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fig. s15 a · 2010. 10. 11. · bmtoll6 669 : bmtoll7-1 630 : bmtoll7-2 624 : bmtoll7-3 623 :...

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  • Fig. S15 A · 2010. 10. 11. · BmToll6 669 : BmToll7-1 630 : BmToll7-2 624 : BmToll7-3 623 : BmToll8 647 : BmToll10-1 643 : BmToll10-2 650 : BmToll10-3 508 : DmToll2 645 : DmToll6
5
B m T o l l 6 1 : B m T o l l 7 - 1 1 : B m T o l l 7 - 2 1 : B m T o l l 7 - 3 1 : B m T o l l 8 1 : B m T o l l 1 0 - 1 1 : B m T o l l 1 0 - 2 1 : B m T o l l 1 0 - 3 - : D m T o l l 2 1 : D m T o l l 6 1 : D m T o l l 7 1 : D m T o l l 8 1 : A g T o l l 6 1 : A g T o l l 7 - : A g T o l l 8 1 : A g T o l l 1 0 1 : A g T o l l 1 1 1 : A m T o l l 6 1 : A m T o l l 8 1 : A m T o l l 1 0 1 : B m T o l l 3 - 1 - : B m T o l l 3 - 2 - : B m T o l l 3 - 3 - : B m T o l l 9 - 1 - : B m T o l l 9 - 2 1 : B m T o l l 1 2 1 : D m T o l l 1 1 : D m T o l l 3 1 : D m T o l l 4 1 : D m T o l l 5 - : D m T o l l 9 1 : A g T o l l 1 A 1 : A g T o l l 1 B - : A g T o l l 5 A 1 : A g T o l l 5 B 1 : A g T o l l 9 1 : A m T o l l 1 : - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M A V P R F S S R Q L H I S R I I I W F M V G F N V A D Q S S L P L K - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Y E A P D D C Q W W L R G P N D A H E V S L T C K L R T I N S E F D T T N - F S V I P S E H T T S L R I E C N - E E M M Y K S S L D D R S - - - - - F A H L V K L R E L V L - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M D T V V I K M I I N T I F F C F V M G A A L T E A P D D - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A D A C F R V A - S V D G M - - - - V E C N V R T L S S D R D V - - - V G S M H S D G T E R L T I R C S - Q L L - I E S T L R D H H - - - - - F G K M Q G L A E I S I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M Y A I A A V F C A L L H F G W T L M P N N - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A D K C A R V T D R G F E S - - - - A V C K I R T L E S E G T A - - - I A S V S S D T S - R L S I E C N - H L L F F E S S L K A H Y - - - - - F K P V P G L V D L S I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M F Q F L T L L F V T F G V N A A Y A R G - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - V D N C S R Q S - K G D N S - - - - T L C R V R T L D A D G S S - - - L A S A P T E T T K R L D I E C N - Q L L L F E S Y L E A N Y - - - - - F Q R F H E L T E L T I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M Y S T W F A N A L L V L S T A F T A R S A S L S A T T N T - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - R Y Q A P D E C G W M T D Y D G A G - - V A L Q C R L R T I N S E L E N T N - F S A I Q P H P T V R L R I E C S - D A L F F Q S S L A P G S - - - - - F R Q L I E L R E L T I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M S L C V L F Y C H A V D R S V A A E T - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - P H E C A Y R S S E A E T S G S T V L F C K I R T I S S L D H L L Q N I S K T H Y D D V I S L H V Q C S E I L F F E S T L T T S A Q K P T G K H T S L G K L R D L V I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M I I N F R G M D S L K - - V W I C F V V V A T A R A H T A P P - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A P T G C Q W D Y S D P K L S E S N F L T C N I K T I G S V D F L F K N I T T A Q A Y N V N K L K L T C T - D L L F F E S S L H M N - - T G S F L G Q L R K L E D L H I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M P A T S S I I T I I A V A A C L L L L V A D A H A - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Q Q Q C N W Q Y G L T T M D - - - - I R C S V R A L E S G T G T P - - L D L Q V A E A A G R L D L Q C S - Q E L L H A S E L A P G L - - - - - F R Q L Q K L S E L R I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M I Y Y M L L I L P V V L A Q D Q Q H T T E S L S T K H H Q Q Q Q L S H S N A I M G E A G V S N S Q L M Q P S T P A R T L R P L T A G A G G D P S L Y D A P D D C H F M P A A G L D Q P E I A L T C N L R T V N S E F D T T N - F S V I P A E H T I A L H I L C N - D E I M A K S R L E A Q S - - - - - F A H L V R L Q Q L S I M A A I L L L L L G F S W S L A V E S A L A P K E S E S S A S A M L G A G T G A A A T V S L S G D Y S S L L S N V P A A S P V P A N P S Q P S G P - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A N Q C S W S Y - N G T S S - - - - V H C A L R L I E R Q P G - - - - L D L Q G A D G S S Q L T I Q C S - E L Y L F E S T L P V A V - - - - - F A R L Q T L E A L R L - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M L A T T H M L Y V L I A T C V I P I F G A A L S K T V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - L Y Q A P D E C R W - - S G G G E H D - I T L V C H L R T I N S E L E N T N - F S V I Q P Q N T V R L R L E C N - D A L F F Q S S L S P D S - - - - - F R S L V E L R D L T I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M S R C E L L L P A L L L L V S V Q V N Y S L Q Y D S A E S S R Y Y H P - - - - - - A G A G - - - - - - - S E P G S N L R - - - - - - - - - - - - Y D A P D D C K Y R I L P G N - - - E V D L A C N L R T V N S E F D N T N - F S V I P A E H T A A L S I L C N - E A I M A R S K L L P N S - - - - - F V H L A R L K A L S L - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M R P S P A L L T V L F G T - I F G V F G A S L S K S L - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - V S Q A P D E C R W - - D G Y T E D D - L T L L C R L R T I N S E L E N T N - F S V L H P E N T V R L R L Q C N - D G L F F Q S S L S P G S - - - - - F K Q L T K L H A L S I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - L S C K L K T I G A T D T L M R N L S S Y Q I E R I N S L R L E C S - D I L F F E S S L E A N Q H S G A F L G S L R R L R D L K I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Q C R I K T I T R T E S L L A N I S S Y Q I D R I K S L K L E C N - D I M F F E S S L E S T T T P G N F L G N L H G L L R L S I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M R G L A G P E G V G R S V S L S L A Y Y Y Y Y L L I P V Y H V L A V T S E L P P R - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - L D L P E H C S W D S R Q D G - - - - - A L T C I H R Y T G N D S L R T N - F S Q A T S E Y V T S I N V V C E D S E S L E N G I L N V D G - - - - - F V Q L W R L R S L R L - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M R G S P A F F A I I L G T I F G V L G A S L S K A L - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - R Y K A P D E C K W V A T G D T E D D - V S L V C R L R T I N S E L E N T N - F S V I Q P Q H T V R L R L E C S - D A L F Y Q S S L S A G S - - - - - F R P L V E L R E L V I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M E A T R V G L A A V L G I V W S L F L N A G P I H G R S I T S - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - L E A P S G C E W K K D G E D G E K G L A C R V R T I A N V A S L I G N L S A I Q V D S I S S L A L E C S - D V L F F E S Q I D G - - - P H G F F S P L P R L E K L R V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M S R L K A A S E L A L L V I I L Q L L Q W P - - - - - - - - - - - - - - G S E - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M K L - - - - - - - - L L T I P D D Y C - - - - - E T Y C G G I C N D T V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M E H S K L W D L R P E V R E R R F K W T S D G Q Q Q Q Q Q Q L G W C N N K D D P P N S H Q K S K S N N D A R N L N S R V R V R A R V R V V P G E M R M G D I N C S N G L G N I R E D Y C - - - - - E I Y L D E L G - - - - - - - - - - - - - - - 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - M K A S R G P R P L V L T A A L T L A L L A H T G H A F L A G - - - - - Y R S G L G L D G F G I - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - A L K P G T K Y R S K D K C H L N R K E I N I I L L L Y Y Q K C F I K L F S R S Q R S G R N N I H S T S T L P S T - - - - - P P S S S M G S V W V C - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M Y - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M P R V S P L V A Y Q R F V R Q V G - - - - - - - S G I E R M E I A E - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M F E S S F : 1 1 4 : 9 7 : 9 1 : 9 0 : 1 0 8 : 1 0 3 : 1 1 1 : - : 9 7 : 1 5 3 : 1 4 1 : 1 0 5 : 1 2 4 : - : 1 0 4 : 6 4 : 6 3 : 1 1 7 : 1 0 6 : 1 1 2 : - : - : - : - : 3 : 6 : 2 6 : 2 4 : 1 0 1 : - : 2 6 : 4 3 : - : 6 9 : 2 : 2 8 : 6 B m T o l l 6 1 1 5 : B m T o l l 7 - 1 9 8 : B m T o l l 7 - 2 9 2 : B m T o l l 7 - 3 9 1 : B m T o l l 8 1 0 9 : B m T o l l 1 0 - 1 1 0 4 : B m T o l l 1 0 - 2 1 1 2 : B m T o l l 1 0 - 3 1 : D m T o l l 2 9 8 : D m T o l l 6 1 5 4 : D m T o l l 7 1 4 2 : D m T o l l 8 1 0 6 : A g T o l l 6 1 2 5 : A g T o l l 7 1 : A g T o l l 8 1 0 5 : A g T o l l 1 0 6 5 : A g T o l l 1 1 6 4 : A m T o l l 6 1 1 8 : A m T o l l 8 1 0 7 : A m T o l l 1 0 1 1 3 : B m T o l l 3 - 1 1 : B m T o l l 3 - 2 - : B m T o l l 3 - 3 1 : B m T o l l 9 - 1 1 : B m T o l l 9 - 2 4 : B m T o l l 1 2 7 : D m T o l l 1 2 7 : D m T o l l 3 2 5 : D m T o l l 4 1 0 2 : D m T o l l 5 1 : D m T o l l 9 2 7 : A g T o l l 1 A 4 4 : A g T o l l 1 B 1 : A g T o l l 5 A 7 0 : A g T o l l 5 B 3 : A g T o l l 9 2 9 : A m T o l l 7 : D N C K I G R W P P G V L S G L R D L R N L T I R T K N T E W A - A M S L E I A S E S F T - A V R Q L E K L D L S F N N I W S F P E N L F C P L T N L V Y L N V S S N R L Q D V S D L G F R E R A - - - V H Q A L I S E Q D G P I P S - T A S A H S T C S L D I E V L D A S S N H F V L M P E - N G F M S L R R L K E L H I H - - D N E I S M V A D K S L S G L K Q L Q I I D L S N N - - - - - - K I V H N C K I L R L P G N V F E A L R G L K S L K I R S M N N E W G I N K E L D F T L G A F N - G L R E L H T L D L A Y N N I R K I P S D L F C A L E N I I S L N L T H N K I K F V D E L G F G H K - - - - - - - - - - - - - - - - - - - - - - - - - - - C G S T L Q R I D L S F N D I M S L P A D S E I L H L R R L T Q L F L Q - - N N K I S E L P T E V F S D L L S L K V V N I S D N - - - - - - A I N S N C K L L S V P D N T F H G L R K L K K L Q L R S K N F E W S P T K N L E L S L N A F N - G L S E L Q S L D L A Q N N I K F I P S G V F C V L E N L N T L N L T Y N R I K T V G Q I G F G Q G - - - - - - - - - - - - - - - - - - - - - - - - - - - C G S S L Q S L D L S H N M I K T I S D G S E L L K L R S L Q H L Y L Q - - H N N I T D I S N E A F D G L I S M R V L N I S H N - - - - - - R L H R N C K L L R I P G N A F E G L R E L K K L S I R S K N Y D W S S N K N L E L S L G T F N - G L R E L Q A L D L G Q N N L K T I P S E V F C P L D N L Q T L N V T G N K L K S V D R L G F G K N - - - - - - - - - - - - - - - - - - - - - - - - - - - C G S G L R R L D L S R N E I K S L P E E S E I I G L K R L Q E L K L Q - - H N N I T D I S G E T F N G L I S L R I L N V S Y N - - - - - - N I Q E Y C K I G N L S D S A F T G L R D L R N L T I R T H N T D W S - T M S L E I T P S A F S R D V Q N L E R L D L S E N N M L V F P D G A L C S L R N L E Y L N M T G N R M R D I S H F Q F S T A H R H - - - - - - - - - - - - - - - - - - - P - T E K C G D N L L I L D L S R N V I D T L P P - N L L N G L R R L Q K F Y V Q - - G N G L T S V A D R S L E G L I S L T T I R F S D N - - - - - - Q L A D R C K L R Q I P A R A F E S F K D L K R L H V T T H N S E W S - A M T M E L N E E A F A - G L N E L V E L N L S N N N I W S T K T E T F C S L Y S L K V L N L T N N H L Q N I K T I G F S D S L R E - - - - - - - - - - - - - - - - - Q N L S L R T C N L V I E T L D M S Y N D L I V V N D - N S L S K L R S L S K L L L Q - - N N A L S N L E G G A F E G L L S L E V L N L S S N - - - - - - F M N E Y C K I R Y V P A T V L S P L R D L T S L T L R S F N N D W P - A M T M E F H A E S F R - G L M E L R T L D L G D N N I Y M L P S E V F C P L F S L E I L N L T N N R I Q D I S E I G F S D W G K G - - - - - - - - - - - - - - - - - P I A P G K S C N T G L K T L D L S R N N I L R L P D - N G L S S L R S L E V L N I Q - - N N L I N E I C D R A F V G L N S L K I L N L S G N - - - - - - K L V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M S M E F H R D T F R - G L T D L R S L D L G D N N I W I L P S E I F C V L Y N L K E L N V T Q N R L Q D I S N L G F S D W G N G - - - - - - - - - - - - - - - - - P T A P G K S C N T V L E T L D M S Y N E I S G L P D - N G L S S L R A L Q K L F L Q - - N N R I S N V A D R A F V G L S D L Q I L N L S T N - - - - - - A L T D A C K L Q R V P P N A F E G L M S L K R L T L E S H N A V W G P G K T L E L H G Q S F Q - G L K E L S E L H L G D N N I R Q L P E G V W C S M P S L Q L L N L T Q N R I R S A E F L G F S E K L C A - - - - - - - - - - - - G S A L S N A N G A V S G G S E L Q T L D V S F N E L R S L P D A W G A S R L R R L Q T L S L Q - - H N N I S T L A P N A L A G L S S L R V L N I S Y N - - - - - - H L V Q Y C K L G R L G R Q V L D G L E Q L R N L T L R T H N I L W P - A L N F E I E A D A F S - V T R R L E R L D L S S N N I W S L P D N I F C T L S E L S A L N M S E N R L Q D V N E L G F R D R S Q E P T N G S T E S T S T T E S A K K S S S S S T S C S L D L E Y L D V S H N D F V V L P A - N G F G T L R R L R V L S V N - - N N G I S M I A D K A L S G L K N L Q I L N L S S N - - - - - - K I V D S C K L L Q L P N N A F E G L A T L K S L R L S T H N S E W G P T R T L E L F P D S L G - G L K Q L T D L D L G D N N L R Q L P S G F L C P V G N L Q V L N L T R N R I R T A E Q M G F A D M N C G - - - - - - - - - - - - - - - - - - - A G S G S A G S E L Q V L D A S H N E L R S I S E S W G I S R L R R L Q H L N L A - - Y N N L S E L S G E A L A G L A S L R I V N L S N N - - - - - - H L E E Y C K L G N L T D G S F R G L Q E L R N L T I R T H N G D W S - T M S L E M A S N S F V - E F R Q L E R L D L S L N N I W L I P D G M V C P L K S L Q H L N A S Y N K I Q D I S N F Y F S A S L S S - - - - - - - - - - - - - - - - - - - R K A R V C G S T L Q S L D L S A N K M V S L P T - A M L S A L G R L T H L N M A - - K N S M S F L A D R A F E G L L S L R V V D L S A N - - - - - - R L T E F C K I A K F S S T V L A G L G D L R N F T L R T H N I A W P - E L N L E I E A D A F G - Q T R N L E V L D L S T N N I W S L P D H L F C S L S G L R S L N I S S N R L Q D V N D L G F R E K G - - - V K D E V E S E G H K T N S S G S V A P P V S C A L D L E D L D V S R N H F V L L P A - A G F G M L K R L K M L K I H - - D N E I S M V G D K A L S G L K E L Q I L D L S S N - - - - - - K L V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 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- - - - - K L V E Y C K I K Y I P A L A F A N M R V L K R L A L S T H N V D W S - V M N L E L H P D S F R - G L T E L K E M H L A D N N I W S L P A E V F C P L Q K L R V L N L T G N R L S D L T Q L M L S D W G N G - - - - - - - - - - - - - - - - - P T E P G R A C N T G L E V L D L S G N D L T L L P D - N G L T A M R S L N A L H L Q - - R N L L K E I A D R A F V G L G T L E V L D L S D N - - - - - - R L T T G C K L V H W P A K V L S G L R D L R N L T I R S L N G R K S - K Y S L E L E S G A L D - S V P Q I E K I D L S W N N I W Q I P E H L F C P L S N L V T L N V S W N M L K D I T E L G F R D I A - - - - - - - - - - E R H P R R Q Q E S T T S P F P C S L D V Q S L D V S N N Q I L V L P A - Y G F S S L K R L R V L N L S - - S N A V S M V A D E A L H G L R S L E T F D L S G N - - - - - - R I V E Y C K I G N L S D D A F K G L K E L R N L T V R T H N T D W S - A M A L D V S G G A F T D E L K Q L E K L D L G E N N M W G I P E G A L C P L V N L E I L N L T R N R L R D V T S F R F T G A S R - - - - - - - - - - - - - - - - - - - - - - - - - C L S K L K E L D L S N N S V E S L P T - A A F S G L T R L H S L D L R - - C N A I S F M A D R A F E G L S S L A V L R L A D N - - - - - - R L A D Y C K I R Y L P A G V F A S A H N L R A L S L I T H N G D W S - A M S L E L H R D S L R - G L A H L Q H L D L A D N N L W T L P A E L L C P V Q S L A T L N L T R N K L Q D I V S L G F S D S - - - - - - - - - - - - - - - - - - - - - - - - A E S C T P S L E V L D L S N N D L T T I H D - R A L T N L R S L T V L K L Q - - E N A I N A V G D H A L A G L T A L H S L N V S S N - - - - - - R L V - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - M V N D C G V P R G T Y T D A V R K L S I T S F H H L T L F F V T - - C S N D T G L S A Q H F D G N D T F H T L Q I D C E - - - - - - T S Y - - - - - - - - - - - - - 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- L T R V P P V F H L S D S M G R W L S Q T V E Y M T F Y G N K F V D R S V - A G E Q Y N M I I N A T G A V E T E P V F S L Q Y Q G - - - - - - T T V H C L W L L L Y N V Y I S R G D L I E V Y K E L S H T I L Y P Q E K S D D L P V E L G Q D G Y S G C I C R A S K Q N G V V V C F G N Y E C R M F P K I K V K C E F L R V R T T V I T N I R K G H L D - - - - - - - - - - - - - - - - - - - - - - - - S L Y F L K V L E I E A N H Q L R H I E A G V F K N L T S L Q Q L S I S Y - N T H L H S I D E H T F I G L V N L R N L T L V N N G - - - F T N I L A A V L L Q V V A A T N I S C P T D A N C T C G G T L A I E L D C N I D G S V V N I N L V P E I Y I N V K C E N A T A L D Y S K L P R C T N I T D S F Q S V S F K D C P L P E T S F K D V L D N M G - - - - - - - - - - - - - - - - - - - - - - - - - V T K T M A L I F Q N A K N L S G Y L D R K H F A G L Q D L T K L L L S - - I N G V I H L P D D A F V D I N K L T W L N I R S K - - - - - - T I Y A S F G R D A C S E M S I D G L C Q C A P I M S E Y E I I C P A N A E N P T F R L T I Q P K D Y V Q I M C N L T D T T D Y Q Q L P K K L R I G E V D R V Q M R R C M L P G H T P I A S I L D Y L G - - - - - - - - - - - - - - - - - - - - - - - - - - - I V S P T T L I F E S D N L G M N I T R Q H L D R L H G L K R F R F T - - T R R L T H I P A N L L T D M R N L S H L E L R A N - - - - - - I E E A S K T C D R E A Y D Y I A T N E Y H L I M R D G H L E V N W K I P D P N I F I I S P I S K E N R L K L N E L - - - - I V S D T S Y P I R - A V D Y L R Q L G V E T V T R F E N Q I N S F K V I E - - - - - - - - - - - - - - - - - - - - - - - R D V H Y I N G P K S L K I I I Q S N L Y L N E I I E - - Y I N K T T D N V N - - E I I I N A Y K T V E N Q Q I A L D N L I F N G K S - - - - - - H L R E N G T C S - I A N N E V T T E D Y Q M K L V F L K L E I N W T S P V F H G W N I F K I C N E T D Y E L V I I S V L G I R S E V D M R I S P A V Q Y L S L L G I R E I S G Y D I Y L P S V L I T E - - - - - - - - - - - - - - - - - - - - - - - M D V H H A N G P K M V T F K Y L Y D S T V N S V I T N N Y I R K T M N N T E - - K I K I Y Y H N T F E K T T L T M E K N I F H G K N - - - - - - K M S - - - - - - - - - - - - - - M L T Y L P V V W L F F A L L V L R S A T G Q I I P L P T F C L G L S P Q C T C A A E G N V V R F H C P D E Y A M L L E V S E P G A S L Y M S Y Y A S T E L Q W L P R - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - F N I S S L V K I E F D A Y I F W P E K F L S D L L K T L G V Q - - T V K T I I F R D R T L E T V V T R D V L N S G N G - - - - - - Y M E F S I Q D G L I I E P D S A T T S S E E A E E V S K E R T D L K S L M L K Y E S D D G N S C L L D L I K D E V I W W Q F P N G T L R D S T K K Y A H K L Y L D L S H G N L K D D S D L F R E A K L S R - - - - - - - - - - - - - - - - - - - - - - K V T I W R T E V F S A A F N T L T A A P F R T L Y S M R E S L K L L S L R G N N F A E L I P D A E D F A R F V N E S R L E A S N S V P H H C E L L L C P A E M R N C S C R S Y T G A E T E I D C P - - - - - - - - - - E A D S T V H L R I E P H Q Y A E M R C Q R N R R Y D F E Q I P Q L S I G D T N R L T I D D C P F P H H Q S I L Q L V S F L G T - - - - - - - - - - - - - - - - - - - - - - - - - T Q V K V L W L K N N A N H E Q S A S L V R H H F A G L D Q L D R L A I S - - N A K L S D I G P D L F E H L P N L T W L D M R D N - - - - - - I F R - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - C P L P V G N Q S L V E L L S V F L - - - - - - - - - - - - - - - - - - - - - - - N R T Q L S S I R S I A F D D N A K H S N K V T L D P H L F S G L Q N L Q L L - - K I N N L T T N A F D N P H L F K H F L H L N N L I - - - - - - I T S C L S L L V L L T A Q A S - G N D C T V E K H S D L V S K A K C P G F N V Q L T L H T N P R Q L E V T C S D K P D F Q L L E N I Q N L P N F K F E E L A Y Q N C P L P V G N Q S L V D L L S A F L - - - - - - - - - - - - - - - - - - - - - - - D R T Q L S S I R R L F F V D N A K L S G Q V T L D P Q L F A D L P A L Q V L - - S M K N S S R M P L D N P E L F K Y L Q S L T W I D - - - - - - L R E C V C L T V L L V A D T S T G N D C T I T N R S R V C W I V E C P G S N V H L S I N V K N R K L N V T C S D K P N F E L L R D Q P N L R S L T F D Q L I Y Q D C P L P V G Y Q S L L E L L S A F L - - - - - - - - - - - - - - - - - - - - - - - D H T Q L S Y I V E L I L I N N A D L S A N V T L D P P L F A G L H K L Q T L - - V I D N Y A V - S F D K P - - - - - - L P L Q Q L P - - - - - - S G V F Y C R N V A V L L P V L L V L L L V V L P S A N N R K A R S V G S V A A A A A P P T D P S D C D L L G C G G I Y E C Y G N G W V N Y L P Y R A G E R Y N I P L S A F H A G A S T Q Q G Q P E C L L G - - - - - - - - - - - - - - - - - - - - - - - - - T A N N Y L P W V T E D G R L T V R P G P H A L D L S S L R L S D H G - - - V Q S L V Q G V S A L I P L E E V L H L S I A R N - - - - - E L T L R W I I F G I V I A T C Y A E I R C P T E Q N C N C Y L S P E G - V F E I Q C P T D S Y S A F V V K V K L Y E R I G I E C V N F P K W I D F P T N V L P P E N V T L L Y F K M C E L P V N Q S L N E I S - - - - - - - - - - - - - - - - - - - - N K L G A Q N I E K L I F H S Y G K L S V L N R K H L Q G F P N L E Y L S L T - - C N N L T N F S N D I F A D V P R L K N L N L R Q N - - - - - - N I Y : 2 9 5 : 2 5 7 : 2 5 1 : 2 5 0 : 2 7 4 : 2 7 1 : 2 7 9 : 1 3 5 : 2 7 2 : 3 3 8 : 3 0 9 : 2 7 1 : 3 0 6 : 4 2 : 2 7 1 : 2 3 2 : 2 3 1 : 2 9 2 : 2 6 7 : 2 7 3 : 6 2 : - : 1 3 5 : 1 5 7 : 1 7 1 : 1 6 9 : 1 8 7 : 1 8 2 : 2 6 5 : 1 4 4 : 2 0 0 : 1 9 6 : 8 6 : 2 3 3 : 1 6 0 : 1 9 1 : 1 7 3 Fig. S15 A

