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Page 1: European Handbook of Dermatological Treatments 2nd Ed.978-3-662-07131...A. Claudy, Service de Dermatologie, Hopital Un ivers ita ire, Hopital Edouard Herriot, Place d'Arsanval, F-69437

European Handbook of Dermatological Treatments 2nd Ed.

Page 2: European Handbook of Dermatological Treatments 2nd Ed.978-3-662-07131...A. Claudy, Service de Dermatologie, Hopital Un ivers ita ire, Hopital Edouard Herriot, Place d'Arsanval, F-69437

Springer-Verlag Berlin Heidelberg GmbH

Page 3: European Handbook of Dermatological Treatments 2nd Ed.978-3-662-07131...A. Claudy, Service de Dermatologie, Hopital Un ivers ita ire, Hopital Edouard Herriot, Place d'Arsanval, F-69437

A.D. Katsambas . T.M. Lotti (Eds.)

European Handbook of Dermatological Treatments

Second Edition

With 63 Figures and 157 Tables

Springer

Page 4: European Handbook of Dermatological Treatments 2nd Ed.978-3-662-07131...A. Claudy, Service de Dermatologie, Hopital Un ivers ita ire, Hopital Edouard Herriot, Place d'Arsanval, F-69437

Professor Andreas D. Katsambas University of Athens 'A. Sygros' Hospital Department of Dermatology 5, I. Dragoumi Street 161 21 Athens Greece

Professor Torello M. Lotti University Unit Allergology Professional and Environmental Dermatology University of Florence Via Alfani 37 50 121 Florence Italy

ISBN 978-3-642-05657-4 ISBN 978-3-662-07131-1 (eBook) DOl 10.1007/978-3-662-07131-1

Cataloging-in-Publication Data applied for

A catalog record for this book is available from the Library of Congress.

Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the Internet at http://dnb.ddb.de

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broad­casting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of Sep­tember 9,1965, in its current version, and permission for use must always be obtained from Springer-Ver­lag Berlin Heidelberg GmbH. Violations are liable for prosecution under the German Copyright Law.

http://www.springer.de

© Springer-Verlag Berlin Heidelberg 2003 Originally published by Springer-Verlag Berlin Heidelberg New York in 2003 Softcover reprint of the hardcover 2nd edition 2003

The use of general descriptive names, registered names, trademarks, etc. in this publications does not imply, even in the absence of a specific statement, that such names are exempt from the relevant pro­tective laws and regulations and therefore free for general use.

Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individ­ual case the user must check such information by consulting the relevant literature.

Cover design: E. Kirchner, Heidelberg Typesetting: Kolam Information Services Pvt. Ltd, Pondicherry, India

Printed on acid-free paper 24/3150/PF - 5 4 3 2 1 0

Page 5: European Handbook of Dermatological Treatments 2nd Ed.978-3-662-07131...A. Claudy, Service de Dermatologie, Hopital Un ivers ita ire, Hopital Edouard Herriot, Place d'Arsanval, F-69437

Diseases

Acne, 3 w.J. Cunliffe

Actinic keratosis, 10 F.M. Camacho-Martinez

Adamantiades-Beh<;:et's disease, 16 Ch.C. Zouboulis

Alopecia areata, 27 R. Happle

Androgenic alopecia, 35

Contents

Chronic actinic dermatitis, 97 G.M.Murphy

Cicatricial alopecia, 101 A. Tosti and B.M. Piraccini

Contact dermatitis, 106 L. Kanerva and A.!, Lauerma

Cutaneous vasculitis, 115 T.M. Lotti, C. Comacchi and I. Ghersetich

Darier's disease, 120 C. Varotti and F. Bardazzi

C. Pierard-Franchimont and G.E. Pierard Dermatitis herpetiformis, 123 C. Gooptu and F. Wojnarowska

Antiphospholipid syndrome, 42 P.G. Vlachoyiannopoulos and H.M. Moutsopoulos

Aphthous stomatitis, 48 G. Laskaris

Apocrine miliaria, 52 H.R. Bruckbauer and H.-J. Vogt

Atopic dermatitis, 54 E.J.M. Van Leent and J.D. Bos

Balanitis, 63 D. Freedman

Basal cell carcinoma, 68 D. Roseeuw, A. D. Katsambas and J.P. Hachem

Bowen's disease, 82 G. Avgerinou

Bullous pemphigoid, 86 A.G. Vareltzidis and P.G. Stavropoulos

Candidiasis, 92 D. Rigopoulos

Dermatomyositis, 126 S. Jablonska and M. Blaszczyk

Dermatophyte infections, 131 A. Tosti and B.M. Piraccini

Drug eruption, 135 J. Revuz

Drug-induced pemphigus, 139 S. Albert and M.M. Black

Drug photosensitivity, 141 P. Santoianni and E.M. Procaccini

Eccrine miliaria, 145 H.R. Bruckbauer and H.-J. Vogt

Epidermolysis bullosa, 147 G. Menchini, B. Bianchi and T.M. Lotti

Erysipelas, 157 M. Balabanova

Erythema multiforme, 159 F.M. Brandao

Erythema nodosum, 163 A. Claudy

Page 6: European Handbook of Dermatological Treatments 2nd Ed.978-3-662-07131...A. Claudy, Service de Dermatologie, Hopital Un ivers ita ire, Hopital Edouard Herriot, Place d'Arsanval, F-69437

