tific papers that have received over one thousand citations. In addition, we were recently informed that Drs. Dan Sorescu and David DeLurgio will also join these individuals and be recognized in early November at the Department of Medi-cine’s Faculty Research Day. There are only 19 members of the MilliPub Club at Emory and 7 of these members are from the Division of Cardiology.

I would also like to announce that we are beginning our de-velopment campaign with for-mer trainees of the fellowship program. As all of you know training is a critical component of our mission and one that is quite frankly very susceptible to the adverse affects to the current economic climate as well as changes in the conflict of interest policy. As a result, we have initiated a develop-ment program to create a train-

The September/October issue of the Divisional Newsletter is focused on our clinical enter-prise. As all of you know, Emory Cardiology encompasses a wide range of clinical activi-ties at multiple sites through-out the city and throughout the state. In this issue we have featured highlights provided by the leadership at some of these sites. The delivery of out-standing cardiovascular care is at the core of the mission of our division.

Also highlighted in this issue is the recent awarding of “MilliPub Club” awards to sev-eral of our distinguished fac-ulty. Drs. Andrew Smith, Angel Leon, R. Wayne Alexander, David Harrison and Kathy Griendling were all initial induc-tees in the School of Medicine “MilliPub Club.” This acknowl-edges individuals who have published one or more scien-

ees fund within the division for the educational activities of our fellows. Drs. Andy Smith, John Merlino and Allen Dollar have generously agreed to help us with this effort. This is a part of the overall School of Medicine campaign but is focused di-rectly on supporting our cardio-vascular trainees. This support is necessary for many aspects of our training program ranging from salary support to special event support and travel for trainees to national meetings. Before we approach our former trainees, we will be approach-ing our faculty to ask for their help in this effort. I urge all of you to consider supporting our trainees fund as this is an ex-tremely critical component of our academic mission.

Introduction from the Director — W. Robert Taylor, MD, PhD

Phys ician Profile : Michael Morris II, MD

Michael Morris, II, MD, joined the cardiology faculty in July 2008 as an Assistant Profes-sor. Dr. Morris attended medical school at Morehouse School of Medicine here in Atlanta. He completed his internal medicine residency training at Mount Auburn Hospital in Cambridge, Massachusetts in 2004. Dr. Morris then moved to New York to do his cardiol-ogy fellowship at State Uni-versity of New York and did a year fellowship in advanced cardiac imaging at St. Luke’s Roosevelt Hospital Center. Dr.

Morris is primarily based at the Emory Heart and Vascular Center in Smyrna. Upon the transition of Dr. J. Arturo Corso, Dr. Morris as-sumed the physician leader-ship role at the Smyrna prac-tice which has shown contin-ued growth. The Emory Heart and Vascular Center at Smyrna is now the second largest cardiac outreach site in the network, making it one of the single largest contribu-tors to Cardiology and Emory Healthcare as a whole.

Emory Cardiology Newsletter

Inside this issue:

ACC lobbying 2

Grady equipment upgrades 2

VAD therapy 3

Heart Failure Group visits 3

FY 09 Research funding 4

Stimulus Grants 4

Faculty research day 5

Staff awards 5

MilliPub club 6

New faculty 7

Recent publications 8

Highlighted publication 9

Recent grants 10

September/October 2009

Michael Morris II, MD

Newsletter Ideas? Please email Kathleen Brill kbrill@emory.edu with any suggestions or feedback.

ECHO Lab On June 10, 2009, digital Echo was implemented at Grady when a Philips Xcelera digital reading and archiving system went live. The reports are uploaded to the Grady NetAccess intranet and are available for review by the ordering physician within four minutes after report finaliza-tion. The associated Web Forum application allows Car-diology Faculty and Fellows to view the ultrasound or an-giographic images throughout the hospital. Echo acquisition, evaluation and reporting is now a paperless process at Grady. Additionally, fellows and attendings are now work-ing in a refurbished reading room.

A new TEE suite is under con-struction across the hall from the cath labs and will be com-pleted in September. It will include three procedure rooms. Stress Testing An expanded stress test lab and dressing area has been constructed recently and is now in use, although not quite com-plete. It will include three test bays, allowing for two tests to be conducted simultaneously. The area will be used for tread-mill and pharmacologic proce-dures, including stress echo and DSE. Other Grady has purchased an Ac-quadex FlexFlow Acquapheresis device which is now available for treatment of CHF patients with refractory fluid overload.

