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Pre l iminaryProgram

Connect ing the

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Stroke Science

E d u c a t i o n. I n s p i r a t i o n. I l l u m i n a t i o n.

strokeconference.org

1Register Today – strokeconference.org/registrationandhousing For the most current program information, please visit strokeconference.org/programming

Program 1 State-of-the-Science Stroke Nursing

Symposium 4 ISC Pre-Conference Symposium I:

Stroke in the Real World: There Will Be Blood: Management and Treatment of ICH

6 ISC Pre-Conference Symposium II: Stroke in the Lab World: Reversing Stroke Translational Research - Bedside-to-Bench and Back Again

7 ISC Program Information 8 ISC Preliminary Program

Back Inside Cover Week-at-a-Glance

Registration/Housing 16 Registration/Hotel Information

Meeting and Membership InformationTelephone: 888-242-2453 (inside the US) 214-570-5935 (outside the US)Hours: M-F, 8:00 am - 5:00 pm CTEmail: [email protected] site: strokeconference.org

RegistrationTelephone: 800-748-3583 and 508-743-8517 (International)Hours: M-F, 8:00 am – 4:00 pm CTFax: 508-743-9611Mail: Stroke Conference Registrations c/o Convention Data Services 107 Waterhouse Road Bourne, MA 02532Email: [email protected]

HousingTelephone: 855-992-3353 (inside the US) 212-532-1660 (outside the US)Fax: 212-779-6128Mail: International Stroke Conference 2018

c/o onPeak LLC 381 Park Avenue South New York, NY 10016Email: [email protected]

Membership ServicesTelephone: 800-787-8984 (inside the US) 301-223-2307 (outside the US)Fax: 301-223-2355Email: [email protected]

Key DatesSept. 13 FAHA/VIP Registration and Housing opensSept. 20 Member Registration and Housing opensSept. 27 Nonmember Registration and Housing opensSept. 27 Late-Breaking Science and Ongoing Clinical Trials Abstract Submission opensOct. 25 Late-Breaking Science and Ongoing Clinical Trials Abstract Submission closesDec. 5 Deadline for Early Registration RatesDec. 6 Advance Registration Rates Apply Jan. 2 Deadline for Advance RegistrationJan. 3 Standard Registration Rates apply/Housing remains open based on availability

*Registration savings depend on registration level and membership tier.

Los Angeles, CaliforniaDiscover Los Angeles. Beaches, mountains, ocean and desert to explore. Theme parks, nightclubs and parks to play in. An incredibly diverse mix of cultures and neighborhoods to discover. Exotic ethnic restaurants, uniquely California cuisine and world-class dining to savor. Shopping, museums, sports, live music and more. Wrap it all up with a sunny climate and lifestyle that is desired the world over. What you’ve got is a wealth of experiences that few other destinations in the world can match. The Sports & Entertainment Capital of the World – Los Angeles!

Contents State-of-the-Science Stroke Nursing Symposium

Tuesday, Jan 23The American Heart Association/American Stroke Association is grateful to the members of the State-of-the-Science Stroke Nursing Symposium 2018 Program Committee for their dedication and leadership provided throughout the year in planning the program.

For Registration and Housing information, please go to strokeconference.org/registrationandhousing. Please note that there is a separate registration fee to attend the Stroke Nursing Symposium.

Symposium DescriptionThe State-of-the-Science Stroke Nursing Symposium is a can’t miss forum designed to provide cutting-edge information for nursing, rehabilitation and other healthcare professionals who treat patients and families in all phases of stroke care from prevention to treatment in the emergency department through rehabilitation. The symposium will update and inform the audience about nursing issues along the continuum of stroke care (primary and secondary prevention, ischemic and hemorrhagic stroke management, rehabilitation and program development). The goal of the program is to share innovative best clinical practices that have been developed to optimize patient outcomes. An exciting plenary program and stimulating break-out sessions are planned to meet educational needs for nurses, rehabilitation and healthcare professionals at various skill levels.

Learning ObjectivesAt the conclusion of the State-of-the-Science Stroke Nursing Symposium, participants should be able to:• Discuss the integration of Mission Lifeline severity-based stroke triage algorithm into

stroke systems of care including:o Challenges in the development of severity-based stroke triage algorithmo Implementation of severity-based stroke triage algorithm

• Explain the stroke bundled payment for care improvement at three organizations including:o Evolution from loss to gain at Penn State Hershey o Benefits of a post-acute network at Abington-Jefferson o Outside the box strategies at Vanderbilt

• Summarize evidence-based strategies for preventing stroke and stroke complications including:o Stroke prevention and preparedness for

African Americans o How a community-based multidisciplinary

outpatient rehab program optimizes stroke survivorship including health, return to work, and overall outcomes

o Optimizing survivorship for patients with hemorrhagic stroke

o Stroke Nursing Research: the beginnings, development, present and future

• Describe advances in clinical research, practice and quality improvement including:o The essentials of non-traumatic subarachnoid

hemorrhage: presentation and initial assessment; acute management options; and prognostic indicators, complications, and sequela

o The needs, design, and implementation of a remote stroke service; and how to overcome the barriers to reap the benefits

o Spinal cord infarction: what causes it; how to recognize and treat it; and provide post-acute care

• Demonstrate how to facilitate admission, progression and discharge for stroke including:o Nurse-led post stroke transitional care; challenges

and strategies for implementing transitional care models; and what is important to patients and their caregivers

o Overview of the current state of stroke survivors and their family caregivers; educational

Program Committee

› Dawn Aycock, BSN, MSN, PhD, Chair

› Michelle Camicia, PhD(c), MSN, CRRN, CCM, FAHA,Vice Chair

› Taura L Barr, PhD, RN, FAHA

› Terrie Black, DNP, MBA, RN, CRRN, FAHA, CVSN Liaison

› Trudy Gaillard, PhD, RN, CDE

› Norma D McNair, PhD, RN, ACNS-BC, FAHA

› Elaine T Miller, PhD, RN, CRRN, FAHA, FAAN ISC Program Committee Liaison

› Sue Pugh, MSN, RN, CNRN, CRRN, CNS-BC, FAHA

› Karen L Saban, PhD, APRN, RN, CNRN, Immediate Past Chair

Register Today – strokeconference.org/registrationandhousing For the most current program information, please visit strokeconference.org/programming

assessment strategies that professionals can use; and how to create and evaluate print and online educational materials

o How to promote a strong stroke support system by partnering with advocates and caregivers to create a supportive network for stroke survivors; encouraging evidence-based medicine collaboration using a novel E-communication tool; and review of secondary stroke prevention clinical practice guidelines used in acute care

Continuing Education Accreditation – NursesThe American Heart Association is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.

For full CME/CE accreditation information on the State-of-the-Science Stroke Nursing Symposium, please visit strokeconference.org

Tuesday, Jan 238:00 am – 5:00 pm

8:00 am – 11:30 am Main Event

Moderators: Dawn M Aycock, RN, PhD, MSN, BSN, Atlanta, GA

Michelle Camicia, MSN, CCRN, Vallejo, CA

Welcome and Opening Remarks from the Stroke Nursing Symposium Program ChairDawn M Aycock, PhD, MSN, BSN, Atlanta, GA

Council Welcome and Remarks from the CVSN Council ChairNancy Marie Trygar Artinian, PhD, RN-BC, FAHA, East Lansing, MI

Stroke Article of the Year Recipient – Article HighlightsGianluca Pucciarelli, Rome, Italy

Integration of Mission Lifeline Severity-based Stroke Triage Algorithm into Stroke Systems of Care:

Challenges in Development of Severity-based Stroke Triage AlgorithmDeborah R Summers, MSN, RN, FAHA, ARNP, Kansas City, MO

Application of Severity-based Stroke Triage AlgorithmLynn Hundley, APRN, CNRN, MSN, RN, Louisville, KY

Stroke Systems of Care Implementation of Severity-based Stroke Triage AlgorithmJean Luciano, MSN, RN, CRNP, CNRN, SCRN, Philadelphia, PA

9:50 am – 10:05 am Break

Stroke Bundled Payment for Care Improvement: Experiences and Unexpected Outcomes at Three Organizations:

Bundle Payment BackgroundKathy Morrison, RN, MSN, Hershey, PA

Benefits of a Post Acute Network at Abington-JeffersonDeborah Murphy, MSN, CRNP, Abington, PA

Evolution from Loss to Gain at Penn State HersheyAlicia Richardson, Hershey, PA

Outside the Box Strategies at VanderbiltKiersten Espaillat, ANP, DNP, Nashville, TN

11:30 am – 1:00 pm Lunch

1:00 pm – 5:00 pmConcurrent A

Stroke Prevention: Evidence Based Strategies for Preventing Stroke and Stroke Complications

Moderators: Daiwai Olson, RN, PhD, CCRN, Dallas, TX

Terrie Black, DNP, MBA, CRRN, FAHA, FAAN, Amherst, MA

Addressing Health Disparities: Stroke Prevention and Preparedness for African AmericansClaudia C Beal, RN, Dallas, TXDawn M Aycock, RN, PhD, MSN, BSN, Atlanta, GAGayenell Magwood, PhD, RN, FAAN, Charleston, SC