VI Contents

Erythrasma, 167 E. Koumantaki-Mathioudaki

Erythroplasia of Queyrat, 169 B.-R. Balda

Factitial dermatitis, 171 N. Tsankov and L. Stransky

Furuncles and carbuncles, 173 D.loannides

Granuloma annulare, 177 C. Ligeron, L. Meunier and J. Meynadier

Hand dermatitis, 182 K. Thestrup-Pedersen

Herpes genitalis, 187 S. Kroon

Herpes simplex virus infection (orofacial), 193 S. Kroon

Herpes zoster, 197 S. Georgala

Hirsutism, 206 D. Rigopoulos

HIV infection and AIDS: present status of antiretroviral therapy, 211 R. Husak and C.E. Orfanos

Hyperhidrosis, 223 B. Brazzini, G. Campanile, G. Hautrnann and T.M. Lotti

Ichthyosis, 229 M. Paradisi and A. Giannetti

Impetigo, 235 S. Veraldi and R. Caputo

Kaposi's sarcoma, 239 J.D. Stratigos, A.C. Katoulis andAJ. Stratigos

Keloids and hypertrophic scars, 248 G. Hautrnann, A. Mastrolorenzo, G. Menchini and T.M. Lotti

Keratoacanthoma, 256 I. Danopoulou

Leg ulcers, 262 A.A. Ramelet

Leishmaniasis, 271 M. Onder and M. Ali Gurer

Lentigo maligna, 275 R. Dawber

Leprosy or Hansen's disease, 280 B. Flageul and I. Dubertret

Lichen planus, 289 A. Rebora

Lichen simplex chronicus, 293 M.L. Gantcheva

Lupus erythematosus, 297 B. Crich and S. Belaich

Lyme borreliosis, 304 J. Hercogova

Lymphomas (primary cutaneous), 309 W.A. van Vloten

Malignant melanoma, 321 B.-R. Balda and H. Starz

Mastocytosis, 330 A.P. Oranje and D. Van Gysel

Melasma, 336 A.D. Katsambas, A.J. Stratigos and T.M. Lotti

Mite bites, 342 G. Leigheb

Molluscum contagiosum, 344 M. V. Milinkovic and L.M. Medenica

Morphoea: circumscribed scleroderma, 352 U.-F. Haustein

Naevi (benign melanocytic), 355 N.G. Stavrianeas and A.C. Katoulis

Necrobiosis lipoidica, 368 E.M. Grosshans

Nummular eczema, 372 H.R. Bruckbauer, S. Karl and 1. Ring

Pediculosis, 377 E. Tsoureli-Nikita, G. Campanile, G. Hautrnann and 1. Hercogova

Pemphigus erythematosus, 382 S. Albert, K.E. Harman and M.M. Black

Page 7: European Handbook of Dermatological Treatments 2nd Ed.978-3-662-07131...A. Claudy, Service de Dermatologie, Hopital Un ivers ita ire, Hopital Edouard Herriot, Place d'Arsanval, F-69437

Pemphigus foliaceus, 384 S. Albert, K.E. Harman and M.M. Black

Pemphigus vegetans, 388 K.E. Harman, S. Albert and M.M. Black

Pemphigus vulgaris, 390 V. Ruocco, S. Brenner and E. Ruocco

Photoageing, 399 N.M. Craven and C.E.M. Griffiths

Pityriasis lichenoides acuta, 402 A. Andreassi and L. Andreassi

Pityriasis lichenoides chronica, 405 L. Rauch and T. Ruzicka

Pityriasis rosea, 408 H. Degreef

Pityriasis rubra pilaris, 411 lV. Cannnnarota, I. Hergocova and T.M. Lotti

Polymorphic light eruption, 416 I. Ferguson

Porphyrias,419 M. Lecha, C. Herrero and D. Ozalla

Pruritus, 427 D. Ioannides

Psoriasis, 433 B. Bonnekoh and H. Gollnick

Purpuras, 4S 1 T.M. Lotti, C. Connacchi and 1. Ghersetich

Pyoderma gangrenosum, 458 M.I. Cannilleri and I.L. Pace

Rosacea, 467 F.C. Powell

Sarcoidosis, 474 S. lablonska

Scabies, 479 A. Gorkiewicz-Petkow

Seborrhoeic dermatitis, 484 I. Faergennann

Seborrhoeic keratosis, 487 A. Picoto

Contents

Sjogren's syndrome, 490 A.G. Tzioufas and H.M. Moutsopoulos

Skin diseases from the marine environment, 494 G. Monfrecola and G. Posteraro

Solar urticaria, 498 M. leannnougin

Squamous cell carcinoma, 501 B. Giannotti and V. DeGiorgi

Subacute cutaneous lupus erythematosus, 505 M.N. Manoussakis and H.M. Moutsopoulos