This has been an exciting year for cardiology at Grady with the arrival of several long-awaited upgrades to the facilities and equipment. These improvements will facilitate and improve patient care in many ways. Cath Lab A new state-of-the-art digi-tal cath lab opened in Janu-ary. The lab is equipped with a Philips FD1010 biplane cam-era system with integrated Volcano IVUS and pressure wire capability. The lab in-cludes a Xims hemodynamic monitoring system and inter-faces with the Philips Xcelera digital reading and archiving system. An Abiomed Impella device is available for percu-taneous LV support.

Page 2

New Equipment Upgrades at Grady b y P a u l H . D ’ A m a t o , M D

ACC lobbying in Washington DC b y J er r e Lut z , M D

The 15th annual American College of Cardiology Legislative Conference was held in Washington, DC in September 2009. Three hundred fifty cardiologists from across the United States attended. Drs. Jerre Lutz and Douglas Morris were among the nine repre-sentatives from the State of Georgia.

The major focus of the congressional visits included gaining support for (1) reversal of the 21% cutback in the Centers for Medicare/Medicaid Spending (CMS) beginning in January 2010 predicated on a flawed formula used to calculate practice expenses and (2) preven-tion of an additional 27% overall reimbursement decrease for cardiac services in the year 2010 predominately for imaging techniques. This data is based on an AMA survey of 3,576 surveys of which only 145 were completed and 55 chosen for review. 20-30 % of these practices had no nurse, no medical administrators and no billing personnel repre-senting a skewed population. Cardiologists work an average of 68 hours per week versus 32 hours/week for the other physicians leading to incorrect practice expense calcula-tions. Cardiovascular morbidity and mortality dropped 50 % in the 1990’s and another 29 % since 2000. These results were not achieved in Europe, Canada or other continents. One wonders why oncology and cardiology have been the recipients of the greatest cut-backs. The results are expected to be non-physician layoffs and lack of patient access. The Weimer-Briley Amendment, which proposed all imaging be done as inpatient in hos-pital with no outpatient imaging allowed after 2013, was withdrawn shortly after the ACC visit. The Baucus Bill in the Senate and HR3200 in the House remain in flux. The position of the College and Cardiologist should be reserved for the final bill. Stay tuned for the next report.

Emory’s Heart Failure Program is piloting “group visits” at their MOT clinic site. “Group visits” are a relatively new model of care delivery where individual patient visits are combined with interactive group education sessions. The heart failure team began piloting monthly group visits in June and will conclude the pilot in October. During each visit, patients have a private encounter with a physi-cian or a nurse practitioner and receive individualized medical care (including vital sign collection, history taking and physical exam), in a private exam room in the heart failure clinic before moving to a meeting room for the group session. During the group sessions, educational emphasis is on patient self-management and behavioral changes that would positively impact disease outcome. The primary goal during these sessions is to empower patients and family members with knowledge and skills to improve self-care and better manage their chronic disease. Each session is facilitated by a physician, nurse, pharmacist, or other professional discipline in caring environment where a combination of didactic, questions and answers, and

open dialogue are encouraged. Topics of discussion are chosen ahead of time and are based on the needs of the group. At the conclusion of this pilot, the fol-lowing topics will have been addressed: current trends in heart failure treatment, symptom manage-ment, medications, low sodium diet, exercise, emo-tional impact of chronic disease and community re-sources. “As the number of patients newly diagnosed with heart failure grows each year, we are challenged to find innovative ways to effectively manage patient care and improve outcomes. The group visit model is a patient and family centered approach to care man-agement where complex needs could potentially be addressed more thoroughly “says Dr. Andrew L. Smith, Associate Professor and Medical Director of the heart failure program. “These visits also allow dialogue that enhances our understanding of the issues confronting our patients, and helps us to better deliver educational messages,” says Angela Murphy, Heart Failure Program Manager.

HeartMate II LVADs, which are very useful for treating patients with congestive heart failure. The technology provides a greater quality of life for patients who are not eligible for donor hearts or who may become a candidate for a donor heart in the fu-ture. Emory implanted its first LVAD, a Novacor, in 1988, and began using the HeartMate II in May 2007. Seven patients at Emory who have the HeartMate II are using the therapy as a bridge to candi-dacy or as a bridge to a trans-plant. “The Joint Commission certifica-tion shows patients who need LVADs as destination therapy that Emory is a leader in the field with the best clinical practices,” re-ports Laura Jacobson, heart transplant services program coordinator. “We achieved this

status because of our experi-enced, multidisciplinary team, our compliance with standards, and our focus on performance

improvement, which positively impacts our clinical outcomes.” In September 2008 Emory’s heart transplant program hired a VAD program coordinator, Ann Pekarek, a nurse practitioner, to help expand the program and manage patients. Dr. David Vega serves as the heart transplant program's surgical director. Many of the program's staff, including senior heart transplant coordina-tor Corby D'Amico, VAD clinical engineer Kevin McTeague, and