Q&A: Networking of Ideas

From Stroke Patient to Stroke Survivor: Models to Optimize Stroke Survivorship:

A Community Based Multidisciplinary Outpatient Rehab Program Optimizes Stroke Survivorship Including Health, Return to Work, and Overall OutcomesJoan C Breen, MD, Haverhill, MA

Optimizing Survivorship for Patients with Hemorrhagic StrokeMarissa DeJesus, MS, Columbus, OH

Discussion

2:45 pm – 3:00 pm Short Break

50 Years of Stroke Nursing Research:

Humble BeginningsMelissa Moreda, Raleigh, NC

Developing Our HistoryKathy Morrison, RN, MSN, Hershey, PA

The Present State of Stroke Nursing ResearchAmanda L Dirickson, MSN, Dallas, TX

The Future of Stroke Nursing ResearchJanice L Hinkle, RN, PhD, CNRN, FAHA, Villanova, PA


Oral Abstracts

Discussion

Nursing Symposium Program Nursing Symposium Program

1:00 pm – 5:00 pmConcurrent B

Acute Care: Advances in Clinical Research, Practice and Quality Improvement

Moderators: Trudy R Gaillard, RN, Cincinnati, OH

Elaine T Miller, PhD, RN, CRRN, FAHA, FAAN, Cincinnati, OH

A World of Hurt: The Essentials of Non-traumatic Subarachnoid Hemorrhage:

Part I: Presentation and Initial AssessmentSusan J Ashcraft, DNP, Fort Mill, SC

Part II: Acute Management OptionsFranklin A Marden, MD, Elk Grove Village, IL

Part III: Prognostic Indicators, Complications, and SequelaElizabeth M Kim, ANP, Redwood City, CA


Remote Stroke Service: A Novel Use of Telemedicine:

Needs, Design, and Implementation of a Remote Stroke ServiceBenjamin Morrow, BS, MSN, Pittsburgh, PA

Preparing for a Remote Stroke Service: Overcoming the Barriers to Reap the BenefitsElizabeth Tedesco, Pittsburgh, PA



Spinal Cord Infarction: Unique Challenges:

Spinal Cord Infarction: What Causes It and How Do You Recognize and Treat It?David N Alexander, MD, Los Angeles, CA

Post-acute Care of the Patient with Spinal Cord InfarctionJay H Rosenberg, MSN, CRRN, West Orange, NJ


Oral Abstracts

Discussion

1:00 pm – 5:00 pmConcurrent C

Rehabilitation & Recovery: Facilitating Admission, Progression and Discharge for Stroke

Moderators: Sue Pugh, MSN, RN, CNRN, CRRN, CNS-BC, FAHA, Baltimore, MD Norma McNair, RN, PhD, ACNS-BC, FAHA, Los Angeles, CA

Nursing Led Post-Stroke Transitional Care:

Evidence-base for Nurse-led Post-stroke Transitional CareSarah Lycan, NP, MSN, AGPCNP-BC, Winston-Salem, NC

Challenges and Strategies for Implementing Transitional Care Models: Getting Clinician and System Buy-inChristina N Condon, NP, Winston Salem, NC

Outcomes Beyond 30 Days: What Is Important to Patients and Their Caregivers?Dawn Becker, RN, BSN, Kinston, NC


Education for Survivors and Family Carers Across the Continuum of Care:

Overview of the Current State of Education for Stroke Survivors and Their Family CarersTheresa L Green, BScN, MSc, PhD, Kelvin Grove, Australia

Educational Assessment Strategies That Professionals Can ImplementBarbara J Lutz, PhD, RN, Hampstead, NC

Create and Evaluate Print and Online Educational MaterialsLinda L Pierce, RN, PhD, Toledo, OH

Discussion

2:45 pm – 3:00 pm

Short Break

Innovative Collaborative Techniques in the Development of an Integrated Comprehensive Stroke System of Care:

Promoting a Strong Stroke Support System: Partnering with Advocates and Caregivers to Create a Supportive Network for Stroke SurvivorsDebbie L Hill, BS, Gainesville, FL

Encouraging Evidence-based Medicine Collaboration Using a Novel E-Communication ToolWende Fedder, DNP, Nashville, TN

Review of Secondary Stroke Prevention Clinical Practice Guidlelines Used in Acute CareKenneth J Gaines, MD, Nashville, TN


Oral Abstracts

Discussion

For the most current program information and speakers, please go to strokeconference.org/nursingsymposium

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Science and Technology Hall (Exhibits)Wednesday and Thursday, Jan 24 - 25, 10:00 am – 4:00 pm

For additional information on the Science and Technology Hall, please go to

strokeconference.org/exhibits.Register Today – strokeconference.org/registrationandhousing

ISC Pre-Conference Symposium I: Stroke in the Real World: There Will Be Blood: Management and Treatment of ICH

ISC Pre-Conference Symposium I: Stroke in the Real World: There Will Be Blood: Management and Treatment of ICH

12:00 pm – 1:00 pmLunch

Moderators: Branko N Huisa, MD, San Diego, CA Latisha Katie Sharma, MD, Los Angeles, CA

1:00 Lock, Stock and Two Barrels: Vascular Lesions in ICH? How to Investigate and ImageChristian Stapf, MD, Montreal, QC Canada

1:30 Q&A

1:40 Larger than Life: ICH Expansion and Size: Does the Size Matter?David Rodriguez-Luna, MD, PhD, Barcelona, Spain

2:00 Q&A

2:10 pm – 2:55 pm

Concurrent IA: The Ugly Truth: Practical Prognostication and Palliation: What is the Evidence?Shouri Lahiri, MD, New York, NY

Concurrent IB: The Dark Knight: Complex Clinical Scenarios in ICH: When to Resume AnticoagulationAshkan Shoamanesh, MD, Ancaster, ON, Canada

Concurrent IC: Cloudy with a Chance of Meatballs: Role of Reversal Agents

Role of Reversal Agents - PROThorsten G Steiner, MD, PhD, Heidelberg, Germany

Role of Reversal Agents - CONDariush Dowlatshahi, MD, PhD, FRCPC, Ottawa, ON, Canada

3:00 pm – 3:45 pm

Concurrent IIA: The Ugly Truth: Practical Prognostication and Palliation: What Is the Evidence?Shouri Lahiri, MD, New York, NY

Concurrent IIB: The Dark Knight: Complex Clinical Scenarios in ICH: When to Resume AnticoagulationAshkan Shoamanesh, MD, Ancaster, ON, Canada

Concurrent IIC: Cloudy with a Chance of Meatballs: Role of Reversal Agents

Role of Reversal Agents - PROThorsten G Steiner, MD, PhD, Heidelberg, Germany

Role of Reversal Agents - CONDariush Dowlatshahi, MD, PhD, FRCPC, Ottawa, ON, Canada

4:00 pm – 5:10 pm

4:00 Gorillas in the Mist: Congophilic Amyloid Angiopathy and Microbleeds: Diagnosis, Prognosis and Implications for TreatmentBranko N Huisa, MD, San Diego, CA

4:30 Q&A

4:40 Kramer vs. Kramer Debate: “Sweet Spot” for Blood Pressure After ICH - PRO Intense TherapyCraig Anderson, MD, PhD, Sydney NSW, Australia

4:50 Kramer vs. Kramer Debate: “Sweet Spot” for Blood Pressure After ICH - PRO Moderate TherapyKen S Butcher, MD, PhD, FRCP(C), Parkville (Melbourne), Australia

5:00 Q&A

5:05 Gone in 60 Seconds: Closing RemarksBruce Ovbiagele, MD, MSc, MAS, FAHA, Charleston, SC

For the most current program information and speakers, please go to strokeconference.org/preconferencesymposium.

Tuesday, Jan 23This Pre-Conference Symposium of the International Stroke Conference is designed to provide cutting edge information for healthcare professionals caring for patients with, or at risk for stroke. This one-day symposium highlights scientific advances in Intracerebral Hemorrhage while emphasizing application in the real world. The symposium informs the audience about issues along the full continuum of ICH care and covers varied topics of interest to healthcare providers working in the emergency department, hospitalist settings, neurosurgery, radiology, general neurology, and other stroke care arenas. This year’s symposium will focus on the management and treatment of intracerebral hemorrhage including: pre-hospital diagnosis and treatment of ICH; ED stabilization and triage of the ICH patient; understand toxic clot constituents and cytotoxicity; a debate on minimally invasive surgery; ICU controversies; how to investigate and image vascular lesions in ICH; effects of size and ICH expansion; and amyloid angiopathy and microbleeds. There will also be a series of challenging breakout sessions. Participants will also have the opportunity to have an informal lunch with the faculty where questions or challenging stroke cases may be discussed.