Syphilis, 512 M.A. Waugh

Systemic sclerosis: scleroderma, 519 U.-F. Haustein

Tick dermatoses, 524 G. Leigheb

Tinea versicolor: pityriasis versicolor, 526 M. Ie Maitre and A. Donnpnnartin

Toxic epidermal necrolysis (Lyell's syndrome), 530 A. Minas

Urethritis: gonococcal, 535 D. Freednnan

Urethritis: non-gonococcal, 541 D. Freednnan

Urticaria, 547 F. Lawlor and A. Kobza Black

Varicella, 554 S. Georgala

VII

Vascular birthmarks: vascular malformations and haemangiomas, 561 X.-H. Gao and G. W Cherry

Vitiligo, 568 A.D. Katsannbas, T.M. Lotti and I.P. Ortonne

Warts and condylomas, 575 I.M. Mascaro and I.M. Mascaro IT

Page 8: European Handbook of Dermatological Treatments 2nd Ed.978-3-662-07131...A. Claudy, Service de Dermatologie, Hopital Un ivers ita ire, Hopital Edouard Herriot, Place d'Arsanval, F-69437

VIII

Xanthomas, 581 A.D. Tosca and J.e. Katsantonis

Methods

Acne scar treatment, 589 L. Rusciani

Biopsy, 593 E. Haneke

Chemical peeling, 599 1. Ghersetich, B. Brazzini and T. Lotti

Cryosurgery, 613 L. Marini

Curettage, 623 E. Haneke

Electrosurgery, 624 E. Haneke

Epiluminescence microscopy of pigmented skin lesions, 628 V. De Giorgi and P. Carli

Lasers, 640 L. Leite

Mohs' surgery, 645 A. Picoto, J.M. Labareda, R. Themido and F. Coelho

Patch testing, 649 A. Katsarou

Photo chemotherapy, 654 e. Antoniou

Photodynamic therapy, 658 A.D. Tosca and M.P. Stefanidou

Sclerotherapy, 664 E. Del Bianco, G. Muscarella and P. Cappugi

Skin augmentation (fillings), 669 L. Rusciani and S. Petraglia

Skin resurfacing with the carbon dioxide laser, 677 B.e. Gee and N.P.J. Walker

UVB phototherapy, 683 e. Antoniou

Contents

Drugs

Antibacterial agents, 687 H. Giamarellou and M. Souli

Antifungal drugs, 700 R.J. Hay

Antihistamines, 711 A.D. Katsambas, A.J. Stratigos and T.M. Lotti

Antiviral drugs, 716 E. Tsoureli-Nikita, G. Hautmann, G. Campanile, A.D. Katsambas and T.M. Lotti

Bleaching agents, 721 W. Westerhof and M.D. Njoo

Corticosteroids: topical, 731 J.G. Camarasa and A. Gimenez-Arnau

Glucocorticoids: systemic, 739 J.G. Camarasa and A. Gimenez-Arnau

Insect repellents, 747 S. Motta and M. Monti

Psychoactive agents, 753 G. Hautrnann and E. Panconesi

Retinoids, 769 J.H. Saurat

Scabicides and pediculicides, 775 A. Gorkiewicz-Petkow

Skin tests, 780 D. Kalogeromitros

Sunscreens, 784 S. Albert and J.L.M. Hawk

Topical anaesthetics, 790 F.B. de Waard-van der Spek and A.P. Oranje

Topical preparations and vehicles, 794 M. Monti and S. Motta

Subject index, 803

Page 9: European Handbook of Dermatological Treatments 2nd Ed.978-3-662-07131...A. Claudy, Service de Dermatologie, Hopital Un ivers ita ire, Hopital Edouard Herriot, Place d'Arsanval, F-69437

list of Contributors

s. Albert, Assistant Professor, Department of Dermatology, Kasturba Medical College, Manipal,

India

A. Andreassi, Istituto di Scienze Dermatologiche, Univ. Deg/i Studi - Policlinico Le Scotte, Viale

Bracci, 53100 Siena, Italy

L. Andreassi, Professor of Dermatology, Direttore Istituto di Scienze Dermatologiche, Univ. Degli Studi

- Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy

C. Antoniou, Associate Professor in Dermatology, University of Athens, "A Sygros Hospital", 5, I Dragoumi St, Kesariani 16121, Athens, Greece

G. Avgerinou, Department of Dermatology, University of Athens, "A Sygros Hospital", 5, I Dragoumi St, Kesariani 16121, Athens, Greece

M. Balabanova, Department of Dermatology, Alexander's Medical University Hospital, 1, Saint G.

Sofiski St, Sofia BG-1431, Bulgaria

B.-R. Balda, Department of Dermatology &

Allergology, Zentralklinikum Augsburg, Stenglinstra~e 2, D-86156 Augsburg, Germany

P. Bardazzi, Department of Dermatology, Faculty of Medicine, University of Bologna, Via Massarenti 1,40138 Bologna, Italy

S. Belaich, Department of Dermatology, Bichat H6pital, Assistance Publique H6pitaux de Paris, 46 rue Henri Huchard, 75018 Paris, France

B. Bianchi, Istituto di Scienze Dermatologiche, Univ. Degli Studi - Policlinico Le Scotte, Viale

Bracci, 53100 Siena, Italy

M.M. Black, St. John's Institute of Dermatology,

Basement, Block 7, St Thomas' Hospital, Lambeth

Palace Road, London, SE1 7EH, U.K.

