Foundation Institute Neurological DiseasesF.I.N.D.cures.net

“Finding Cures, Building Hope”Presented By Mark Colo

Director / SecretaryPrepared for Our Valued Donors

Market SummaryWhat is a Neurological Disease

• The brain, spinal cord, and nerves make up the nervous system. Together they control all the workings of the body.• A neurological disorder is any disorder of the body nervous system. Structural, biochemical or electrical abnormalities in the brain,

spinal cord or other nerves can result in a range of symptoms. • Direct causes may include genetic disorders, congenital abnormalities, infections, lifestyle, environmental health such a malnutrition,

brain injury, spinal cord injury and nerve injury. • Indirect causes from other areas of the body may include blood vessel disorders, cardiovascular problems, autoimmune

abnormalities leading to neurological deterioration. • Neurological disorders can be categorized into two categories, Central Nervous System Disorders and Peripheral Nervous System

Disorders. • There are more than 600 neurologic diseases known to man.

Market Summary

• A United Nations report in 2007 found that nearly 1 in 6 (17%) of the world’s population suffer from a neurological disorder of some sort.

• Neurological Diseases receive the second most funding behind cancer research which is still the #1 most funded disease.

• In 2015 the U.S. burden of disability caused by neurological diseases was 320 Billion dollars. The donations raised by Neurological Foundations equated to 3.2 Billion dollars, equal to just 1% of the cost.

• Neurological Disease represents 6.3% of the Global Burden of Disease. (G.B.D)

• The Neurological Diseases that account for the largest percentage of Disability Adjusted Living Years (D.A.L.Y) is Alzheimer’s, Parkinson’s, Multiple Sclerosis, Epilepsy, Autism, Stroke, Concussion and Major Depression Disorder.

Neurological Disease (N.D.) Statistics

Impact of the U.S. Economy

2015 2020 2025 2030

320 B

422 B524 B

640 B

Time

U.S.

B.D.

Cos

t in

Bill

ions

The United States Burden of Disability (U.S.B.D) – Nearly 14 million people living in the U.S. suffer from life altering neurological diseases at an economic cost of more than $320 Billion. That figure will double in the next 15 years.

Where is the Money Going?

Injury - Traumatic brain injuryMigraines

Multiple SclerosisNeurosciences

Parkinson's DiseaseMajor Depression Disorder

Sleep ResearchStem Cell Research

Stem Cell Research - Embryonic - HumanStroke

SuicideSix Year Donation Trend

Alzheimer's Parkinson's Multiple Sclerosis Stroke Concussion Autism MDD 2011 2012 2013 2014 2015 2016

D.A.L.Y.’s Based on Income Level

Epliepsy

Alzheimer's

Parkinson's

Multiple Sclerosis

Stroke (C.V.A.)

Concussion (T.B.I.)

0 200 400 600 800 1000 1200

Disease Frequency by Income Bracket

High Upper Middle Lower Middle Low

Sample Size100,000 Patients

Dise

ase

Freq

uenc

y

Income

Financial Impact to Family (F.I.F.) in Lost Income

Epilepsy Alzheimer's Parkinson's Muliple Sclerosis Stroke (C.V.A) Concussion (T.B.I.) Average0100000200000300000400000500000600000700000800000900000

1000000

$597,298.00

$831,024.00

$457,063.00 $447,838.00

$779,085.00 $779,085.00$648,566.00

Lost Income due to Neurological Disease

U.S. Median Income $52,000. Lost Income

1. The patient first notices something is not right. You may discuss your symptom with a close friend or loved one. Unsure of the friendly diagnosis's your receiving, you schedule an appointment with your general M.D for an opinion.

2. Your Doctor asks a few questions, considers your symptoms and then refers you to a (Neurologist) who in most cases “Generalist’s” in neurology.

3. The Diagnosis – After a few tests the Neurologist states his most likely diagnoses. Bob, this looks like you have Alzheimer's. The patients words that follow may include explicative adjectives or expressions of doubt. Fear, disbelief, bitterness, and shock are common emotions that soon surface.

4. Following your second, third or fourth opinion with credentialed specialists, the reality sets in that your diagnosis is accurate and your life is about to change significantly. In most cases the emotional acceptance and adjustment may take several months or as long a one year.

5. You then consider your options – Do Nothing, Go Organic, Take Medications, Take my life? (Never an option!).

6. It’s not atypical for patient the patient to meet with a Psychiatrist to order an (Anti-Depressant)

“The Diagnosis”

A Common Sequence of Events

1) Financial – How and when will this impact my income? Can I cover my future expenses? What cash flow will I need to Survive? Do I need to change my financial portfolio from aggressive to conservative?

2) Protection – Is my Living Trust up to date? Do I have a Medical Directive in place? Are my assets protected from probate? Are there any tax loop holes I can leverage to pay less in taxes?