Learning ObjectivesAfter participating in this activity, participants will be able to:• Discuss pre-hospital diagnosis and treatment

of ICH• Define how to stabilize and triage an ICH

patient in the ED • Explain toxic clot constituents and cytotoxicity • Analyze whether minimally invasive surgery is

appropriate or not • Paraphrase the evidence of ICU controversies• Demonstrate how to investigate and image

vascular lesions in ICH • Identify if size matters in ICH expansion • State the diagnosis, prognosis and implications

for treatment of congophilic amyloid angiopathy and microbleeds

• Deduce whether to use intense or moderate therapy in order to obtain the “sweet spot” for blood pressure after ICH

• Cite the evidence for practical prognostication and palliation

• Calculate when to resume anticoagulation in complex clinical scenarios in ICH

• Explain the pros and cons for the role of reversal agents

The American Heart Association/American Stroke Association is grateful to the members of the ISC Pre-Conference Symposium 2018 Program Committee for their dedication and leadership provided throughout the year in planning the program.

Program Committee› Ted Wein, MD, FRCPC, FAHA, Chair

› Dariush Dowlatshahi, MD, PhD, FRCPC

› Branko Huisa-Garate, MD

› Navaz Karanjia, MD

› Patrick D Lyden, MD

› William Mack, MD

› Nerses Sanossian, MD

› Latisha Sharma, MD

› Sid Starkman, MD

› Paul Vespa, MD

› Gene Yong Sung, MD, MPH

› Wengui Yu, MD, PhD

› Bruce Ovbiagele, MD, MSc, FAHA (ISC Program Committee, Chair)

› Miguel A Perez-Pinzon, PhD, FAHA (ISC Program Committee, Vice Chair)

Continuing Medical Education Accreditation – PhysiciansThe American Heart Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Continuing Medical Education Accreditation – Physician AssistantsAAPA accepts Category I credit from AOACCME, Prescribed credit from AAFP, and AMA PRA Category 1 Credit™ from organizations accredited by ACCME.

For full CME/CE accreditation information on the ISC Pre-Conference Symposium, please visit strokeconference.org.

Please note that there is a separate registration fee to attend the ISC Pre-Conference Symposium I.

Tuesday, Jan 239:00 am – 5:10 pm

9:00 am – 12 Noon

Moderators: Nerses Sanossian, MD, Los Angeles, CA Navaz P Karanjia, MD, San Diego, CA

9:00 WelcomeBruce Ovbiagele, MD, MSc, MAS, FAHA, Charleston, SC

9:05 Scoop and Run: Pre-hospital Diagnosis and Treatment of ICHNerses Sanossian, MD, Los Angeles, CA

9:20 Q&A

9:30 The Golden Hour: ED Stabilization and Triage of the ICH PatientOpeolu Adeoye, MD, Cincinnati, OH

9:50 Q&A

10:00 The Killing Fields: Toxic Clot Constituents and CytotoxicityGuohua Xi, MD, Ann Arbor, MI

10:30 Q&A

10:40 Double Indemnity: Surgery or Not? Minimally Invasive Surgery, Evidence and Debate – PRODaniel F Hanley, MD, FAHA, Baltimore, MD

10:55 Double Indemnity: Surgery or Not? Minimally Invasive Surgery, Evidence and Debate – CON

11:10 Q&A

11:20 Apocalypse Now: ICU Controversies: Where Is the Evidence?Navaz P Karanjia, MD, San Diego, CA

11:50 Q&A

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ISC Pre-Conference Symposium II: Stroke in the Lab World: Reversing Stroke Translational Research – Bedside-to-Bench and Back Again

Tuesday, Jan 23A new translational research paradigm will be explored, representing a shift from benchside-to-bedside, to reverse translation - bedside-to-bench. This pre-conference event is designed to address challenges facing traditional “forward-translation” stroke research. Despite four decades of research investigating mechanisms involved in ischemic brain injury, for example, we have yet to develop an FDA-approved neuroprotective agent. Is forward translation the only approach we should be taking? How can we take advantage of human samples, from biofluids to tissue, to help guide our future stroke research? This half-day symposium brings together leading researchers who have successfully achieved reverse translation, starting with human samples, and applying cutting-edge big data techniques to identify genes/proteins of relevance. Though reverse translation assures relevance to human disease, how can we leverage traditional bench approaches to truly understand the significance of these findings? We will further explore examples of next steps needed to understand molecular mechanisms implicated by the genes/proteins identified by these new “omic” techniques.

After participating in this activity, participants will be able to:• Define how human genetics can be used

to identify new targets involved in stroke pathogenesis

• Discuss the utility of the blood transcriptome to understand stroke etiology and subtypes

• Apply a systems biology approach to integrating big data across the “omics”

• Explain how to exploit animal models to understand underlying mechanisms of GWAS hits

• Describe the use of human tissue to create in vitro models of disease

The American Heart Association/American Stroke Association is grateful to the members of the ISC Pre-Conference Symposium II 2018 Program Committee for their dedication and leadership provided throughout the year in planning the program.

Program Committee› Jin-Moo Lee, MD, PhD, Chair

› Daniel Woo, MD

› Bruce Ovbiagele, MD, MSc, FAHA (ISC Program Committee, Chair)

› Miguel A Perez-Pinzon, PhD, FAHA (ISC Program Committee, Vice Chair)



For full CME/CE accreditation information on the ISC Pre-Conference Symposium II, please visit strokeconference.org.

Please note that there is a separate registration fee to attend the ISC Pre-Conference Symposium II.

Tuesday, Feb 211:00 pm – 5:00 pm

Moderators: Jin-Moo Lee, MD, PhD, Saint Louis, MO

Daniel Woo, MD, Cincinnati, OH

1:00 Failure of Traditional Forward Translation: The Case of NeuroprotectionJin-Moo Lee, MD, PhD, Saint Louis, MO

1:15 Genomics Approach to Reverse Translation Martin Dichgans, MD, Munich, Germany

1:55 Probing Biofluids to Understand Disease Pathogenesis: A Transcriptomics Approach Frank Ray Sharp, MD, Sacramento, CA

2:35 – 2:45 Break

2:45 Integrating Big Data across the Omics: A Systems Biology ApproachPhilip De Jager, MD, New York, NY

3:25 Bedside-to-Bench: Choosing the Right Animal Model to Understand GWAS Hits

4:05 Harvesting Human Cells to Develop “Disease-in-a-dish” Adam Engler, PhD, La Jolla, CA

4:45 Q&A

For the most current program information and speakers, please go to strokeconference.org/programming.

ISC Program InformationThe American Heart Association/American Stroke Association is grateful to the members of the International Stroke Conference 2018 Program Committee for their dedication and leadership provided throughout the year in planning the program.

Program Committee

76

Program DescriptionThe International Stroke Conference is the world’s premier meeting dedicated to the science and treatment of cerebrovascular disease. This 2½-day conference features more than 1,500 compelling presentations that emphasize basic, clinical and translational sciences as they evolve toward a better understanding of stroke pathophysiology with the goal of developing more effective therapies. Join us and network with more than 4,500 colleagues in the stroke field from around the world with wide-ranging expertise and experience. Clinical Sessions focus on community risk factors; emergency care; acute neuroimaging; acute endovascular and acute nonendovascular treatment; diagnosis of stroke etiology; cerebral large artery disease; in-hospital treatment; clinical rehabilitation and recovery; and health services, quality improvement, and patient-centered outcomes. Basic Science Sessions focus on vascular biology in health and disease; basic and preclinical neuroscience of stroke recovery; and experimental mechanisms and models. Further specialized topics include pediatric stroke; intracerebral hemorrhage; nursing; preventive strategies; vascular cognitive impairment; aneurysms; subarachnoid hemorrhage; neurocritical care; vascular malformations; and ongoing clinical trials. Presentations on these topics attract a wide range of healthcare professionals and investigators including adult and pediatric neurologists; neurosurgeons; neuroradiologists and interventional radiologists; physiatrists; emergency medicine specialists; primary care physicians; hospitalists; nurses and nurse practitioners; rehabilitation specialists; physical, occupational, and speech therapists; pharmacists; and basic researchers spanning the fields of cerebrovascular function and disease.

Learning ObjectivesAt the conclusion of the International Stroke Conference, participants should be able to:• Identify recent advances in basic models of stroke and their translation to clinical research• Evaluate recent advances in the diagnosis, treatment, prevention and rehabilitation of cerebrovascular

disease• Analyze new and ongoing advances in clinical research through late-breaking science and ongoing

clinical trials sessions• Discuss new research, treatments and interventions with scientists and investigators working in all areas

of cerebrovascular disease• Interpret the rapidly changing areas within the stroke spectrum such as emerging options for the

diagnosis and treatment of acute stroke, mechanisms of stroke recovery, and the impact of vascular cognitive impairment

• Appraise the diverse challenges presented by cerebrovascular disease to specific populations, including ethnic and racial minorities, women, children, and developing communities

CME/CE DisclosureAll persons who develop and/or control educational content in CME/CE activities sponsored by the American Heart Association will disclose to the audience all financial relationships with any commercial supporters of this activity as well as with other commercial interests whose lines of business are related to the CME/CE-certified content of this activity. In addition, presenters will disclose unlabeled/unapproved uses of drugs or devices discussed in their presentations. Such disclosures will be made in writing in course presentation materials.



Continuing Education Accreditation – NursesThe American Heart Association is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.

For full CME/CE accreditation information on the International Stroke Conference, please visit strokeconference.org.