B. Bonnekoh, Department of Dermatology and

Venereology, Otto-von-Guericke-University, Leipziger Str. 44, D-39120 Magdeburg, Germany

J.D. Bos, Department of Dermatology, Academic Medical Centre, University of Amsterdam, PO Box 22700, Meibergdreef9, 1100 DE Amsterdam, The Netherlands

P.M. Brandao, Department of Dermatology,

Hospital Garcia de Orta, Av. Torrado Silva, 2800 Almada, Portugal

B. Brazzini, Dipartimento di Scienze Derm, Universita degli studi di Firenze, Via Deg/i Alfani 37,1-50121 Firenze, Italy

S. Brenner, Department of Dermatology, TelAviv­Sourasky Medical Centre, Tel Aviv, Israel

H.R. Bruckbauer, Dermatologist and

Allergologist, Marktplatz 7B, D-85375, Neufahrn, Germany

P.M. Camacho-Martinez, Universidad

de Sevilla, Departamento de Dermatologia, Avda. Republica Argentina 22, 5 D, Sevilla, Spain

J.G. Camarasa (deceased), Departmentof Dermatology, Hospital del Mar. IMIM, Universittat Autonoma de Barcelona, Passeig Maritim 25-29, 08003 Barcelona, Spain

M.J. Camilleri, Mayo Clinic, Rochester, MN,

USA

N. Cammarota, Istituto di Scienze Dermatologiche, Univ. Degli Studio di Siena -Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy

G. Campanile, Dipartimento di Scienze Derm,

Universita degli studi di Firenze, Via Degli Alfani

37,1-50121 Firenze, Italy

P. Cappugi, DepartmentofDermatological Science, University of Florence, Via degli Alfani 37,50121

Florence, Italy

R. Caputo, Institute of Dermatological Sciences, IRCCS, University of Milan, Via Pace 9, 1-20122 Milan, Italy

Page 10: European Handbook of Dermatological Treatments 2nd Ed.978-3-662-07131...A. Claudy, Service de Dermatologie, Hopital Un ivers ita ire, Hopital Edouard Herriot, Place d'Arsanval, F-69437

x List of Contributors

P. Carli, Dipartimento di Scienze Derm, Universita

deg/i studi di Firenze, Via Deg/i Alfani 37, 1-50121

Firenze, Italy

G.W. Cherry, Oxford Wound Healing

Institute, Department of Dermatology,

Churchill Hospital, Old Road, Headington,

Oxford, OX3 7LJ, U.K.

A. Claudy, Service de Dermatologie, Hopital

Un ivers ita ire, Hopital Edouard Herriot, Place

d'Arsanval, F-69437 Lyon Cedex 03, France

F. Coelho, Superiori Technician Pharmacy, Centro

de Dermatologia Medico-Cirurgica, ARS de Lisboa e

Vale do Tejo, I, Rua Jose Estevao 135, 1150 Lisboa,

Portugal

C. Comacchi, Dipartimento di Scienze Derm,

Universita degli studi di Firenze, Via Degli Alfani

37,1-50121 Firenze, Italy

N.M. Craven, Section of Dermatology, University

of Manchester, "Hope Hospital", Manchester, M6

8HD, U.K.

B. Crickx, Department of Dermatology, Bichat

Hopital, Assistance Publique Hopitaux de Paris, 46

rue Henri Huchard, 75018 Paris, France

W.]. Cunliffe, Skin Research Centre, The General

Infirmary at Leeds, Great George St, Leeds, LS1

3EX, U.K.

I. Danopoulou, Department of Dermatology,

University of Athens, "A Sygros Hospital", 5, I

Dragoumi St, Kesariani 16121, Athens, Greece

R. Dawber, Department of Dermatology,

Churchill Hospital, Old Road, Headington, Oxford,

OX3 7LJ, U.K.

H. Degreef, Universitaire Ziekenhuizen, Leuven

Dermatologie, UZ st. Rafael, Kapucijnenvuer 33, B-

3000 Leuven, Belgium

V. De Giorgi, Department of Dermatology,

Universita degli studi di Firenze, Via Degli Alfani

37,1-50121 Firenze, Italy

F.B. de Waard-van der Spek, Department of

Dermato-Venereology, University Hospital

Rotterdam - Dijkzigt/Sophia, Molewaterplein 60,

3015 GJ Rotterdam, The Netherlands

E. Del Bianco, Department of Dermatological

Science, University of Florence, Via degli Alfani 37,

50 121 Florence, Italy

A. Dompmartin, Department of

Dermatology, Center Hospitalier Universitaire

Caen, Avenue Georges Clemenceau, 14033

Caen Cedex, France

L. Dubertret, Department of Dermatology, Hopital

Saint-Louis, 1 Avenue Claude Vellefaux, 75475,

Paris Cedex 10, France

]. Faergemann, Associate Professor, Department

of Dermatology, Sahlgrenska University Hospital, S-

41345 Gothenburg, Sweden

]. Ferguson, Consultant Dermatologist,

Photobiology Unit, University Department of

Dermatology, Ninewells Hospital and Medical

School, Dundee, DD1 9SY, U.K.

B. Flageul, Department of Dermatology, Hopital

Saint-Louis, 1 Avenue Claude Vellefaux, 75475,

Paris Cedex 10, France

D. Freedman, Department of Medicine, University

College, Dublin, and St James' Hospital, Dublin,

Ireland

M.L. Gantcheva, Department of Dermatology,

Alexander's Medical University Hospital, 1, SaintG.