The ETC's ventricular assist device (VAD) program received a golden stamp of approval after The Joint Commission survey on August 17-18 granted the pro-gram Disease Specific Care Certi-fication for Destination Therapy (DT). As a result, the Centers for Medicare and Medicaid Services (CMS) will provide reimburse-ment for the care of these pa-tients at Emory Hospital. This is good news for heart failure pa-tients in this region who need a VAD as destination therapy. Emory’s VAD program is the only certified program in the state and one of 80 centers in the U.S. Destination therapy is for heart failure patients who need left ventricular assist device implants (LVADs) as permanent therapy rather than as a bridge to heart transplantation or to candidacy on the heart transplant waiting list. Destination therapy offers many patients with end stage heart failure an option to resume a more normal lifestyle and im-prove their quality of life. The VAD program is currently providing care to seven patients who have received implants for destination therapy in the past two years. The program uses

Page 3 Emory Cardiology Newsletter

September/October 2009

Emory Premiere Destination for VAD Therapy

Heart Failure Group Vis its b y D r . An d r e w L . S m i t h , As s o c i a t e P r o f e s s o r ,

M e d i c a l D i r e c t o r o f H e a r t Fa i l u r e P r o g r a m

physical therapist Amelia Hasel-den, have been with the program since 1988. “The program carefully evalu-ates each patient's medical and psychosocial factors before sur-gery, and each patient's device therapy options are tailored to his or her individual circumstances,” says Dr. Vega. The program also provides a mentoring program so that individuals living successfully with VADs can talk with patients considering a VAD. “Our goal is to safely integrate patients treated with VAD therapy back to their respective communities,” he says. Dr. Andrew Smith, medical director of the program, opened the Center for Heart Failure in 1990, and he and his team man-age the medical care of VAD patients before and after implan-tation. “Going through the proc-ess for Joint Commission certifica-tion impressed upon me how talented, experienced and com-mitted our staff is, reports Dr. Smith. “A patient with a VAD is cared for in multiple areas within our system and receives excellent care. It takes the right people and a lot of effort to create a quality VAD program.”

Emory’s heart transplant program team

Cardiology Division research funding increased 54% in FY 2009, setting an all-time high. Total Cardiology Division grants and contracts awarded was $16,481,004 for the fiscal year ending August 31, 2009. The increase is up from $10, 699,354 in FY 2008. Approximately $12.85 million of FY 2009 research funding came from federal sources such as Na-tional Institutes of Health and Department of Defense. Our external funding from these spon-sors grew 75% from $7.34 million in FY 2008. These numbers do not include approximately $2 million dollars of recent stimulus funded grants that our faculty received in September. Those grants will further add to this impressive total.

Page 4

Cardiology Research Funding Increases 54% in FY2009

Phase II Study: Mobilization of progenitor cells in peripheral arterial disease—Arshed Quyyumi, MD—NIH Grand Opportunity Grant—$1,180,494/yr This study tests whether stimulation of progenitor cell release from the bone marrow will improve symptoms and outcomes in patients with PAD by either enhancing endothelial dysfunction or pro-moting development of functional collaterals, or both. Nox4 and Cardiac fibrosis — Dan Sorescu, MD—NIH R01 Supplement—$273,118 The purpose of this supplement award is to iden-tify the mechanisms by which Smad2/3 and FOXO3A regulate expression of Nox4 mRNA and protein. Sex differences in myocardial ischemia triggered by emotional factors after MI — Viola Vaccarino, MD PhD—NIH R21 Supplement—$291,952 Young and middle-aged women tend to have higher mortality and complication rates after a heart attack. This epidemiological/genetic set of studies evaluates risk factors connected with heart disease in women such as: depression and history of trauma and biological changes in the heart, brain and inflammation in response to stress.

Economic consequences of advanced testing for subclinical cardiovascular disease—Leslee Shaw, PhD—NIH Challenge Grant—$498,026/yr This study aims to evaluate 5-year cost for heart disease care in over 6 thousand individuals, and will further compare costs of heart disease care in subgroups of adults with low to high risk cardiac biomarkers. It will also compare costs in addition to the added benefit of improved detection of heart disease risk using several cardiac bio-markers. NoxR1, A Regulator of Nox4-dependent cy-toskeletal remodeling in vascular cells – Kathy Griendling, PhD—NIH R01—$484,375/yr This proposal will characterize a new protein, termed NoxR1, that appears to be the first known regulator of the Nox4 NADPH oxidase. Nox4 plays a role in a number of basic cellular functions, including senescence, survival and differentiation, possibly by controlling cytoskeletal remodeling . Mechanisms linking Depression to Cardiovascu-lar Risk – Viola Vaccarino, MD, PhD—NIH R01—$780,847/yr This proposal will further clarify the role of de-pression on CVD using a prospective design to study changes over time in CVD measures. This continuation twins heart study project offers a unique opportunity to examine CVD progression as a function of depression in a genetically infor-mative sample.

