farmacodinamia (pharmacodynamics) - higher education. slides
TRANSCRIPT
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FARMACODINAMIAJorgeH.Ramirez.MD,MSc.
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MECANISMOSDEACCIONDEFARMACOS
1.RECEPTORES2.ENZIMAS3.CANALESIONICOS4.TRANSPORTADORES5.DNA6.VARIOS
1.METABOTROFICO 2.IONOTROFICO
3.INTRACELULAR4.RECEPTOR-ENZIMA
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1.RECEPTORES2.ENZIMAS3.CANALESIONICOS4.TRANSPORTADORES5.DNA6.VARIOS
AcidoAraquidonico
MECANISMOSDEACCIONDEFARMACOSProstaglandinasTromboxanos
Leucotrienos
COXLOX ASA-Ibuprofeno
Angiotensinogeno AngiotensinaI
AngiotensinaIIVasoconstriccionAldosterona
ECA
Renina
Captopril
NO(+)
GMP GMPcGuanilatoCiclasa
Fosfodiesterasa
Sildenafilo
Vasodilatacion
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1.RECEPTORES2.ENZIMAS3.CANALESIONICOS4.TRANSPORTADORES5.DNA6.VARIOS
MECANISMOSDEACCIONDEFARMACOS
SustratoFalso:α-metildopa
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1.RECEPTORES2.ENZIMAS3.CANALESIONICOS4.TRANSPORTADORES5.DNA6.VARIOS
MECANISMOSDEACCIONDEFARMACOS
Anestesicoslocales
Minoxidil
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1.RECEPTORES2.ENZIMAS3.CANALESIONICOS4.TRANSPORTADORES5.DNA6.VARIOS
MECANISMOSDEACCIONDEFARMACOS
DigoxinaNa+
K+
Na+
Ca+2
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1.RECEPTORES2.ENZIMAS3.CANALESIONICOS4.TRANSPORTADORES5.DNA6.VARIOS
MECANISMOSDEACCIONDEFARMACOS
Agentesalquilantes:Ej.Ciclofosfamida
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1.RECEPTORES2.ENZIMAS3.CANALESIONICOS4.TRANSPORTADORES5.DNA6.VARIOS
MECANISMOSDEACCIONDEFARMACOS
Antiacidos
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1.RECEPTORES2.ENZIMAS3.CANALESIONICOS4.TRANSPORTADORES5.DNA6.VARIOS
MECANISMOSDEACCIONDEFARMACOS
DiureticososmoticosManitol
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1.RECEPTORES2.ENZIMAS3.CANALESIONICOS4.TRANSPORTADORES5.DNA6.VARIOS
MECANISMOSDEACCIONDEFARMACOS
Sucralfate
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1.RECEPTORES2.ENZIMAS3.CANALESIONICOS4.TRANSPORTADORES5.DNA6.VARIOS
1.RECEPTORES2.ENZIMAS3.CANALESIONICOS4.TRANSPORTADORES5.DNA6.VARIOS
MECANISMOSDEACCIONDEFARMACOS
RECEPTORESSOLUBLES:ETANERCEPT
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1.RECEPTORES2.ENZIMAS3.CANALESIONICOS4.TRANSPORTADORES5.DNA6.VARIOS
QUELANTES(EDTA)
MECANISMOSDEACCIONDEFARMACOS
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RECEPTORES
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INTERACCIONESFARMACO-RECEPTOR
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RECEPTORMETABOTROFICO
Receptoresdeadrenalina(αyβ),acetilcolina(muscarinico),dopamina.
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TRANSDUCCIONDESEÑALESPORRECEPTORMETABOTROFICO
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TRANSDUCCIONDESEÑALESPORRECEPTORMETABOTROFICO
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RECEPTORIONOTROFICO
GABA-A5HT-3NMDANICOTINICO
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RECEPTOR-ENZIMA
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RECEPTORESINTRACELULARES(ESTEROIDE)
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ENANTIOMEROS
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ENANTIOMEROS
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AGONISTAS
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ANTAGONISTAS
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