Sofiski St, Sofia BG-1431, Bulgaria

X.-H. Gao, Department of Dermatology , No.1

Hospital of China Medical University, Shenyang,

China 110001

B.C. Gee, Department of Dermatology, Queen's

Medical Centre, Nottinghan, NG72UH, U.K.

S. Georgala, Department of Dermatology,

University of Athens, "A Sygros Hospital",

5, I Dragoumi St, Kesariani 16121, Athens, Greece

I. Ghersetich, Department of Dermatology,

Universita deg/i studi di Firenze, Via Degli Alfani

37,1-50121 Firenze, Italy

H. Giamarellou, Professor ofInternal

Medicine, Infectious Diseases Specialist, Fourth

Department of Internal Medicine, Sismanoglion

General Hospital, 15126 Maroussi, Attikis,

Athens, Greece

A. Giannetti, Department of Dermatology,

University of Modena, 71 Del Pozzo str. 41100,

Modena, Italy

B. Giannotti, Dipartimento di Scienze Derm,

Universita deg/i studi di Firenze, Via Deg/i Alfani

37,1-50121 Firenze, Italy

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List of Contributors XI

A. Gimenez-Arnau, Department of

Dennatology, Hospital del Mar. IMIM,

Universitdad Autonoma de Barcelona,

Passeig Maritim 25-29, 08003 Barcelona, Spain

H. Gollnick, Department of Dermatology

and Venereology, Otto-von-Guericke­

University, Leipziger Str. 44, D-39120

Magdeburg, Germany

C. Gooptu, ICRF Cancer Medicine Research

Unit, St. James' University Hospital, Beckett

Street, Leeds, LS9 7TF, U.K.

A. G6rkiewicz-Petkow, Department of

Dermatology, Warsaw School of Medicine,

Koszykowa 82A, 02-008 Warsaw, Poland

C.E.M. Griffiths, Section of Dennatology,

University of Manchester, "Hope Hospital",

Manchester, M68HD, U.K.

E.M. Grosshans, Head of the

Dermatological Clinic, Faculte de Medecine,

1, Place de l'hOpital, F-67091 Strasbourg

Cedex, France

M. Ali Gurer, DepartmentofDennatology, 11 kat,

Gazi University School of Medicine, 06510 Besevler,

Ankara, Turkey

J.P. Hachem, Akademisch Ziekenhuis

Vrije Universiteit Brussel, Department of

Dennatology, 101, Laarbeeklaan, B-1090

Brussels, Belgium

E. Haneke, Professor of Dennatology, Inst.

Dennatol Klinikk BunCFs, Lokkeasveien 3, 1337

Sandvika, Norway

R. Happle, Department of Dennatology,

Philipp University of Mar burg,

Deutschhausstraf!,e 9, D-35033 Marburg,

Gennany

K.E. Harman, st. John's Institute of

Dermatology, Basement, Block 7, St

Thomas' Hospital, Lambeth Palace Road,

London, SE1 7EH, U.K.

U.-F. Haustein, DepartmentofDennatology,

University of Leipzig, Stephanstraf!,e 11, 04103

Leipzig, Germany

G. Hautmann, Specialist in Dennatology

and Venereology, Dipartimento di Scienze

Derm, Universita deg/i studi di Firenze,

Via Degli Alfani 37, I-50121 Firenze, Italy

].L.M. Hawk, Department of Environmental

Dermatology, Guy's, King's and Thomas' School of

Medicine, St John's Institute of Dermatology, St

Thomas' Hospital, Lambeth Palace Road, London,

SE1 7EH, U.K.

R.J. Hay, Faculty of Medicine and Health Sciences,

Queen's University Belfast, Whitla Medical

Building, 97 Lisbum Road, Belfast, BT9 7BL, U.K.

J. Hercogova, Department of Dennatology and

Venereology, Charles University 2nd Medical School,

Motol University Hospital, V uvalu 84, 150 06

Prague 5, Czech Republic

C. Herrero, Servei de Dennatologia, Hospital

Clinic, Facultat de Medicina, Universidad de

Barcelona, c/ Villarroe117017, E-08036 Barcelona,

Spain

R. Husak, Klinik und Poliklinik fur

Dennatologie, Universitatsklinikum Benjamin

Franklin der FU Berlin, Fabeckstr. 60-62, 14195

Berlin, Gennany

D. Ioannides, Assistant Professor ofDennatology,

Department of Dennatology and Venereology,

Aristotle University Medical School, 3 PP Gennanou

Street, 54622 Salonika, Greece

S. J ablonska, Department of Dermatology,

Warsaw School of Medicine, Koszykowa 82A,

02-008 Warsaw, Poland

M. Jeanmougin, PoliC/inique de Dennatology,

Hospital St Louis, 1 Avenue Claude Vellefaux,

75475 Paris, Cedex 10, France

D. Kalogeromitros, Departmentof

Dennatology, University of Athens, "A Sygros

Hospital", 5, I Dragoumi St, Kesariani 16121,

Athens, Greece

L. Kanerva, Finnish Institute of Occupational

Health, Topeliuksenkatu 41 aA, FIN-00250

Helsinki, Finland

S. Karl, Dermatologist and Allergologist Marktplatz

7B, D-85375 Neufahm, Gennany

A.C. Katoulis, Department ofDennatology

and Venereology, University of Athens, "A Sygros

Hospital", 5, I Dragoumi St, Kesariani 16121,

Athens, Greece

A.D. Katsambas, University of Athens, 'A. Sygros'

Hospital, Department of Dermatology, 5, l.