Select ARRA Stimulus Grants for Cardiology Divis ion

Schedule 8:00 am – 12:00 pm Selected research presenta-tions given by faculty 12:00 – 1:00 pm Keynote address “Systems Pathobiology and Human Dis-ease” by Dr. Joseph Loscalzo, MD, PhD, Chairman, Depart-ment of Medicine and Physi-cian in Chief, Brigham and Women’s Hospital, Harvard School of Medicine 1:00 – 2:30 pm Lunch and poster presentations by faculty and judging of post-ers

2:30 pm “Research accomplishments in the DOM” and presentation of poster winners, Dr. R. Wayne Alexander, MD, PhD, Chair, Department of Medicine 3:00 pm Adjourn

Please join us Thursday, No-vember 5, 2009, for the second annual Department of Medi-cine Faculty Research Day to celebrate our research efforts across the department. This event will bring together re-searchers from all divisions and will provide an opportunity to share exciting new findings, facilitate scientific exchange and identify potential new collaborations. Faculty in the Department of Medicine will give oral presen-tations and poster presenta-tions. Trainees and faculty from other departments are wel-come to attend the presenta-tions given by faculty from the Department of Medicine.

Reminder—Faculty Research Day November 5, 2009

Page 5

Jiten Ghelani, Division Adminis-trator, received the COMPASS Leadership Award.

Department of Medicine “Project SEED” Staff Awards and Recognition Celebration was held August 13. Here are Cardiology Division staff who received special recognition. Con-gratulations to all for your exemplary service.

Judy Wynn, Accounting Assistant, Sr., was nominated for the Mary Nell McDonald Outstanding Service Award.

Carolyn Morris, Administrative Assistant, Sr., was nominated for the Mary Nell McDon-ald Outstanding Service Award.

Chuong Pham,

Sponsored

Research Ad-

ministrator,

was nomi-

nated for the

IMPACT Ser-

vice Award.

Jeanette Zahler,

Administrative

Assistant, was

honored for 30

years service at

Emory.

Emory Cardiology Newsletter

September/October 2009

“Project SEED” Staff Awards

Page 6

The MilliPub Club was formed to honor and recognize current Emory faculty who have published papers that have garnered more than 1,000 citations. Such a paper is commonly considered a “citation classic” and represents high impact scholarship. A reception was held to honor selected members. Dean Thomas Lawley and Associate Dean Ray Dingledine made the presentations. Drs. Andrew Smith, Angel Leon, R. Wayne Alexander, David Harrison and Kathy Griendling were all initial inductees in the MilliPub Club. Drs. Dan Sorescu and David DeLurgio will also join these individu-als and be recognized in early November at the Department of Medicine’s Faculty Research Day. There are only 19 members of the MilliPub Club at Emory and 7 of those are from Cardiology.

Mill ipub Club — Researchers Honored September 23

1994 Circulation Res Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW.

1991 Nature Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE.

2000 Circulation Res NAD(P)H oxidase: role in cardiovascular biology and disease. Griendling KK, Sorescu D, Ushio-Fukai M.

1996 J Clin Inves Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. Rajagopalan S, Kurz S, Münzel T, Tarpey M, Freeman BA, Griendling KK, Harrison DG.

1993 J Clin Inves Hypercholesterolemia increases endothelial superoxide anion production. Ohara Y, Peterson TE, Harrison DG.

2000 Circulation Res Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Cai H, Harrison DG.

2002 New Engl J Med Cardiac resynchronization in chronic heart failure. Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, Kocovic DZ, Packer M, Clavell AL, Hayes DL, Ellestad M, Trupp RJ, Underwood J, Pickering F, Truex C, McAtee P, Messenger J; MIRACLE Study Group. Multi-center InSync Randomized Clinical Evaluation.

Cardiology Millipub Papers

Newly inducted MilliPub Club Members from Cardiology: Drs. Leon, Griendling, Alexander & Smith

Kathy Griendling, PhD, and Raymond Dingledine, PhD, Associate Dean for Research

Page 7

Farewell to departing faculty

Farewel l to Drs . Randy Mart in, Mujeeb Jan, Bobby Khan, Ste ve S igman and Jose Torres . We

apprec iate your contribution to Emory Uni vers ity and wish you the best in the future.