Legal DisclaimerThe International Stroke Conference is a scientific and educational meeting for the purpose of exchanging and discussing research results and scientific developments in the field of cerebrovascular disease. Accordingly, the American Heart Association/American Stroke Association cannot and does not offer any assurance or warranty of the accuracy, truthfulness or originality of the information presented at the conference.

› Bruce Ovbiagele, MD, MSc, FAHA, Chair

› Miguel A Perez-Pinzon, PhD, FAHA, Vice Chair

› Opeolu Adeoye, MD

› Craig Anderson, MD, PhD

› Kyra J Becker, MD, FAHA, Past Chair

› Sunghee Cho, PhD

› Helena Chui, MD, FAHA

› Andrew Ducruet, MD

› Heather Fullerton, MD, MAS

› Karen Furie, MD, MPH, FAHA, Stroke Council Chair

› Argye E Hillis, MD

› Judy Huang, MD

› Jong S Kim, MD, PhD

› Louis Kim, MD

› Eng Lo, PhD, FAHA

› Elaine T Miller, PhD, RN, CRRN, FAHA

› Thanh Nguyen, MD

› Alejandro Rabinstein, MD

› Tatjana Rundek, MD, PhD

› Gustavo Saposnik, MD, MSc, FAHA, FRCPC

› Magdy Selim, MD, PhD, FAHA

› Amanda Thrift, PhD, PGDipBiostat

› Amytis Towfighi, MD

› Kazunori Toyoda, MD, PhD, FAHA, FESO

› Georgios Tsivgoulis, MD, PhD, MSc, FESO

› Max Wintermark, MD, MAS, MBA

› Midori Yenari, MD, FAHA


ISC Preliminary Program ISC Preliminary Program

Please note that sessions are subject to change. For the most current program information, go to strokeconference.org/programming.

Wednesday, Jan 247:00 am – 7:00 pm

7:00 am – 8:30 am

Intracranial Atherosclerosis: Burden of Stroke in Asians (an AHA/ASA and Chinese Stroke Association Joint Symposium) (Diagnosis of Stroke Etiology)Moderators: Teruyuki Hirano, MD, PhD, Mitaka,

Japan Marc I Chimowitz, MB, CHB,

Charleston, SC

Acute Stroke Imaging for Intracranial AtherosclerosisDong-Eog Kim, MD, PhD, Goyang, Korea, Republic of

Acute Reperfusion Therapy for Intracranial AtherosclerosisShinichi Yoshimura, MD, Nishinomiya, Japan

Acute Antithrombotic Therapy for Intracranial AtherosclerosisLiping Liu, MD, Beijing, China

Hypolipidemic Therapy and Risk Factor Management for Intracranial AtherosclerosisOh Young Bang, MD, Seoul, Korea, Republic of

Diabetes and Stroke Mini-SymposiumPre-Diabetic States: Should We Treat Early and Often after Stroke?(Preventive Strategies)Moderators: Philip B Gorelick, MD, MPH,

FAHA, Grand Rapids, MI David Wang, DO, FAHA, Peoria, IL

Global Burden of Obesity, Metabolic Syndrome and Diabetes

Insulin Resistance and Metabolic Syndrome: An Appropriate Target for Stroke PreventionDawn Kleindorfer, MD, Cincinnati, OH

Optimal Use of Pioglitazone in Stroke PreventionWalter N Kernan, MD, New Haven, CT

Managing Diabetes After StrokeJoshua Z Willey, MD, New York, NY

Role of Neuroimaging in Stroke Prevention, Treatment and Recovery (Acute Neuroimaging)Moderators: Steven Warach, MD, Austin, TX, David S Liebeskind, MD, Los

Angeles, CA

MRI Guided Treatment of Patients with Resolved or Minimal SymptomsRichard Leigh, MD, Towson, MD

MRI of the Vessel Wall in Acute Stroke PatientsTanya Turan, MD, Charleston, SC

MRI Guided Treatment of Patients Who Are Otherwise Ineligible for Revascularization Due to an Unknown or Extended Time WindowAmie Hsia, MD, Washington, DC

Emerging Applications of MRI in Stroke Treatment and RecoveryJochen Fiebach, MD, Berlin, Germany

Tough Decisions in ICH (Intracerebral Hemorrhage)Moderators: Laura C Gioia, MD, Montreal, QC,

Canada Magdy Selim, MD, PhD, Boston,

MA

Reversal of Coagulopathy: When, What, Who and Why?Thorsten G Steiner, MD, PhD, Heidelberg, Germany

Long Term Management of Anticoagulation Associated ICHAshkan Shoamanesh, MD, Ancaster, ON, Canada

The Use of Statins in Patients with ICHGuido Falcone, MD, New Haven, CT

Anti-edema Therapy in ICH: Why, When and What?Joao A Gomes, MD, Cleveland, OH

Oral Abstract Sessions

8:30 am – 8:45 am Short Break

8:45 am – 10:15 am

Diabetes and Stroke Mini-SymposiumImpact of Diabetes on Stroke: From Bench to Bedside (Experimental Mechanisms and Models)Moderators: Craig E Brown, MD, Victoria, BC,

Canada Xiaoying Wang, MD, PhD,

Charlestown, MA

Epidemiology of Diabetic StrokeWuwei Feng, MD, Mount Pleasant, SC

Considering Hyperglycemia in Acute Ischemic StrokeKaren C Johnston, MD, FAHA, Charlottesville, VA

Mechanisms of Increased Post-stroke Brain Injury in DiabetesKunjan Dave, MSc, Miami, FL

The Role of Vascular Injury on Outcome Following Diabetic Ischemic StrokeAdviye Ergul, MD, Augusta, GA

Stroke Outcome in Animal Models with Comorbidities: Translational Impact of Novel Therapeutic Targets (Experimental Mechanisms and Models)Moderators: Gregory J Bix, MD, Lexington, KY John H Zhang, MD, PhD, Loma

Linda, CA

Neuroprotective Role of Adropin in Both Young and Aged Experimental Models of Ischemic StrokeEduardo Candelario-Jalil, PhD, Gainesville, FL

A Peptide Mimetic of Tyrosine Phosphatase STEP Confers Neuroprotection in Normotensive and Hypertensive Models of Ischemic StrokeSurojit Paul, PhD, Albuquerque, NM

CD36-mediated Inflammatory Response in Hyperlipidemic StrokeSunghee Cho, PhD, White Plains, NY

Corticosteroids Reinvigorate Microglial Responses and Repair of Microbleeds in the Diabetic BrainCraig E Brown, MD, Victoria, BC, Canada

Tackling Stroke in Low and Middle Income Countries: Placing Proof in Pragmatism; a WHO-Lancet Commission on Stroke in Low and Middle Income Countries (an AHA/ASA and World Health Organization Joint Symposium) (Community/Risk Factors)

Moderator: Mayowa Owolabi, MBBS, MSc, DrM, MWACP, FMCP, FAAN, Ibadan, Nigeria

The Global Burden of Stroke: Real Data, Model-based Estimates, and Data Gaps

Primary and Secondary Stroke Prevention: Best Buys for Total Population ImpactM Patrice Lindsay, BScN, PhD, Etobicoke, ON, Canada

Improving Hyperacute and Acute Care in Low Resource Settings: Innovations and AdaptationsSheila Martins, MD, Porto Alegre, Brazil

Stroke Recovery and Rehabilitation: Improving the Quality of Life of Stroke Survivors in Low and Middle Income CountriesFoad Abd Allah, MD, Cairo, Egypt

Understanding Disordered Sleep and Stroke (Nursing)Moderators: Janice L Hinkle, RN, PhD, CNRN,

FAHA, Washington, DC Norma McNair, RN, Los Angeles,

CA

Relationships of Disordered Sleep to Primary and Secondary StrokeSrikant Rangaraju, MBBS, Atlanta, GA

Disordered Sleep in Acute and Chronic Phase of StrokeSmi Choi Kwon, PhD, Seoul, Korea, Republic of

PSD and Disordered Sleep: Does Treatment of PSD Alter Disordered Sleep in Chronic Phase?Pamela H Mitchell, RN, Seattle, WA

Interaction of Stroke Survivor Disordered Sleep and Family Caregiver SleepBarbara J Lutz, RN, PhD, Hampstead, NC


10:15 am – 10:30 am Short Break/Science and Technology Hall

10:30 am – 12:00 Noon Opening Main Event

Moderators: Bruce Ovbiagele, MD, MSc, FAHA, Charleston, SC

Miguel Perez-Pinzon, PhD, FAHA, Miami, FL

AHA Presidential AddressJohn J Warner, MD, MBA, Dallas, TX

ISC Program Chair WelcomeBruce Ovbiagele, MD, MSc, FAHA, Charleston, SC

Thomas Willis Award Presentation

Late-Breaking Science Oral Abstracts

12:00 Noon – 1:30 pm Science and Technology Hall

Fellow and Early Career/Stroke Leader Roundtable Luncheon (ticket required; seating is limited)

Advance Practice Providers’ Luncheon (ticket required; seating is limited)

1:30 pm – 2:30 pm

Game of Strokes

In this exciting, interactive session, 3 teams of stroke professionals from around the world will compete in a fast and furious Jeopardy-style quiz session complete with both verbal and video questions. Use the ISC 2018 Mobile Meeting App to play along with this thrilling game in the session room and test your stroke knowledge. The teams will be comprised of stroke leaders from Africa, Europe and the Middle East; Asia, Australia and South America; and Canada and the US.