Dragoumi Street, 16121 Athens, Greece

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XII List of Contributors

J.C. Katsantonis, Department of Dermatology, Faculty of Medicine , University of Crete, Heraklion 71110, Crete, Greece

A. Katsarou, Department of Dermatology, University of Athens, "A Sygros Hospital", S, I Dragoumi St, Kesariani 16121, Athens, Greece

A. Kobza Black, St John's Institute of Dermatology, Lambeth Palace Road, London, SE1 7EH, U.K.

E. Koumantaki-Mathioudaki, Department of Dermatology and Venereology, University of Athens, "A Sygros Hospital", 5, I Dragoumi St, Kesariani 16121, Athens, Greece

S. Kroon, Department of Dermatology and Venereology, Heise Stavanger, SiR, University of Bergen, Pb 8100,4068 Stavanger, Norway

J .M. Labareda, Centro de Dermatologia Medico­Cirurgica, ARS de Lisboa e Vale do Te;o, I, Rua Jose Estevao 135, 1150 Lisboa, Portugal

G. Laskaris, Head, Oral Medicine Clinic, Department of Dermatology, University of Athens, "A Sygros Hospital", 5, I Dragoumi St, Kesariani 16121, Athens, Greece

A.I. Lauerma, Skin and Allergy Hospital Helsinki, University Central Hospital, Meilahdentie 2, 00250 Helsinki, Finland

F. Lawlor, Newham Dermatology Unit, St Andrew's Hospital, London, E3 3NT, U.K., and St John's Institute of Dermatology, St Thomas' Hospital, London, SE17 EH, U.K.

M. Lecha, Servei de Dermatologia, Hospital Clinic, Facultat de Medicina, Universidad de Barcelona, c/ Villarroe117017, E-08036 Barcelona, Spain

M. Ie Maitre, 1 Avenue de 6 Juin, F-14000 Caen, France

G. Leigheb, Dermatology Clinic, Via Pansa 4, 1-28100 Novara, Italy

L. Leite, Calcada da Nuda 82-1, Lisboa, Portugal

C. Ligeron, Service de Dermatologie, Centre Hospitalier Caremeau, 30900 Nimes, France

T.M. Lotti, Dipartimento di Scienze Dermatologiche, Universita degli Studi di Firenze, Via Degli Alfani 37,1-50121 Firenze, Italy

M.N. Manoussakis, Departmentof Pathophysiology, School of Medicine, National University of Athens, 75 Mikras Asias St, 11527 Athens, Greece

L. Marini, SDC Studio Dermo Chirurgico, Via Pio Riego Gambini 35,34138 Trieste, Italy

J .M. Mascaro, Departmento de Dermatologia, Hospital Clinico, Universidad de Barcelona, Casanova, 143,08036, Barcelona, Spain

J.M. Mascaro Jr, Departmento de Dermatologia, Hospital Clinico, Universidad de Barcelona, Casanova, 143, 08036, Barcelona, Spain

A. Mastrolorenzo, Dipartimento di Scienze Derm, Universita degli studi di Firenze, Via Degli Alfani 37, 1-50121 Firenze, Italy

L.M. Medenica, Department of Dermatology and Venereology Clinical Centre of Serbia, School of Medicine, University of Belgrade, 2 Pasterova St, 11000 Belgrade, Yugoslavia

G. Menchini, Istituto di Scienze Dermatologiche, Univ. Degli Studi - Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy

L. Meunier, Centrum Gruene Gentechnik, Staatliche Lehr- und Forschungsanstait, Breitenweg 71, 67435, Neustadt an der Weinstrasse, Germany

J. Meynadier, Service de Dermatologie, Hopital st. Eloi, 2 Avenue Berlin Sans, F-34295 Montpellier Cedex 5, France

M.V. Milinkovic, Department of Dermatology and Venereology, Clinical Centre of Serbia, School of Medicine, University of Belgrade, 2

Pasterova St, 11000 Belgrade, Yugoslavia, and Harvard Skin Disease Research Center, Brigham and Women's Hospital, Department of Dermatology, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA

A. Minas, Department of Dermatology, Aristotle University Medical School, 124 Delphon Street, 54643 Salonika, Greece

G. Monfrecola, DepartmentofPatologia Sistemica Section of Dermatology, Universim di Napoli 'Federico II', Via S. Pansini 5,80131 Napoli, Italy