Meet our new faculty Meenakshi Bhalla, MD, has joined the cardiology faculty as Assistant Professor of Medicine. Dr. Bhalla attended medi-cal school in India at Indira Gandhi Medical School. She completed internal medicine resi-dency training at SUNY Buffalo in 2006 and then moved to Univer-sity of Missouri, Co-lumbia, for her cardiology fellowship training, which she completed in June 2009. Dr. Bhalla will be based primarily at Emory Heart and Vascular Center at Cartersville as a general cardiologist. Michael McDaniel, MD, has joined the cardiology faculty as Assistant Professor

of Medicine. Dr. McDaniel received his Doctorate of Medicine from Medi-cal College of Georgia in 2002 and com-pleted his residency

training at Emory in 2005. He then en-tered our cardiology fellowship program and recently completed his interven-tional cardiology training here in June 2009. Dr. McDaniel will be based pri-marily at Emory Heart and Vascular Center locations at Eastside and Rock-dale and at Grady Memorial Hospital as an interventional cardiologist.

Faisal Merchant, MD, has joined the cardiol-ogy faculty as Assistant Professor of Medi-cine. Dr. Merchant received his Doctorate of Medicine from Duke Univer-sity School of Medicine in 2003. He subsequently com-pleted residency and cardiol-ogy training at Massachu-setts General Hospital. Dr. Merchant will be based pri-marily at Emory Heart and Vascular Center locations at Emory Eastside and Rockdale, and at Emory University Hospital as a general cardiologist. Modele Ogunniyi, MD, MPH, has joined the cardiology faculty as Assistant Professor of

Medicine. Dr. Ogunniyi received her Doctorate of Medicine from the Univer-sity of Ibadan in Nigeria and her Master of Public Health degree from Johns Hopkins University. Dr. Ogunniyi subsequently completed a fellowship in Preventive Medicine and

Public Health at the CDC, and then com-pleted residency training at Morehouse School of Medicine. She completed her car-diology training at Vanderbilt University this past month. She will be based primarily at Grady Memorial Hospital as a general cardi-ologist.

Alejandra San Martin, PhD, has joined the cardiology faculty as Assistant Professor of Medicine. Dr. San Mar-tin obtained her PhD in cellular and molecular biology at Universidad Catolica de Chile in Santiago. She has been a post-doctoral fellow in our basic research area since 2004 and has been studying the role of redox-sensitive and insensitive signaling pathways leading to migration in vascular smooth muscle cells. Dr. San Martin has an NIH K99/R00 Grant to continue her investi-gation of vascular smooth muscle cell migra-tion. Her lab and office will be in the Wood-ruff Memorial Research Building. David Vadnais, MD, has joined the cardiol-ogy faculty as Assistant Professor of Medi-cine. Dr. Vadnais completed his residency at UCLA Medical Center in Los Angeles and

obtained his Doctorate of Medicine degree from Emory University School of Medicine. Dr. Vadnais com-pleted his cardiology train-ing in our fellowship pro-gram in June 2009. He will be based primarily at Emory

University Hospital Midtown as a general cardiologist.

Emory Cardiology Newsletter

September/October 2009

Page 8

Recent publications

1: Major depression and coronary flow reserve detected by positron emission tomography.

Vaccarino V, Votaw J, Faber T, Veledar E, Murrah NV, Jones LR, Zhao J, Su S, Goldberg J, Raggi JP, Quyyumi AA, Sheps DS, Bremner JD. Arch Intern Med. 2009 Oct 12;169(18):1668-76.

2: Many Americans Have Prediabetes and Should Be Considered for Metformin Therapy.

Rhee MK, Herrick K, Ziemer DC, Vaccarino V, Weintraub WS, Narayan KM, Kolm P, Twombly JG, Phillips LS. Diabetes Care. 2009 Oct 6. [Epub ahead of print]

3: Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis.

Nam D, Ni CW, Rezvan A, Suo J, Budzyn K, Llanos A, Harrison D, Giddens D, Jo H. Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1535-43. Epub 2009 Aug 14.

4: In vivo assessment of blood flow patterns in abdominal aorta of mice with MRI: implications for AAA localization.

Amirbekian S, Long RC Jr, Consolini MA, Suo J, Willett NJ, Fielden SW, Giddens DP, Taylor WR, Oshinski JN. Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1290-5. Epub 2009 Aug 14.

5: Effect of a psychoeducational intervention on depression, anxiety, and health resource use in implantable cardioverter defibrillator patients.

Dunbar SB, Langberg JJ, Reilly CM, Viswanathan B, McCarty F, Culler SD, O'Brien MC, Weintraub WS. Pacing Clin Electrophysiol. 2009 Oct;32(10):1259-71.