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Page 1: Fig. S15 A · 2010. 10. 11. · BmToll6 669 : BmToll7-1 630 : BmToll7-2 624 : BmToll7-3 623 : BmToll8 647 : BmToll10-1 643 : BmToll10-2 650 : BmToll10-3 508 : DmToll2 645 : DmToll6

BmToll6 1 :BmToll7-1 1 :BmToll7-2 1 :BmToll7-3 1 :BmToll8 1 :BmToll10-1 1 :BmToll10-2 1 :BmToll10-3 - :DmToll2 1 :DmToll6 1 :DmToll7 1 :DmToll8 1 :AgToll6 1 :AgToll7 - :AgToll8 1 :AgToll10 1 :AgToll11 1 :AmToll6 1 :AmToll8 1 :AmToll10 1 :BmToll3-1 - :BmToll3-2 - :BmToll3-3 - :BmToll9-1 - :BmToll9-2 1 :BmToll12 1 :DmToll1 1 :DmToll3 1 :DmToll4 1 :DmToll5 - :DmToll9 1 :AgToll1A 1 :AgToll1B - :AgToll5A 1 :AgToll5B 1 :AgToll9 1 :AmToll 1 :

--------------------------------------MAVPRFSSRQLHISRIIIWFMVGFNVADQSSLPLK-------------------------------------YEAPDDCQWWLRGPNDAHEVSLTCKLRTINSEFDTTN-FSVIPSEHTTSLRIECN-EEMMYKSSLDDRS-----FAHLVKLRELVL--------------------------------------------MDTVVIKMIINTIFFCFVMGAALTEAPDD----------------------------------------ADACFRVA-SVDGM----VECNVRTLSSDRDV---VGSMHSDGTERLTIRCS-QLL-IESTLRDHH-----FGKMQGLAEISI---------------------------------------------------MYAIAAVFCALLHFGWTLMPNN----------------------------------------ADKCARVTDRGFES----AVCKIRTLESEGTA---IASVSSDTS-RLSIECN-HLLFFESSLKAHY-----FKPVPGLVDLSI---------------------------------------------------MFQFLTLLFVTFGVNAAYARG-----------------------------------------VDNCSRQS-KGDNS----TLCRVRTLDADGSS---LASAPTETTKRLDIECN-QLLLFESYLEANY-----FQRFHELTELTI-------------------------------------------MYSTWFANALLVLSTAFTARSASLSATTNT------------------------------------RYQAPDECGWMTDYDGAG--VALQCRLRTINSELENTN-FSAIQPHPTVRLRIECS-DALFFQSSLAPGS-----FRQLIELRELTI-----------------------------------------------------MSLCVLFYCHAVDRSVAAET----------------------------------------PHECAYRSSEAETSGSTVLFCKIRTISSLDHLLQNISKTHYDDVISLHVQCSEILFFESTLTTSAQKPTGKHTSLGKLRDLVI-----------------------------------------MIINFRGMDSLK--VWICFVVVATARAHTAPP---------------------------------------APTGCQWDYSDPKLSESNFLTCNIKTIGSVDFLFKNITTAQAYNVNKLKLTCT-DLLFFESSLHMN--TGSFLGQLRKLEDLHI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPATSSIITIIAVAACLLLLVADAHA----------------------------------------QQQCNWQYGLTTMD----IRCSVRALESGTGTP--LDLQVAEAAGRLDLQCS-QELLHASELAPGL-----FRQLQKLSELRI------------------------------------MIYYMLLILPVVLAQDQQHTTESLSTKHHQQQQLSHSNAIMGEAGVSNSQLMQPSTPARTLRPLTAGAGGDPSLYDAPDDCHFMPAAGLDQPEIALTCNLRTVNSEFDTTN-FSVIPAEHTIALHILCN-DEIMAKSRLEAQS-----FAHLVRLQQLSIMAAILLLLLGFSWSLAVESALAPKESESSASAMLGAGTGAAATVSLSGDYSSLLSNVPAASPVPANPSQPSGP----------------------------------------ANQCSWSY-NGTSS----VHCALRLIERQPG----LDLQGADGSSQLTIQCS-ELYLFESTLPVAV-----FARLQTLEALRL-------------------------------------------MLATTHMLYVLIATCVIPIFGAALSKTV--------------------------------------LYQAPDECRW--SGGGEHD-ITLVCHLRTINSELENTN-FSVIQPQNTVRLRLECN-DALFFQSSLSPDS-----FRSLVELRDLTI-------------------------------------MSRCELLLPALLLLVSVQVNYSLQYDSAESSRYYHP------AGAG-------SEPGSNLR------------YDAPDDCKYRILPGN---EVDLACNLRTVNSEFDNTN-FSVIPAEHTAALSILCN-EAIMARSKLLPNS-----FVHLARLKALSL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRPSPALLTVLFGT-IFGVFGASLSKSL--------------------------------------VSQAPDECRW--DGYTEDD-LTLLCRLRTINSELENTN-FSVLHPENTVRLRLQCN-DGLFFQSSLSPGS-----FKQLTKLHALSI-----------------------------------------------------------------------------------------------------------------------------------LSCKLKTIGATDTLMRNLSSYQIERINSLRLECS-DILFFESSLEANQHSGAFLGSLRRLRDLKI------------------------------------------------------------------------------------------------------------------------------------QCRIKTITRTESLLANISSYQIDRIKSLKLECN-DIMFFESSLESTTTPGNFLGNLHGLLRLSI-------------------------------MRGLAGPEGVGRSVSLSLAYYYYYLLIPVYHVLAVTSELPPR-------------------------------------LDLPEHCSWDSRQDG-----ALTCIHRYTGNDSLRTN-FSQATSEYVTSINVVCEDSESLENGILNVDG-----FVQLWRLRSLRL--------------------------------------------MRGSPAFFAIILGTIFGVLGASLSKAL--------------------------------------RYKAPDECKWVATGDTEDD-VSLVCRLRTINSELENTN-FSVIQPQHTVRLRLECS-DALFYQSSLSAGS-----FRPLVELRELVI-----------------------------------------MEATRVGLAAVLGIVWSLFLNAGPIHGRSITS---------------------------------------LEAPSGCEWKKDGEDGEKGLACRVRTIANVASLIGNLSAIQVDSISSLALECS-DVLFFESQIDG---PHGFFSPLPRLEKLRV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLRYYL------------------------------------------------------------------------------------------------------------------------------------------------------------MSRLKAASELALLVIILQLLQWP--------------GSE---------------------------------------------------------------------------------------------------------------------------------------------------------------MKL--------LLTIPDDYC-----ETYCGGICNDTV--------------------------------------------------------------------------------------MEHSKLWDLRPEVRERRFKWTSDGQQQQQQQLGWCNNKDDPPNSHQKSKSNNDARNLNSRVRVRARVRVVPGEMRMGDINCSNGLGNIREDYC-----EIYLDELG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCPKYIWDVIVLVCLFLGNVR-----------EAYTE----------------------------------------------------------------------------------------------------------------------------------------------------MKASRGPRPLVLTAALTLALLAHTGHAFLAG-----YRSGLGLDGFGI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALKPGTKYRSKDKCHLNRKEINIILLLYYQKCFIKLFSRSQRSGRNNIHSTSTLPST-----PPSSSMGSVWVC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MY-----------------------------------------------------------------------------------------------------------------------------------------------------------------MPRVSPLVAYQRFVRQVG-------SGIERMEIAE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFESSF

: 114: 97: 91: 90: 108: 103: 111: -: 97: 153: 141: 105: 124: -: 104: 64: 63: 117: 106: 112: -: -: -: -: 3: 6: 26: 24: 101: -: 26: 43: -: 69: 2: 28: 6

BmToll6 115 :BmToll7-1 98 :BmToll7-2 92 :BmToll7-3 91 :BmToll8 109 :BmToll10-1 104 :BmToll10-2 112 :BmToll10-3 1 :DmToll2 98 :DmToll6 154 :DmToll7 142 :DmToll8 106 :AgToll6 125 :AgToll7 1 :AgToll8 105 :AgToll10 65 :AgToll11 64 :AmToll6 118 :AmToll8 107 :AmToll10 113 :BmToll3-1 1 :BmToll3-2 - :BmToll3-3 1 :BmToll9-1 1 :BmToll9-2 4 :BmToll12 7 :DmToll1 27 :DmToll3 25 :DmToll4 102 :DmToll5 1 :DmToll9 27 :AgToll1A 44 :AgToll1B 1 :AgToll5A 70 :AgToll5B 3 :AgToll9 29 :AmToll 7 :

DNCKIGRWPPGVLSGLRDLRNLTIRTKNTEWA-AMSLEIASESFT-AVRQLEKLDLSFNNIWSFPENLFCPLTNLVYLNVSSNRLQDVSDLGFRERA---VHQALISEQDGPIPS-TASAHSTCSLDIEVLDASSNHFVLMPE-NGFMSLRRLKELHIH--DNEISMVADKSLSGLKQLQIIDLSNN------KIVHNCKILRLPGNVFEALRGLKSLKIRSMNNEWGINKELDFTLGAFN-GLRELHTLDLAYNNIRKIPSDLFCALENIISLNLTHNKIKFVDELGFGHK---------------------------CGSTLQRIDLSFNDIMSLPADSEILHLRRLTQLFLQ--NNKISELPTEVFSDLLSLKVVNISDN------AINSNCKLLSVPDNTFHGLRKLKKLQLRSKNFEWSPTKNLELSLNAFN-GLSELQSLDLAQNNIKFIPSGVFCVLENLNTLNLTYNRIKTVGQIGFGQG---------------------------CGSSLQSLDLSHNMIKTISDGSELLKLRSLQHLYLQ--HNNITDISNEAFDGLISMRVLNISHN------RLHRNCKLLRIPGNAFEGLRELKKLSIRSKNYDWSSNKNLELSLGTFN-GLRELQALDLGQNNLKTIPSEVFCPLDNLQTLNVTGNKLKSVDRLGFGKN---------------------------CGSGLRRLDLSRNEIKSLPEESEIIGLKRLQELKLQ--HNNITDISGETFNGLISLRILNVSYN------NIQEYCKIGNLSDSAFTGLRDLRNLTIRTHNTDWS-TMSLEITPSAFSRDVQNLERLDLSENNMLVFPDGALCSLRNLEYLNMTGNRMRDISHFQFSTAHRH-------------------P-TEKCGDNLLILDLSRNVIDTLPP-NLLNGLRRLQKFYVQ--GNGLTSVADRSLEGLISLTTIRFSDN------QLADRCKLRQIPARAFESFKDLKRLHVTTHNSEWS-AMTMELNEEAFA-GLNELVELNLSNNNIWSTKTETFCSLYSLKVLNLTNNHLQNIKTIGFSDSLRE-----------------QNLSLRTCNLVIETLDMSYNDLIVVND-NSLSKLRSLSKLLLQ--NNALSNLEGGAFEGLLSLEVLNLSSN------FMNEYCKIRYVPATVLSPLRDLTSLTLRSFNNDWP-AMTMEFHAESFR-GLMELRTLDLGDNNIYMLPSEVFCPLFSLEILNLTNNRIQDISEIGFSDWGKG-----------------PIAPGKSCNTGLKTLDLSRNNILRLPD-NGLSSLRSLEVLNIQ--NNLINEICDRAFVGLNSLKILNLSGN------KLV----------------------------------MSMEFHRDTFR-GLTDLRSLDLGDNNIWILPSEIFCVLYNLKELNVTQNRLQDISNLGFSDWGNG-----------------PTAPGKSCNTVLETLDMSYNEISGLPD-NGLSSLRALQKLFLQ--NNRISNVADRAFVGLSDLQILNLSTN------ALTDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQ-GLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCA------------GSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQ--HNNISTLAPNALAGLSSLRVLNISYN------HLVQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWP-ALNFEIEADAFS-VTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSQEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPA-NGFGTLRRLRVLSVN--NNGISMIADKALSGLKNLQILNLSSN------KIVDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLG-GLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCG-------------------AGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLA--YNNLSELSGEALAGLASLRIVNLSNN------HLEEYCKLGNLTDGSFRGLQELRNLTIRTHNGDWS-TMSLEMASNSFV-EFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSS-------------------RKARVCGSTLQSLDLSANKMVSLPT-AMLSALGRLTHLNMA--KNSMSFLADRAFEGLLSLRVVDLSAN------RLTEFCKIAKFSSTVLAGLGDLRNFTLRTHNIAWP-ELNLEIEADAFG-QTRNLEVLDLSTNNIWSLPDHLFCSLSGLRSLNISSNRLQDVNDLGFREKG---VKDEVESEGHKTNSSGSVAPPVSCALDLEDLDVSRNHFVLLPA-AGFGMLKRLKMLKIH--DNEISMVGDKALSGLKELQILDLSSN------KLV--------------------------------------------------------------------------------------------------------------------------------------------------VSKLRRLQHLNLE--FNNISEVHGDALAGLGSLRTLNLSYN------HLEEYCKIANLSEGSFQGLKQLVNLTLRTHNTDWS-SISLDIAPQVFTSELAKLQRLDLSQNNMWSVPDGFICPLARLSYINLTQNRLRDLSVFHFSASLST-------------------RLSKKCGSSIVTLDLSHNTIDNLPP-AIFSGLGKLTDLRLQ--SNGLNYIADRAFEGLVSLSRLELSLN------RLTEYCKIKYVPSMVLATLRDLRSLSLRTHNTDWS-AMNLEFHPESFR-GLTELKRLDLADNNIWALPTDVFCPLFSLRHLNLTRNRLTDVSQLGFSDWGNG-----------------PTAPGKACNTGLEVLDLSHNDLLALPD-NGLSSLRSLSVLMLQ--DNLLTALADRSFVGLGSLKVLNMSSN------KLVEYCKIKYIPALAFANMRVLKRLALSTHNVDWS-VMNLELHPDSFR-GLTELKEMHLADNNIWSLPAEVFCPLQKLRVLNLTGNRLSDLTQLMLSDWGNG-----------------PTEPGRACNTGLEVLDLSGNDLTLLPD-NGLTAMRSLNALHLQ--RNLLKEIADRAFVGLGTLEVLDLSDN------RLTTGCKLVHWPAKVLSGLRDLRNLTIRSLNGRKS-KYSLELESGALD-SVPQIEKIDLSWNNIWQIPEHLFCPLSNLVTLNVSWNMLKDITELGFRDIA----------ERHPRRQQESTTSPFPCSLDVQSLDVSNNQILVLPA-YGFSSLKRLRVLNLS--SNAVSMVADEALHGLRSLETFDLSGN------RIVEYCKIGNLSDDAFKGLKELRNLTVRTHNTDWS-AMALDVSGGAFTDELKQLEKLDLGENNMWGIPEGALCPLVNLEILNLTRNRLRDVTSFRFTGASR-------------------------CLSKLKELDLSNNSVESLPT-AAFSGLTRLHSLDLR--CNAISFMADRAFEGLSSLAVLRLADN------RLADYCKIRYLPAGVFASAHNLRALSLITHNGDWS-AMSLELHRDSLR-GLAHLQHLDLADNNLWTLPAELLCPVQSLATLNLTRNKLQDIVSLGFSDS------------------------AESCTPSLEVLDLSNNDLTTIHD-RALTNLRSLTVLKLQ--ENAINAVGDHALAGLTALHSLNVSSN------RLV------------------------------------------------------------------------------------------------------------------------------MVNDCGVPRGTYTDAVRKLSITSFHHLTLFFVT--CSNDTGLSAQHFDGNDTFHTLQIDCE------TSY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRLLLMALCAWWLRPGVQAARPACGRARDCVAGHHLNDEFFFTVHGQNLVINFSEAQYVELECPEGVALGGAGMPSFD-----------------------GGARVLN-----------VTLRRCSIGADSLADALGALN--ISVLERLSLKDTPPGSLSALHLRGLE------HLL------MILKIIKLLKFFLLFIASAETRKTQKCLTGYMTDVQTWVNEDGVLTKTIDQSTAIDLSSHFDPVPFLHQIMSEFKTDNGQRVRYLSLAKCR--------------------------LTRVPPVFHLSDSMGRWLSQTVEYMTFYGNKFVDRSV-AGEQYNMIINATGAVETEPVFSLQYQG------TTVHCLWLLLYNVYISRGDLIEVYKELSHTILYPQEKSDDLPVELGQDGYSGCICRASKQNGVVVCFGNYECRMFPKIKVKCEFLRVRTTVITNIRKGHLD------------------------SLYFLKVLEIEANHQLRHIEAGVFKNLTSLQQLSISY-NTHLHSIDEHTFIGLVNLRNLTLVNNG---FTNILAAVLLQVVAATNISCPTDANCTCGGTLAIELDCNIDGSVVNINLVPEIYINVKCENATALDYSKLPRCTNITDSFQSVSFKDCPLPETSFKDVLDNMG-------------------------VTKTMALIFQNAKNLSGYLDRKHFAGLQDLTKLLLS--INGVIHLPDDAFVDINKLTWLNIRSK------TIYASFGRDACSEMSIDGLCQCAPIMSEYEIICPANAENPTFRLTIQPKDYVQIMCNLTDTTDYQQLPKKLRIGEVDRVQMRRCMLPGHTPIASILDYLG---------------------------IVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFT--TRRLTHIPANLLTDMRNLSHLELRAN------IEEASKTCDREAYDYIATNEYHLIMRDGHLEVNWKIPDPNIFIISPISKENRLKLNEL----IVSDTSYPIR-AVDYLRQLGVETVTRFENQINSFKVIE-----------------------RDVHYINGPKSLKIIIQSNLYLNEIIE--YINKTTDNVN--EIIINAYKTVENQQIALDNLIFNGKS------HLRENGTCS-IANNEVTTEDYQMKLVFLKLEINWTSPVFHGWNIFKICNETDYELVIISVLGIRSEVDMRISPAVQYLSLLGIREISGYDIYLPSVLITE-----------------------MDVHHANGPKMVTFKYLYDSTVNSVITNNYIRKTMNNTE--KIKIYYHNTFEKTTLTMEKNIFHGKN------KMS--------------MLTYLPVVWLFFALLVLRSATGQIIPLPTFCLGLSPQCTCAAEGNVVRFHCPDEYAMLLEVSEPGASLYMSYYASTELQWLPR------------------------------FNISSLVKIEFDAYIFWPEKFLSDLLKTLGVQ--TVKTIIFRDRTLETVVTRDVLNSGNG------YMEFSIQDGLIIEPDSATTSSEEAEEVSKERTDLKSLMLKYESDDGNSCLLDLIKDEVIWWQFPNGTLRDSTKKYAHKLYLDLSHGNLKDDSDLFREAKLSR----------------------KVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPHHCELLLCPAEMRNCSCRSYTGAETEIDCP----------EADSTVHLRIEPHQYAEMRCQRNRRYDFEQIPQLSIGDTNRLTIDDCPFPHHQSILQLVSFLGT-------------------------TQVKVLWLKNNANHEQSASLVRHHFAGLDQLDRLAIS--NAKLSDIGPDLFEHLPNLTWLDMRDN------IFR-------------------------------------------------------------------------------CPLPVGNQSLVELLSVFL-----------------------NRTQLSSIRSIAFDDNAKHSNKVTLDPHLFSGLQNLQLL--KINNLTTNAFDNPHLFKHFLHLNNLI------ITSCLSLLVLLTAQAS-GNDCTVEKHSDLVSKAKCPGFNVQLTLHTNPRQLEVTCSDKPDFQLLENIQNLPNFKFEELAYQNCPLPVGNQSLVDLLSAFL-----------------------DRTQLSSIRRLFFVDNAKLSGQVTLDPQLFADLPALQVL--SMKNSSRMPLDNPELFKYLQSLTWID------LRECVCLTVLLVADTSTGNDCTITNRSRVCWIVECPGSNVHLSINVKNRKLNVTCSDKPNFELLRDQPNLRSLTFDQLIYQDCPLPVGYQSLLELLSAFL-----------------------DHTQLSYIVELILINNADLSANVTLDPPLFAGLHKLQTL--VIDNYAV-SFDKP------LPLQQLP------SGVFYCRNVAVLLPVLLVLLLVVLPSANNRKARSVGSVAAAAAPPTDPSDCDLLGCGGIYECYGNGWVNYLPYRAGERYNIPLSAFHAGASTQQGQPECLLG-------------------------TANNYLPWVTEDGRLTVRPGPHALDLSSLRLSDHG---VQSLVQGVSALIPLEEVLHLSIARN-----ELTLRWIIFGIVIATCYAEIRCPTEQNCNCYLSPEG-VFEIQCPTDSYSAFVVKVKLYERIGIECVNFPKWIDFPTNVLPPENVTLLYFKMCELPVNQSLNEIS--------------------NKLGAQNIEKLIFHSYGKLSVLNRKHLQGFPNLEYLSLT--CNNLTNFSNDIFADVPRLKNLNLRQN------NIY

