evidence based medicine for the athletic trainer: what is it? july 11, 2015 boc approved ebp ceus...
TRANSCRIPT
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Evidence Based Medicine for the Athletic Trainer: What is It?
July 11, 2015
BOC Approved EBP CEUs
Evidence-Informed Clinical Practice for the Athletic Trainer:
…while others wandered around…and dined with the rich and powerful …we on the other hand labored diligently…we first learned all the things that were creditably discovered by the ancients; then through deeds we both tested and practiced them.
-Galen (129-217 CE [disputed])Method of Medicine 9.4, 10.609K
Jennifer M. Medina McKeon, PhD, ATC, [email protected]
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…while others wandered around…and dined with the rich and powerful …we on the other hand labored diligently…we first learned all the things that were creditably discovered by the ancients; then through deeds we both tested and practiced them.
-Galen (129-217 CE [disputed])Method of Medicine 9.4, 10.609K
“EBP is just a fad.”
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What EBP is not…
“All this EBP stuff just means that they think that clinicians are all supposed to become researchers now”
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We all know that you can prove anything with statistics…
…I recently proved that nobody likes statistics, except a few professors
- Chottiner (1990)
“EBP means that we all need to be doing stats on everything.”
What EBP is not…
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What EBP is not…
“EBP means that someone should read all the research that’s out there on a topic, and tell me what to do.”
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What EBP is not…
“Ideally, we would like to see a clinician encounter an injury, and right there, pull out a laptop or tablet, and look up the most recent article on that injury, and incorporate what the study says right there on the spot.”
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What is the EBP?
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Evidence-Based Practice
Patient Values
Clinical Experience
Best Available Evidence
“Integration of the best available research evidence with clinical experience
and patient values to make clinical decisions” – Sackett et al, BMJ 1996.
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Hierarchy of Clinical Research Evidence
Meta-analysesSystematic Reviews
Randomized Clinical Trials
Cohort Studies(Prospective)Case-Control Studies
(Retrospective)Case SeriesCase StudiesUnpublished Clinical Observations
More Control
Less Risk of Bias
More Subjects Involved B
ET
TE
R R
ES
EA
RC
H E
VID
EN
CE
HA
RD
ER
TO
DO
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Critical Appraisal
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Critical Appraisal
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Critical Appraisal
More than Peer Review
Vital Step to making INFORMED clinical decisions
Combination of External Evidence (the stuff you find) & the Internal Evidence (the stuff you know)
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Critical Appraisal
More than Peer Review
Vital Step to making INFORMED clinical decisions
Combination of External Evidence (the stuff you find) & the Internal Evidence (the stuff you know)
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Critical Appraisal
More than Peer Review
Vital Step to making INFORMED clinical decisions
Combination of External Evidence (the stuff you find) & the Internal Evidence (the stuff you know)
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Critical Appraisal
More than Peer Review
Vital Step to making INFORMED clinical decisions
Combination of External Evidence (the stuff you find) & the Internal Evidence (the stuff you know)
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What is the BEST SPECIAL TEST???What is the BEST TREATMENT???
What makes a test good?Accurate (Valid)Consistent results (Reliable)
YUCK – that sounds like research
RESEARCH EVIDENCE
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What makes a test good?Accurate (Valid)Consistent results (Reliable)
YUCK – that sounds like research
RESEARCH EVIDENCE: The Best Tests
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What makes a test good? Accurate (Valid)Consistent results (Reliable)
RESEARCH EVIDENCE: The Best Tests
SENSITIVITY SPECIFICTY
Definition Proportion of patients WITH the injury who test POSITIVE
Proportion of patients WITHOUT the injury who test NEGATIVE
100% Sensitivity (Perfect Score)
Test correctly identifies every person who HAS the injury
Test correctly identifies every person who DOES NOT HAVE the injury
Outcome True Positive Rate True Negative Rate
“Ideal” Test Result Negative Positive
“Ideal” Test Interpretation(What to tell the Patient)
Definitely NEGATIVE(Patient is OK)
Definitely POSITIVE(Patient is Injured)
“The RULE” RULE OUT (SnOUT)If Test is Negative, You can Rule Out injury (Patient is OK)
RULE IN (SpIN)If Test is Positive, You can Rule In injury (Patient is Injured)
Poor Test Lots of FALSE NEGATIVES Lots of FALSE POSITIVES
Adapted from http://www.aaronswansonpt.com/sensitivity-and-specificity/Accessed January 23, 2015