Remote Ischemic Conditioning: Triggering an Ischemia Tolerant State (Acute Nonendovascular Treatment)Moderators: David Hess, MD, Augusta, GA William Meurer, MD, Ann Arbor, MI

RIC in Acute Ischemic StrokeGrethe Andersen, Aarhus, Denmark

RIC in Subarachnoid HemorrhageNestor R Gonzalez, MD, Los Angeles, CA

RIC in Intracranial AtherosclerosisMarc I Chimowitz, MD, FAHA, Charleston, SC

RIC in Cerebral Small Vessel DiseaseLatisha Sharma, MD, Los Angeles, CA

The Neurovascular Unit Coming of Age (Vascular Biology in Health and Disease)Moderators: MingMing Ning, MD, Boston, MA Francesca Bosetti, PharmD, PhD,

Bethesda, MD

We Can Now Actually Image the NVU in Real-timeJaime Grutzendler, MD, New Haven, CT

The “New” NVU Can Also Be Leveraged for RecoveryS Thomas Carmichael, MD, PhD, Los Angeles, CA

How Cellular Therapies Affect the NVUJieli Chen, MD, Detroit, MI

Wrap-up: How the NVU Has Affected Translation and Has Clinical Meaning for PatientsCostantino Iadecola, MD, FAHA, New York, NY

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Trends in the Managment of Subarachnoid Hemorrhage and Cerebral Vasospasm (SAH and Other Neurocritical Management)Moderators: Peter Kan, MPH, Houston, TX Joshua William Osbun, MD, St

Louis, MO

Natural History and Clinical Outcomes of SAH: Current State of the ArtB Gregory Thompson, MD, Ann Arbor, MI

Diagnosis and Management of Cerebral VasospasmMichael Levitt, MD, Seattle, WA

Advances in the ICU Management of SAHAbhijit Lele, MD, Seattle, WA

Recent Scientific Advances and Ongoing Trials in the Management of VasospasmNima Etminan, MD, Mannheim, Germany


2:30 pm – 3:00 pm Break/Science and Technology Hall

3:00 pm – 4:00 pm

CED (Cerebrovascular Education and Discovery) Talks

In this compelling session, leaders in the stroke field will give short yet powerful talks that put forth rousing ideas regarding stroke research, education, or policy. Each talk will last for approximately 18 minutes with 4 minutes of questions from audience per talk. In order to keep the presentations highly interactive and energetic, a minimum of slides will be used.

Speakers: Donna M Ferriero, MD, San Francisco, CA

Thomas G Brott, MD, Jacksonville, FL

Philip Bath, DSc, FRCP, Nottingham, United Kingdom

A M Hakim, MD, PhD, FAHA, Ottawa, ON, Canada

Improving the Efficiency of Clinical Trial Design (Health Services, Quality Improvement, and Patient-Centered Outcomes)Moderators: Michael Hill, MD, Calgary, AB,

Canada Craig S Anderson, MD, FAHA,

Sydney, NSW, Australia

Cluster Clinical TrialsSandy Middelton, PhD, Darlinghurst, NSW, Australia

Utility-weighted Disability OutcomeJeff Saver, MD, Los Angeles, CA

Randomised RegistriesYing Xian, MD, Durham, NC

Platform Trials with Co-enrollment Bo Norrving, MD, Lund, Sweden

Recent Genetic Conditions in Stroke (Diagnosis of Stroke Etiology)Moderators: Tatjana Rundek, MD, PhD, Miami,

FL Natalia S Rost, MD, Boston, MA

Monogenic Disorders Related to Stroke in the YoungJukka Putaala, MD, Helsinki, Finland

Genetics of Functional Outcome After Stroke Arne Lindgren, MD, Lund, Sweden

Pharmacogenomics and Stroke Outcome Guillaume Pare, MD, Hamilton, ON, Canada



4:15 pm – 5:15 pm

AIS Guidelines Session

Moderators: William J Powers, MD, FAHA, Chapel Hill, NC

Alejandro A Rabinstein, MD, Rochester, MN

Systems of CareOpeolu Adeoye, MD, Cincinnati, OH

IV ThrombolysisAlejandro A Rabinstein, MD, Rochester, MN

Endovascular TreatmentThabele M Leslie-Mazwi, MD, Boston, MA

In-hospital CareWilliam J Powers, MD, FAHA, Chapel Hill, NC

Physical Activity and the Brain: Maximising Recovery and Function Post-stroke (Clinical Rehabilitation and Recovery)Moderators: Janet Prvu Bettger, ScD, FAHA,

Durham, NC Virginia J Howard, MSPH, PhD,

Birmingham, AL

Physical Activity and Exercise: A Complex Intervention with Multiple EffectsDave Saunders, PhD, Edinburgh, United Kingdom

Exercise to Promote Neuroplasticity Following StrokeMichelle N McDonnell, PhD, Adelaide, Australia

Robotics and Innovations in Rehabilitation

TelerehabilitationSteven C Cramer, MD, Orange, CA

Targeting Astrocytes for Stroke Therapy (Basic and Preclinical Neuroscience of Stroke Recovery)Moderators: Amutha Selvamani, MSc, College

Station, TX Raghu Vemuganti, PhD, Madison,

WI

MiRNA Modification in AstrocytesCreed Stary, MD, PhD, Stanford, CA

rAAV Mediated IGF-1 Gene Transfer in Aging Astrocytes Improves Stroke OutcomesFarida Sohrabji, PhD, Bryan, TX

Targeting Aquaporin-4 in Astrocytes to Reduce EdemaJerome Badaut, PhD, Bordeaux, France

Cellular Plasticity Within the Stroke ScarJason Hinman, MD, PhD, Los Angeles, CA

Telestroke 3.0. Beyond Acute Ischemic Stroke: Leveraging Technology for Stroke Management throughout the Continuum of Care and Outreach (Health Services, Quality Improvement, and Patient-Centered Outcomes)Moderators: Jeffrey Switzer, DO, Evans, GA Andrew M Southerland, MD,

Charlottesville, VA

Telestroke Networks Providing Community Education: Stroke ECHOPeter Hannon, MD, Salt Lake City, UT

International Collaborations in TelestrokeAnnemarei Ranta, MD, PhD, Wellington, New Zealand

To Transfer or Not: Using Telestroke for Inpatient Stroke Follow-upHeinrich J Audebert, MD, Berlin, Germany

Telestroke for Outpatient Stroke Follow-upChristine Anne Holmstedt, DO, Charleston, SC


5:30 pm – 6:30 pm Professor-led Poster Tours by Category: Moderated Presentation and Q&A with Poster Presenters

6:30 pm – 7:00 pm Poster Session with Poster Presenters

Thursday, Jan 257:00 am – 6:45 pm

7:00 am – 8:30 am

Women and Stroke Mini-SymposiumSex Differences in the Effectiveness of Stroke Therapies (Basic and Preclinical Neuroscience of Stroke Recovery)Moderators: Jaroslaw Aronowski, MD, PhD,

Houston, TX Ken Arai, PhD, Charlestown, MA

Sex Differences in Cell Death PathwaysLouise D McCullough, MD, PhD, FAHA, Houston, TX

Gender and Post-stroke ImmunityHalina Offner, MD, Portland, OR

Gender Disparity in Mononuclear Phagocytes Response and RemodelingXiaoming Hu, MD, Pittsburgh, PA

Sex Differences in Ischemic Stroke Recovery: TRPM2Paco Herson, PhD, Aurora, CO

Unruptured Aneurysms: Novel Insights and Treatment Concepts (Aneurysm)Moderators: Robert D Brown, MD, Rochester,

MN Sandra Narayanan, MD, Detroit, MI

Pathogenesis of Aneurysm Formation, Growth and RuptureMervyn Vergouwen, MD, Utrecht, Netherlands

New Imaging Techniques for Evaluation of Unruptured Intracranial Aneurysms: Beyond Size and LocationWaleed Brinjikji, MD, Rochester, MN

Preventive Medical Treatment for Unruptured AneurysmsNima Etminan, MD, Mannheim, Germany

Endovascular Therapy of Unruptured Aneurysms: An Expanding HorizonAjay K Wakhloo, MD, Boston, MA

An AHA/ASA and World Heart Federation Joint SymposiumTBD



8:45 am – 10:15 am

Driving Stroke Systems Change: Innovative Solutions to Global Resource Challenges (an AHA/ASA and World Stroke Organization Joint Symposium)Moderators: Karen L Furie, MD, MPH, FAHA,

Providence, RI M Patrice Lindsay, BScN, PhD,

Etobicoke, ON, Canada

Increasing Access to Stroke Care in Low Middle Income CountriesJeyaraj D Pandian, MD, Ludhiana, India

Addressing Barriers to Stroke Care in Middle Income Countries with Two-tiered Payment Systems (Public and Private Hospitals)Ayrton Roberto Massaro, MD, Sao Paulo, Brazil