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List of Contributors XIII

M. Monti, Istituto Clinico Humanitas,

Unit of Dennatology, University of Milan,

Via Manzani 56, 1-20089 Rozzano, Milan, Italy

S. Motta, Istituto Clinico Humanitas,

Unit of Dermatology, University of Milan,

Via Manzani 56, 1-20089 Rozzano, Milan, Italy

H.M. Moutsopoulos, Departmentof

Pathophysiology, School of Medicine, National

University of Athens, 75 Mikras Asias St, 11527

Athens, Greece

G.M. Murphy, National Photobiology Unit,

Beaumont Hospital, Dublin 9, Ireland

G. Muscarella, Department ofDennatological

Science, University of Florence, Via degli Alfani 37,

50121 Florence, Italy

M.D. Njoo, DepartmentofDennatology, Academic

Medical Centre, University of Amsterdam, PO Box

22700, Meibergdreef9, 1100 DE Amsterdam, The

Netherlands

M. Onder, Department of Dennatology, Gazi

University School of Medicine, 06510 Besevler,

Ankara, Turkey

A.P. Oranje, Department of Dennatology,

University Hospital Rotterdam - Dijkzigt/Sophia,

Molewaterplein 60, 3015 GJ Rotterdam, The

Netherlands

C.E. Orfanos, Klinik und Poliklinik fur

Dermatologie, Universitatsklinikum Benjamin

Franklin der FU Berlin, Fabeckstr. 60-62, 14195

Berlin, Gennany

]. -P. Ortonne, Department of Dennatology,

University of Nice, Hopital de l'Archet 2, 151, route

St-Antoine de Ginestiere, F-06202 Nice, Cedex 3,

France

D. Ozalla, Servei de Dennatologia, Hospital Clinic,

Facultat de Medicina, Universidad de Barcelona, c/ Villarroell7017, E-08036 Barcelona, Spain

J.L. Pace, 59 Marquis Scicluna St, Naxxar NXR 03,

Malta

E. Panconesi, Specialist in Dennatology and

Venereology, Dipartimento di Dermatologia,

Universita degli studi di Firenze, Via Degli Alfani

37,1-50121 Firenze, Italy

M. Paradisi, "San Gallicano" Institute, Rome,

Italy

S. Petraglia, Catholic University, Dept of

Dennatology, L.go A. Gemelli 8, 00168 Rome,

Italy

A. Picoto, Centro de Dennatologia Medico­

Cirurgica, ARS de Lisboa e Vale do Tejo, I, Rua Jose

Estevao 135, 1150 Lisboa, Portugal

G .E. Pierard, Department of Dennatopathology,

CHV Sart Tilman, B-4000 Liege, Belgium

C. Pierard-Franchimont, Department of

Dermatopathology, CHV Sart Tilman, B-4000

Liege, Belgium

B.M. Piraccini, Department of Dennatology,

University of Bologna, Via Massarenti 1, 40138

Bologna, Italy

G. Posteraro, Department ofPatologia Sistemica

Section of Dennatology, Universita di Napoli

'Federico II', Via Pansini 5,80131 Napoli, Italy

EC. Powell, Regional Centre of Dermatology,

Mater Miseraecordia Hospital, Eccles Street, Dublin-

7, Ireland

E.M. Procaccini, Department of Dennatology,

Universita "Federico II" de Napoli, Via S. Pansini 5,

80131 Napoli, Italy

A.A. Ramelet, 2 Place Benjamin-Constant, CH-

1003 Lausanne, Switzerland

L. Rauch, Department of Dennatology-Hautklinik,

Moorenstrasse 5, 40225 Dusseldorf, Gennany

A. Rebora, Department ofDennatology, University

of Genoa, Genoa, Italy

]. Revuz, Service de Dennatologie, Henri Mondor

Hospital, 51, Ave du Marechal de Lattre de Tassigny,

F-9401O Creteil Cedex, France

D. Rigopoulos, Department of Dennatology,

University of Athens, "A Sygros Hospital", 5, I

Dragoumi St, Kesariani 16121, Athens, Greece

]. Ring, Department of Dermatology and

Allergy Biederstein, Technical University

Munich, Biedersteinerstraf5e 29, D-80802

Munich, Gennany

D. Roseeuw, Akademisch Ziekenhuis Vrije

Universiteit Brussel, Department of Dennatology,

101, Laarbeeklaan, B-1090 Brussels, Belgium

E. Ruocco, Department of Dermatology,

School of Medicine and Surgery, Second University of

Naples, Via S. Pansini 5,80131 Napoli, Italy

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XIV List of Contributors

V. Ruocco, Head, Department of Dermatology, School of Medicine & Surgery, Second University of Naples, Via S. Pansini 5,80131 Napoli, Italy

1. Rusciani, Department of Dermatology, Catholic University of Sacred Heart, Largo A. Gemelli 8, 00168 Rome, Italy

T. Ruzicka, Department of Dermatology­Hautklinik, Moorenstraf!,e 5, 40225 Diisseldorf,

Germany

P. Santoianni, Department of Dermatology, Universita "Federico II" de Napoli, Via S. Pansini 5, 80131 Napoli, Italy

J .H. Saurat, Clinique & Policlinique de Dermatologie, Hopital Universitaire, CH-1211 Geneva 14, Switzerland

M. Souli, Fourth Department of Internal Medicine, Athens University School of Medicine, Sismanoglio General Hospital, 1 Sismanogliou Str., 15126

Maroussi, Attikis, Athens, Greece

H. Starz, Department of Dermatology and Allergology, Klinikum Augsburg, Stenglinstraf!,e 2, D-86156 Augsburg, Germany

N.G. Stavrianeas, Department of Dermatology, University of Athens, "A Sygros Hospital", 5, I Dragoumi St, Kesariani 16121, Athens, Greece