: 295: 257: 251: 250: 274: 271: 279: 135: 272: 338: 309: 271: 306: 42: 271: 232: 231: 292: 267: 273: 62: -: 135: 157: 171: 169: 187: 182: 265: 144: 200: 196: 86: 233: 160: 191: 173

Fig. S15 A

Page 2: Fig. S15 A · 2010. 10. 11. · BmToll6 669 : BmToll7-1 630 : BmToll7-2 624 : BmToll7-3 623 : BmToll8 647 : BmToll10-1 643 : BmToll10-2 650 : BmToll10-3 508 : DmToll2 645 : DmToll6

BmToll6 296 :BmToll7-1 258 :BmToll7-2 252 :BmToll7-3 251 :BmToll8 275 :BmToll10-1 272 :BmToll10-2 280 :BmToll10-3 136 :DmToll2 273 :DmToll6 339 :DmToll7 310 :DmToll8 272 :AgToll6 307 :AgToll7 43 :AgToll8 272 :AgToll10 233 :AgToll11 232 :AmToll6 293 :AmToll8 268 :AmToll10 274 :BmToll3-1 63 :BmToll3-2 - :BmToll3-3 136 :BmToll9-1 158 :BmToll9-2 172 :BmToll12 170 :DmToll1 188 :DmToll3 183 :DmToll4 266 :DmToll5 145 :DmToll9 201 :AgToll1A 197 :AgToll1B 87 :AgToll5A 234 :AgToll5B 161 :AgToll9 192 :AmToll 174 :

ALPQDLFKDCRPVIKEIYLQNNSISVLSPSLFANLEQLLALDLSNNHLTSTWINENTFTGLIRMVLLNLSNNRLTKLEPKIFKDLYTLQILNVQHNMLENIAADTFSPMNNLHTLILSYN--------KITHIDAYALNGLYVLSLLSIDNNRLEELHPKAFRNTSS--LQDLNLNGNRLKKVPIALR--NMRLLRYLPEGLFHNTR-EIREIYMQNNELEILPKRIFNRLEQLLVLDLSANKLKSDHIEDETFSGLIRLIVLDLSHNVLTRITRNIFKDLFCLQILSLNNNSIGYVEDNAFSPLYNLHTLNLGQN--------MLHAVEDHMFNGLFILNKLNVNNNLLSFVSVNAFKNCSD--LKELDLSSNKLTKIPEAIL--QLPFLKTLPEGLFVNAR-ELREIYLNDNSIYELARGIFHRLEQLIVLDISSNQLTSNHIDDGTFLGLIRLIVLNLSNNALTRVDGKTFKDLFVLQILNLKNNSIGYIEDNAFLPLYNLHTLNLAEN--------RLHTIDENLFNGLFVLSKLTLNNNLLVNIDRKAFKNCSD--LKELDLSSNQLLEVPEALW--ELPFLKFIPEGTFASTK-ELREVYLNNNLLFELARGVFHRLEQLLVLDLSYNQLSSAHIDGGTFVGLIRLVILNLSNNALTRIDSKTFKDLFFLQILDLRNNSIGYIEENTFLPLYNLHTLNLAEN--------RLHMIDEYLFNGLFVLSKLNLNNNLLINIDINAFKNCSD--LKELDLSSNQLLDVPNAIW--ELSQLKSLPPELFSDTK-ELKEIYLNNNTITVLAPGLFSDLVQLLVLDLSYNELTSDWINTSTFSGLKRLVYLDFSHNRVTKLEIALFRDLHNLQILKMQDNFIEHIPENVFGSLSNLHTLTLSNN--------RLTNIESHAFTGLQALSVLSVDSNRISRINPQALRNCSN--LQDLHINGNRLDEVPEALK--EIPQLKTLPPDLFSETK-SLKEINLSNNTINNLPPGLFDNLDQLQVLDLSLNELTSQWINKNTFVGLLRLVILNLSYNKLSRIDRYMLQDLYSLQKLNLEHNDISTIDKHAFSELRNLHSLTLSNN--------QLVHIETHLFTDLHVLHELFIDNNKIKHIEDNAFDNMTA--IEDLSLNDNFLSSVPASIR--KLRSLRAVPPELFQSSR-VIREISLGNNSLSVLAPGLLEGLDQLEKLDLSRNRLTNDWVNRDTFAGLIRLVILNLSYNLLARIDPKSFHDLNNLQVLNLDNNAIETISNGAFAELRNLHQLSISDN--------KLKSLNEYVFSNLFVLSQLYLDNNQISSIHERSFENITY--LQDLGLNGNSLSVIPDGIK--RLRFLKALPPEMFQSSR-DIKQIYLNNNSLSVLAPGLLEGLDQLQILDLSVNELTSEWINRDTFSGLVRLIVLNLSHNRITKIDALLFQDLNNLQFLSLEYNNVGRIAEGAFSNLKNLHSLSLAHN--------NIIEVDSGHFSNLYVLNQLFLDGNRITKVDIRSFENITK--LHDLGLSGNQLTDVPEAIK--TLRFLTSLPSEAFAGNK-ELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAEN--------RLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSD--LKELDLSSNQLTEVPEAVQ--DLSMLKALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHN--------KLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSA--LQDLNLNGNQLKTVPLALR--NMRHLRTLPEGLFAGSK-ELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAEN--------RLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSD--LKELDLSSNQLNEVPRALQ--DLAMLRSLPPELFAETK-QLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRN--------RISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQ--LQDLHLNDNKLQAVPEALA--HVQLLKALPTDLFRDPAQSIQEIYLQNNSISVLSPGLFSKLEQLQALDLSQNQLTSAWVNRDTFAGLIRLVLLNLASNKITKLESEIFSDLYTLQILNLRHNQLEIIAADTFSPMNNLHTLLLSHN--------KLKYLDAYSLNGLYALSLLSLDNNALTGVHPEAFRNCSS--LQDLNLNGNELTQVPLALK--DMRLLRTLPGGLFAGSR-DLREIHLQGNQIYELPRGLFHRLEQLLVLDLSRNQLSSHHVDNGTFSGLIRLVVLNLAHNALTRIDARTFAELYFLQILDLRNNSIGYIEDNAFLPVYNLHTLNLAEN--------RLHTLDDRLFNGLFVLSKLTLNNNLISIVEPNVFRNCSD--LKELDLSSNQLTEVPYAIR--DLSMLRNLPPELFSEAK-HIKEIYLQNNSLNVLAPGIFSDLKQLLVLDLSNNELTSEWINPATFGVVQAHPTRSFKQQNNEARAHDLPRSDQRAGVALRKTS--SKASAKTFLGLGALHTVILSNN--------RLCTVDHFTFSGLNSLALLSLDYNRISRIDRQALRNHSA--LQELHLNGNKLLQVPDALY--DVPLLRALPPETFQSTR-ELRQIYLQNNSLSVLAPGMLEGLDRLEILDLSHNELTSEWVKRNTFAGMKRLVVLEIAHNALTKIDRHVFRELYSLQILNLEANQIESIADNAFSDLKNLVALTLSHN--------RLKRIEQHHFSELYVLNQLYVESNLIESMHGRALENLTN--LNDLNLNDNRLTEIPEGLG--KLRFLKALTPELFVSSR-KIRQVYLQNNSLSVLAPGVFEGLDRLETLDLSRNQLTSTWVKRDTFAGQVRLVVLNLGHNQLSKVDQHVFKGLYSLQILNLEHNAIELLADGAFSDLKNLHALFLSHN--------RLRQIEPYHFSELYVLNQLILESNQIAYIHERAFENLTH--LHDLSLNDNRLEEIPSGMK--SLKFLQALPTEMFRDAAKSLKELRLQNNSISVLSPGLVADMNQLVALDLSRNALTSSWLNSATFSGLIRLVLLNLSHNRVTRLDPALFKDLYTLQILNLQYNEIETIPADTFAPMSNLHTLDLAYN--------RLTYLDAYSLNGLFALSLLSLDSNQLEGIHPDAFRNCSS--MQDLNLSGNSLDGIPVALK--DMRMLRSLPPELFSDAR-NIQEIHLRNNTLNVLPPGLFTELAQLLVLDLSHNELTAEWVNAATFVGLVRLVVLDLSNNRIARLDPAVFRDLYSLQILRLQENLLESLPENTFSALYNLHTLLLSYN--------LLTVIDATTLSGLYVLNLLSLDNNRLHTINPAALRNASS--LQEFHLNRNQLESVPDALK--ATPLLRALPPELFSKTR-ELRELILSNNSLAVLAPGLLDNLDELQILDLSGNELTNRWVNRDTFSRLVRLVILDLSHNALTKIDGHVFKGLYSLQILKLEHNEIETLTDGCFGSLTNLHMLTLSHN--------RIARFDPAHTIGLTTLNQLFMDANKVRSLHRHVFDNLTG--LQDLSLRGNYLTEIPYAVR--VLRSLKTSLDLRFLDSLPDLKNLTVENVIMPPLP-----AHNKLTFVTISTGSPRSVGQPWGGCSELEDLIIMDWKINFLP--DRWLANCQKLITIQMLRLTELYRLPAQMFSS---------------------------------PSLSAIVISECHVNSLPADLAAGAVN--LTVLDVSNNYIEKLNHLFEAEQMLHLQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLDLEGTRGMPLRVEAGALLPLVNLRMLQLNRVQMASLQFPPTLHSLQLWFVGETR--LDLSGLDQLRALVVHEKESVTVSALTAGSLESVVLDARRVSFPAASRPRSIRRLVLVNWNETDLSARCDDVELLQLRGWVGEE-------------PAPPRRWLSHCKK--LREFRMSFARQKSVTPGLLDGAENLEDVWSTSIEYVSFPSLKELDLRRCSIQVLRSNMFRGMPSLEALYIGENEIY--QVESNTFAGLNKLLHLDFSRNEAFDSTGSPKNLITPQTPLFDGLTSLVSLDLSFTKMSKRNVAVLTGLG---------------------PNLRRLSICDTGLQDLRSDIFSKTN---LTYLDLSENNGILNTPNILRGLEDTLVAITPAFKPSILPALRGLDISENAFEIIPEDAFVPMKGTTLMKLDLNLCRLDFIHPKSFLPLKNLRELHIGENDLNSTLIGDFLLKMKDERIYLMYLDLSGMGFRKNPPRDLMEIIAETSVRRLILSHNQFEFIDDDSFPKMENIELMDLRKVLAMQIGSNAFNPHKFPNLKVLLLSGNNLPGLHKAPFSDQLLFLDLSEELFKPLER--LETLEISHNHMTNITSNLFSHLSFLRKLSLWQSNVT--WFSQDFFNGVDVLEELDLSSNGLNKLPATIFKPLKKLKKLTLFSNKFSSLPKNLFIGNNELETVVILNN------DVKLRVLPERLFGNLPNLKQVYVQRSGIEVVPRDTFKNSPA--ITNISLAFNDLKRLPEEVFN-NQINLLMPSHLFDDLEN--LESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHN--LTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNN------RVPLATLPSRLFANQPELQILRLR-AELQSLPGDLFEHSTQ--ITNISLGDNLLKTLPATLL-EHQVNLLSLTFIGFQIENLSTKPFAQFINLKRMVLTNCTVRNLTFLR--TLQKSLEHLELDIDNEVDLKYFTNFSSLKFMKVRNYIPNKNFTALICT--HKNCNFIRGINGLECPKLCQCLYIIDDLELNIDCSNLGLLQIPPLPIPSYGGVKLNFSNNSLSQLPTMTLPGYKL--VKRLDVSRNRLTNLSINHLPAKLDYLDALIFNGLKIKGLTNNTFENLTSLNTLIFDNVFLKDLSFLRSSTLQSSLTYCIMKVDNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHN--LKSLDVSYNQLTSLSVSQLPESLHYLDTSQPENITTWH-----------------------FGSVPGLKKFKFFSHVPELQESIFHGFDTLRDLHLSVNVTTLPGNMLSTVNGTLKTLTIESPGIVSFGNPLLRELQQLRNLSLALIHP---FHERDKQLQPHFFGSMTNLEEVRLAS-ATSSVNRSMFKGTNK--LQLIKMNGNDDLMELPGEIFLDQVNLKLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTN-----------FLTYSYQLQLPTLEMALSLIYGLKIQQNVFKYLPE--LIYLDLSHSKMTRNSAVAFAHLGDKLKLPATIFDALPK--LRVLELSFNSLEELDPRLLRHLPNLRLLTLWHNKLR--TLSRAAFAGVPELERLDLSSNQLESVPGDLFADLPHLTELAMGVNNFRTLPDGLFRANRELRKVKLASQR------VELETLPHDLLQMLPALDQVSLERVGLVSLPGTLLFGSAN--LTQLNLANNRLHQLPEDLLR-DQKALQNKCIPGKCSHQLKQLET-FSIED--SEISIIPIELVSNLTHLQSLSFRNNSLKQVERFAMLSSLTHLNFGYNQLVSLHNDVFYGLPKLEGLDLSSNKLTRLSAELFGKNKNLMDFLADNQ------HSSGLVLEDKLFAGLIMLQKVSVSNCNITVLPEKLFAGATE--IQIINLSNNKLRSLPENLFRNLSNLVEGDGGSRNSKVLLHTLTQLTTLELTENELTTLPTELITDLPSLGSLTLYHNKLERIEQFADLPNLTSLDLTYNELDTLQEDVFYKLPNLTHLFLNSNKLTSLPSGLLKRNTKLIVFRADNQ------HGSGLVLGDELFAGLTMLEDVSVSNCKLTTLPEGLFTAASK--LTKLDVSDNKLQSLPENLLRHSSILKENR-FSGSILHQLQQKQHRHSIAEGDWEMNIMPSGLVSIVPNLQMLTLHRHNFKQIEHFAKLPSLTYFNISSNQLMSLHDDMFYGLPNLTFIDLSSNKLTRLSAKLFLMNKNLNNFIADNQ------NGSGLVLEDKLFADLRRLIKVSVSNCKITALPECLFAGATG--ITFIDFSSNKLQSLPEHLFRGLSNLRWVPSPTLKKFQNVRLLSLSGNFFTEFSNDTAEHNRLPLLTKLRVLDMRNCSLRTLPEAFFRNVNLEYLFLSHNRITTLPAEIFYPLRSLLHLDLSNMDTRRTGEERIENPFMKLIAGVDLH--------------QDIFFPLISLVFLDLSNTRLEYQAFIALRSVQR-RVQYVSYCNIGLPAIVDYLFVSKKIAMLSLSEIFNYIPN--LEILELGDNKLKEIDVNTFKPLKALKMLNMWGNKFT--EFKSNIFDNLVSLNSLDVSSNHLNTLPNDIFAKLVNLKLLHLAWNNFSSLPEGLLQHNVKLNKVKLSNNR------ISMKTLPNGLFANLKNLKEIELNNNDLIELPDLFHDSIS---LEIIDLSFNNLESLPEYLFA-NLVNLT