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What makes a test good? Accurate (Valid)Consistent results (Reliable)
RESEARCH EVIDENCE: The Best Tests
Adapted from http://www.aaronswansonpt.com/sensitivity-and-specificity/Accessed January 23, 2015
SENSITIVITY SPECIFICTY
Definition Proportion of patients WITH the injury who test POSITIVE
Proportion of patients WITHOUT the injury who test NEGATIVE
100% Sensitivity (Perfect Score)
Test correctly identifies every person who HAS the injury
Test correctly identifies every person who DOES NOT HAVE the injury
Outcome True Positive Rate True Negative Rate
“Ideal” Test Result Negative Positive
“Ideal” Test Interpretation(What to tell the Patient)
Definitely NEGATIVE(Patient is OK)
Definitely POSITIVE(Patient is Injured)
“The RULE” RULE OUT (SnOUT)If Test is Negative, You can Rule Out injury (Patient is OK)
RULE IN (SpIN)If Test is Positive, You can Rule In injury (Patient is Injured)
Poor Test Lots of FALSE NEGATIVES Lots of FALSE POSITIVES
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What makes a test good? Accurate (Valid)Consistent results (Reliable)
RESEARCH EVIDENCE: The Best Tests
Adapted from http://www.aaronswansonpt.com/sensitivity-and-specificity/Accessed January 23, 2015
SENSITIVITY SPECIFICTY
Definition Proportion of patients WITH the injury who test POSITIVE
Proportion of patients WITHOUT the injury who test NEGATIVE
100% Sensitivity (Perfect Score)
Test correctly identifies every person who HAS the injury
Test correctly identifies every person who DOES NOT HAVE the injury
Outcome True Positive Rate True Negative Rate
“Ideal” Test Result Negative Positive
“Ideal” Test Interpretation(What to tell the Patient)
Definitely NEGATIVE(Patient is OK)
Definitely POSITIVE(Patient is Injured)
“The RULE” RULE OUT (SnOUT)If Test is Negative, You can Rule Out injury (Patient is OK)
RULE IN (SpIN)If Test is Positive, You can Rule In injury (Patient is Injured)
Poor Test Lots of FALSE NEGATIVES Lots of FALSE POSITIVES
“New Rule” High SNNNHigh SeNsitivity, Negative test, Negative pt.
High SPPPHigh SPecificity, Positive test, Positive pt.
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BiasComparison
Generalizability
RESEARCH EVIDENCE: The Best TestsQUESTIONS TO ASK
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Generalizability
Is the Test Relevant to your practice?
Who was the Test performed on?BiasComparison
QUESTIONS TO ASK
RESEARCH EVIDENCE: The Best Tests
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BiasComparison
Generalizability
RESEARCH EVIDENCE: The Best Tests
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Who did the Test?Was the Test compared to a Gold Standard?Was the Test tried in a group of Patients who could conceivably have the Injury?
QUESTIONS TO ASK
BiasComparison
Generalizability
RESEARCH EVIDENCE: The Best Tests
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BiasComparison
Generalizability
RESEARCH EVIDENCE: The Best Tests
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BiasComparison
Generalizability
Did the testers “know” if the patient had the Injury?Did ALL patients tested also get tested with the Gold Standard?
QUESTIONS TO ASK
RESEARCH EVIDENCE: The Best Tests
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RESEARCH EVIDENCE: The Best Tests
BiasComparison
Generalizability1. Is the Test Relevant to your practice?
2. Who was the Test performed on?
3. Who did the Test?
4. Was the Test compared to a Gold Standard?
5. Was the Test tried in a group of Patients who could conceivably have the Injury?
6. Did the testers “know” if the patient had the Injury?
7. Did ALL patients tested also get tested with the Gold Standard?
QUESTIONS TO ASK
Improve your ability to Critically Analyze Diagnostic Test research
IMPROVE YOUR OWN PRACTICE
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=
PREDICTION
BEST PREDICTORS
Get rid of these…they don’t add much
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Clinical Prediction Rules (the other CPR)
Combination of 3 or more specific patient characteristics that provides a quantifiable probability for diagnosis (or prognosis or benefit for a procedure)
Best combination of S/S to predict probability of Injury
Calculated for Maximized Prediction
Support the decisions that you make
Considerations
Must be validated
Do not guarantee n outcome (a probability)
Used fore making predictions, not recommendations (what is likely to happen, not what to do next)
“Suggest” vs. “Recommend” next course of action Clinical Decision Rule
Application, not Development
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Clinical Prediction Rules (the other CPR)
Combination of 3 or more specific patient characteristics that provides a quantifiable probability for diagnosis (or prognosis or benefit for a procedure)
Best combination of S/S to predict probability of Injury
Calculated for Maximized Prediction
Support the decisions that you make
Considerations
Must be validated
Do not guarantee an outcome (they’re a probability)
Used fore making predictions, not recommendations (what is likely to happen, not what to do next)
“Suggest” vs. “Recommend” next course of action (vs. Clinical Decision Rule)
Application, not Development
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RESEARCH EVIDENCE: The Best Treatments
What makes a treatment good?
