extension of bayesian procedures to integrate and to blend multiple external information into...
TRANSCRIPT
![Page 1: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/1.jpg)
Extension of Bayesian procedures to integrate and to blend multiple external information
into genetic evaluations
J. Vandenplas1,2, N. Gengler1
1University of Liège, Gembloux Agro-Bio Tech, Belgium2National Fund for Scientific Research, Brussels, Belgium
2012 ADSA-ASAS Joint Annual MeetingPhoenix, AZ, July 15-19
![Page 2: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/2.jpg)
Introduction
• Most reliable EBV if estimated from all available sources
• Most situations– Multiple sources (e.g., dairy breeds)
• Traditional genetic evaluations• International second step (Interbull)
Animals with few (or no) local data: low accuracy– Development of genomic selection
New genomic information sources
Strategies for integration / blending of those multiple external evaluations
![Page 3: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/3.jpg)
External information
• Most situations– EBV and REL from other genetic evaluations
– Information not taken into account by a local BLUP No double-counting between local and external evaluations
– Only available for some animals• Having, or not, phenotypic information in the local BLUP• Present in the pedigree of the local BLUP
• Special case: MACE-EBV
![Page 4: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/4.jpg)
Aim
To integrate/blend multiple a priori known external information into a local evaluation
Using a Bayesian approach– Based on
• Legarra et al. (2007)• Quaas and Zhang (2006)• Vandenplas and Gengler (2012)
![Page 5: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/5.jpg)
• Mixed model equations
– : Inverse of genetic (co)variances matrix– : vector of local observations – : vector of estimated local fixed effects– : vector of estimated local EBV
–
L1
L1
L
L111
11
yRZ'
yRX'
u
βGZRZ'XRZ'
ZRX'XRX'
ˆ
ˆ
Regular BLUP
-10
-1-1 GHG
G0,uL MVNp
LβLy
Lu
![Page 6: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/6.jpg)
Methods
• Assumption: A priori known information of– n sources of external information:
• n vector of external EBV
• n prediction error (co)variances matrices
– Issue: only available for some animals
and : (partially) unknown
– EBV and REL from another genetic evaluation
– Information not taken into account in a local ssGBLUP• Not from an external genomic evaluation
No double-counting between local and external evaluations
– Only available for some animals• Having, or not, phenotypic or genomic information in the local
ssGBLUP• Present in the pedigree of the local ssGBLUP
ni1 EEE D,...,DD ,...,
Lu
ni1 EEE uuu ˆ,...,ˆ,...,ˆ
iEuiED
![Page 7: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/7.jpg)
Methods
• For each source i: Estimation of – Available: External EBV of external animals ( )
– Local animals: prediction of external EBV ( )
Correct propagation of external information
1*EE*EE
1*EE
*LE
*EEEL )(G,uGG)uu( i
iiiii
ˆˆˆ MVNp
iEu
*
EE
ELE
i
i
i u
uu
ˆ
ˆˆ
Predicted external EBV
Available external EBV
iELu
*EEi
u
![Page 8: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/8.jpg)
Methods
• For each source i: Estimation of
: Inverse of genetic (co)variances
matrix of
iED
10
11 GAG
iEu
ii E11
E ΛGD
0 Δ
Δ
)ΔG(ΔΛ
j
j
j1
0jEi
:ninformatio localonly withanimals For
traits t1,...,k ; 1diag:animals external For
animals a1,...,j sources; n1,...,i ;diag block
))REL(REL( ijkijk
![Page 9: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/9.jpg)
n
1iE
1EL
1
L1
L
Ln
1iE
111
11
iiiuDyRZ'
yRX'
u
βΛGZRZ'XRZ'
ZRX'XRX'
ˆˆ
ˆ
Methods
• Integration of n external information
L1
L1
L
L111
11
yRZ'
yRX'
u
βGZRZ'XRZ'
ZRX'XRX'
ˆ
ˆ
Sum of n least square parts of LHS of n hypothetical BLUP of n sources of
external EBV
Sum of n RHS of n hypothetical BLUP of n
sources of external EBV
![Page 10: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/10.jpg)
Methods
• Blending of n external information– Assumption: no local records in
n
1iE
1EL
n
1iE
1
iiiuDuΛG ˆˆ
Ly
![Page 11: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/11.jpg)
Methods
• Issue: double-counting of information among external animals Estimation of contributions due to relationships and due to
own records
All only depend on contributions due to own recordsiEΛ
![Page 12: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/12.jpg)
Simulation: blending
• 100 replicates • 2 populations
– ±1000 animals/population– 5 generations– Random matings / cullings– Observations (Van Vleck, 1994)
• Milk yield for the first lactation • Heritability : 0.25
– Fixed effect• Random herd effect within population
![Page 13: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/13.jpg)
Simulation: blending
• Performed evaluations
Information External BLUP
Local BLUP
Blending BLUP
Joint BLUP
Pedigree
External population
Local population + 50 external sires used locally
Phenotypes
External observations
Local observations External information
External EBV and REL (50 external sires)Local EBV and REL (all population)
![Page 14: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/14.jpg)
Simulation: blending
• Performed evaluations
Information External BLUP
Local BLUP
Blending BLUP
Joint BLUP
Pedigree
External population
Local population + 50 external sires used locally
Phenotypes
External observations
Local observations External information
