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Electron Microscopy data: structure variability Electron microscopy MDTCS Fab TSR TSR CUB MDTCS Fab TSRs

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Page 1: Electron*Microscopy*data:*structure*variability* · I CYS Spacer 2 3 4 pnding 5678 D4-CK binding Gys Spacer exosite Scissile bond domain recognition binding (Unravelled VWF) Ca2+-bindin

Electron  Microscopy  data:  structure  variability  

Electron  microscopy  

MDTCS  

Fab  

TSR  

TSR  

CUB  MDTCS  

Fab  

TSRs  

Page 2: Electron*Microscopy*data:*structure*variability* · I CYS Spacer 2 3 4 pnding 5678 D4-CK binding Gys Spacer exosite Scissile bond domain recognition binding (Unravelled VWF) Ca2+-bindin

Hypothesis  

Page 3: Electron*Microscopy*data:*structure*variability* · I CYS Spacer 2 3 4 pnding 5678 D4-CK binding Gys Spacer exosite Scissile bond domain recognition binding (Unravelled VWF) Ca2+-bindin

Acknowledgements  

LaTrOn  (Laboratory  for  Thrombosis  Research),  KU  Leuven  kulak:  •  Prof.  Dr.  Hans  Deckmyn  •  Prof.  Dr.  Simon  De  Meyer  

•  Prof.  Dr.  Karen  Vanhoorelbeke  

•  Dr.  Karen  De  Ceunyck  

•  Dr.  Hendrik  Feys  •  Dr.  Dirk  Lievens  •  Dr.  Wim  Maes  

•  Elien  De  Cock  •  Frederik  Denorme  

•  Benedicte  Nuycens  •  Irina  Por+er  

•  Elien  Roose  •  Sebas+en  Verhenne  •  Elien  Vermeersch  

•  Inge  Pareyn  •  Vicky  Van  Muylder  

•  Aline  Vandenbulcke  •  Nele  Vandepuce  

Baxter  Innova+ons  GmbH:  Dr.  Hanspeter  RoRensteiner    Washington  University  School  of  Medicine:  Prof.  Dr.  Evan  Sadler  


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