6: Induced cardiovascular procedural costs and resource consumption patterns after coronary artery calcium screening: results from the EISNER (Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) study.

Shaw LJ, Min JK, Budoff M, Gransar H, Rozanski A, Hayes SW, Friedman JD, Miranda R, Wong ND, Berman DS. J Am Coll Cardiol. 2009 Sep 29;54(14):1258-67.

7: Calcification in atherosclerosis.

Alexopoulos N, Raggi P. Nat Rev Cardiol. 2009 Sep 29. [Epub ahead of print]

8: Differential Healing After Sirolimus, Paclitaxel, and Bare Metal Stent Placement in Combination With Peroxisome Proliferator-Activator Receptor {gamma} Agonists. Requirement for mTOR/Akt2 in PPAR{gamma} Activation.

Finn AV, John M, Nakazawa G, Polavarapu R, Karmali V, Xu X, Cheng Q, Davis T, Raghunathan C, Acampado E, Ezell T, Lajoie S, Eppihimer M, Kolodgie FD, Virmani R, Gold HK. Circ Res. 2009 Sep 24. [Epub ahead of print]

9: Prognostic value of adenosine stress cardiovascular magnetic resonance in patients with low-risk chest pain.

Lerakis S, McLean DS, Anadiotis AV, Janik M, Oshinski JN, Alexopoulos N, Zaragoza-Macias E, Veledar E, Stillman AE. J Cardiovasc Magn Reson. 2009 Sep 21;11(1):37.

10: Redox control of vascular smooth muscle migration.

San Martin A, Griendling K. Antioxid Redox Signal. 2009 Sep 8. [Epub ahead of print]

11: Anemia, hemorrhage, and transfusion in percutaneous coronary intervention, acute coronary syndromes, and ST-segment elevation myocardial infarction.

Willis P, Voeltz MD. Am J Cardiol. 2009 Sep 7;104(5 Suppl):34C-8C. Review.

12: Usefulness of elevations in serum choline and free F2)-isoprostane to predict 30-day cardiovascular outcomes in patients with acute coronary syndrome.

LeLeiko RM, Vaccari CS, Sola S, Merchant N, Nagamia SH, Thoenes M, Khan BV. Am J Cardiol. 2009 Sep 1;104(5):638-43. Epub 2009 Jun 24.

13: Asian Americans: diabetes prevalence across U.S. and World Health Organization weight classifications.

Oza-Frank R, Ali MK, Vaccarino V, Narayan KM. Diabetes Care. 2009 Sep;32(9):1644-6. Epub 2009 Jun 9.

14: Glucose challenge test screening for prediabetes and undiagnosed diabetes.

Phillips LS, Ziemer DC, Kolm P, Weintraub WS, Vaccarino V, Rhee MK, Chatterjee R, Narayan KM, Koch DD. Diabetologia. 2009 Sep;52(9):1798-807. Epub 2009 Jun 26.

15: Palpitations after a pacemaker generator exchange: a new algorithm-induced cause of endless loop tachycardia.

Velasquez-Castano JC, Lloyd MS. Heart Rhythm. 2009 Sep;6(9):1380-2. Epub 2009 Apr 1. No abstract available.

16: Glycemic status and incident heart failure in elderly without history of diabetes mellitus: the health, aging, and body composition study.

Kalogeropoulos A, Georgiopoulou V, Harris TB, Kritchevsky SB, Bauer DC, Smith AL, Strotmeyer E, Newman AB, Wilson PW, Psaty BM, Butler J; Health ABC Study. J Card Fail. 2009 Sep;15(7):593-9. Epub 2009 Apr 25.

17: Echocardiography and risk prediction in advanced heart failure: incremental value over clinical markers.

Agha SA, Kalogeropoulos AP, Shih J, Georgiopoulou VV, Giamouzis G, Anarado P, Mangalat D, Hussain I, Book W, Laskar S, Smith AL, Martin R, Butler J. J Card Fail. 2009 Sep;15(7):586-92. Epub 2009 Apr 28.

18: Exposure to low-dose ionizing radiation from medical imaging procedures.

Fazel R, Krumholz HM, Wang Y, Ross JS, Chen J, Ting HH, Shah ND, Nasir K, Einstein AJ, Nallamothu BK. N Engl J Med. 2009 Aug 27;361(9):849-57.

19: Novel solid-state-detector dedicated cardiac camera for fast myocardial perfusion imaging: multicenter comparison with standard dual detector cameras.