: 479: 440: 434: 433: 457: 454: 462: 318: 455: 522: 492: 454: 490: 225: 452: 415: 414: 476: 450: 456: 216: -: 314: 327: 367: 352: 369: 372: 459: 311: 383: 379: 271: 421: 347: 372: 355

BmToll6 480 :BmToll7-1 441 :BmToll7-2 435 :BmToll7-3 434 :BmToll8 458 :BmToll10-1 455 :BmToll10-2 463 :BmToll10-3 319 :DmToll2 456 :DmToll6 523 :DmToll7 493 :DmToll8 455 :AgToll6 491 :AgToll7 226 :AgToll8 453 :AgToll10 416 :AgToll11 415 :AmToll6 477 :AmToll8 451 :AmToll10 457 :BmToll3-1 217 :BmToll3-2 1 :BmToll3-3 315 :BmToll9-1 328 :BmToll9-2 368 :BmToll12 353 :DmToll1 370 :DmToll3 373 :DmToll4 460 :DmToll5 312 :DmToll9 384 :AgToll1A 380 :AgToll1B 272 :AgToll5A 422 :AgToll5B 348 :AgToll9 373 :AmToll 356 :

TLDLG----ENQITSLEEPGFVGLHNVYGLRLIGN---KIENISKDVFSDLPTLQILNLARNKLKHVDVNAFDTLTNLQAIRLDANRLTDIQGLFVNIPSLLWLNVSDNQIEWFDYTVIPSGLQWLDLHSNNIKELGNNYRMDKELRLQTLDASFNKMTKISTYSIPSSVELLFLNDNQIIQVEAQTFVGKTNLTRSLDLG----ENLLTEITNNSFQNLSQLTGLRLIDN---QIGNLTAGMFWALPGLQVLNLAKNKIQSIETETFQKNTQLEAVRLDGNFVSDINGVFVALTKLLWLNLSENHLVWFDYAFIPGNLKWLDIHANFIEILGNYYKIQKELHIKTLDVSHNRLATISPMSIPNSVELLFINNNLISSVETDTFLEKRNLTRTLDLG----ENQLSNFRNGSFKNLNQLTGLRLIDN---QIGNLSVGMFWDLPSLQVLNIAKNKILSIERETFIRNTQLEAIRLDGNFLSDINGVFSTLASLLWLNLSENHLVWFDYAFVPSNLKWLDIHGNFIEHLGNYYKLQEEIRIKTLDVSHNRISEISPMAIPNSVELLFINNNFLNAIHVNTFFDKKNLTRTLDLG----ENQIKDIKNGSFKSLDQLTGLRLIDN---QIGNLSVGMFSELPSLQVLNLAKNKILAVELGSFQNNKQLEAIRLDGNFISDINGVFSRLMSLLWLNLSENHLVWFDYAFIPSNLKWLDVHGNFIEHLGNYYKLQDEIRIKTLDVSHNRIVDISPLAIPNSVELLFINNNHINNIQVNTFMEKHNLTRTLDLG----ENLIVSIENASFMTMEQMYGLRLTEN---NIGNISKGVFDRMTSLKILNLSRNKIHKIEAGSFDGNINLQAIRLDGNYLTDIGGLFAKLPNLVWLNISDNRLEWFDYAMIPTGLQWLDIHANRIAELGNYFEIESQLSLSTFDASSNKLTEITGSAIPNSVQMLYLNDNLISKVQSYTFFKKPNLTRSLDIG----NNNITHLTRENFRGLSELFGLRLVDN---KVTNLNEDTFEHLPQLQVLNLASNKIRHVASGCFRKNINLKLLRMDGNEITKFDGIFSTLNSLVWLNMSANKLSYFDFRSFPESLEWLDLHKNSISTYKND-DTHSNVNIKLLDLSYNNITEITVTSIPNSVEKLYLNDNNIQNIQVGSFSKLQRLSTSLDIG----KNNITKVTNTSFEGLEELYGLRLVDN---YISSIPKDTFSTLPSLQLLNLASNKIETIEQDAFVSNPTLKAIRLDGNSLTDIRGVFNKLSTLGWLNISENRLIYFDYSYIPDNLEWLDLHSNNITKLENEKNVQRN--IRMLDASFNALENVDALSIPDSIENLFLNNNKIHTIHPGTFLQKRDLEKSLDLG----MNKITKVITSHFDGLDDLYGLRLVGN---KIEKISKDTFAALPSLQILNLASNNIDQIDDGAFASNQQLKAIGLDGNKLVDLKGIFTKTQPLVWLNVSNNELLWFDYSHIPSNLEWLDMHENKIDKLDDTYGLKETTMVKMLDVSNNKIKSVDELSFPSSIETVVLNNNNIEKVSPGTFLQKYNLNKTLDLG----ENQISEFKNNTFRNLNQLTGLRLIDN---RIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARTVDLG----ENMITVMEDSAFKGLGNLYGLRLIGN---YLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRTLDLG----ENQIRTFDNQSFKNLHQLTGLRLIDN---QIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARTLDVG----ENMISQIENTSITQLESLYGLRMTEN---SLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRTVDLG----ENSISVIEEPGFRGMNNLYGLRLISN---NIENITRKAFKDLPSLQILNVARNKISYIEKGAFEPAVSVQAIRLDGNLLSDIDGLFTSMPNLVWLNISDNKLEHFDYSHIPPHLQWLDLHRNELTELTNRYGLDNQLHLQTLDASFNRLTRVTPATIPNSIEFLFLNDNLIVHVEPHCFTHKTNLTRALDLG----ENQIARIENGTFANLNQLTGLRLIDN---QIENVTVGMFADLPRLSVLNLAKNRVQNIERGSFDRNLDIEAIRLDGNFLTDINGIFATLASLLWLNLAENHLVWFDYAFIPSNLKWLDIHGNYIESLGNYYKLQEEIKVN--------------------------------------------LARTLDLG----ENHISNIDNASFRHMAHLYGLRLTEN---NIEIIRRGTFEAMKSLHILNLSQNRLKTVEQASFDNNTKLQAIRLDGNYLTDIAGLFTKLPNLLWLNISDNHLEVFDYALIPTGLQWLDIHANKITELGNYFEIESQLALSTIDASSNQLTEITGSAIPNSVELLYLNDNLISKVQSYTFFKKPNLTRSLDLG----KNRISAVSNASFEGLEQLLGLRLVEN---RITNISRDAFVTLSSLHVLNLASNQIRHIDQSAFSSNPTIRAIRLDNNELEDISGVFTSLPALVFLNVSDNQIRLFDYSHFPVSLEWLDMHQNNITELGNYYDLNN-LQIKMLDVSFNRLTSVDAKCIPDSIETLFLNNNALEEVAAGTFLSKRSLEKSLDLG----KNQIAEINNSSFEGLEELMGLRLVDN---QISEISRDTFFALSTIHVLNLASNRIRHIDQSAFSSNPTLRAIRLDNNELEDVSGVFTSLSSLVYLNISDNNIGWFDYSHYPQSLEWLDIHKNNISELGNRYDVGNWFQLKMLDVSHNKLRQINASSFPHNIETILMNNNHIEEIAPETFTGKEHIVKTLDLG----ENQIRSLNRPGFRGMSSLYGLRMIGN---EITNVTVEDFAELPALQILNLARNKIETVEDGVFTANPALQAIRLDSNLLQDMSGMFASAPGLLWLNMSDNMIVQFDYGYLPEKLQWMDLHKNLIMDLG---IAPQAMRLQTLDVSFNRLTRIHSRSIPDSIELLFVNDNMIQTVEPQTFADKKNLTRTLDLG----ENLISEIPSGTFDHVSQLYGLRLTEN---HIGNLSKGVFDRIKELKILNLAMNRIQYIEPGTFDENANLQAIRLDGNQLTDIAGLFTNLSNLVWLNVSDNKLRWFDYAMIPTGLQWLDIHSNEIRELGNYFEIESQLNLSIFDASENKLTEITGNAIPMSVERLYLNDNQISKVQSYSFFKKPNLTTTLDLG----NNHVSRIENDSFVGLGELYGLGLVDN---KLENVSREAFAALPALQVLNLANNYIRHVEQSAFAANPVLRAIRLDGNQLTEIRGAFTSLSTLVWLNVSDNKLLWFDYSHLPASIEWLDIHANQISELGNYYAVRNTLRIKMLDASYNQIGEIGEANVPDSVETLFLNNNKIRTVGPATFFQKRSLQKYLDVS----VNLVSAMSLGLLSRLQSPLALRVDGA---DQAHRCRVNWSHYGGGDVIEITEIFPWPVLSSLTELSLRYSDAR------AICPEWGEAMPSLQLLNLTHTPITALQYS------------------------------------------------DIELLRYKNWEVDLRRNTDLAIMYSRDDFEK---------------MPICIYYRRN---------------------LFSKITSLKKLN-LSNNKLKVEAVGALGTLVS---------LQVLSLSDNPTLMDLCPGNSNAHVGSGTSPLKALT---------------------ELDELRLGHTGVSHVCSDWRTSMKQLSLLDLSYTNITSLSYLDFHYERSGSKKLGLT-----SCQIDTLPVDLFKENRNLRIIDLSHN---KLQTLPSGLFSNLRNLKELN-LSNNKLQTAAVGTLGSLVS---------LQDLNLSHNPPLLDLCSGGSDAFIVSGTSPLKALT---------------------ELEELRLGHTGVSHVCSDWRTSMKQLRLLDLSYTNITSLSYLDFHYEHSGSKEVLYAN------TIGTGRVDMLKNFHRLEILQLLNN---EITSLPQEVAATWRSLQILDLNKNRIITWFEPIFSLIPNLK--------------------------------------------------------------------------------------------FLALKHNNINVIREDMIVDFRNISYLSDNKGSPTNPMYYEIDRNTFVQSKELKILNLAFN---RIRAIFEYTFRGLENLQILSMENGTLYHIGDKSFKPLKRLEMLNLANNPLEQNE----NLTSSMFDGLNDLKILILENCGIKRFYD-----------------------------------DDNIFEMMPNLTHLVLRNNQLYYISAETLKPLKLLKVNLDLS----HNKIFDLATRTFSTLVRLEILNLCNN---QLVFIDGSLFSSLLSLIDLNIENNNLKIITSDLFRNNKQRMSISLANNNLDFEQTVYAN--------------------------------------------------------------------------------NCLSLEPRSPFANTYNLKLSLDLS----NNRLTHLPDSLFAHTTNLTDLRLEDN---LLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHG--------------------------------LLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVSFN-----EIINMGNDVIKYLRTVPIFKQTGNQW---TIHCDDKPLLNFFRHLKLIIRMKSAEMKPMFLHSLTELPKGFL----KFLGKHFIWLGVRKQEYYLINEEQLLQSMHRKLNNLNTIMSIYKYMEWLHRKLIFVNREYDLFYIRQMAAPCPHKCECCYSRDSLILKIDCRNKFVYNFP---DIVARNSRIRHN-----KITTLSPQVVEYLYSVNVFNQYGNKW---SIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKG-------SFVENFFVQN--IDQLYLEANEDEIIDAFGPSDKYFN-----LKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTTLDLS----CNAIVTLHEDVFKGLGNLTLLDLSKN---RLTNLSSTIFAPLTSLNVLRLNKNSLTAMSPSVFQDVVSLN----------------------------------------------------------------------------------------------------------YIEMVNTQFYGFLSLC-----YTAIPMVSSTIFKNTVLEGLDLSGNPYLSYNIIDDAFDGIANTLKYLYFERSNIKDLEWSKSLKNLQVLGLAGN-NINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNN---------------------------------------------SALRVLNLRSNTINMLSNEMLKDFERLDYVLQLQ----HNQLTGLPAGLLRNTVELHTLRLSHN---QIGELSAVALQALTKLQELYLDHNQLYTIELHAFKQTTALHT----------LHLQVNQLAFETLNTLPATAPDTGDQEQLTDHIPAPDEFSLLAQDGTPFQHLHQLRELDLSSNWLTAVPRDLLLNTHELQRLNLTRNNITSLTYANLQFLAPAITVLNLQK----NKLKSMLPDTLLADAAQLQTLNLCHN---KLTTVNKHLLQSLGNLSKLQLSHNLLYLIDVDAFKSQSKSLTS----LKLDHNRLTLHAKNNGATFGNTEINSSSWVLFSTLHK----------------------VRRLDLSYNAIDHLFVPFQNFMESLHTLILSHNLITHIGYAELSFLF-NLEGLYLQH----NELINMLPDTLLQSTNKLRILNLGHN---KLTTLSKYLLDSKNSLEELHLEYNQLYMIDRDAFISQAQSLKM----LNLSHNQVALHVNGTDVFYLDGKTYYISQTPFYILAQ----------------------LTDLDLSD--------------------------------KDFSFLSPKIEKLYLQD----NELMRMLPDTLLQDAINLRVLHLCYN---KLTMLNKHLLKSLRHLEKLHLEHNQLHMIDVDAFTSQTESLIT----LNLSRNSITLNEDNRDVFYSNEEINITSGIIFSTLNK----------------------VKYLDLSFNAIVKILDPFKNFMKGLRTLDLSHNLITHVGYKDLLFPSPNIDLDISYN----VGVAQSLHSASFTLLADSLEVLYFKD---SMVQQLN-WLVPLQRLRVLNLRGNILRMLQRESFANLTNLEQLDLSYNYISAWNQQILTTTTALQSVN--------------------------------------------------------------------LRNNSIVILTTDMLYDFSRLSAKLIIS----NNKLTSLPDGIFSKLKKLIILDLSHN---NLTSISRYLFSDLISLQNLNMEKNQLKIIEETSFNFLTKLRIAKFSNNQLTFNTSINSYIDEYGMRSPFQSCSS---------------------------------LEELYLDKNNISDIFGDWLVTHVKLKKLNLQFNQIQEISIRDLQFLSNSIE

: 668: 629: 623: 622: 646: 642: 649: 507: 644: 711: 681: 643: 679: 370: 641: 603: 603: 662: 639: 645: 351: 129: 471: 422: 521: 461: 526: 553: 633: 394: 528: 558: 433: 552: 510: 492: 511

Fig. S15 A (Cont. 1)

Page 3: Fig. S15 A · 2010. 10. 11. · BmToll6 669 : BmToll7-1 630 : BmToll7-2 624 : BmToll7-3 623 : BmToll8 647 : BmToll10-1 643 : BmToll10-2 650 : BmToll10-3 508 : DmToll2 645 : DmToll6

BmToll6 669 :BmToll7-1 630 :BmToll7-2 624 :BmToll7-3 623 :BmToll8 647 :BmToll10-1 643 :BmToll10-2 650 :BmToll10-3 508 :DmToll2 645 :DmToll6 712 :DmToll7 682 :DmToll8 644 :AgToll6 680 :AgToll7 371 :AgToll8 642 :AgToll10 604 :AgToll11 604 :AmToll6 663 :AmToll8 640 :AmToll10 646 :BmToll3-1 352 :BmToll3-2 130 :BmToll3-3 472 :BmToll9-1 423 :BmToll9-2 522 :BmToll12 462 :DmToll1 527 :DmToll3 554 :DmToll4 634 :DmToll5 395 :DmToll9 529 :AgToll1A 559 :AgToll1B 434 :AgToll5A 553 :AgToll5B 511 :AgToll9 493 :AmToll 512 :