3) Relocation – When do I begin looking for a lower cost of living community. What goods can I liquidate and what expenses can I eliminate? When should I engage a Realtor or Van Line agent for cost estimates.

4) Education – Aside from educating oneself of his or her neurological condition. The significant other or family members often recognize the need to increase their income to support their loved one.

5) Research – The patient is in a much better place than they were a month ago, hope comes slowly, but surely. At this stage the patient becomes curious about their condition and begins learning more about treatment, proper exercise, nutrition, preventative measures and any medical breakthroughs on the horizon.

The Only Constant is Changeand Change Begets Decision Making

Decisions of Paramount Importance

FINDcures is a 503 (c) Non-Profit Organization and the premier Neurological Disorder Foundation whose business model is built primarily around life transitional support services. Our first priority is the emotional and physical wellbeing of the patient, our second priority is to find cures for the Octagon of Diseases we target. Our objective is to build a “Perimeter of Hope” around every patient we serve. Beginning first by providing effective coaching and immediate support in conjunction with the patients initial diagnosis, second by addressing their financial concerns (Such as Financial Planning and Living Trusts), third in offering assistance for their legal concerns (i.e. Taxes & Probate), fourth by addressing their cost of living concerns (i.e. downsizing and relocation needs) fifth by providing family educational assistance (i.e. School grant’s and paid tuition) to afford family members an avenue to increase income and support their loved one, and sixth by providing ongoing informational support regarding research, treatments and potential cures for the patient’s particular disease.

Our driving commitment is to “FINDcures and Build Hope” in everything we do.

Who are we and how can we Help?

The FINDcures Family of Funds

Patient

Financial

Legal

RelocationEducation

Research

Where do your donations go? Financial Planning -Living Trust, Medical Directive

Protection – ProbateTaxes, Estate Planning

Downsizing – Cost of Living Adjustment, Real Estate, Rental Search, Van Line and D.I.Y. Moving

School Grants, Paid Tuition, Books & School Resource Subsidy

Find Cures for the Diseases we Target

15%

15%

15%15%

25%

Our Business Model

Building a

“Perimeter of Hope”

“Finding Cures Bringing Hope”

Our Targeted Diseases

“The Octagon of Diseases”We Target

“Finding Cures Bringing Hope”

Alzheimer’s Disease

Alzheimer’s Disease

• Approximately 100 000 patients die with AD each year, making it the fourth leading cause of death in the US.

• Prevalence also increases exponentially with age, rising from 3% among those 65–74, to almost 50% among those 85 or older

• In terms of total costs to society, AD is the third costliest disease in the US after cancer and coronary heart disease

• Average annual costs of caring for patients with AD have been estimated at US$80–100 billion in the US

• 5.4 million people in the US have Alzheimer’s disease (AD). one new case appearing every 33 seconds

• By 2025 the direct cost to American society will be about $307 Billion

• 60% of Alzheimer’s patients are cared for by family members and loved ones. These caregivers rate the emotional stress of caring for their loved one as high or very high.

Parkinson’s Disease

Parkinson’s Disease• It’s estimated that 1 million people in the U.S. have Parkinson’s and 50,000 new cases are diagnosed in the US each year.

• The true prevalence of Parkinson’s disease is difficult to assess, because the disease is far advanced before the diagnosis is made.

• The P.D.B.D. in the United States from Parkinson’s Disease is around 25B

• Medication costs for PD patient average $2,500 a year, and therapeutic surgery can cost up to $100,000 dollars per patient

• Incidence of Parkinson’s increases with age, but an estimated four percent of people with PD are diagnosed before age of 50. There is on average a 2/1000 – 4/1000th of one percent chance of being diagnosed with Parkinson’s Disease. That meant the odds of me getting Parkinson’s before age 50 was represented by this number: .000008, I beat the odds! Does anyone want to join me in Las Vegas?

• Parkinson’s robs the patient of rem sleep, is asymmetrical (affecting one side of the body more than the other) produces chemical depression, affects speech, swallowing, cognitive thought, and memory. It is often described as a glacier, it’s large, immovable, continues on its forward motion and nothing yet can stop it. Common visual symptoms include: tremor, balance issues, tight facial muscles, a stern look and minimal blinking. Parkinson’s patients make the best extra’s in the T.V. series “The Walking Dead”.

Multiple Sclerosis

Multiple Sclerosis (M.S.)• In the United States, MS affects approximately 400,000 people. 200 new patients are diagnosed every week.

• M.S. is the breakdown of Myelin, a substance that protects nerve cells. Without Myelin the body attacks itself causing scare tissue referred to as sclerosis.

• M.S. causes remissions and relapses referred to as exacerbations.

• The disease affects critical thinking, memory, concentration, problem solving and spatial relations leading to frustration, depression and anger.

• Known as the “Silent or Invisible Disease”, M.S. is often hard to detect in the patient.

