Natalia Zuleta Rendón

Medicine Student

3rd Semester

NER and repair

of mismatches

is the principal

defense

against UV rays

These

factors may

lead to incorrect

addition of

bases during

replication

TARGETING PTEN MAY PREVENT

SKIN CANCER

Phosphatase and tensin

homolog ( PTEN ) is

a protein that, in

humans, is encoded by

the PTEN gene .

Regulate of the cell

cycle , preventing cells

from growing and

dividing too rapidly

TARGETING PTEN MAY PREVENT

SKIN CANCER

The degree

of inactivation is

proportional to the

aggressiveness of

the disease, that is, the

less work the worse the

prognosis gene for the

patient.

TARGETING PTEN MAY PREVENT

SKIN CANCER Plays a role as a key modulator of the AKT-

mTOR signaling pathway controlling the

tempo of the process of newborn neurons

integration during adult neurogenesis. May

be a negative regulator of insulin signaling

and glucose metabolism in adipose tissue.

With the discovery of this gene could prevent

several types of cancer since its action is to

prevent cells from multiplying rapidly. Also

important to note that if there is a good

diet can increase your activity. This gene will

be a challenge to modern science as if it

can increase its activity was abolished many

cancers. (endometrial cancer, prostate and

breast)

ULTRAVIOLET LIGHT AFFECTS FUNCTION

OF PROTEIN IN EWING’S SARCOMA

The genetic circuitsaltered in cancerprocesses include theactivation or inhibitionof various genes andproteins.

In the case of Ewing'ssarcoma, EWS proteinalterations inducechanges in theexpression of variousgenes, thus affecting theability to detect andcorrect DNA damage.

ULTRAVIOLET LIGHT AFFECTS FUNCTION

OF PROTEIN IN EWING’S SARCOMA

The EWS protein stops being joined to the

genes it regulates and relocates to structures

located within the cell nucleus known as

nucleoli. The relocation results in changes in

the expression of the genes regulated by

EWS, and these changes are important for an

appropriate response to DNA damage.

ULTRAVIOLET LIGHT AFFECTS FUNCTION

OF PROTEIN IN EWING’S SARCOMA

UV radiation can also

produce pyrimidine

dimers (TT)

block transcription

which also leads to skin

cancer.

The DNA repair mechanisms are the most

active response to UV light. Without them we

could not expose any type

of radiation (solar or conventional light)

because it would be fatal for the skin. This

study can conclude that these

mechanisms should be preserved to

prevent many diseases and have a good

quality of life.

Through recentadvances humanitycould prevent andcure many diseases thatare deadly and havehigh prevalence.

With the manipulationof genetic material, DNAanalysis could knowthat disease willdevelop each person andwhat is the best way tocure them.

If they are

created more consistent treatment to

genetic damage, medicine could increase the

quality of life of patients, always

seeking wellness and cure disease with few

adverse effects.

For medicine is

very important to be hand

in hand with

advances genetic

Nothing

less eradicated multiple

cancers, congenital

diseases and diseases

caused by bad DNA repair

mechanisms.

MARTINEZ S., Lina Maria. Biología Molecular. 6 ed.

Medellín: UPB. Facultad de Medicina, 2011. 56 p.

Cancer Research (July 26, 2011). Targeting PTEN May

Prevent Skin Cancer. Science Daily. Retrieved August 11,

2011, from

http://www.sciencedaily.com/releases/2011/07/11072613

2351.htm

Journal Molecular Cell (August 3, 2011). Ultravioler Light

Affects Function of Protein Involved in Ewing’s Sarcoma,

Study Finds. Science Daily. Retrieved August 11, 2011,

from

http://www.sciencedaily.com/releases/2011/08/11080413

3444.htm