figure 1 regulation of systemic functions by signaling through g protein pathways. s r neves et al....
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Figure 1 Regulation of systemic functions by signaling through G protein pathways.
S R Neves et al. Science 2002;296:1636-1639
Published by AAAS
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Backpropagation of action potentials (APs)in different morphologies with identical channel types and distributions
Philipp Vetter, Arnd Roth and Michael Häusser J Neurophysiol 85:926-937, 2001.
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Sensitivity of backpropagation to voltage-gated channel density in different cell types
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Morphological determinants of backpropagation. A: relationship between the number of dendritic branchpoints and gNa,thresh
B: rate of increase in membrane area withdistance from the soma (dA/dx)
C: relationship between the maximum slope of the smoothed dA/dx distribution and gNa,thresh
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Forward propagation depends on dendritic geometry. A–C: forward propagation of a dendritic AP was simulated successively at all dendritic locations in a nigral dopamine neuron (A), a layer 5 pyramidal cell (B), and a cerebellar Purkinje neuron (C)
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Dendritic Plateau Potentials
X. Cai, C.W. Liang, S. Muralidharan, J.P. Kao, C.M. Tang and S.M. Thompson Neuron 44 (2004), pp. 351–364
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Block of SK Channels in Distal Dendrites Facilitates the Triggering of Action Potential with Dendritic Glutamate Application
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Apamin-Sensitive Ca2-Activated K Channels in the Distal Dendrites Are Responsible for Repolarization of Plateau Potentials
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Nickel-sensitive T-type and apamin-sensitive SK channels maintained the high precision of pacemaker spiking in dopaminergic neurons.
Wolfart J , Roeper J J. Neurosci. 2002;22:3404-3413
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Inhibition of T-type channels evoked bursting in a subpopulation of
dopaminergic midbrain neurons.
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Focal activation of mGluRs induces a wave of Ca2+
Morikawa H, Khodakhah K, Williams JT J Neurosci. 2003 Jan 1;23(1):149-57
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Simultaneous blockade of IP3- and cADPR-induced signaling inhibits mGluR IPSCs. A, Intracellular dialysis of both heparin (1 mg/ml) and 8-NH2-cADPR (50 μm) nearly abolished mGluR IPSCs. The cell was first recorded with a control internal solution to obtain a control
IPSC amplitude (IPSC1) at ∼10 min after the onset of recording.
Morikawa H et al. J. Neurosci. 2003;23:149-157
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Proposed intracellular signaling cascade mediating the mGluR-induced Ca2+ mobilization.
Morikawa H et al. J. Neurosci. 2003;23:149-157
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Block of SK channels increases the firing rate of Purkinje neurons.
Womack M D , Khodakhah K J. Neurosci. 2003;23:2600-2607
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SK channels affect the action potential afterhyperpolarization in Purkinje neurons.
Womack M D , Khodakhah K J. Neurosci. 2003;23:2600-2607
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Block of SK channels increases the firing rate but maintains the trimodal pattern in cells that have the trimodal pattern of activity.
Womack M D , Khodakhah K J. Neurosci. 2003;23:2600-2607