Building Stroke Care Systems in a Single-payer Model: The Canadian ExperienceGordon Gubitz, MD, FRCPC, Halifax, NS, Canada

Nationwide Implementation of Thrombectomy in GermanyChristos Krogias, MD, PhD, Bochum, Germany

Women and Stroke Mini-SymposiumThe Paola De Rango Memorial Session on Stroke in Women: An International Perspective on the Medical, Genetic, and Social Factors that Impact Sex Differences (Preventive Strategies)Moderators: Valeria Caso, PhD, Perugia, Italy Cheryl Bushnell, MD, Winston

Salem, NC

Stroke Risk in Women: Should Stroke Prevention Look Different than Men?Kathryn M Rexrode, MD, Boston, MA

The Epidemic of Elderly Women with Atrial Fibrillation: What Is the Best Stroke Prevention Approach?Karol E Watson, MD, PhD, FAHA, Los Angeles, CA

Epigenetics and the Second X Chromosome: Back to the Basics of Sex DifferencesStacie L Demel, MD, East Lansing, MI

Social Factors Related to Outcomes in Women after Stroke: Physical and Cognitive FrailtyTatjana Rundek, MD, PhD, Miami Beach, FL


Overview of MarkVCID and Biomarker SelectionSteven M Greenberg, MD, PhD, FAHA, Boston, MA

Multimodal MRI Biomarkers of Cerebral Small Vessel DiseaseJulie Schneider, MD, Chicago, IL

Fluid-based Biomarkers of Cerebral Small Vessel DiseaseDonna M Wilcock, PhD, Lexington, KY

International Biomarker Programs and Collaboration OpportunitiesMartin Dichgans, MD, Munich, Germany

Predicting and Enhancing Recovery from Aphasia and Cognitive Syndromes After Stroke (Clinical Rehabilitation and Recovery)Moderators: Randolph S Marshall, MD, New

York, NY Elisabeth B Marsh, MD, Baltimore,

MD

Augmenting Language Rehabilitation with tDCSPeter Turkeltaub, MD, Washington, DC

Novel Approaches to Language RehabilitationLeora Cherney, PhD, BC-ANCDS, Chicago, IL

Predicting Aphasia Recovery: Influence of Lesion Location and MedicationsArgye E Hillis, MD, Baltimore, MD

Predicting Aphasia Recovery with Brain Imaging

Reperfusion Therapy in the Extended Time Window: A New Reality (Acute Endovascular Treatment)Moderators: Aquilla S Turk, DO, Charleston, SC Diederik W Dippel, MD, Rotterdam,

Netherlands

Patient Selection in the Wake of the DAWN TrialRaul G Nogueira, MD, Decatur, GA

Future Directions: Who Should We Treat and Who Should We StudyGregory W Albers, MD, Stanford, CA

Current Reality: Epidemiology and Systems ImplicationsPooja Khatri, MD, FAHA, Cincinnati, OH

Imaging Selection: Who Should We Treat and Who Should We Study?Tudor G Jovin, MD, Pittsburgh, PA

Small Cerebral Vasculature in Health and Ischemic Brain Disease (Vascular Biology in Health and Disease)Moderators: Jialing Liu, PhD, San Francisco,

CA Joanna Wardlaw, MD, Edinburgh,

United Kingdom

Structure and Function of Cerebral Parenchymal Arterioles: What Do Stroke Neurologists Need to Know?Marilyn Cipolla, PhD, Burlington, VT

Genetic Clues to Healthy Brain Microvasculature: Translational InsightsJames E Faber, PhD, Chapel Hill, NC

Targeted Treatments of Small Vessel Pathologies: From Bench to BedsidePatricia Musolino, MD, PhD, Boston, MA

Clinical Approach to Diagnosis and Treatment of cSVD: Acute Manifestations and Silent DeclineEric E Smith, MD, Calgary, AB, Canada

Social Determinants of Stroke in Latin America (an AHA/ASA and Pan American Health Organization Joint Symposium)Moderators: Maria C Zurru, MD, Bsas,

Argentina Salvador Cruz-Flores, MD, El

Paso, TX

Social Determinants of Cardiovascular Disease and StrokeEdward Havranek, MD, Denver, CO

Addressing the Social Determinants of Stroke in South AmericaSheila Martins, MD, Porto Alegre, Brazil

A Tale of Two Social Realities: Mexico ExperienceFernando Gongora-Rivera, MD, Monterrey, Mexico

Addressing Social Determinants of Stroke: Pan American Health Organization Perspective

Through Different Lenses: Cerebral Arteriopathies in Young Stroke Patients (Pediatric Stroke)Moderators: Aneesh B Singhal, MD, Boston,

MA Laura L Lehman, MD, Boston, MA

Cerebral Arteriopathy in the Young Stroke Patient: The “Pediatric” Approach to Evaluation and ManagementHeather Fullerton, MD, San Francisco, CA

Cerebral Arteriopathy in the Young Stroke Patient: The “Adult” Approach to Evaluation and ManagementFrank-Erik de Leeuw, MD, PhD, Nijmegen, Netherlands

At What Age Does Atherosclerosis Emerge as a Cause of Stroke in the Young?Sharon Poisson, MD, Aurora, CO

The Controversial Role of Steroids for Cerebral Arteriopathy in the YoungMark MacKay, MBBS, FRACP, Parkville, Australia


5:15 pm – 6:15 pm Professor-led Poster Tours by Category: Moderated Presentation and Q&A with Poster Presenters

6:15 pm – 6:45 pm Poster Session with Poster Presenters

Friday, Jan 267:00 am – 12:30 pm

7:00 am – 8:30 am

Minorities and Stroke Mini-SymposiumAddressing Racial and Ethnic Disparities in Stroke Care (an AHA/ASA and American Academy of Neurology Joint Session) (Community/Risk Factors)Moderators: Dawn Kleindorfer, MD, Cincinnati,

OH Lewis Morgenstern, MD, FAHA,

Ann Arbor, MI

ISC Preliminary ProgramISC Preliminary Program

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The Role of the Government Agencies in Fostering the Stroke Innovation Ecosystem (an AHA/ASA and US Governmental Agencies Joint Symposium) (Health Services, Quality Improvement, and Patient-Centered Outcomes)Moderator: Walter Koroshetz, MD, FAAN,

Bethesda, MD

NINDS: StrokeNetClinton Wright, MD, MS, Rockville, MD

CDC: Coverdell Registry Robert Merritt, MD, Atlanta, GA

FDA: Neurointerventional and Neurorehabilitation DevicesCarlos Pena, PhD, Silver Spring, MD

Fogarty: Global Brain Disorders ProgramClaudia Moy, PhD, Bethesda, MD


10:15 am – 10:30 am Short Break/Science and Technology Hall

10:30 am – 12:00 Noon Thursday Main Event



William M Feinberg Award Presentation


12:00 Noon – 1:30 pm Science and Technology Hall

Nursing and Rehabilitation Professionals Luncheon (ticket required; seating is limited)

Basic Science Networking Luncheon (ticket required; seating is limited)

1:30 pm – 3:00 pm

Atrial Fibrillation and Newer Emboligenic Cardiac Diseases (Diagnosis of Stroke Etiology)Moderators: Hans-Christoph Diener, MD,

Essen, Germany Scott E Kasner, MD, Philadelphia,

PA

How to Detect Covert Atrial FibrillationRolf Wachter, MD, Leipzig, Germany

How to Detect Extra-AFib Emboligenic Cardiac DiseasesHooman Kamel, MD, New York, NY

How and When to Prevent Cardiac EmbolismKazunori Toyoda, MD, Suita, Japan

How to Form Partnership between Cardiology and NeurologyRichard Bernstein, MD, PhD, Chicago, IL

Brain Health Mini-SymposiumBrain Health: A Cocktail for Healthy Aging (Vascular Cognitive Impairment)Moderators: Lee H Schwamm, MD, Boston, MA Philip B Gorelick, MD, MPH, FAHA,

Grand Rapids, MI

7&7: An Overview of the American Heart Association/American Stroke Association’s Advisory on Brain HealthPhilip B Gorelick, MD, MPH, FAHA, Grand Rapids, MI

The Central Role of the Neurovascular UnitCostantino Iadecola, MD, FAHA, New York, NY

The Sundowner: Vascular Contributions to Cognitive Impairment and DementiaEric E Smith, MD, Calgary, AB, Canada

Corpse Reviver: Recommendations of the Taskforce on Brain Health and Healthy Aging of the AHALee H Schwamm, MD, Boston, MA

Women and Stroke Mini-SymposiumBrain Vascular Malformation and Pregnancy (Vascular Malformations)Moderator: William Mack, MD, Los Angeles,

CA

Counseling and Management of Incidental Arteriovenous Malformations During PregnancyM Christopher Wallace, MD, MSc, FRCSC, FACS, Kingston, ON, Canada

Embolization of Brain Arteriovenous Malformations During Pregnancy: Pros and ConsBabu Welch, MD, Dallas, TX

Management of Ruptured Arteriovenous Malformation during PregnancyMika Niemela, MD, PhD, Helsinki, Finland