Esteves FP, Raggi P, Folks RD, Keidar Z, Wells Askew J, Rispler S, O'Connor MK, Verdes L, Garcia EV. J Nucl Cardiol. 2009 Aug 18. [Epub ahead of print]

20: Correlation Between Carotid Intimal/Medial Thickness and Atherosclerosis. A Point of View From Pathology.

Finn AV, Kolodgie FD, Virmani R. Arterioscler Thromb Vasc Biol. 2009 Aug 13. [Epub ahead of print]

Highlighted Publication

Exposure to low-dose ionizing radiation from medical imaging procedures

Fazel R, Krumholz HM, Wang Y, Ross JS, Chen J, Ting HH, Shah ND, Nasir K, Einstein AJ, Nallamothu BK.

N Engl J Med. 2009 Aug 27;361(9):849-57.

Using claims data for nearly 1 million individuals over a 3-year period (2005-2007), this study estimated exposure to ionizing radiation from medical imaging in the US. 2% of the population were exposed to 20 mSv or more every year, which- when gen-eralized to the US population- suggested that over 4 million individuals in the US are exposed to these doses annually. CT and nuclear medicine scans accounted for 3/4 of all radiation exposure and about 80% of exposure occurred in the outpatient setting. SPECT myocardial perfusion imaging alone accounted for over 1/5 of the overall radiation exposure. The authors sug-gested raising physician and patient awareness, avoiding unnec-essary studies, promoting research to determine where imaging is most beneficial, and continued technological advances in imaging as key approaches to enhancing radiation safety.

Page 9

Recent publications (cont)

21: Low-density lipoprotein apheresis as a treatment option for

hyperlipidemia.

Mehta PK, Baer J, Nell C, Sperling LS. Curr Treat Options Cardiovasc Med. 2009 Aug;11(4):279-88.

22: Management of the statin-intolerant patient.

Smiley III WH, Khan BV, Sperling LS. Curr Treat Options Cardiovasc Med. 2009 Aug;11(4):263-71.

23: Comparison of hydrophilic guidewires used in endovascular procedures.

Niazi K, Farooqui F, Devireddy C, Robertson G, Shaw RE. J Invasive Cardiol. 2009 Aug;21(8):397-400.

24: Risk assessment and predictive value of coronary artery disease testing.

Shaw LJ, Narula J. J Nucl Med. 2009 Aug;50(8):1296-306. Review.

25: Nox proteins in signal transduction.

Brown DI, Griendling KK. Free Radic Biol Med. 2009 Jul 21. [Epub ahead of print]

26: Serum resistin concentrations and risk of new onset heart failure in older persons: the health, aging, and body composition (Health ABC) study.

Butler J, Kalogeropoulos A, Georgiopoulou V, de Rekeneire N, Rodondi N, Smith AL, Hoffmann U, Kanaya A, Newman AB, Kritchevsky SB, Vasan RS, Wilson PW, Harris TB; Health ABC Study. Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1144-9. Epub 2009 Apr 16.

27: The C242T CYBA polymorphism as a major determinant of NADPH oxidase activity in patients with cardiovascular disease.

Mehranpour P, Wang SS, Blanco RR, Li W, Song Q, Lassègue B, Dikalov SI, Austin H, Zafari AM. Cardiovasc Hematol Agents Med Chem. 2009 Jul;7(3):251-9.

28: Myocardial deformation imaging of the systemic right ventricle by two-dimensional strain echocardiography in patients with d-transposition of the great arteries.

Kalogeropoulos AP, Georgiopoulou VV, Giamouzis G, Pernetz MA, Anadiotis A, McConnell M, Lerakis S, Butler J, Book WM, Martin RP. Hellenic J Cardiol. 2009 Jul-Aug;50(4):275-82.

29: Percutaneous left atrial appendage occlusion for patients in atrial fibrillation suboptimal for warfarin therapy: 5-year results of the PLAATO (Percutaneous Left Atrial Appendage Transcatheter Occlusion) Study.

Block PC, Burstein S, Casale PN, Kramer PH, Teirstein P, Williams DO, Reisman M. JACC Cardiovasc Interv. 2009 Jul;2(7):594-600.