VDLYAN-----------------QITSMDLNALRLTPVDPG------RPLPEFYIGGNPFQCDCTMEWLQRINKLDH-LRQHPRVMDLESIYCKLLYNRERTYIPLIEAESSQFLCTYKTHCFTLCQCCDFDACDCEMTCPSNCTCYHDQPWS---ANIVDCSAAGYS-EIPNSIPMDATELYLDGNNFGGLTSHAVDMYAN-----------------EIESLDINSLRISRVSED------RTLPEFYISGNPFRCDCNMKWLLLINSITS--RQYPRVMDLENVICKESYVRGVKYLSVTSLHLKDFLCKYETYCPDNCECCDLNDCDCKTYCPTNCSCYHDSSKS---TSVVDCSVQQLK-VVPTAFPIDATHIYLDGNVYSELGETFVDMYAN-----------------EINHLELNSLRLSTVPGN------KTLPEFYIGGNPFQCDCTMEWLPIINNMTA-MRQYPRVMDLENVLCKMTNTRSGTHVPLTNLKTTDFLCKYETHCFAICHCCDYDACDCEMTCPHNCTCYHDPLWN---TNVVDCSGQSSM-EIPQKIPMDATEVFLDGNNIRELQNHVVDIYAN-----------------EISHLDINSLRLSPVPLN------KSLPEFYIGGNPFDCDCSMEWLPLINNMTT-MRQHPRIMDLENVLCKMTHTRGVTHIPLSNLKSTDFLCTYETHCFTLCRCCDYVACDCQMTCPYNCSCYHDPTWN---KNVVDCSSQSAI-EIPEKIPMDATEVYLDGNDFKILQNYAVDLYGN-----------------KITSLDPNSLRISAVPQD------KSVPEFFIGGNPLECDCTMEWLQKINTGNR-ARTQPKLMDLDSIHCKLLYSRGNAFVPLIEAAPHQFLCKYESHCHALCHCCDFDACDCEMTCPNNCTCYHDPSWS---ANVVECSNAGYTNDLPEKIPMEATELYLDGNSIKELPSHAVTLNNN-----------------KLVHLDMNAFRLDQIDED------SDLPEFFISGNTFICDCSMEWIQRINHLSH-SRQYPRVLDLDKALCSLVHSRAKRKKLIIDMSPSDFLCPYESHCFALCQCCDFVACDCEMICPNDCRCYHDIPWN---ANVVDCSNAGYT-EVPKHIPMDATEIYLDGNHISHLG---VVVTDN-----------------KLRTVELSAFTLPHIPKH------KTLPNFFIANNPFVCNCHMIWLQKINLWNH-MRQYPRFMDLESVMCEVVNNKYGGKANLVDVPETQFLCSYETHCSSNCFCCEFEACDCKMTCPEGCSCFHDSNWN---SNVIDCSNVGYT-EIPEKIPMDATELYLDGNDFGALGSHLVMLYSN-----------------KIKTLELGAFAISSVPDD------KDLPEFYISENPFVCDCTMEWLQTINQVSD-LRQRPRVMDLESVRCSLTHSRRKSETLLLEVKSSEFLCEYESHCFTVCHCCDFDACDCKMTCPDRCSCYHDQTWTT--TNVVDCSNAGYD-HVPDRIPMDATEIYLDGNSLKELGNHVVDLYAN-----------------VLSKISLNALRVAPVSAE------KPVPEFYLGGNPFECDCSMEWLQRINNLTT--RQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWA---TNIVDCGRQDLA-ALPNRIPQDVSDLYLDGNNMPELEVGHVDLYAN-----------------QITTLDIKSLRILPVWEH------RALPEFYIGGNPFTCDCNIDWLQKINHITS--RQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWS---TNIVECSGAAYS-EMPRRVPMDTSELYIDGNNFVELAGHSVDLYAN-----------------QLSKLQLQQLRVAPVVAP------KPLPEFYLGGNPFECDCTMDWLQRINNLTT--RQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWS---TNVVDCGGQQTT-ELPRRVPMDSSVVYLDGNNFPVLKNHAVDLVRN-----------------RLTTLEPNALRLSPIAED------REIPEFYIGHNAYECDCNLDWLQKVNR--E-SRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWT---SNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAVDLYAN-----------------QLTSLDIKALRLQPVPED------KQIPEFYIGGNPFVCDCNIDWLQKINHVTS--RQYPTINDIETVYCKLMYNRERSYIPLIEAEPKHFLCSYNTHCFALCHCCEFDACDCEMTCPNNCACYHDNSWS---TNIVECSAAGYT-DIPNNIPMDTTEVYIDGNNLVELSGHSVDLYAN-----------------ALKKLQLHQLRVAPAPPTT----ERPLPEFYLGGNPFECDCSMEWMQRVNNLTT--RQHPKIMDLPNVECIMPHARGSPIRPIVSLQPKDFLCRYETHCFALCHCCDFDACDCEMTR--------------------------------------------------------VDLFGN-----------------KITTLDPNALRISAVPDD------RPLPEFYIGGNPYQCDCNLNWLQKSNI--D-SRTQPRLMDLDSIYCKLLYNRGRTYVPLVEALPNQFLCKYDTHCFALCHCCDFYACDCKMECPKQCTCYHDQSWS---SNVVDCSRAGYDDRLPDQIPMDSTQIYLDGNNFRSLSSHAVVLYGN-----------------YLRKLEIGALALTRVADD------REVPAFYLGDNPIHCDCTMEWLQGINKLAH-LRQHPRVMDLDTVLCTMEHERGASIRPLMDLRPHDFLCRYETHCFATCHCCEFDACDCKMTCPDRCSCYHDHTWK---ANIVDCGSADYT-EVPEHIPMDASTIYLDGNELRQLASHQVVLYGN-----------------RLRRIEMSALALTPWPDT------RMLPEFYLGDNLIHCDCTMEWLQRINELAY-LRQYPQVKDLDSVHCSMEHERGEQRRPLMAMRASEFLCRYEAHCFATCHCCDFDACDCKMACPDRCRCYHDTAWE---SNIVDCGSAGLS-LVPAKIPMDATDIYLDGNNLGALGSHVVDLYAN-----------------QIVKMNLSAFQLTPVPNY------RQLPEFYIGGNPFICDCTTEWLQRINSLSL--RQHPRVMDLESVYCRLPYDRHKSFIPLLEAKPSQFLCTYKAHCFALCHCCDFDACDCEMTCPTNCTCYHDQSWS---ANVVDCSNSGYK-TLPGRLPMDATEVYLDGNNFGELNSHSVELKGN-----------------QIRNLEPYALRISAVPPD------KPLPEFYIGDNQYLCDCTMEWLQRVNRQNQ-TRVQPRVMDLESIYCKLLYDREHAFVPLVEASHSQFLCKYDTHCFALCHCCDFDACDCEMTCPSNCTCYHDQSWS---ANVVDCSNGGHANKLPEQIPMDATRLYLDGNDLRLVSSHAVVLYGN-----------------EIRSLDVAAISLQTVPDD------AELPQFYIGDNPILCNCTMEWLPRINEMAARLRQHPRVMDLDSVTCEMVHARATPRRPLLSLKSKDFVCRYEAHCFALCHCCDFDACDCEMTCPDNCSCYHDHSWS---SNVVDCSNAGYN-HVPERIPMDATEIYLDGNELGELGSHVVMLDQN------------------------------------------TTSAKLWLDTPYSCNCSWYWFARILQEKP-----------------------------------------------------------QYIKLPEFECFVPESTAT------------------------------------------LTVNFN---------------GTPVSELTVDAGNYKSVIADL-----ASASVKIILRATLPCDCLDYWTALAFG-------------------NLSTQAQDSVELLCREEERGSLADALERE------SLECAESSLCEDQEGCTCSVRPDLSHGVVATASCEGAGLD---EMPSRLKFKEAPAWRLMLAHN----LTVNFN---------------GTPVTELTVDAGNYKSVIADL-----ASASVKIILRATLPCDCSDYWTALAFG-------------------DLSTQAQDSVELLCREEERGSLADALERE------SLECAESSLCEDQEGCTCSVRLDLSLGVVATASCEGAGLD---EMPSRLKFKEAPVWRLMLAHN----LALAGN----------------------------------------------------FFMCNCNSRDFLETAARNE---------------------------------------------------------------RNRQNGYIKSVYES------------------------------------------LDLSEN---------------------------------------------------------LFVSWWQPLFLASG-----------------------------------------------------------------------------------------------------------------------LNLSHN----------------------------------------------------AFRISFVDWWINGHET--------------------------------------------------------------------------------------------------------------------------VNMTHN-----------------KIRRIALPEDVHLGEGYN------NNLVHVDLNDNPLVCDCTILWFIQLVRGVH------------KPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDK---ALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLR--LMGKQN---------------MSSPMELHLSKNNISNITIAM-----LPKELRFLDLRFNNLVTLDDKVLSYLK--K----------------NSIKTKLSGNPWNCDCKSRSVLSILRDHEPLEYDVTLKRCNISPTDCPDVCVCCLDNLTWP--SFIVDCRGEGLL---QMPSLSS------------------LYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHL-----LPENITYLDVRNNLLKYLDDGVIAFLEYRE----------------NITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELS---EIPQLPTPTYGQTTLVFERNSLKKWATLLMN----------------------------------------------------YEAVVCTNDEACQYKS-------------------------------------------------------------AEWQCDPRCICWVQRSVG---SLIVDCRGTSLEELPDLPRTTLLSTVLKVGNNSLTSLP--LSLGDN----------------------------------------------------DFICDCHLRAVVEVAAANN----------------------------------------------------------KDADCSYRLLNYSQNAVG---EEVISLAES-------------------------------DLRHNS------------------IFEIDLADMERLVLLEPRNFDEQTGRARVLLNDNPLHCNCIAYAFAQYIQNRL-------------ATAVYDRFELVANELTCHGPEHLEGALIKDVPTRELLCELDTPSTAIRHCPAPCRCYIRPEDTG---VIIDCSGQALTEVPELPRPTTFGYRFIELHLENNNIS--VNLKSN---------------KIAHLDFNLTSIPSHHL---------FNGPIQLNDNP-FNCDCMSYPLVTYLK--------------------AESYSSKSDMLEGLQCAQPLKLLGLQLQDVQLEDLICAIDASSGFCPAECKCYKRAVDQC---AIVNCTASNLT---RVPVIHSPSIIECNFIELHLAQN--VNLESN---------------RITMFTFNDSKKSTFSNRSIN-----TPRQILLADNS-LNCDCISS--------------------------------------------------------------------------SLCKCYKRAVDQG---AIVNCTAANLT---RVPVIKSPSIIGRNMIELYLEQN--VNLESN---------------KITHLDFDRSRIETRHR---------LPKEILLANNP-LNCDCMSYPLVTYLK--------------------AEPDSSKSFLLKGLQCAHPSKLFGLQPQDVQLEDLVCEIDTFSEFCPAECKCYKRAVDQC---AIVNCNAANLT---RVPIIHSPSNIGRNFIELHLAQN--MGLGGN----------------------------------------------------TIQCSCNYVKFLRNILHNR---------------------------------------------------------------TDVAGAYTISAEP-------------------------------------------VNLTNN-----------------KIKHINLNEAKEIARFQQD-----SRNVMIYIENNPIECDCDIFNFLLYLEG------------------KLDPNVYKYFHIMPGCLTCQNPQKFKGKEIVKLE-SKKFICQISNPCPNECTCYSQQSNKE---FTVNCSEKNLTSVPRNIKTLLNYKLVIDLTDN-------

: 836: 796: 791: 790: 815: 807: 817: 676: 811: 878: 848: 810: 846: 487: 808: 771: 771: 829: 808: 814: 404: 273: 615: 461: 541: 483: 682: 688: 805: 472: 580: 718: 576: 645: 653: 530: 656

BmToll6 837 :BmToll7-1 797 :BmToll7-2 792 :BmToll7-3 791 :BmToll8 816 :BmToll10-1 808 :BmToll10-2 818 :BmToll10-3 677 :DmToll2 812 :DmToll6 879 :DmToll7 849 :DmToll8 811 :AgToll6 847 :AgToll7 488 :AgToll8 809 :AgToll10 772 :AgToll11 772 :AmToll6 830 :AmToll8 809 :AmToll10 815 :BmToll3-1 405 :BmToll3-2 274 :BmToll3-3 616 :BmToll9-1 462 :BmToll9-2 542 :BmToll12 484 :DmToll1 683 :DmToll3 689 :DmToll4 806 :DmToll5 473 :DmToll9 581 :AgToll1A 719 :AgToll1B 577 :AgToll5A 646 :AgToll5B 654 :AgToll9 531 :AmToll 657 :

