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Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

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Page 1: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5

Q&A M 4/4from 5-6:30pmTBA

Today: Smoking andReliable Sources

Page 2: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Tobacco Use in the US, 1900-1999

0

500

1000

1500

2000

2500

3000

3500

4000

4500

5000

190019051910191519201925193019351940194519501955196019651970197519801985199019952000Year

Per Capita Cigarette Consumption

0

10

20

30

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50

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90

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Age-Adjusted Lung Cancer Death

Rates*

*Age-adjusted to 2000 US standard population.

Source: Death rates: US Mortality Public Use Tapes, 1960-1999, US Mortality Volumes, 1930-1959, National Center for Health Statistics, Centers for Disease Control and Prevention, 2001. Cigarette consumption: Us Department of Agriculture, 1900-1999.

Per capita cigarette consumption

Male lung cancer death rate

Female lung cancer death rate

Page 3: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Development: differentiating cells to become an organism

Page 4: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources
Page 5: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Inverse relationship between smoking and weight: more smoking : less weight

Page 6: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Effect of smoking on fetal development and how that can affect adults

Page 7: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Adults exposed to smoke as fetuses have higher risk of obesity and heart disease

Page 8: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

What is the connection?

Page 9: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Obesity, Diabetes, Heart Disease, High Blood Pressure, Some Cancers all may have some origins during fetal development.

Page 10: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Adults metabolism may react to poor nutrition as fetuses…

Adaptation of Thriftiness/Catch Up Growth.

Page 11: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Adults metabolism may react to poor nutrition as fetuses…Adaptation of Thriftiness/Catch Up Growth.

Study of babies born during Dutch famine of 1944-45…

Page 12: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Adults metabolism may react to poor nutrition as fetuses…Adaptation of Thriftiness/Catch Up Growth.

Study of babies born during Dutch famine of 1944-45…

20 years later found that these babies had higher rates of obesity.

Page 13: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Adults metabolism may react to poor nutrition as fetuses…Adaptation of Thriftiness/Catch Up Growth.

Study of babies born during Dutch famine of 1944-45…

20 years later found that these babies had higher rates of obesity.

Precise mechanism is not known

Page 14: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

What about smoking?

17,000 births studied and checked at age 16 and 33.

Fetuses exposed to smoking had increased rate of obesity.

Page 15: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

What about smoking?

17,000 births studied and checked at age 16 and 33.

Fetuses exposed to smoking had increased rate of obesity and more smoking meant more obesity.

Page 16: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

What about smoking?

17,000 births studied and checked at age 16 and 33.

Fetuses exposed to smoking had increased rate of obesity and more smoking meant more obesity.

For Mom’s who abstained during pregnancy, no effect on fetus or as adult.

Page 17: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

What about smoking?

17,000 births studied and checked at age 16 and 33.

Fetuses exposed to smoking had increased rate of obesity and more smoking meant more obesity.

Smoking during first trimester had same effect as during whole pregnancy.

Page 18: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

What about smoking?

For diabetes more than 10 cigarettes per day gave a 4 times greater risk of diabetes.

Page 19: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

What about smoking?

Risk of high blood pressure also increases with increased exposure to fetus of smoking during pregnancy

Page 20: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Why?

Page 21: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Why?

Nicotine can inhibit hunger and increase energy expenditure.

This can lead to poor fetal nutrition.

Page 22: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Why?

Nicotine causes constriction of blood vessels, and may limit blood flow to the fetus.

Page 23: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

AAL 38.8

Mammalian circulation

Page 24: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Nicotine causes blood vessels to constrict

Page 25: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Why?

CO in blood decreases delivery of O2 to fetus.

Page 26: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Why?

These are all indirect affects leading to “adaptation to thriftiness”…

Nicotine can inhibit hunger and increase energy expenditure.

Nicotine causes constriction of blood vessels, and may limit blood flow to the fetus.

CO in blood decreases delivery of O2 to fetus.

Page 27: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Why?

Nicotine and other toxins in smoke may directly affect hormones that direct fetal development.

Page 28: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Hormones are molecules produced in one cell and signal another.