Emory Cardiology Newsletter

September/October 2009

Recent Presentations at National Meetings

AHA 63rd High Blood Pressure Research Conference 2009 P257/P257 - The Role of T cell Costimulation in Hypertension and Vascular Inflammation Antony Vinh, Louise A McCann, Lena Blinder, Jorg Goronzy, Cornelia Weyand, David G Harrison, Tomasz J Guzik 030 - Interleukin 17 Is Critical to Angiotensin II--Induced Hypertension and Vascular Dysfunction in Vivo Meena Madhur, Tomasz Guzik, Louise McCann, David Harrison P318/P318 - GTP Cyclohydrolase I Phosphorylation and Interaction with GTP Cyclohydrolase Feedback Regulatory Protein Determine Endothelial Cell Tetra-hydrobiopterin Levels and Nitric Oxide Production Li Li, Wei Chen, Emory Univ, Atlanta, GA; John Salerno, Kennesaw State Univ, Kennesaw, GA; David G Harrison 067 - Ischemia-Induced Oxidative Injury in the Renal Proximal Tubule Is Specifi-cally Prevented by Tempol-Folate Conjugate Sarah F Knight, Emory Univ, Atlanta, GA; Kousik Kundu, Niren Murthy, Georgia Inst of Technology, Atlanta, GA; W Robert Taylor Heart Failure Society of America Scientific Meeting 2009 HF Family Caregiver Outcomes and Associated Factors Sandra B. Dunbar, Patricia C. Clark, Rebecca A. Gary, Christina Quinn, Carolyn M. Reilly, Andrew Smith, Melinda Higgins Journal of Cardiac Failure - August 2009 (Vol. 15, Issue 6, Pages S108-S109) Predicting Risk among Patients Listed for Heart Transplantation: Is It the Same as a General Heart Failure Population? Vasiliki V. Georgiopoulou, Andreas P. Kalogeropoulos, Amna Altaf, Nida Arif, Perry Anarado, Danesh Kella, Maryah Mansoor, Grigorios Giamouzis, Syed A. Agha, Wendy Book, Sonjoy Laskar, Andrew L. Smith, Javed Butler Journal of Cardiac Failure - August 2009 (Vol. 15, Issue 6, Page S102) Hemodynamic Parameters and Renal Function in Patients Hospitalized for Heart Failure Mahdi Chowdhury, Perry Anarado, Imad Hussain, Amanda Methvin, Andreas P. Kalogeropoulos, Vasiliki V. Georgiopoulou, Vikas Bhalla, Deepa Mangalat, Jeffrey Shih, Syed A. Agha, Wendy Book, Sonjoy R. Laskar, Andrew L. Smith, Javed Butler Journal of Cardiac Failure - August 2009 (Vol. 15, Issue 6, Page S95) Cardiac Index, Maximal Oxygen Consumption, and Outcomes in Patients with Advanced Heart Failure Amanda Methvin, Perry Anarado, Mahdi Chowdhury, Imad Hussain, Andreas P. Kalogeropoulos, Vasiliki V. Georgiopoulou, Vikas Bhalla, Deepa Mangalat, Jeffrey Shih, Syed A. Agha, Wendy Book, Sonjoy R. Laskar, Andrew L. Smith, Javed Butler Journal of Cardiac Failure - August 2009 (Vol. 15, Issue 6, Page S95) Hemodynamic Correlates of Outcomes in Patients Hospitalized for Heart Failure Imad Hussain, Perry Anarado, Andreas P. Kalogeropoulos, Mahdi Chowdhury, Vasiliki V. Georgiopoulou, Amanda Methvin, Vikas Bhalla, Deepa Mangalat, Jeffrey Shih, Syed A. Agha, Wendy Book, Sonjoy R. Laskar, Andrew L. Smith, Javed Butler Journal of Cardiac Failure - August 2009 (Vol. 15, Issue 6, Pages S98-S99)

Emory Cardiology Newsletter

September/October 2009

Recent Grants (For NIH ARRA Stimulus grants received see pg 4)

Congratulations to faculty and fellows who have published articles and received grants recently. We are proud to have such a productive group! Please let us know about new publi-cations and grants by email at kbrill@emory.edu

Kathy Griendling—NIH PPG Program Project Grant Diverse Roles of of Reactive Oxygen Species in Vascular Dis-ease—NIH P01HL095070—$2,360,539/yr Viola Vaccarino—NIH K24 Midcareer Investigator Award in Patient Oriented Research — Mind-body interactions in Car-diovascular Disease—NIH K24HL077506—$176,882/yr Young-sup Yoon—NIH R21 Identification of Novel Endothelial Progenitor Cells— NIH R21HL097353—$232,500/yr W. Robert Taylor—NIH R01 Osteopontin and Collateral Vessel Growth — NIH R01HL092150—$361,700/yr Neal Dickert—NIH F32 Ethics in resuscitation research: Under-standing and incorporating community views—NIH F32HL095358 —$51,710/yr Sergey Dikalov—AHA Grant in Aid—Role of Mitochondrial oxidative stress in endothelial dysfunction and hypertension—$77,000/yr Michael Lloyd—Medtronic—Stimulus Intensity in Left Ven-tricular Leads and Response to Cardiac Resynchronization Therapy Trial—SILVER CRT