FIGRKNLKILYANNSNIDALYNNTFSGLKRLTILHLEKNNIKELLGFELSPLENLRELHLQDNKIHYIDNRTFMELRHLEVLRLEGNNIYGFAVWQFTMN------PYLVEISLSRNPWSCDCQYMHKFRNWFKNNLGKVEDANKITCVFDNVTNA--------------VGPLMADF----NSTICTSHVGG---FDSMRNAYVIYLNASNIIIIRNNTFSQLRDLRILHLDNNKLKQLRGLEFSKLSSLKELYLQSNLIEYISNETFSQLGALEVLRLDGNRLVNYGLWHLD------NNKKLQTLFIGNNNWSCDCKYLQGFLTYVSQNIEKVLDIHSLWCVNEKLKP---------------VKKPLNLN-----ITVCSEISE----FIGRQKMRTLYVNNSNVDSIQNRTFSGLNSLQILHLGNNKLKELKGYEFQQLNNLKELFLQNNLISHIANISFLSLKSLELLRLDGNRLVDFGVWSFS------NNLNLKALSLGNNLWSCKCRYLQELTAFLAENAQKIIDITDVWCWNGDAKPP--------------QKKELNLN-----GTACSDYYAD---FIGRKNMRSLYVNSSQVESVHNKTFAGLSSLITLHLGNNKLKHLNGYEFEHLTQLNELYLQDNFISHIANLTFSTLYSLRILRLDGNRLIDFSIWSLN------ANKQLSSLSIGNNMWSCKCRYLQKFTAFISDNVPKIVDVTDISCWNVDTKTT--------------QKKELNLN-----GTICSDYYAG---FIGRKKLKILFLNASHIEIVHNRTFNGLKELEVLHLDHNSVTSIEGQEFNGLDNLRELYLNNNKIKNIGKEMFNHMSRLRILHLHRNYLISLSVWQIN--------PAITEITLSYNPWSCDCEYTEMFREWTKRVSS-VTDLSNIQCVYTQGNTS--------------NILVLNDT----VFDDPSSGFKIAY----------------------NHVFIGKKKLQGTSFGKHKLVELKGDEFLHLNSLNELYLDHNAITHVANNTFSSLKSLSVLRIDDNKLVNFFPWKLLASS----SESLAHVSIEGNQYSCDCKSIAELDSWLRRDPGDPEKMLCTDSEGKPTKIT--------------IASVLSHCKEYMGSISDPTMSRD---FIGKKKLHKLYLNNSNIASIDNDTLNGLHSLNILHLENNHLVELSGGEFSQIKHLRELYLNDNLLKSVPNKTFEVLSSLRTVYLQENKIFDLD--KKLS-----HIMHLDNVNVRGNVFTCTCDNIASLQNWLKKIHE--DPLEVFCVDEN----------------QLISNLTVFDAIDKCHGSNVMDNTVP---FIGKKKLQVLYLNNSNIDIIQNRTFNGIDSLRVLHLENNNLEVLRNTQFTRLPHLNELYLSSNKIKFIENDTFNYLPSLEFLDLDNNGYVDYMPWRVIS-----DSDPRMRVSVDGNNWICDCKDVAQLNQWLIKKSK--DTENMMCYFAH----------------GQPMNKTIATVAKECKTETTTEETG----LTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQY--------RHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAG------------------IKRELELIGNLANGPDCSDLLDA---FLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSAN------PYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNN------------------ATSVLREK----NGTKCTLRDG----FIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATH--FGTR-LKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFN---ATGAACTDYYSG---FIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAVWNFLP-------SYLNELRLASNPWTCSCEFIDKLRDYINRHEY-VVDKLKMKCD-VISGNS--------------TQQMVIYP----GSGEPAS-----LPFIGRKNLRVLYANHSNIEAIYNTTFIGLRRLTILHLENNAIRKLYGHEFSALESLRELYLQGNRIAYIEDHTFAELRKLEVLRLDGNRITSFEVWQLSAN------PYLVEIALANNLWTCDCGFVNKLRSYLQSNADKIVDANEISCSYNN------------------ATSILRD-----NGTKCTFREG--------------------IATIQNRTFAGLTALQALHLEDNALQRIHGYEFENLALLRELYLQNNGLQSIANGSFAPLYSLRVLRLDGNRLVTMPLFQLQAAQ--GNLQALQSLSLGRNPWSCRCRFLPELTAFVADNAVIVQDPQDVYCADDG------------------VHRELDFN---VS-AACSDFYAG---FLGRKRLKILFLNGSNVETVSNRTFYGLKELEILQLDHNLLTALNGFEFEGLDSLKELFLQYNRIASIANHTFDHLHGLKILRLDHNRLVEFNVW-LLP-------KQLNDIRLAFNAWSCECDYVTRFQEYLKTYDF-VRDRHKIRCASYVSSNA--------------TIAPATQP----ADASQASPAEEPLPFIGKKKLEVLYLNGSNIRDVHNRTFNGIPSLRVLHLENNYINELRGFEFDQLTNLNELYLDHNAIAYVGERTFESLRFLEVVSLSDNRISEFRPWQAF--AAAGETGSLARVALDGNRWRCDCESLRRMQRWIRTVSGNFELQRMICADSRVVADA----IASCDSRQGGGVFGAGAEAGEVDGDGPPAVHR----FIGKKKLKSLYLNGSRIESLNNKTFAGIPALEVLHLEQNGLEQLSGAEFEQLRELKELYLHRNALASIGNRSFYYQKSLEVLTIEENKLKGVRPWELLPLPSGGPDGAYRSVSLEGNALECSCELLPKLLDWLERMYR--SNGSAAQSEEQTESSE----ETSWGEFQCAGGKPLPDVVKECEGQRPAVVPVA---FIGRKNLQILYANDSNIIAIRNHTFSGLKRLLVLHLENNKISVLNGVELKPLENLKELYLQNNLLTYIDNGTFLPLRQLEVLRLENNRLGAFAVWQLGQN------PYLVDIGLSSNPWNCECSFLDRVREWMSRNRAKISDWRSVTCSLGIP------------------IILPANG----SVINCAALTG----FIGRKKLKVLFLNSSNIEIVQNRSFNGLRDLEDLHLQDNKIRELKGHEFEGLDALRLLYLHRNRISSIGNDTFSTLRSLRVLRLEGNRLTVLAVWTL---------PNSIEISLSGNPWSCECDYLRSYREWIREASARVTDASALRCVY---NVT--------------EFEAFGDQ----VFADNEFGFRLVADFIGKRRLEVLYLNNSGISGIHNFTFNGVGALRVLHLEDNALRELRGFEFDQLERMSELYLDHNAIATVGNTTFKKMRNLEVLRLDSNRIVNFRPWEALP---SVGDSTRTVVALEGNAWSCECGNAAKLRGWLAEHRG--DPEKMYCRD---------------------GVETLAQAMNRCGDPSTEAVSR----------------------------TMDLRYNRLSTVDEEVLQKMFGSS------------------------------------------------------------KVEYHLAGNPIPCLCNNS-AFVVALQHHQHQVKDYRDLSCIGGGSIDQAN-------------------------------------------------------HIQTVRFQDLPDTILELDLRNNSLHRLDGPT---------------------ASKLSTVP----------------------------------LWIANNSLDCTCHGY-DLVTNLELCVLDMEQATCDDGTPLIEAQINDPT-----------------------------------------------------HIQTVRLQDLPDTILELDLRNNSLHRLDGPT---------------------ASKLSTVP----------------------------------LWIANNSLDCTCYGY-DLVTKLGPHVRDMEQATCDDGTSLKEAQNGDPS------------------------------------------------KNLFLYHRGFEDFNTLIAQRKPVVFENSISEWDNEEES---------------------------------------------------------VYLLTDFYGRNYICASFASDEGEAIFMGDVPTCYARRDMQYDEKMIKN---------------------------------------------------------------------VKPITLNLKNNKLSHFSMSMIQDISYLLENNGN----------------------------------------------SRIEIELMDNIFICDCSSMYKMYSWLQANGSEVLRKFIQSSKFQCSSPDIWED------------------------KRVADYLSS-----------------------VDVSHNAIKTLVAYNEYSDLYEGVTRKP------------------------------------------------------------LKELWVFNNPIQCVCNNYMFVDLLQDVTNRKIMDARLFRCPKWQITFCS----------------------------------------------------------LPSANTPGYESVTSLHLAGNNLTSIDVDQLP--TNLTHLDISWNHLQMLNATVLGFLNR---------------------------TMKWRSVKLSGNPWMCDCTAK-PLLLFTQDNFERIGDRNEMMCVNAEMPTR---------------------------------------------------------------------RVTYVDLRNNNLTALSQKN---------------------RSSIENRS--------------------------------LKLHLLDNPWSCSCNDI-EKINFMKSVSSSIVDFTEIKCSN-GEKLVSINQ------------------------------------PSSLLPGYSSVTRFYLAHNRLSDIDQLPDKLEYLDISNNNFSALDDRV---------------------RGFLQKRMN----------------------------SSQLQLSLFGNPWTCRCEDK-DFLVFVKEQAKNIANASAIQCIDTGRSLIEVEE--------------------------------------------------------TVSEHSGYANVSGLFLSDNNLTSLGSGDQLP-DNLTHLDVRGNQIQSLSEEFLLFLQEP---------------------------NNTMTLSLSGNPITCGCESL-SLLFFVRTNPQRVRDIADIVCTKQKKSFQ----------------------------------------------------------LIIDRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDG-------------------------DLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTN----------------------------------------------------------ALPDSTTASGSSGWAEVRELYASNNSIAALAADQLPR--SLRLLDLSRNRLTTLDGPLAESLTAS---------------------------TTLTTVRLAHNDWTCQCETT-QLLTFAHANQRRIEDFGRLRCSDGRPLEQ--------------------------------------------------------NIRYLSNEGEGWNSVRWLNVSNNRLIALSAESLPKNLEL--LDVSGNQLTEIDAVFIQKLKS----------------------------STLLNITLSSNPWKCDCAN--PLLTFAVDNAARITDYVVLQCIDGQPINSATLK----------------------------------------------------MIKELSNVGEGWNTIRRLNIANNSFTTLPGD-----------------------TFIIKLNH----------------------------TALRNISLSANPWDCHCEN--PLLAFAVDNAARITGYSTLQCSDGQPINSATLN----------------------------------------------------KLHYLSNAGEGWNFVRWLNVSNNSLGSLSAESLPEMLEL--LDVSGNQLTEIDAALIVKLNQ----------------------------STLHNISLALNPWDCYCEN--QLLTFVVNNVARITDYYTLQCIDGKPINLATLK-------------------------------------------------------LIVGRRGSGTISNKLSLQHVQLFDYEESE------------------------------------------------------------YLCMNFTSNQKLDPLELQDCMIPEDELINSDIPEEGEDEPAHAKN----------------------------------------------------------KLSEMPSLTEIGLDNIQISKLLLS-NNDIHEVSMDGLQSNIELELHNNNISKLEPNVLQFLNN------------------------------SSSLTLHGNPWICDCDTR-DLLSFIQTKISDIRNSSLITCKDMNISMIK---------------------------------------

: 1005: 962: 959: 958: 983: 961: 985: 845: 978: 1042: 1035: 974: 1009: 640: 977: 957: 958: 993: 974: 980: 477: 360: 702: 547: 636: 560: 789: 764: 915: 579: 689: 830: 688: 736: 765: 604: 766

Fig. S15 A (Cont. 2)

Page 4: Fig. S15 A · 2010. 10. 11. · BmToll6 669 : BmToll7-1 630 : BmToll7-2 624 : BmToll7-3 623 : BmToll8 647 : BmToll10-1 643 : BmToll10-2 650 : BmToll10-3 508 : DmToll2 645 : DmToll6

BmToll6 1006 :BmToll7-1 963 :BmToll7-2 960 :BmToll7-3 959 :BmToll8 984 :BmToll10-1 962 :BmToll10-2 986 :BmToll10-3 846 :DmToll2 979 :DmToll6 1043 :DmToll7 1036 :DmToll8 975 :AgToll6 1010 :AgToll7 641 :AgToll8 978 :AgToll10 958 :AgToll11 959 :AmToll6 994 :AmToll8 975 :AmToll10 981 :BmToll3-1 478 :BmToll3-2 361 :BmToll3-3 703 :BmToll9-1 548 :BmToll9-2 637 :BmToll12 561 :DmToll1 790 :DmToll3 765 :DmToll4 916 :DmToll5 580 :DmToll9 690 :AgToll1A 831 :AgToll1B 689 :AgToll5A 737 :AgToll5B 766 :AgToll9 605 :AmToll 767 :