P.G. Stavropoulos, Second Department of Dermatology, University of Athens, "A Sygros Hospital", 5, I Dragoumi St, Kesariani 16121, Athens, Greece

M.P. Stefanidou, Department of Dermatology, Heraklion University General Hospital, Heraklion, Crete, Greece

1. Stransky, Unit of Contact Dermatitis and Occupational Diseases of the Skin, Medical

University, Alexander's Medical University Hospital, 1, Saintg. Sofiski St, Sofia BG-1431, Bulgaria

A.J. Stratigos, Department of Dermatology,

University of Athens, "A Sygros Hospital", 5, I Dragoumi St, Kesariani 16121, Athens, Greece

J.D. Stratigos, Department of Dermatology, University of Athens, "A Sygros Hospital", 5, I

Dragoumi St, Kesariani 16121, Athens, Greece

R. Themido, Centro de Dermatologia Medico­

CiTUrgica, ARS de Lisboa e Vale do Tejo, I, Rua lose Estevao 135, 1150 Lisboa, Portugal

K. Thestrup-Pedersen, University of Aarhus, Department of Dermatology, Marselisborg Hospital, DK-8000 Aarhus C, Denmark

A.D. Tosca, Department of Dermatology, Heraklion

University General Hospital of Crete, Heraklion, 71110 Crete, Greece

A. Tosti, Department of Dermatology, University of Bologna, Via Massarenti 1, 40138 Bologna, Italy

N. Tsankov, Department of Dermatology, Alexander's Medical University Hospital, 1, Saint g. Sofiski St, Sofia BG-1431, Bulgaria

E. Tsoureli-Nikita, Istituto di Scienze Dermatologiche, Univ. Degli Studi - Policlinico Le

Scotte, Viale Bracci, 53100 Siena, Italy

A.G. Tzioufas, Department of Pathophysiology, School of Medicine, National University of Athens, 75 Mikras Asias St, 11527 Athens, Greece

E.J.M. Van Leent, Department of Dermatology, Academic Medical Centre, University of Amsterdam, PO Box 22700, Meibergdreef9, 1100 DE Amsterdam, The Netherlands

W.A. van Vloten, Department of Dermatology, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands

A.E. Vareltzidis, Department of Dermatology, University of Athens, "A Sygros Hospital", 5, I Dragoumi St, Kesariani 16121, Athens, Greece

C. Varotti, Department of Dermatology, University of Bologna, Via Massarenti 1, 40138 Bologna, Italy

S. Veraldi, Institute of Dermatological Sciences, fRCCS, University of Milan, Via Pace 9, f-20122

Milan, Italy

P.G. Vlachoyiannopoulos, Departmentof Pathophysiology, School of Medicine, National

University of Athens, 75 Mikras Asias St, 11527 Athens, Greece

H.-J. Vogt, Department of Dermatology and Allergy Biederstein, Technical University

Munich, Biedersteinerstraf!,e 29, D-80802

Munich, Germany

N.P.J. Walker, Department of Dermatology,

Churchill Hospital, Old Road, Headington, Oxford, OX3 7Ll, U.K.

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List of Contributors xv

M.A. Waugh, Genito Urinary Medicine

Department, The General Infirmary at Leeds, Great

George St, Leeds, LS1 3EX, U.K.

W. Westerhof, Netherlands Institute for

Pigmentary Disorders/AMC IWO gebouw,

Meibergdreef 35, 1105 AZ Amsterdam, The

Netherlands

F. Wojnarowska, Department of Dermatology,

Churchill Hospital, Old Road, Headington, Oxford,

OX3 7LT, U.K.

Ch.C. Zouboulis, Klinik und Poliklinik fUr

Dermatologie, Universitiitsklinikum Benjamin

Franklin der FU Berlin, Fabeckstr. 60-62, 14195

Berlin, Germany

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Preface

This handbook presents the combined work of many prominent dermatologists from throughout Europe, based on their profound knowledge and clinical experi­ence in various fields of dermatology. The purpose of this manual is to provide an easy to use guide that describes not only the many dermatological diseases diag­nosed today, but also the analogous drugs and methods of treatment available. Hence, as indicated in the title, derma­tologists and non-dermatologists will find its contents to be most useful and concise.

The manual is divided into three main sections: Diseases, Methods, and Drugs. The first part of the handbook defines each disease with brief information on its etiology and pathophysiology. This is followed by a short account of diagnostic procedures and an extensive discussion of treatment and therapy. The authors have not only presented classic and modern approaches to treatment, but also pro­vided their personal recommendations on the bases of their expertise. The middle

section describes up-to-date methods and the possible use of therapeutic equipment for diagnosis and treatment. The final section provides an alternative approach, indicating where medication and drugs could be an appropriate choice in the treatment of dermatological diseases.

This second edition of the European Handbook of Dermatological Treatments has been minimally revised and retains the exact form of the previous publication.

The response received from the initial publication was enthusiastic and the book was widely accepted. It has been a great pleasure to provide this handbook to fellow colleagues and new dermatolo­gists in the continuing endeavour to treat dermatological and cutaneous diseases.

We wish to express our gratitude to all the distinguished colleagues who contributed towards this venture.

Andreas Katsambas, Torello Lotti 2003