free paper session - usg and clinical assessment of peripheral enthesitis in indian spa pts - dr...
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![Page 1: FREE PAPER SESSION - USG and clinical assessment of peripheral enthesitis in Indian SpA pts - Dr Saumya Ranjan Tripathy](https://reader034.vdocument.in/reader034/viewer/2022042906/58a30c871a28abea508b6e5f/html5/thumbnails/1.jpg)
Ultrasonographic and clinical assessment of peripheral enthesitis
in Indian spondyloarthritis patients
Dr Saumya Ranjan Tripathy Senior Resident, Department of Rheumatology
KGMU, Lucknow
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Disclosures
• No disclosures
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Background • Enthesitis is hypothesized to be the primary manifestation of
spondyloarthritis1
• Ultrasonography (USG) is an emerging tool to detect enthesitis
• Data on prevalence of enthesitis detected by USG in spondyloarthritis from India is lacking
1. Danda D, Shyam Kumar NK, Cherian R, Cherian AM. Enthesopathy: clinical recognition and significance. Natl Med J India.2001;14(2):90-92.
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AIMS AND OBJECTIVES
1. Determine the prevalence of enthesitis in spondyloarthritis patients clinically and using ultrasonography
2. Correlate ultrasonographically detected enthesitis and clinical enthesitis (MASES enthesitis score)
3. Correlate ultrasonographically detected enthesitis with various disease activity scores
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Methods
Inclusion criteria:• Patients satisfying ASAS
criteria for axial and/or peripheral spondyloarthritis
• Age 16-45 years
Exclusion criteria:• Trauma involving entheseal
sites• Diabetes mellitus• Previous surgery involving
knee or ankle• Corticosteroid injections at
the sites under evaluation in the last 6 weeks
• Peripheral neuropathy of lower limbs
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Methods
B-mode settings used• Dynamic range (40-50dB)• Gray Scale frequency
(10-13 MHz)• Gray Scale gain (50-80 dB)
PD mode settings used: • Pulsed repetition frequency
(400-800 Hz) • PD-gain (highest possible
gain with minimum background noise)
Sonography with multi-frequency linear-array transducer (8-13MHz) of Logiq E; GE Medical Systems Ultrasound machine.
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Methods The following entheseal sites were screened bilaterally:
1. Plantar fascia insertion on calcaneus 2. Achilles tendon insertion on calcaneus3. Quadriceps tendon insertion on superior pole of patella4. Patellar tendon origin from inferior pole of patella5. Patellar tendon insertion on tibia
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Methods • USG parameters evaluated (Terslev et al, 2014 OMERACT
definitions):Sl. no. Parameter Presence Absent
1 Erosion 1 0
2 Increased thickness 1 0
3 Hypoechogenicity 1 0
4 Intra-tendinous calcification 1 0
5 Enthesophyte 1 0
6 Power Doppler signals (grade) 1-3(as per Kiris et al ,
2006)
0
USG SCORE TOTAL
PD SCORE ∑ (power Doppler grades @ all sites)
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Methods • Clinical evaluation of peripheral enthesitis using MASES
(Maastricht Ankylosing Spondylitis Enthesitis Score)
• Prevalence of clinical and USG- detected enthesitis was estimated and compared
• Spearman’s correlation co-efficient was used to co-relate clinically and USG- detected enthesitis with MASES score, BASDAI, BASFI and ASDAS-ESR.
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Results
• Fifty-two spondyloarthritis patients were recruited
Distribution of patients
Ankylosing Spondylitis (n=37)
Psoriatic arthritis (n=11)
Reactive arthritis (n=2)
IBD associated arthritis (n=2)
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Results
0204060
Comparison between enthesitis detected clinically & by USG
Number of patients
94 %
69 %P <0.01
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Representative USG images
Increased thickness and hypoechogenicity @ Achilles tendon
Erosion @ Achilles tendon in longitudinal and transverse planes
Intratendinous calcification and enthesophyte@ Achilles tendon
INTRA TENDINOUS CALCIFICATION
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Representative USG images(POWER DOPPLER)
@ Achilles insertion Calcaneal insertion of Plantar fascia
@ Distal insertion of patellar tendon
on tibia
@ Proximal origin of patellar tendon from patella
@ Quadriceps tendon insertionon patella
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Frequency of USG findings
Erosion
Increase
d thick
ness
Hypoech
ogenici
ty
Enthesophyte
IT calci
fication
Power doppler s
ignal
0
20
40
60
80
100
Total number of sites screened : 520 (52 patients X 10 sites each)
number of sites
28
92
65
2811
79
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Frequency of entheseal sites involved
Achille
s
Plantar
fasci
a
Quadric
eps
Patella
r tendon orig
in
Patella
r tendon in
sertion0
1020304050607080
Number of en-theseal sites
71
28 2834
25
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Correlation of USG scores and PD scores with MASES and disease activity indices
Correlation of USG score with BASDAI
0 5 10 15 200
2
4
6
8
10 r=-0.007p=0.96
USG Score
BAS
DAI
Correlation of USG score with BASFI
0
20
40
60
80 r=0.11,p=0.42
USG Score
BAS
FI
Correlation of USG score with ASDAS ESR
0
2
4
6 r=0.12,p=0.4
USG Score
ASD
AS E
SR
Correlation of USG score with MASES
0
5
10
15 r=0.14,p=0.29
USG Score
MAS
ES
Correlation of PD score with MASES
0
5
10
15 r=0.27,p=0.048
PD SCORE
MSA
ES
Correlation of PD score with ASDAS ESR
0
2
4
6 r=0.18,p=0.19
PD SCORE
ASD
AS E
SR
Correlation of PD score with BASFI
0
20
40
60
80 r=0.18,p=0.18
PD SCORE
BAS
FI
Correlation of PD score with BASDAI
0
2
4
6
8
10r=0.14,p=0.29
PD SCORE
BAS
DAI
USG-score and PD-score did not correlate with BASDAI, BASFI or ASDAS-ESR.
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Other important observations • PD-signals were positive in 69.2 % of Spondyloarthritis patients – Including 27 sites without any other clinical or USG finding
• One patient with clinical enthesitis did not have USG findings including power Doppler signals
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Discussion This observational study highlights
• The presence of subclinical enthesitis which may have future therapeutic implications
• Detection of subclinical enthesitis will help in diagnosis of spondyloarthritis
• However the study is limited by its small sample size
• Lack of correlation with activity indices needs further analysis
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Conclusion
• Ultrasonography including Power Doppler is better than clinical examination for detection of enthesitis
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Thank you