------------------------------------SSSIIENQVINDYLPLLLIALCVFVVSSALICGVFYWRRELRVWVYYHCG-FRMCYKSTTFDEEA---DKDRLFDAYISYSVKDEAFVAQMLAPGLESTDPSFRLCLHYRDFNASAYVADT-------IIEAVESSKR--TIIVLSKNFINNEWCRFEFK---------------------------------NSMMSA----FFVSHNLPLLASAITGFMLILLILALIFTFRYACRMWLYSNCG----IKLSPL--AFK---DTDKLYDAYVCYSPKDEEFVIETLARELENGYPSYHLCLHYRDVPHFEATYAQFPD---LVVEATEASRR--IIVVLTNNFITTEWSQIEFR---------------------------------NSVIGN----MLVSNYVPMMVSTLTGFMLILLALVLLFLFRDSLRVWLYTNCG----IRVFSLPGTFE---ENQKLYDAYVCYSPKDEESVVQSLVNELENGNPSYHLCLHYRDIPHHGAQYMQCAP---PDVETAEASKR--IIIVLTRNFMQTEWSRYEFR---------------------------------DSVIDN----ILVSNYMPMMVTTLSGFMLIMLVILVIFIFRDTVRIWLFTSCG----IRLFPFNGAYD---DTDKLYDAYVCYSPKDDDFVIQTLAAELENGNPSYHLCLHYRDIPQHNVAYMQCTL---PLPECAEASKR--IILVLTRNFIETEWSRFEFR--------------ENGTLCTGLPSINNSINGNLTATRTIITNEDVQDYIPLLIATLGGFLLVLILSVMLFIYRQEMRVWCHSRFG-VRLFY-RASDLE-----DSEKMYDAFVCYSSKDEAWVTEELASSLERGDPSYKLCLHYRD--VGGYVTDK-------IRQAVESSRR--TIMILSENFLRSEWVRYELK------------------------------------EVISKSVFLPDNYFAVICGIIIIVVVICLIFAIFYAFRYEVSDWVYTKYGVPLFKEQSCPNVDHVMEGNPNHMYDYYVICNTKDTGFIYHNIMSEIEFR----KMCSKSFSLNEATLNILTLDS----FSKSPKLSKR--LLIVLTNNFICNDLSDIQFK-------------------------------TENQPYQYDEVSTIKLNFVPLLAVVLISVILILLFGALAFSFRQNVRLWAHSKYGVRLFKSASIQESELD----RDRLYDGYAVYSLLDDDFVSKVVAPEMEH--SGYTMCFHYRDLQHGPDNYLCEQ-----ITNAAESSKR--ILVFVSFNFLQNEWCKATFK-------------------------------TETLKRLFIESNDGVENYIPYIAAVLIIAIILLLMCALLFMFREDFKLWMHSRYGIRIFSSSPRDLNDS-----KNKRFDAFFVYNPRDEDFVTRAVSSELEN--MGHTLCLQHRDLQL-IERRSGDS-----LVSAAESSKR--LIIVLSINFLQQEWYAPESK---------------------------------SASNISSSQDLAGGYRLPLLAAVLV-LIFLVVVLIIVFVFRESVRMWLFAHYG----VRVCEP--RFE---DAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHLQ--------LVEGARASRK--IILVLTRNLLATEWNRIEFR------------------------------------VAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQL---DKERPNDAYFAYSLQDEHFVNQILAQTLEN-DIGYRLCLHYRDVNINAYITDA-------LIEAAESAKQ--FVLVLSKNFLYNEWSRFEYK---------------------------------GSMLQ----HGIPESYIPLLAAALA-LLFLLVVIAMVFAFRESLRIWLFAHYG----VRVFGP--RCE---ESEKLYDAVLLHSAKDSEFVCQHLAAQLETGRPPLRVCLQHRDLAHDATHYQ--------LLEATRVSRR--VVILLTRNFLQTEWARCELRVVQCSQTLPLGLD-NNFNYAEQAG-GENASN--ATSTKMILNQPPKLDYIPILVAILTAFIFVMICISLVFIFRQEMRVWCHSRFG-VRLFYNAQKDVDKN---EREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPET-------IVQAIDSSRR--TIMVVSENFIKSEWCRFEFK------------------------------------MSSIVHRQEIEDMLPLLLVATCAFVGFFGLIFGIFCYRKELKVWVHSG-----LCYKSGTFVNEY---DKDRLYDAYITYSLQDEHFVSQILTSTLEN-DIGFRLCLHYRDLNANAYLADT-------IVEAVESSKR--AILVLSKSFLYNEWTRFEFK---------------------------------RSVLPG---DGLPETYIMLMALAVV-LVCLLLLAVLMFVFREPLRFWLFSRYG----VRVFGP--RCE---DSEKLYDAILLYSAKDAELVARSIAGELENGRPPLRLCLQHRDLPEDASHLQ--------LLEASRASRR--IVVLLSRNFLQTEWSRCELRDGAGTGDFLVYYD-NSSTLCTGAIPLENVINGNLTSRKTILSPQPIEGYIPLLVTGLFGFSLVIILTLVLFVFRQEMRVWFHSKFG-VRLFY-RNADIDKN---ERDKLFDAFISYSSKDEAFVAEELAPMLENEDPSYKLCLHYRDFPVGAYIADN-------ILQAVESSRR--TIMVLSENFIKSEWCRFEFK-------------------------------TVLLGHGLIGG-----GYVPLLAAILVAIIGTALIVALACVFRQDVRLWAHARYGVRLVKDPIIVGGRKEP--DSDRLYDCYLVHSVHDSDFVGRLLGAELQL--HGYSVCQHHRDVHPGA--FLADS-----LQSAADSARK--LLLVVSMNFLQTEWSQPQFR-------------------------------TATVQRTIINDD--FIDYLPLLIAVLAGLVLTIMLVALVVLFRQDVCLWAHSRYGVRLCKDPLTALERCE---DSEKLYDAYLLYSAADADLVTSQIGQELEH--HGYGMCLHYRDVHGGAG-FLGDT-----VQSAADASRK--LVLFVSVKFLQLEWSQPEFR------------------------------------TTSVIETRPLEAYLPLLLATAVLIFAMVALVCGAFRHRRTLRTWAASRCG-LRACYKTAAFE------DQEKPFDAYISYSAVDESFVSTILVPGLET---SYRLCLHYRDLGAGSNVADA-------VAEAADSSRR--TILVLSKNFLHGEWARFEFKGRSDEEERREKHGNESSASCTGAASAENDAHRNLTKT--IIEKQVLQDYLPLLVTTLVASSLVVLLCLLGFVFRQEFRVWFHSRFG-VRIFY-RSHEVDRD---DRDKLFDAFISYSSKDEAFVAEELAPVLEMGNPSYKLCLHYRDFPVGSFIADT-------IVQAVESSRR--TIMVLSENFIKSEWCRFDFK--------------------------------GIQEIPLLGG-----NLVPLLAGALVAVIAISLFVALAFAFRQDVRLWAHARYGLRLGKTSAPPDEERD------RLYDGYIVYSERDEDFVSRFLAAELEQ--SGLALCLHWRDLPPAR---AQEA-----VPPAAAAARR--IVIIFSPVFLANEWQHAEFR--------------------------------------MRAICFYERLPVYAGVAASLCFLLILILVVLYYRYRNEILVIMYSSG--------WFSCCLIEDELDKDKRYDVFISFAYGDSSFVSDTLLPRLEGPPNEFSACVHYRDWVPGNWVPAL-------IAHSVAQSRR--TIIVLSKNFLSSVWALLEFR--------------------------------------ECSSFVTVTVSLIS----ALALLAVMVAVTAGCGMRPEMRLRVKVLLLR-----LGWLPRRPEP--DDGRRFDAFVSYAHEDE-AVVEELVKRLEVG-HGYRLCLHYRDWPPGEWIHV-------QIAASVQAARR--TLIVVSRHFLRSKWARQEFR--------------------------------------ECSSALVVATSLIS----ALALLAVMVAVTAGCVMRPEMRLRIKVLLLR-----LGWLPRRPEP--DDGRRFDAFVSYAHEDE-AVVEELVKRLEVG-HGYRLCLHYRDWAPGEWIHV-------QIAASVQASRR--TLIVVSRHFLRSKWARQEFR--------------------------------------------------QYKLIALILLPCVLLPLLMLFVFRRTIFYFLIMMRN---SAALTMINKDKTGVDGTIFNYDVFVSYCNEDRVWVLDHLLPQLESN-CNISVCLHERDFQIGLSILEN-------IVACMDRSRA--IMLIISKRFLMSQWCQFEMH--------------------------------IKTLRCLMTEKMTNIMYLVWTAPSLVAVALILFIIVFIFKFKTYIRYWMFLAKLALGRNFRRKSGKHVET---KDYKYDAFISYCSEDRDFVVHMIN-NLELEPPFLKLCVYERDFDIGSFISEA-------VLKSVNESKY--VILVISNGFAKSQWCRWETQ-------------------------------------------IRVLTISAIILGLCVMYAVITMAYYIYKCRAYETLKWKLSLLS---------------KKGIRIIEQELIIRYSEKDEEFVMKEILPTLKN---EKNLKVYTNAIRCPSDISPD------NLKTCVKDAYKYTTLIVFSPNYLTTAYSNVDIK--------------------------------MVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHN--------LLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPEN-------IMRSVADSRR--TIIVLSQNFIKSEWARLEFR--------------------------------------HIVCPSDLFYYLAL----AISLVATIIALNFLIWFRQPVLVWFYEHGVC-----LSLSAKR-EL--DKDKRFDAFLAFTHKDE-ALLEEFVDRLERGRPRFQLCFYLRDWLAGESIPD-------CIGQSIKDSRR--IIVLMTENFMNSTWGRLEFR--------------------------------------TDICPSVLIYYTSL----AVSLLIIALSINVFICFRQPIMIWFYEHEIC-----LSLAARR-EL--DEDKKYDAFLSFTHKDE-DLIEEFVDRLENGRHKFRLCFYLRDWLVGESIPD-------CINQSVKGSRR--IIILMTKNFLKSTWGRLEFR-------------------------------------QMEAFELCPSYVLLISCVVGGLVIVICLLTVFYLMFQQELKIWLYNNN--------LCLWWVSEEELDKDKTYDAFISYSHKDE-ELISKLLPKLESGPHPFRLCLHDRDWLVGDCIPEQ-------IVRTVDDSKR--VIIVLSQHFIDSVWARMEFR-------------------------------------------TVIAVMGSLVGACILGFIIYLKRWHIHYYYSSLKSAALLSSAS-----KESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEET-GDVSICLHERDFQIGVTILDN-------IISCMDRSYS--LMLIISSKFLLSHWCQFEMY-----------------------------------MTLSDLCVDRTHMIVLTCVIVSVVACLVAALSLVYYTYKLELKVWLFKHG--------LCLWLVAEEELDRDKLYDAFVSYSHKDEAFITEHLVPTLERDPMNFKLCWHVRDWTPGEMISSQ-------ISSSVEQSRR--TIIVLSSSFLESLWGQLEFR--------------------------------------ELCAWLTLFRLYIVSAAVAVAFIGCILTIWLYVKYNLEIKVWLFKHNL------LQWFATEEQI--DMNKRYDAFISYSHKDEEFVTKELLPKLESEELNFKICWHVRDFMPGEMIAN-------EITKAVEESRR--TIIILSLNYLESVWGQIEFS--------------------------------------DLCAWPTTLKFYIS-AAVSLVLAACLLAIWLYMKYSLEIKVWLFKHNL------LQWLVTEEQI--DMDKRYDAFISYSHKDEEFVTDQLLPRLESEELNFKICWHVRDFMPGEMIAT-------QITKAVEDSRR--TIIILSLNYLESVWGQMEFN--------------------------------------ELCGTIILSRLYIS-VAVSMASVGCLLCIWLYAKFNLAIKVWLFRHNL------LQWLVTEEHT--DMNKRYDAFISYSHKDEDFVTKELLPRLESEELNFKICWHVRDFVPGEMIANELLYYSFQIAKAVEESRR--TIIILSLNYFESMWGQMEFS--------------------------------------HTLVYILVSVAVSFLILTGVGLFYYWFHIKYFFKIMKNSAVLSFFNDE-------KLYLDKSGLLKEADFHYDVFVSYSNADRSWVLDHLLPNMEG-VSQINLCLHERDFEVGYGILEN-------IISCMDRSRC--LMLIVSESFLLSHWCQFEMH-----------------------------------MTEADFCPTYTTLIILLSLSLAVSGMIIGLLAAIYYRYQREIKVWLYAHQF--------CLWLITEDELDKDKLYDAFISYSHKDEDFVVNELVPKLENGPKPFKLCLHFRDWLAGEWIPTQ-------IARSVEESRR--TIVVLSPNFLESVWGRMEFR

: 1152: 1107: 1106: 1105: 1147: 1111: 1137: 995: 1121: 1189: 1174: 1153: 1151: 780: 1158: 1104: 1108: 1134: 1154: 1121: 618: 496: 838: 680: 787: 689: 936: 900: 1051: 720: 827: 974: 829: 876: 912: 745: 910

BmToll6 1153 :BmToll7-1 1108 :BmToll7-2 1107 :BmToll7-3 1106 :BmToll8 1148 :BmToll10-1 1112 :BmToll10-2 1138 :BmToll10-3 996 :DmToll2 1122 :DmToll6 1190 :DmToll7 1175 :DmToll8 1154 :AgToll6 1152 :AgToll7 781 :AgToll8 1159 :AgToll10 1105 :AgToll11 1109 :AmToll6 1135 :AmToll8 1155 :AmToll10 1122 :BmToll3-1 619 :BmToll3-2 497 :BmToll3-3 839 :BmToll9-1 681 :BmToll9-2 788 :BmToll12 690 :DmToll1 937 :DmToll3 901 :DmToll4 1052 :DmToll5 721 :DmToll9 828 :AgToll1A 975 :AgToll1B 830 :AgToll5A 877 :AgToll5B 913 :AgToll9 746 :AmToll 911 :

TALHEVLKE-----RRRRLIIILLGD--IPNRDIDPELRLCLKAN----TCIEWGDRQFWQKLRFAMPQALQKALRK-----NPNKLIIVAVGP-VP----RDPELKSYFKTG----LEITWKEKRFWERLRYAMPQGLHEALKG-----CIYKLVLIEECS-VVADAMCDPDLRPYLKTG----SRLRWGQKGFWERLRYIMPQALHEIVKS-----RIYTLVIIEEGS-ILPEAECDPDLRPYLKTS----SRIRWGQNKFWEKLRYAMPSAMTHVLRD-----RRKRLIVVLLGQ--VSQKDLDQDLRLYIKTN----KCLNANDRLFWEKLKFALPNIFFGYLKSLN-RSESNKVIFINIVDNIQLSDELCFALDKFKNIS--------WNDPRFWDRFMVLLNAAIKHVITTIHPSIRRHRVVFILTTD--VSALNLDVDFQSYLKTC----NVLLWGEKKFWEKIRFVMPAAVQSAINSVNVRHRRQKIIFLVTTD--LSGINIDPDLKVLLKTC----TVIVWGERNCWEKLNFRLPNAFHESLRG-----LAQKLVIIEETS-VSAEAEDVAELSPYLKSVPS--NRLLTCDRYFWEKLRYAIPSALHELVK------RRKRVVFILYGD--LPQRDIDMDMRHYLRTS----TCIEWDDKKFWQKLRLALPRSVHDALRG-----RPQKLVIIEEPE-VAFEAESDIELLPYLKTSAV--HRIRRSDRHFWEKLRYALPSAHQSVLRD-----RRRRLIVIVLGE--VPQKELDPDLRLYLKTN----TYLQWGDKLFWQKLRFALPGAIHEVLK------RRRKLIIILYGD--LPQRDLDADMRLYLRTN----TCIEWDDKKFWQKLRIALPRAVHDALRG-----RPHKLVVVEEGGGVLLEAENDVELVPYLKTTTV--TRVRRGDRHFWEKLRYALPSAHHQVLRD-----RRRRLIVILLGE--VPQKDLDPDIRLYLKTN----TYLQWGDKLFWEKLRFALPVALQSVIESIRPAHRRHKIVLVLTAP--VEIVAMDPIMHLLIRTC----TVACWGERKFWDKLRYALPAALQAALELIRPSRRKQRIVLITSVP--GSMLAMDPIMDILARTC----TVIAWDDRRFWDKLRFAMPAALRDALKG-----KGRSVILLLVGG--VCPRDLDADLKKRISSH----TVLVWGDKLFWQKLRFAMPSAHHQVLRD-----RRRRLILVLVGD--VHQRDLDPDIRLYLKTN----TYLQWGDKLFWEKLRFALPAALRTALESIRPGSRKRRVVVLLAT----EAPARDPEFQLLLQTC----TVVVWGEKRFWEKLRFAMPTAHVQALED------GRVRLIVILLDDVTNDARIDDELRAYLSTN----TFIRWGDALFWNKLLYALPQAHAAALRD------VTPRLVLLFLEPPHRLP-LDAELRSYIRIN----TYLLWTDPWFWHKLKLALPQAHAAALRD------IIPRLVLLFLEPPHRLP-LDAELRSYIRIN----TYVLWTDPWFWHKLKLALPLAQHRLLET------RRNDLILVLLEEIPRRIRPTTLHYLMLTKTYIIWPKVAHERNIFWRRLRKGLVLAEYHRIFLEDG---TSYDPLVLVRIGDVQNKYLTTTLKYLLKTKIYH-TWDENNQDEFWKKLRNVLTKIHSEMLKA---------EYTVYVFVDIGPENFLYVFLKSQRDTN----TMVVWGEANFWLKFLVTLAAAHRSALNE------GRSRIIVIIYSDIGDVEKLDEELKAYLKMN----TYLKWGDPWFWDKLRFALPLALHATSRD------RCKRLIVVLYPNVKNFDSLDSELRTYMAFN----TYLERSHPNFWNKLIYSMPLALHATSRD------RCKRLIVVLYPDVEHFDDLDSELRAYMVLN----TYLDRNNPNFWNKLMYSMPIAYQATLQD------KRKRIIIILYRELEHMNGIDSELRAYLKLN----TYLKWGDPLFWSKLYYAMPLAQHRIFEVS-----KEHLILVFLEDIPRRKRPKTLQYLMDVKTYIK-WPTAKEDRKLFWKRLKRSLETAHLQSMAE------RRNRLIIIIYGDIGNIYDLEPELRAYLHTN----TYVRWGDPWFWDKLRFAMPTAYLQSLAD------KCNRVIPIIYQDIGDIEQLDPQLQAYLKTN----TYVRWDDPWFWEKLHYAMPTAYLQSLED------KRNRVIPIIYQDIGDIDQLDPELRAYLKTN----TYVRWDDPWFWDKLHYAMPAAYLQSLVD------KHNRVIPIIYQDIGDIDQLDPQLRAYLKTN----TYVRWDDPWFWDKLHYAMPLAQHRLLET-----RRDELILVLLEDIPRRKCPKTLSYLLKTKTYIKWPTKSVHEQALFWKRLHKTLLVAHCQALSE------RRSKVILILYDEIGPINNLDPELKAYMSMN----TYVKWGDPWFWDKLRYALP

: 1209: 1161: 1164: 1163: 1204: 1170: 1199: 1057: 1181: 1245: 1234: 1210: 1207: 841: 1215: 1166: 1170: 1191: 1211: 1181: 676: 553: 895: 742: 851: 744: 994: 958: 1109: 778: 889: 1032: 887: 934: 970: 808: 968

TIR domainTM

Fig. S15 A (Cont. 3)

Page 5: Fig. S15 A · 2010. 10. 11. · BmToll6 669 : BmToll7-1 630 : BmToll7-2 624 : BmToll7-3 623 : BmToll8 647 : BmToll10-1 643 : BmToll10-2 650 : BmToll10-3 508 : DmToll2 645 : DmToll6

DmToll6AgToll6

BmToll6

1000

AmToll6

998

DmToll8AgToll8BmToll8

AmToll8

898

905

1000

1000

DmToll7AgToll7

DmToll2

1000

BmToll7-2BmToll7-3

BmToll7-1

1000

1000

985

1000

1000

AgToll10AgToll11

AmToll10

1000

BmToll10-3BmToll10-2

979

960

BmToll10-1

1000

680

997

BmToll9-2AgToll9DmToll9

BmToll9-1

859

1000

BmToll12BmToll3-3

BmToll3-2DmToll3

DmToll4

1000

1000

BmToll3-1

972

DmToll5

696

AgToll1BAgToll5B

AgToll5A

1000

AgToll1A

1000

AmTollDmToll1

737

527

297

373

581

694

749

1000

0.05

Fig. S15 B


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