External EBV and REL (50 external sires)
Local EBV and REL (all population)
![Page 15: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/15.jpg)
Simulation: blending
• Performed evaluations
Information External BLUP
Local BLUP
Blending BLUP
Joint BLUP
Pedigree
External population
Local population + 50 external sires used locally
Phenotypes
External observations
Local observations External information
External EBV and REL (50 external sires)
Local EBV and REL (all population)
![Page 16: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/16.jpg)
Simulation: blending
• Performed evaluations
Information External BLUP
Local BLUP
Blending BLUP
Joint BLUP
Pedigree
External population
Local population + 50 external sires used locally
Phenotypes
External observations
Local observations External information
External EBV and REL (50 external sires)
Local EBV and REL (all population)
![Page 17: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/17.jpg)
Comparison with joint BLUP
• Rank correlations (r+SD)
Rankings more similar to those of the joint BLUP
Evaluation Local animals External sires
Without external information
Local BLUP 0.95 ± 0.02 0.54 ± 0.11
Only external information Blending BLUP
With double-counting 0.99 ± 0.004 0.97 ± 0.01
Without double-counting >0.99 ± 0.000 >0.99 ± 0.001
![Page 18: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/18.jpg)
Comparison with joint BLUP
• Mean squared errors (MSE+SD)- Expressed as a percentage of the local MSE
Importance of double-counting
Evaluation Local animals External sires
Without external information
Local BLUP 100.00 ± 26.7 100.00 ± 24.5
Only external information Blending BLUP
With double-counting 21.20 ± 6.2 6.83 ± 1.9
Without double-counting 0.48 ± 0.2 0.23 ± 0.1
![Page 19: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/19.jpg)
Conclusion
• Bayesian Mixed Model EquationsRankings most similar to those of a joint BLUP– Importance of double-counting among animals
![Page 20: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/20.jpg)
Conclusion
• Bayesian Mixed Model EquationsRankings most similar to those of a joint BLUP– Importance of double-counting among animals
Bayesian procedure – Reliable integration/blending of multiple external
information– Simple modifications of current programs– Applicable to multi-traits models
![Page 21: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/21.jpg)
Special case: MACE
• Integration of MACE-EBV– Genetic evaluations– Single-step genomic evaluations (cf. oral presentation at this meeting)
Issue: included local information
Estimation of external information free of local information:
*L
1*LM
1ME
1E uDuDuD ˆˆˆ
![Page 22: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/22.jpg)
Special case: MACE
• Integration of MACE-EBV
*L
1*LM
1ML
1L
L1
L
L
L1*
L1
M1
L1
LL1
L
L1
LL1
L
uDuDyRZ'
yRX'
u
βDDGZRZ'XRZ'
ZRX'XRX'
ˆˆˆ
ˆ
![Page 23: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/23.jpg)
Special case: MACE
• Integration of MACE-EBV
*L
1*LM
1ML
1L
L1
L
L
L1*
L1
M1
L1
LL1
L
L1
LL1
L
uDuDyRZ'
yRX'
u
βDDGZRZ'XRZ'
ZRX'XRX'
ˆˆˆ
ˆ
Inverse of (combined genomic -) pedigree based
(co)variances matrix
![Page 24: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/24.jpg)
Special case: MACE
• Integration of MACE-EBV
*L
1*LM
1ML
1L
L1
L
L
L1*
L1
M1
L1
LL1
L
L1
LL1
L
uDuDyRZ'
yRX'
u
βDDGZRZ'XRZ'
ZRX'XRX'
ˆˆˆ
ˆ
Inverse of (combined genomic -) pedigree based
(co)variances matrix
Inverse of prediction error (co)variances
matrix of MACE-EBV
![Page 25: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/25.jpg)
Special case: MACE
• Integration of MACE-EBV
*L
1*LM
1ML
1L
L1
L
L
L1*
L1
M1
L1
LL1
L
L1
LL1
L
uDuDyRZ'
yRX'
u
βDDGZRZ'XRZ'
ZRX'XRX'
ˆˆˆ
ˆ
Inverse of (combined genomic -) pedigree based
(co)variances matrix
Inverse of prediction error (co)variances
matrix of MACE-EBV
Inverse of prediction error (co)variances matrix of local EBV
![Page 26: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/26.jpg)
Special case: MACE
• Integration of MACE-EBV
*L
1*LM
1ML
1L
L1
L
L
L1*
L1
M1
L1
LL1
L
L1
LL1
L
uDuDyRZ'
yRX'
u
βDDGZRZ'XRZ'
ZRX'XRX'
ˆˆˆ
ˆ
Inverse of (combined genomic -) pedigree based
(co)variances matrix
Inverse of prediction error (co)variances
matrix of MACE-EBV
Inverse of prediction error (co)variances matrix of local EBV
RHS of an hypothetical BLUP of MACE-EBV
![Page 27: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/27.jpg)
Special case: MACE
• Integration of MACE-EBV
*L
1*LM
1ML
1L
L1
L
L
L1*
L1
M1
L1
LL1
L
L1
LL1
L
uDuDyRZ'
yRX'
u
βDDGZRZ'XRZ'
ZRX'XRX'
ˆˆˆ
ˆ
Inverse of (combined genomic -) pedigree based
(co)variances matrix
Inverse of prediction error (co)variances
matrix of MACE-EBV
Inverse of prediction error (co)variances matrix of local EBV
RHS of an hypothetical BLUP of MACE-EBV
RHS of an hypothetical BLUP of local EBV
![Page 28: Extension of Bayesian procedures to integrate and to blend multiple external information into genetic evaluations J. Vandenplas 1,2, N. Gengler 1 1 University](https://reader030.vdocument.in/reader030/viewer/2022032705/56649dd35503460f94aca8d6/html5/thumbnails/28.jpg)
Acknowledgements
• Animal and Dairy Science (ADS) Department,University of Georgia Athens (UGA), USA
• Animal Breeding and Genetics Group of Animal Science Unit, Gembloux Agro-Bio Tech - University of Liège (ULg – GxABT), Belgium
• National Fund for Scientific Research (FNRS), Belgium