ESHRE Members’ information session 

New task force - Fertility and viral disease Enrico Semprini (Italy)

Wednesday 30 June 2010

ESHRE 26th Annual Meeting,Rome.

New: Task Force – Fertility and Viral Diseases

Coordinator: Augusto E. Semprini

Aim: This Task Force aims to offer a platform of collaboration between ESHRE and the "Centres for Reproductive Assistance Techniques in HIV in Europe" (CREATHE), which is a non-profit association committed to improving the quality and availability of safer conception options to couples who are affected by HIV and/or other transmissible infections and who wish to become parents.

• These couples are nowadays subject to discrimination regarding their basic rights for parenthood and for having a family, due to the fear of transmitting the infection to the healthy partner while attempting at conception.

• CREAThE O.N.L.U.S. is an NGO registered under Italian law .(www.creathe.org)

• CREAThE is an open network welcoming the inclusion of all figures involved in the field of reproductive care to couples with HIV. To

Task Force – Fertility and Viral Diseases

The key objectives of CREATHE are:

• To promote the availability of services of assisted reproduction to couples affected by HIV or by other sexually transmitted infections.

• To promote the offer of services of specific sperm washing to clinical centres unequipped in carrying out this method who intend to offer reproductive assistance to couples affected by HIV or by other sexually transmitted infections.

• To spread knowledge and experience regarding the method of sperm washing and regarding reproductive assistance to couples affected by HIV or by other sexually transmitted infections, to physicians and biologists who intend applying this method.

BELGIUMSaint-Pierre hospital, Bruxelles

Erasme hospital, Bruxelles

DENMARKRigshospitale, CopenhagenFRANCEHospital Paule de Viguier, Toulouse

CMCO-SIHCUS, SchiltigheimCHU de LyonHòpital Cochin, ParisHòpital Pitié-Salpètrière, ParisCHU de Rennes

BELGIUMSaint-Pierre hospital, Bruxelles

Erasme hospital, Bruxelles

DENMARKRigshospitale, CopenhagenFRANCEHospital Paule de Viguier, Toulouse

CMCO-SIHCUS, SchiltigheimCHU de LyonHòpital Cochin, ParisHòpital Pitié-Salpètrière, ParisCHU de Rennes

ITALYStudio Semprini, Milano Centro di medicina preventiva, Verona

NETHERLANDSAcademisch Medisch Centrum, Amsterdam

SPAINHospital Galdakao-UsansoloHU Virgen de las Nieves, Granada

SOUTH AFRICAUniversity hospital, Pretoria

SWITZERLANDKantonsspital St. Gallen, St. GallenClinique La Source, Lausanne

U.K.

 Chelsea&Westminster hospital, London 

GERMANYFertility Center, Berlin 

ISRAELRambam hospital, Haifa

Reproductive Centres

Where do we come from?

• Insemination of HIV-negative women with processed semen of HIV-positive partners. (AE Semprini -Lancet. 1992)

• NATURAL CONCEPTION IN HIV-NEGATIVE WOMEN WITH HIV-INFECTED PARTNERS (L Mandelbrot Lancet 1997)

• QUANTIFICATION OF HIV IN SEMEN: CORRELATION WITH ANTIVIRAL TREATMENT AND IMMUNE STATUS (PL Vernazza- AIDS 1997)

• REPRODUCTIVE COUNSELLING FOR HIV-DISCORDANT COUPLES(AE Semprini- Lancet 1997)

NSCs

Motil spermatozoa

HIV Infection

yesyes

NoNo

Percoll Gradient

45%

90%

HIV in semen: sperm washingHIV in semen: sperm washing

Insem.45%

90%

Gradient

„swim-up“

Semen preparation: sperm washingSemen preparation: sperm washing

Publications

• Safety and efficacy of sperm washing in HIV-1-serodiscordant couples where the male is infected:results from the European CREAThE network. Bujan L, Hollander L et al. for the CREAThE network. AIDS 21:1909–1914, 2007

Establishing the safety profile of sperm washing followed by ART for the treatment of HIV discordant couples wishing to conceive. A E Semprini , L Bujan et al. Hum Reprod. 2007 Jul 3

HIV-discordant couples and parenthood: how are we dealing with the risk of transmission?Vernazza PL; Hollander L et al. AIDS 20(4): 635, 2006

Multicenter Quality Control of the Detection of HIV-1 Genome in Semen Before  Medically Assisted Procreation. Pasquier C, Anderson D et al. and The CREAThE Network. J Med Virol 78: 877-882, 2006

•

Projects

• Retrsospective evaluation of the safety and efficacy of semen washing in HIV discordant couples

• Retropsective evaluation of the outcome of infertility treatment in HIV positive women

• SHARE – Studying HIV And Reproduction in Europe – European registry of reproductive assistance to couples with HIV

• Multicenter Quality Control of the Detection of HIV-1 Genome in Semen Before Medically Assisted Procreation

Previous Collaboration with CDC

• CONRAD's Mission

• CONRAD's overall goal is to improve reproductive health, especially in developing countries.  Our main objective is to help develop safe, acceptable, affordable products and methods that provide contraception and/or prevent the sexual transmission of HIV/AIDS and other infections

• Manuscript submitted for publication

Task Force – Fertility and Viral Diseases

ESHRE- CREAThE Ongoing projects

• Web survey on the “Management of HIV-patients requesting reproductive assistance”

• SHARE protocol and database

• Pre Congress Course in Stockolm 2011 “Assisted Reproduction in couple with HIV”

• Campus for healthcare professionals “ Viral Infections in Reproductive medicine “ Berlin 2012

• Position Papers