professor at MIT, Dept. of Chemistry, Member Defense Science Board, former Dir. of CIA

Our Technology Thoroughly vetted and widely recognized – over 172 scientific publications

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Our Technology Recognized in the popular media

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High Performance Taking Shape

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Problem: –  Conventional integrated circuits (ICs) are rigid, brittle and

planar, thereby restricting form factors

–  Flexible organic circuits lack performance and reliability

Solution: –  New ways to use old materials that enable different forms

of electronics, with stretchable, curvilinear, rugged forms and high performance

Conformal Electronics Use Cases

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Mimic Nature Through Revolutionary Shapes, Sizes, & Configurations

Synthetic Sensing

Diagnose and Influence Tissue Functions with High Spatial & Temporal Resolution

Interventional Circuits &

MC10 Technology: Key Features

Distributed Network of Electronics Can Undergo Significant Folding, Bending and Stretching Without Sacrificing Performance

-  Is compatible with conventional foundries to take advantage of

-  High performance (> GHz) -  Low cost and high yield

MC10 Technology:

-  Ultrathin, high performance electronics -  Proprietary handling technology -  Proprietary interconnect designs -  Conformal polymeric substrates

Key Platform Features:

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Appl. Phys. Lett (2006).

protect sidewalls; etch undercuts

etch trenches

Adv. Func. Mater. (2007). 10/5/11 9 mc10 • confidential

Si: Flexible When Very Thin

micro-CMOS CMOS ‘printer’

released arrays of ultrathin, micro-CMOS ‘chiplets’

‘Printable’ Semiconductor Devices

target substrate (e.g. plastic sheet)

interconnect print, repeat

stamp

25 µm

10/5/11 10 mc10 • confidential

Semprius

Mechanics of Bending

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10/5/11 mc10 • confidential 12

200 µm

micro- CMOS

200 µm

Initial Stretched, ~60%

0.2 0.1

Stretched (60%) Released

strain (%) 0 0.05 0.15 ~20 % prestrain

‘Stretchable’ Interconnects

1.  Electrodes

2.  Photodiodes

3.  Thermocouples

4.  Pressure/contact

5.  LEDs

6.  Photovoltaics

A multitude of sensors can be integrated with control electronics such as multiplexors, amplifiers, and radios

Stretchy IC Arrays Easy to Integrate Heterogeneous Devices & Materials

Integrated Arrays of Sensors and Control Electronics:

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CASE STUDY 1

Balloon Catheter

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Soft Electronics

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Multifunctional Optoelectronic Catheters

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inflate

1 mm

µ-LEDs

temp sensor

electrode

500 µm

Pt

+

Pt resistor 200µm Au wire Au sensor

-

LED 100µm

-  Mapping / Stimulation / Ablation

-  Temp. Sensing / Flow

-  Drug Activation

deflate

Nature Materials, In Press

MC10 Integrated PVI Product Improved “One-Shot” Ablation

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Ablation Balloons

Multi-Electrode Catheters

+

Long Procedure Times High Repeat Procedure Rate

Procedure times reduced Fewer Repeat Procedures

There is currently no single device that is safe and easy to use to treat AF

In Vivo Testing of Mapping Balloon

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MGH Animal Electrogram Data Lasso (left) and MC10 (right) data equivalence demonstrated

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•  Conformal electronics used for direct contact with soft tissue inside the heart

•  High performance electronics allows consolidation of existing tools and opportunity for entirely new sensing

Conclusion

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CASE STUDY 2

Wearable “Skin Mounted” Electronics

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Today’s “Wearable” Electronics

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•  New Products Constantly Hitting the Market

•  Increasingly ‘wearable’ form factors

•  Still “in the box” and constrained to rigid housings

Concept: Skin/Tissue-like Electronics

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1) Ultra-thin (~5 µm), ultra-light (~1 mg/cm2)

2) Ultra-low modulus (~5 kPa)

3) Air/water permeable; waterproof

The Future

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The Next Generation of Devices

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Respiration Hydration

HRM/ECG

Multimodal, Self Powered Health Stickers!

Low Profile Wearable Electronics

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Ultrathin “tattoo like” electronics possible

Results in high performance, light weight electronic stickers that can be worn on the body

•  5 - 50um thickness = Extremely low profile

•  Conformal

•  Engineered to match the modulus of the skin for improved adhesion

•  Capable of bending and stretching while maintaining electronic performance

•  Battery-less design points possible

Epidermal Electronics System--Results

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Epidermal Electronics System--Results

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Epidermal Electronics System--Results

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•  Power –  Conventional Batteries –  Thin Film –  Solid State –  Wireless

•  I/O –  Conventional Wires –  Visual Indications –  Wireless

•  Electronic Design –  Size of Components –  Product-Specific Layouts

•  Packaging –  Biocompatibility –  Environmental Stability –  Adhesives

On-Going R&D

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•  MC10 is commercializing an array of conformal electronics systems based on the thin, high performance electronics platform licensed from the University of Illinois.

•  Our process technology uses very thin inorganic materials, unique interconnect designs, and transfer printing technology to create thin, high performance electronic systems.

•  Doing so enables “Electronics Anywhere” with particularly valuable applications on and in the body.

•  We are actively seeking new Joint Development Partners for our technology.

Summary

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Contact: Ben Schlatka VP Business Development Bschlatka@mc10inc.com

3/22/11