Emerging Hot Topics in Milk Science

Danielle G. Lemay, PhDGenome Center

University of California-DavisOctober 26, 2015

Overview

• IMGC’s e-newsletter: “SPLASH! milk science update”

• This year’s most popular topics• Fun facts about SPLASH!

– Who writes it– Who reads it

• Emerging hot topics for next year and beyond

IMGC’s monthly e-newsletter

SPLASH! content on IMGC websitehttp://milkgenomics.org

Many ways to subscribe

• Attend an IMGC Symposium (we’ll add you)

• Text SPLASHMILK to 22828 (in the U.S.)

• Click on “Join our mailing list” in a forwarded e-newsletter

• Join on milkgenomics.org• Email dglemay@ucdavis.edu

Number of Articles Published in SPLASH!

Which articles were the most popular in 2015?

Readers love a controversy

• Association != Causality• Hypothesis: milk-drinking and non-drinking subjects have different

genetic backgrounds that influence their health independent of milk consumption

Novel benefits of cow’s milk

More benefits of human milk oligosaccharides

• Feed beneficial gut bacteria• Act as decoys for pathogenic bacteria• Reduce inflammation in intestines

Microbes and milk

Changing views on dairy fat

New technologies

Molecular signals in milk

Mammary gland epigenetics

Can we find the jewels in the junk DNA?

See talk by Dr. Monique Rijnkelson Tuesday morning

Human milk as a commodity

Improving milk production with genetics

Comparing Mammals

http://milkgenomics.org/newsletter-archive

Cow’s milk ingredients improve infant formula

Dr. Bing Wang will talk about lactoferrin and cognition Tuesday afternoon

Control of cow’s milk fat composition

Benefits of dairy for metabolic health

Explore synergistic opportunities

Accelerate progress

Goal: Something for everyone

SPLASH! Editorial Team (2015)

Prof. Foteini Kakulas

Prof. Peter Williamson

Dr. Lauren Newmark

Prof. Katie Hinde

Dr. Lillian SandoAnna Petherick

Dr. Danielle Lemay

Dr. SandeepRavindran

IMGC Impact: SPLASH newsletter

ConferenceAttendees

NewsletterSubscribers

Number of People

ConferenceAttendees

NewsletterSubscribers

Number of People

WebsiteVisitors

IMGC Impact: SPLASH online

NEW VISITORS RETURNING

For every 1 person attending the conference,6,000 people are visiting the website.

SPLASH! content online

82,266 page views

Sept 2014-2015

Average time spent on a page?

2.15 minutes

How do people reach SPLASH content?

Over 2000 Facebook shares!

Who is reading SPLASH?

Top countries: US, India, UK, Australia, Canada, Denmark, New Zealand, Phillipines, Netherlands, Germany

Who is reading SPLASH?

Top cities: New Dehli, London, Melbourne, Sydney, New York

Future

Beneficial effects of dairy

• Cardiovascular disease • Metabolic disease• Weight loss & body composition• Bone health• New! Role of dairy in healthy aging • New! Health effects of milk fat• New! Effects of dairy on inflammation• New! Effects of dairy on gut health

New tools to help farmers select most profitable cows

• Improvements in genomic selection of dairy cattle• New tools for assessing phenotypes

– Scanning milk samples with mid-infrared spectrometry– On-farm sensors to monitor cows

Learn about new methods today with talks by Dr. Cameron Clark, Dr. Toni Reverter, and Mary Abdelsayed

Milk Production, Sustainability, & Food Choices

Cows are part of the solution!

For more about the web of food choices,stay for the talks on Wednesday morning by Dr. Stephen Simpson and Dr. David Raubenheimer

For improving milk production, see talks by Dr. Peter Thomson and Dr. Peter Williamson on Tuesday AM

Milk microRNAs

• What are they? Do they survive milk processing?• Do they survive digestion?• Do they affect the consumer?

See talks on Tuesday afternoon!

Dr. Christophe LefevreDr. Meagan Gillespie

Milk miRNA expression, transfer, and effects of milk processing

Milk and offspring development

• Acquisition of tolerance of self, food, microbes

Talk on Wednesday morning by Dr. Bernd Stahl

Milk and offspring development

• Metabolic programming

Talk at noon today by Dr. Jennie Brand-Miller

Talk on Wednesday morning by Dr. Ross Tellam

Immunity

Viruses and (human) milk

• CMV• HIV• Rotavirus• RSV• Retroviruses• Bacteriophages

Bovine milk exosomes

• What are they? How does nature use them? How might we use them?

• A flavor delivery system?• A drug delivery system?

What would Dr. van de Loo do?See his exciting talk next!

Peptides in milk

See talk by Dr. David Dallason Tuesday afternoon

Anti-fungal? Prebiotic?

Milk glycans & gut bacteria

• What is the fate of milk glycans in the gastrointestinal tract?

• Which bacteria consume milk glycans?• What is the impact on the host?

See talk this afternoon by Dr. Steven Frese

Milk oligosaccharides for infant formula

Who will win the race to full-scale production of diverse milk sugars?• Extraction, purification from bovine milk• Chemo-enzymatic synthesis• Synthesis by genetically engineered microbes

http://milkgenomics.org/newsletter

Synbiotics: bovine milk and probiotics

• Human milk and gut microbes co-evolved• Many human milk components are in cow’s milk• Are there specific bovine milk components and

specific probiotics that together (synbiotics) have beneficial effects on the host?

Tuesday afternoon talk by Dr. Veronique Demers-Mathieuand later this morning by Megan Sanctuary

Novel fermented dairy products

Better control of microbes inmilk production &

processing

Antimicrobial resistance is a growing issueNew methods to monitor microbesNew solutions to control microbes for better safety, longer shelf life

Create the Future

Ideas on how to increase number of subscribers

Send suggestions for topics, feedback, announcements, etc, to Danielle Lemay at dglemay@ucdavis.edu

AcknowledgmentsASSOCIATE EDITORSAnna PetherickProf. Foteini KakulasProf. Katie HindeDr. Lauren NewmarkDr. Lillian SandoProf. Peter WilliamsonDr. Sandeep Ravindran

Assistance with material for slides: Tasslyn GesterCora MorganErik Kwok Cora Morgan, Tasslyn Gester

FUNDING PROVIDED BY

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