• Patients are advised to “Stay Cool” because heat has been known to spike symptoms.

• Without disease modifying therapy about 1/3 of the people diagnosed with M.S. will be in a wheel chair within 20 years.

• Women are twice as likely to have the disease verses men.

Epilepsy

Epilepsy• Epilepsy is a sudden electrical surge to the brain. It’s been described as a tightening of the muscles to beyond the point of

discomfort and then bashing your appendages against a solid object.

• 150,000 people are diagnosed with Epilepsy in the U.S. annually. 1 in 26 people will be diagnosed with Epilepsy during their lifetime. There are 2.5M people living in the U.S. with Epilepsy.

• Hippocrates wrote the first book on epilepsy in 400BC. He claimed that people with epilepsy did not have the power of prophecy.

• It’s a fallacy that one can swallow the tongue during an Epileptic occurrence. Don’t put anything in the mouth.

• The official color for Epilepsy Awareness is Lavender

• There are about 1.2M people in the U.S. with Epilepsy.

• People do die from Epilepsy. About 22,000 to 42,000 deaths in the U.S. each year.

Stroke

Stroke (C.V.A.)• 80% of Strokes are preventable. On average, one American dies from stroke every 4 minutes.

• Stroke is a brain attack, it occurs when blood flow to an area of brain is cut off.

• Every year, more than 795,000 people in the United States have a stroke.

• There are nearly 7 million stroke survivors in the U.S. Stroke is the 5th leading cause of death in the U.S.

• Stroke costs the United States an estimated $34 billion each year.

• Temporary stroke symptoms are called transient ischemic attacks (TIA). They are warning signs prior to actual stroke and need to be taken seriously.

• Family history of stroke increases your chance for stroke.

• The country's highest death rates from stroke are in the southeastern United States.

Concussion

Concussion (T.B.I.)• Most cases of traumatic brain injury are concussions.

• In 2010 there were approximately 2.5 million traumatic brain injuries in the U.S., they accounted for 30% of all injury related deaths with direct and indirect costs totaling 76.5 Billion dollars.

• In the US, athletes suffer from roughly 300,000 concussions every year.

• High school football accounts for 47 percent of all reported sports concussions, with 33 percent of concussions occurring during practice. After football, ice hockey and soccer pose the most significant head health risk.

• A professional football player will receive an estimated 900 to 1500 blows to the head during a season.

• Impact speed of a professional boxers punch: 20 mph.

Impact speed of a football player tackling a stationary player: 25 mph.

Impact speed of a soccer ball being headed by a player: 70 mph.

Major Depressive Disease

Major Depressive Disorder (M.D.D) • According to CDC, 9% of all adults in the U.S, are depressed at least occasionally, 3.4% of people suffer from major depression. 60% of

people who die by suicide had depression or another mood disorder.

• The cost of depression in the U.S. (lost productivity and increased medical expenses) is $83 billion annually, the global cost over ones lifetime is estimated to be 2.6 trillion dollars.

• Depression often coexists with physical disorders common among the elderly, such as stroke, other cardiovascular diseases, Parkinson's disease, and chronic obstructive pulmonary disease.

• Nineteen percent of Americans will suffer from depression at some time during their lives.

• Causes of MDD include biological, psychological, and social factors caused in childhood impacting the individual’s view of the world.

• There are many different types of depression, the following are the most prevalent in our society: Major Depression, Persistent Depressive Disorder, Bipolar Disorder, Seasonal Affective Disorder, Psychotic Depression, Postpartum Depression, Premenstrual Dysphoric Depression, Situational Depression and Atypical Depression. Abraham Lincoln was believed to have suffered from Clinical Depression a major depression Disorder (M.D.D).

Advisory Board Members

Dr. Howard Federoff named CEO of UC Irvine Health Renowned physician, researcher is currently vice chancellor for health affairs

On January 21, 2016 Irvine, California, – Dr. Howard Federoff, vice chancellor for health affairs at the University of California, Irvine, has been named CEO of the UC Irvine Health system. His appointment, made by Chancellor Howard Gillman, was approved today by the University of California Board of Regents.

A Neurosurgeon for 25 years. Massimo “Mass” Fiandaca is currently an Associate Professor in Residence who oversees the Departments of Neurology and Neurological Surgery at UC Irvine. Now Co-Director of Dr. Howard Federoff' s Translational Laboratory and Biorepository (TLaB). Research focus on human blood-derived biomarkers of neurological disorders and traumatic brain injury.

Our Fundraising Goals

April 30th 2016 August 30th 2016 November 26th January 1st, 2017$0.00

$1,000.00 $2,000.00 $3,000.00 $4,000.00 $5,000.00 $6,000.00 $7,000.00 $8,000.00 $9,000.00

$10,000.00

Fundraising Goal

Thank You! For Your Participation

F.I.N.D.cures.net“Find Cures, Build Hope”