Genetic Considerations of AVMs: Role of GenderHelen Kim, PhD, San Francisco, CA

Sickle Cell Disease and Stroke in Populations of African Ancestry (an AHA/ASA and African Academy of Neurology Joint Symposium) (Community/Risk Factors)Moderator: Barbara Vickrey, MD, MPH, New

York, NY

An Update on the Epidemiology of Stroke in AfricaRufus Akinyemi, MBBS, Ibadan, Nigeria

Genetics of Sickle Cell Disease and Stroke

Predicting Stroke in Sickle Cell Disease: Experience with Transcranial Doppler in AfricaFoad Abdallah, MD, Al-Manial, Cairo, Egypt

Stroke Prevention: Hydroxyurea Trial Among Indigenous Africans and African Americans


3:00 pm – 3:30 pm Break/Science and Technology Hall

3:30 pm – 5:00 pm

Brain Health Mini-SymposiumMarking Vascular Cognitive Impairment: MarkVCID (Vascular Cognitive Impairment)Moderators: Roderick Corriveau, PhD,

Bethesda, MD Rebecca Gottesman, MD,

Baltimore, MD


Pre-hospital Emergency and Acute CareSalvador Cruz-Flores, MD, MPH, El Paso, TX

Care Transitions, Rehabilitation and RecoveryVirginia J Howard, PhD, Birmingham, AL

Global PerspectivesSeana Gall, BSc, Hobart, Australia

Future DirectionsClaudia Moy, PhD, Bethesda, MD

Cerebral Collateral Circulation, Diagnosis and Therapeutic Implications in Large Vessel Stroke (Cerebral Large Artery Disease)Moderators: Colin P Derdeyn, MD, FAHA, Iowa

City, IA Dileep R Yavagal, MD, Miami, FL

Advances in Imaging of Cerebral Collateral Circulation Richard Aviv, MD, Toronto, ON, Canada

Using Collateral Status as a Guide to Acute Stroke TreatmentDavid S Liebeskind, MD, Los Angeles, CA

What Did We Learn about the Cerebral Collateral Circulation from Recent Endovascular Trials?Mayank Gotal, MBBS, Calgary, AB, Canada

New Therapeutic Approaches to Augment Collateral CirculationItalo Linfante, MD, Miami, FL

Thrombectomy Mini-SymposiumPrehospital Approaches to Maximize the Public Health Impact of t-PA and Thrombectomy (Emergency Care Systems)Moderators: Tracy E Madsen, MD, ScM,

Providence, RI Laura Heitsch, MD, St Louis, MO

Mobile Stroke Units Are Not the Answer: Challenges in Implementation, Sustainability and Cost-effectivenessAndrew W Asimos, MD, Charlotte, NC

The Future Is Now for Mobile Stroke UnitsJames C Grotta, MD, Houston, TX

Prehospital Telemedicine Is the Only Viable AnswerAndrew M Southerland, MD, Charlottesville, VA

Do You Really Want Paramedics Waking You Up for Suspected Strokes? Impact on ED and Hospital OvercrowdingPrasanthi Govindarajan, MD, MAS, Stanford, CA

Using Technology to Optimize Patient Access: A Practical Approach

Translating Innovations in Stroke Rehabilitation to Improve Recovery and Quality of Life Across the Globe (an AHA/ASA and World Federation for Neurorehabilitation Joint Session) (Clinical Rehabilitation and Recovery)

Moderators: Mayowa Owolabi, MBBS, MSc, DrM, MWACP, FMCP, FAAN, Ibadan, Nigeria

David C Good, MD, Hershey, PA

Neuroplasticity, Stem Cell Therapy, and Neural Repair in Stroke RecoveryBruce H Dobkin, MD, FRCP, Los Angeles, CA

Neurostimulation, Neuroimplants, Brain Computer Interface, Robotics and Stroke Recovery

Pragmatic Solutions for Stroke Recovery and Improved Quality of Life in Low and Middle Income SettingsRaymond K Reichwein, MD, Hershey, PA

Stroke Recovery and Rehabilitation Research: Priorities, Prospects, and Funding OpportunitiesAlexander Dromerick, MD, Washington, DC



8:45 am – 10:15 am

Minorities and Stroke Mini-SymposiumBest Practices and Innovations in Engaging Minority and Rural Communities in Stroke Clinical Trials (an AHA/ASA and American Academy of Neurology Joint Session) (Community/Risk Factors)Moderators: Mai N Nguyen Huynh, MD,

Oakland, CA Ralph L Sacco, MD, Miami, FL

Knowing Your Community (and Developing a Community Advisory Board)Lesli Skolarus, MD, Ann Arbor, MI

Engaging the Community and Maintaining the RelationshipBernadette Boden-Albala, PhD, New York, NY

Communications to Build Trust (Communicating with Your Community) Brett M Kissela, MD, Cincinnati, OH

Dissemination of Findings and Sharing Information

Thrombectomy Mini-SymposiumChallenges in Post-thrombectomy Management (In-hospital Treatment)Moderators: Adam S Arthur, MD, MPH, FAANS,

FACS, Memphis, TN George Tsivgoulis, MD, Athens,

Greece

ReocclusionJ Mocco, MD, MS, New York, NY

Reperfusion HemorrhagePeter D Schellinger, MD, PhD, FESO, FAHA, Minden, Germany

BP ManagementAndrei V Alexandrov, MD, Memphis, TN

Oxygenation and VentilationPanayotis Varelas, MD, PhD, Detroit, MI

The Global Impact of Hypertension and Stroke: A Call to Action (an AHA/ASA and World Hypertension League Joint Symposium) (Preventive Strategies)Moderators: Werner Hacke, MD, PhD, FAHA,

Heidelber, Germany Daniel T Lackland, DPH,

Charleston, SC

High Blood Pressure Treatment in Diabetic Patients to Lower Stroke RisksPhilip B Gorelick, MD, MPH, FAHA, Grand Rapids, MI


Salt Intake and Blood Pressure Level with Increased Stroke Risks

Blood Pressure Measurement and Global Stroke PreventionJanet Wright, MD, Baltimore, MD

Blood Pressure Level and Kidney Disease: Global Stroke RisksRaymond Townsend, MD, Villanova, PA

The Intersection of Vascular and Neurodegenerative Dementia (a Stroke journal session)Moderators: Marc Fisher, MD, FAHA, Boston,

MA Vladimir Hachinski, CM, MD,

FRCPC, DSc, London, ON, Canada

Vascular/Neurodegenerative Interactions: The Clinicopathological EvidenceCharlotte Cordonnier, MD, PhD, Lille, France

Vascular Dysregulation: The First Phase of Alzheimer Disease

Pathophysiology of Vascular DysregulationCostantino Iadecola, MD, FAHA, New York, NY

Dementia – Now What?Vladimir Hachinski, CM, MD, FRCPC, DSc, London, ON, Canada



10:30 am – 12:30 pm Closing Main Event



Crossfire Debates

Anticoagulation Therapy Should Not Be Restarted in Patients with Anticoagulation-related Lobar Intracerebral Hemorrhage

Hemicraniectomy vs Not in Patients Over 60

Prolonged Cardiac Ambulatory Monitoring Wide Use vs Not?

David G Sherman Award Presentation


Closing RemarksMiguel Perez-Pinzon, PhD, FAHA, Miami, FL

Poster Hall Viewing HoursTo provide additional hours for poster viewing, the Poster Hall will be open during these hours:

Wednesday, Jan 24 8:00 am – 7:00 pmThursday, Jan 25 8:00 am – 6:45 pm

Moderated Poster ToursProfessor-Led Poster Tours by Category: Moderated Q&A with Poster PresentersLeaders in the stroke field will take groups of attendees around speaker-attended posters for a brief presentation by and a Q&A with the poster presenters. Poster tours will be arranged by category. Professor-led poster tours are scheduled as follows:

Wednesday, Jan 24 5:30 pm – 6:30 pmThursday, Jan 25 5:15 pm – 6:15 pm

Poster Sessions with Poster Presenters: One-on-one Time with the Poster PresentersThese posters are different from the posters presented in the Professor-Led Poster Tours above.

Wednesday, Jan 24 6:30 pm – 7:00 pmThursday, Jan 25 6:15 pm – 6:45 pm

Please go to strokeconference.org/programming for additional information about the Poster Sessions.

E-postersE-posters will be viewable in the Poster Hall from 8:00 am – 7:00 pm. Registered ISC attendees can also view the E-posters online at strokeconference.org.

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Registration and Housing

Registration and Housing for ISC, the Stroke Nursing Symposium, and both ISC Pre-Conference Symposia opened as follows:FAHA Members Sept 13AHA/ASA Members Sept 20Nonmembers Sept 27

Join AHA/ASA Professional Membership Today and Save on Registration!• Stroke Professionals, save up to $960 on ISC

registration.• Nurses, save up to $300 on the Stroke Nursing

Symposium registration and up to $685 on ISC registration.

Registration savings dependent on registration level and membership tier.