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RESEARCH EVIDENCE: The Best Treatments
Posing a Clinical Question
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RESEARCH EVIDENCE: The Best Treatments
Posing a Clinical Question
P
I
C
O
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RESEARCH EVIDENCE: The Best Treatments
Posing a Clinical Question
P Patient or Problem or PopulationWhat are the most important Characteristics of your Patient?
I
C
O
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RESEARCH EVIDENCE: The Best Treatments
Posing a Clinical Question
P Patient or Problem or PopulationWhat are the most important Characteristics of your Patient?
IIndependent Variable(Intervention or Assessment or Exposure)
What is the main Intervention, Prognostic factor, Diagnostic factor, or Exposure you are considering for your patient?
C
O
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RESEARCH EVIDENCE: The Best Treatments
Posing a Clinical Question
P Patient or Problem or PopulationWhat are the most important Characteristics of your Patient?
IIndependent Variable(Intervention or Assessment or Exposure)
What is the main Intervention, Prognostic factor, Diagnostic factor, or Exposure you are considering for your patient?
C Comparison or ControlWhat is the main alternative to the Intervention / Assessment / Exposure?
O
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RESEARCH EVIDENCE: The Best Treatments
Posing a Clinical Question
P Patient or Problem or PopulationWhat are the most important Characteristics of your Patient?
IIndependent Variable(Intervention or Assessment or Exposure)
What is the main Intervention, Prognostic factor, Diagnostic factor, or Exposure you are considering for your patient?
C Comparison or ControlWhat is the main alternative to the Intervention / Assessment / Exposure?
O Outcome of Interest What is considered “success”
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RESEARCH EVIDENCE: The Best Treatments
Posing a Clinical Question
P Patient or Problem or PopulationWhat are the most important Characteristics of your Patient?
IIndependent Variable(Intervention or Assessment or Exposure)
What is the main Intervention, Prognostic factor, Diagnostic factor, or Exposure you are considering for your patient?
C Comparison or ControlWhat is the main alternative to the Intervention / Assessment / Exposure?
O Outcome of Interest What is considered “success”
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RESEARCH EVIDENCE: The Best Treatments
QUESTIONS TO ASK
The PEDro Scale http://www.pedro.org.au/english/downloads/pedro-scale/Accessed January 23, 2015
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RESEARCH EVIDENCE: The Best Treatments
BiasComparison
Generalizability
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RESEARCH EVIDENCE: The Best Treatments
QUESTIONS TO ASK
BiasComparison
Generalizability
Who was the Treatment performed on?
Did all of the patients present similarly?
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RESEARCH EVIDENCE: The Best Treatments
BiasComparison
Generalizability
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RESEARCH EVIDENCE: The Best Treatments
BiasComparison
Generalizability
QUESTIONS TO ASK
(In other words, were the patients who received the treatment Really better than the controls?)
Did they compare the Groups?
Were they meaningfully different?
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RESEARCH EVIDENCE: The Best Treatments
BiasComparison
Generalizability
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RESEARCH EVIDENCE: The Best Treatments
BiasComparison
Generalizability
QUESTIONS TO ASK
Did the individuals involved already have an “idea” of what should happen?
In other words: No Blinding of - Patients- Therapists- Investigators
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RESEARCH EVIDENCE: The Best Treatments
BiasComparison
Generalizability
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RESEARCH EVIDENCE: The Best Treatments
BiasComparison
Generalizability1. Who was the Treatment performed on?
2. Who Did all the patients present similarly?
3. Did they compare the groups?
4. Where they meaningfully different?
5. Did the individuals involved have an “idea” of what should happen
QUESTIONS TO ASK
Improve your ability to Critically Analyze Intervention research
IMPROVE YOUR OWN PRACTICE
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RESEARCH EVIDENCE: Summary
Specifically, we covered:
• Sackett’s 3-pronged EBP model
• Levels of Evidence
• Critical appraisal - Diagnosis (Diagnostic accuracy & CPRs)
• Critical appraisal - Intervention (PICO, Therapeutic studies)
We focused on Foundational concepts of EBP
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Evidence-Based Practice
Patient Values
Clinical Experience
Best Available Evidence
“Integration of the best available research evidence with clinical experience
and patient values to make clinical decisions” – Sackett et al, BMJ 1996.
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Read not to
contradict and
confute, nor to
believe and take
for granted…but
to weigh and
consider
- Francis Bacon (1561-
1626)