foodstuffs and their energy contents © michael palmer 2014
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Foodstuffs and their energy contents
© Michael Palmer 2014
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Carbon pools in carbohydrate and fat metabolism
© Michael Palmer 2014
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Triacylglycerol and its cleavage products
© Michael Palmer 2014
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Solubilization of fat by detergents
© Michael Palmer 2014
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Uptake and re-packaging of digested fat in the small intestine
© Michael Palmer 2014
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The lymphatics drain excess fluid from the interstitial space
© Michael Palmer 2014
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Chylomicrons are drained from the intestine through the lymphatics, bypassing the liver
© Michael Palmer 2014
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Lipoprotein lipase extracts triacylglycerol from chylomicrons
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Two activated forms of fatty acids
© Michael Palmer 2014
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Activation of fatty acids and transport to the mitochondrion
© Michael Palmer 2014
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Reactions in β-oxidation
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Shared reaction patterns in β-oxidation and TCA cycle
© Michael Palmer 2014
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The reaction mechanism of thiolase
© Michael Palmer 2014
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Utilization of propionate
© Michael Palmer 2014
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Organ relationships in triacylglycerol utilization
© Michael Palmer 2014
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Brown fat tissue
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Medium-chain fatty acids
● contain less than 12 carbon atoms
● low content in most foods, but relatively high (10–15%) in palm seed and coconut oil, from which they are industrially prepared
● triglycerides with medium chains are more soluble and more rapidly hydrolyzed by gastric and pancreatic lipase
● not efficiently re-esterified inside intestinal cells; systemic uptake mostly as free fatty acids
● reach mitochondria by diffusion, without prior activation to acyl-CoA and acyl-carnitine
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Ketone body metabolism
© Michael Palmer 2014
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Synthesis of acetoacetate and β-hydroxybutyrate
© Michael Palmer 2014
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Decarboxylation of acetoacetate
© Michael Palmer 2014
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Acetone can serve as a precursor for gluconeogenesis
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Anticonvulsant effects of acetone and acetol
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The acetyl-CoA carboxylase reaction
© Michael Palmer 2014
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The structure of fatty acid synthase
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Phosphopantetheine acts as a flexible tether in acyl carrier protein
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Fatty acid synthase reactions (1)
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Fatty acid synthase reactions (2)
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Mitochondrial export of acetyl-CoA via citrate
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Mitochondrial export of acetyl-CoA via acetoacetate
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Elongation and desaturation of fatty acids
● elongases reside in mitochondria and endoplasmic reticulum
● chemistry of elongation similar to β-oxidation in mitochondria, similar to fatty acid synthase in the ER
● desaturases occur in the ER, introduce double bonds at various positions
● double bonds are created at least 9 carbons away from the ω end—ω-3 fatty acids cannot be formed and are therefore essential
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Cerulenin, an antibiotic that irreversibly inhibits fatty acid synthase
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Fatty acid synthase inhibition slows tumor growth in mouse experiments
© Michael Palmer 2014
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The glyoxylate cycle
© Michael Palmer 2014
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Reactions in the glyoxylate cycle
© Michael Palmer 2014