Page 29: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Why?

Nicotine and other toxins in smoke may directly affect hormones that direct fetal development.

Including hormones that direct brain development.

Page 30: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

So,

Smoking during pregnancy may have indirect and/or direct affects on fetal development, and these affects may manifest themselves in adults.

Page 31: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Correlation of weight (BMI) %

Identical twins reared together 80

Identical twins reared apart 72

Fraternal twins reared together 43

Biological siblings 34

Parents and children living together 26

Adopted children and parents 4

Unrelated children living together 1

Nature and Nurture:Correlation of weight and relatedness

The nature of environmental influences on weight and obesity: A behavior genetic analysis. Grilo, Carlos M.; Pogue-Geile, Michael F.; Psychological Bulletin, Vol 110(3), Nov 1991. pp. 520-537. And two books by Matt Ridley: Nature via Nurture (2003) and Genome: the Autobiography of a Species in 23 Chapters (1999)

Page 32: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

See:http://sciencenow.sciencemag.org/cgi/content/full/2009/203/3?rss=1(and/or)

Disentangling prenatal and inherited influences in humans with an experimental designFrances Ricea, Gordon T. Haroldb, Jacky Boivinb, Dale F. Hayb, Marianne van den Breea, and Anita ThaparaPNAS early editioncgidoi10.1073pnas.0808798106

Fetal exposure to smoking can have several affects on children, including:-decreased birth weight-increased anti-social behavior

Are these affects genetic or environmental?

Page 33: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

In Vitro Fertilization- fertilization occurs in a lab, and then the embryo is implanted into a woman's uterus.

Usually the pregnant woman is related to the embryo, but sometimes they are unrelated.

Page 34: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

The average birth weight for all babies born to smoking mothers was lower...

Page 35: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Anti-social behavior was only different if the child and mother were related...

Page 36: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

birth weight

anti-social behavior

...So birth weight reductions were strongly nurture (environmental)

...while increases in anti-social behavior were strongly nature (genetic)

Page 37: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Experiment Written Report:Title- Concisely describe your experiment.AuthorAbstract- Summarize your work. Do not exceed 250 words.Introduction-Results-Discussion-Materials and Methods-References- include: author name(s), article title, journal or book title, volume and page number, and year of publication

Staple your approved proposal to the back of your written report.

Page 38: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

What is a reliable source?

xkcd.com

Page 39: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Building Blocks of Scientific Literature

peer review

What is peer review?

Page 40: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

In a peer reviewed journal each article is looked at by an editor, and then it is then sent to two anonymous reviewers.

These reviewers send comments back to the associate editor.

Page 41: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

After each article is sent to the editor, it is then sent to two anonymous reviewers.

These reviewers send comments back to the editor.

They give suggestions for improvement as well as an opinion about whether it should be published or not.

Page 42: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

The editor then has three choices:

Accept paper as is. (rare)

Accept paper and ask for some changes.

Reject paper. (20-80% rejection rate in physical sciences*)

*Scholarly Consensus and Journal Rejection Rates. Lowell L. Hargens (Feb., 1988) American Sociological Review 53: 139-151andBang for Your Buck: Rejection Rates and Impact Factors in Ecological Journals. The Open Ecology Journal (2008) L.W. Aarssen, T. Tregenza, A.E. Budden, C.J. Lortie, J. Koricheva and R. Leimu 1: 14-19

Page 43: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Who reviews papers?

Other researchers knowledgeable in the field.

Page 44: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

What is a reliable source?

xkcd.com

Page 45: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

What is a reliable source?

Page 46: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

What is a reliable source?

Can be a great source of sources...

Page 47: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

What is a reliable source?

Who was the author(s)?Why was it written?Where was it published?Who checked/reviewed the article?

xkcd.com

Page 48: Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5 Q&A M 4/4 from 5-6:30pm TBA Today: Smoking and Reliable Sources

Exam 2 T 4/5 in class (bring cheat sheet) Take-home 2 due 4/5

Q&A M 4/4from 5-6:30pmTBA

Today: Smoking andReliable Sources