Join online today at professional.heart.org/membership (Promo Code DHJ13622)

HOW TO REGISTER

Web: Register online and book your hotel at strokeconference.org/registrationandhousing. Promo Code DM501

Phone, Fax or Mail: For registration instructions and downloadable forms, go to strokeconference.org/registrationandhousing. A one-time $20 service charge will be assessed if you choose one of these options.

Onsite Registration: Onsite registrants must have a photo ID. For security reasons, you cannot register another attendee or pick up another attendee’s registration materials.

Please visit strokeconference.org/registrationandhousing for the following information:• Registration Reminders/Deadlines• Membership Information• Registration Refund/Cancellation Policy• Hotel Information including Cancellation Policy• Conference Hotels and the Hotel Map• Onsite Registration Information and Registration

Hours• Registration Rates

Registration Fees: International Stroke Conference 2018 Early Rate Advance Rate Standard Registration Categories Until Dec 5 Dec 6–Jan 2 Jan 3–26

Premium Emeritus Member $75 $175 $275

Premium Professional Plus Member $400 $500 $600

Premium Professional Member $500 $600 $700

General Professional Member $900 $1,000 $1,200

Professional Associate Member $900 $1,000 $1,200

Student Trainee Member $200 $300 $400

Early Career Member1 $300 $400 $500

Nurse/Allied Health/Other Premium Professional $250 $350 $450 Plus Member2

Nurse/Allied Health/Other Premium Professional Member2 $350 $450 $550

Nurse/Allied Health/Other General Professional Member2 $400 $500 $600

One Day Only Wednesday or Thursday Member $275 $375 $475

One Day Only Friday Member $200 $300 $400

Nonmember* $1,060 $1,160 $1,360

Early Career Nonmember** $900 $1,000 $1,100

Nurse/Allied Health/Other Nonmember***§ $735 $835 $935

Student/Trainee Nonmember**** $400 $500 $600

One Day Only Wednesday/Thursday Nonmember $375 $475 $575

One Day Only Friday Nonmember $300 $400 $500

Spouse/Adult Family Member (Exhibits Only) $100 $200 $300

Registration and Housing

Registration Fees: State-of-the-Science Stroke Nursing Symposium 2018

Member $150 $250 $350

Professional Associate Member $250 $350 $450

Nonmember $250 $350 $450

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1 Early Career Member: has received professional degree within the past five years2 Nurse/Allied Health/Other: includes EMT, Paramedic, Technician, Therapist

* Nonmember price: includes 6-month complimentary AHA General Professional Membership.** Early Career Nonmember price: includes 6-month complimentary AHA Early Career Membership.*** Nurse/Allied Health/Other Nonmember price: includes 6-month AHA General Professional Membership.**** Student/Trainee Nonmember price: includes 6-month AHA Student/Trainee Membership.§ Nurse/Allied Health/Other: includes EMT, Paramedic, Technician, Therapist.

Registration Fees: ISC Pre-Conference Symposium I: Stroke in the Real World: There Will Be Blood: Management and Treatment of ICH

Member and Nonmember $125 $150 $250

Registration Fees: ISC Pre-Conference Symposium II: Stroke in the Lab World: Reversing Stroke Translational Research – Bedside-to-Bench and Back Again

Member and Nonmember $25 $25 $25

Register Online Today! strokeconference.org/registrationandhousing

Promo Code DM101

Pre-Conference Symposium II: Stroke in the Lab World: Reversing Stroke Translational Research: Bedside-to-Bench and Back Again

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SymposiaSocial Determinants of Stroke in Latin America (AHA/ASA and Pan

Am Health Org Joint Symp)

Cerebral Arteriopathies in Young Stroke Patients

Small Cerebral Vasculature in Health and Ischemic Brain Disease

Marking Vascular Cognitive Impairment

Reperfusion Therapy in the Extended Time Window

Predicting & Enhancing Recovery from Aphasia & Cognitive Syndromes after Stroke


OPENING MAIN EVENTPresidential Address

ISC Program Chair Welcome Thomas Willis Award

PresentationLate-Breaking Science

Oral Abstracts

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Women and Stroke Symposium

Sex Differences in the Effectiveness of Stroke Therapies

SymposiumAHA/ASA and World Heart

Federation Join Symposium

SymposiumUnruptured Aneurysms: Novel

Insights and Treatment Concepts

Oral Abstracts


An International Perspective on the Medical, Genetic,

and Social Factors that Impact Sex Differences

SymposiumDriving Stroke Systems Change:

Innovative Solutions to Global Resource Challenges (an

AHA/ASA and World Stroke Organization Joint Symposium)

SymposiumThe Role of the Government Agencies in Fostering the

Stroke Innovation Ecosystem (an AHA/ASA and US

Governmental Agencies Joint Symposium

Oral Abstracts

THURSDAY MAIN EVENT

William M Feinberg Award Presentation


PROFESSOR-LED POSTER TOUR

SESSIONS (60 MINS)

REGULAR POSTER SESSIONS (30 MINS)

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Brain Vascular Malformation and Pregnancy

SymposiumSickle Cell Disease and Stroke in

Populations of African Ancestry (an AHA/ASA and African Academy of

Neurology Joint Symposium)

SymposiumBrain Health

SymposiumAtrial Fibrillation and Newer

Emboligenic Cardiac Diseases

Oral Abstracts

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State-of-the-Science Stroke Nursing Symposium

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Diabetes and Stroke Symposium

Pre-Diabetic States: Should We Treat Early and Often after Stroke?

SymposiumIntracranial Atherosclerosis: Burden of Stroke in Asians

(an AHA/ASA and Chinese Stroke Association Joint Symposium)

SymposiumRole of Neuroimaging in

Stroke Prevention, Treatment and Recovery

SymposiumTough Decisions in ICH

Oral Abstracts

Minorities and Stroke Symposium

Addressing Racial and Ethnic Disparities in Stroke Care

SymposiumTranslating Innovations in

Stroke Rehabilitation to Improve Recovery and Quality of Life across the Globe (an AHA/

ASA and World Federation for Neurorehabilitation Joint Session)

SymposiumCerebral Collateral

Circulation, Diagnosis and Therapeutic Implications in

Large Vessel Stroke

SymposiumPrehospital Approaches to

Maximize the Public Health Impact of t-PA and Thrombectomy

Oral Abstracts

Minorities and Stroke Symposium

Best Practices and Innovations in Engaging Minority and

Rural Communities in Stroke Clinical Trials

SymposiumThe Global Impact of

Hypertension and Stroke: A Call to Action (an AHA/ASA

and World Hypertension League Joint Symposium)

SymposiumChallenges in Post-

thrombectomy Management

SymposiumThe Intersection of Vascular

and Neurodegenerative Dementia (a Stroke

journal session)

Oral Abstracts

CLOSING MAIN EVENT

Crossfire Debates

David G Sherman Award Presentation


ISC Program Chair’s Closing Remarks

Diabetes and Stroke Symposium

Impact of Diabetes on Stroke: From Bench to Bedside

SymposiumTackling Stroke in Low and Middle Income Countries; a WHO-Lancet Commission on

Stroke in Low and Middle Income Countries (an AHA/ASA

and WHO Joint Symposium

SymposiumUnderstanding Disordered Sleep

and Stroke

SymposiumStroke Outcome in Animal Models with Comorbidities:

Translational Impact of Novel Therapeutic Targets

Oral Abstracts

SymposiumCED Talks

(Cerebrovascular Education and

Discovery)

SymposiumBugher Foundation

Session

SymposiumRecent Genetic

Conditions in Stroke

SymposiumImproving the

Efficiency of Clinical Trial Design

Oral Abstracts

SymposiumAIS Guidelines

Session

SymposiumPhysical Activity and the Brain: Maximising

Recovery and Function Post-stroke

SymposiumTelestroke 3.0. Beyond Acute

Ischemic Stroke

SymposiumTargeting Astrocytes for Stroke Therapy

Oral Abstracts

PROFESSOR-LED POSTER TOUR

SESSIONS (60 MINS)

REGULAR POSTER SESSIONS (30 MINS)

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Quiz SessionGame of Strokes

SymposiumThe Neurovascular Unit Coming of Age

SymposiumRemote Ischemic

Conditioning: Triggering an

Ischemia Tolerant State

SymposiumTrends in the

Management of SAH and Cerebral

Vasospasm

Oral Abstracts

Pre-Conference Symposium I: Stroke in the Real World: There Will Be Blood: Management and Treatment of ICH

International Stroke Conference 2018


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life is why® es por la vida® ®

Please remember the American Heart Association in your will.

Thank you for being a valued member of the American Heart Association/American Stroke Association (AHA/ASA)!

Stop by our Booth #445 onsite at ISC 2018 to discuss your benefits, renew your membership or learn about how to become a Fellow of the American Heart Association!

If you don’t have a chance to stop by and would like to renew your membership, please go to professional.heart.org/membership and enter code DHJ136ZZ.

We look forwarding to providing you valuable science, networking, and resources in 2018!

DS-12919 ISC 2018 PrelimProg Member Ad.indd 1 11/27/17 10:58 AM

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Educat ion. Inspirat ion. I l luminat ion.Register online today at strokeconference.org, Promo Code DM101

Register Today – strokeconference.org/registrationandhousing

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