fundamental dosimetry quantities and concepts: review introduction to medical physics iii: therapy...
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Fundamental Dosimetry Quantities and Concepts: Review
Introduction to Medical Physics III: Therapy
Steve Kirsner, MSDepartment of Radiation Physics
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Some Definitions SSD SAD Isocenter Transverse (Cross-
Plane) Radial (In-plane) Sagittal Coronal Axial Supine Prone
Cranial Caudal Medial Lateral AP/PA Rt. & Lt. Lateral Superior Inferior RAO/RPO/LAO/LPO
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Fundamentals
Review of Concepts Distance, depth, scatter effects
Review of Quantities PDD, TMR, TAR, PSF
(definition/dependencies) Scatter factors Transmission factors Off-axis factors
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Distance, Depth, Scatter Distance
From source to point of calculation
Depth Within attenuating
media Scatter
From phantom and treatment-unit head
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Distance, Depth, Scatter
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Scatter Concepts Contribution of
scatter to dose at a point
Amount of scatter is proportional to size and shape of field (radius). increase with increase in length
Think of total scatter as weighted average of contributions from field radii. SAR, SMR
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Equivalent Square The “equivalent
square” of a given field is the size of the square field that produces the same amount of scatter as the given field, same dosimetric properties.
Normally represented by the “side” of the equivalent square
Note that each point within the field may have a different equivalent square
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Effective Field Size The “effective” field size
is that size field that best represents the irregular-field’s scatter conditions
It is often assumed to be the “best rectangular fit” to an irregularly-shaped field
These are only estimates
In small fields or in highly irregular fields it is best to perform a scatter integration
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Effective Field Size Must Account for
flash, such as in whole brain fields. Breast fields and larynx fields.
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Blocking and MLCs It is generally assumed that tertiary blocking
(blocking accomplished by field-shaping devices beyond the primary collimator jaws) affects only phantom scatter and not collimator or head scatter
Examples of tertiary blocking are (Lipowitz metal alloy) external blocks, and tertiary MLCs such as that of the Varian accelerator
When external (Lipowitz metal) blocks are supporte by trays, attenuation of the beam by the tray must be taken into account
It is also generally assumed that blocking accomplished by an MLC that replaces a jaw, such as the Elekta and Siemens MLCs, modifies both phantom and collimator (head) scatter.
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Effective Fields Asymmetric Field Sizes
Must Account for locaton of Central axis or calculation point.
There is an effective field even if there are no blocks.
…cax
Calc.Pt.
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Inverse Square Law
The intensity of the radiation is inversely proportional to the square of the distance.
X1D12 = X2D2
2
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Percent Depth Dose (PDD) PDD Notes Characterize variation
of dose with depth. Field size is defined
at the surface of the phantom or patient
The differences in dose at the two depths, d0 and d, are due to:
Differences in depth Differences in
distance Differences in field
size at each depth
0/ dd DDPDD
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PDD: Distance, Depth, Scatter Note in mathematical description of PDD
Inverse-square (distance) factor Dependence on SSD
Attenuation (depth) factor Scatter (field-size) factor
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PDD: Depth and Energy Dependence PDD Curves
Note change in depth of dmax
Can characterize PDD by PDD at 10-cm depth
%dd10 of TG-51
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PDD: Energy Dependence
Beam Quality effects PDD primarily through the average attenuation coefficient. Attenuation coefficient decreases with increasing energy therefore beam is more penetrating.
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PDD Build-up Region Kerma to dose
relationship Kerma and dose
represent two different quantities
Kerma is energy released
Dose is energy absorbed
Areas under both curves are equal
Build-up region produced by forward-scattered electrons that stop at deeper depths
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PDD: Field Size and Shape Small field sizes dose due to
primary Increase field size increase scatter
contribution. Scattering probability decreases
with energy increase. High energies more forward peaked scatter.
Therefore field size dependence less pronounced at higher energies.
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PDD: Effect of Distance Effect of inverse-
square term on PDD As distance increases,
relative change in dose rate decreases (less steep slope)
This results in an increase in PDD (since there is less of a dose decrease due to distance), although the actual dose rate decreases
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Mayneord F Factor The inverse-square term within the PDD
PDD is a function of distance (SSD + depth) PDDs at given depths and distances (SSD) can be
corrected to produce approximate PDDs at the same depth but at other distances by applying the Mayneord F factor
“Divide out” the previous inverse-square term (for SSD1), “multiply in” the new inverse-square term (for SSD2)
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Mayneord F Factor
Works well small fields-minimal scatter
Begins to fail for large fields deep depths due to increase scatter component.
In general overestimates the increase in PDD with increasing SSD.
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PDD Summary
Energy- Increases with Energy Field Size- Increases with field size Depth- Decreases with Depth SSD- Increases with SSD Measured in water along central axis Effective field size used for looking
up value
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The TAR The TAR …
The ratio of doses at two points:
Equidistant from the source
That have equal field sizes at the points of calculation
Field size is defined at point of calculation
Relates dose at depth to dose “in air” (free space)
Concept of “equilibrium mass”
Need for electronic equilibrium – constant Kerma-to-dose relationship
fsd DDTAR /
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The PSF (BSF) The PSF (or BSF) is a
special case of the TAR when dose in air is compared to dose at the depth (dmax) of maximum dose
At this point the dose is maximum (peak) since the contribution of scatter is not offset by attenuation
The term BSF applies strictly to situations where the depth of dmax occurs at the surface of the phantom or patient (i.e. kV x rays)
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The PSF versus Energy as a function of Field Size In general, scatter
contribution decreases as energy increases
Note: Scatter can
contribute as much as 50% to the dose a dmax in kV beams
The effect at 60Co is of the order of a few percent (PSF 60Co 10x10 = 1.035
Increase in dose is greatest in smaller fields (note 5x5, 10x10, and 20x20)
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TAR Dependencies
Varies with energy like the pdd-increases with energy.
Varies with field size like pdd- increases with field size.
Varies with depth like pdd- decreases with dept.
Assumed to be independent of SSD
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The TPR and TMR Similar to the TAR, the
TPR is the ratio of doses (Dd and Dt0) at two points equidistant from the source
Field sizes are equal Again field size is
defined at depth of calculation
Only attenuation by depth differs
The TMR is a special case of the TPR when t0 equals the depth of dmax
0/ td DDTPR
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TPR/TMR Dependencies
Independent of SSD TMR increases with Energy TMR increases with field size TMR decreases with depth
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From: ICRU 14
Relationship between fundamental depth-dependent quantities
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PDD / TAR / BSF Relation
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Approximate Relationships:PDD / TAR / BSF / TMR
BJR Supplement 17
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Limitations of the application of inverse-square corrections
It is generally believed that the TAR and TMR are independent of SSD
This is true within limits Note the effect of purely
geometric distance corrections on the contribution of scatter
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Effect of scatter vs. distance:TMR vs. field size The TMR (or TAR or
PDD) for a given depth can be plotted as a function of field size
Shown here are TMRs at 1.5, 5.0, 10.0, 15.0, 20.0, 25.0, and 30.0 cm depths as a function of field size
Note the lesser increase in TMR as a function of field size
This implies that differences in scatter are of greater significance in smaller fields than larger fields, and at closer distances to calculation points than farther distances
Varian 2107 6 MV X Rays (K&S Diamond)
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Scatter Factors Scatter factors describe
field-size dependence of dose at a point
Need to define “field size” clearly
Many details … Often wise to separate
sources of scatter Scatter from the head
of the treatment unit Scatter from the
phantom or patient Measurements
complicated by need for electronic equilibrium
Kerma to dose, again
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Wedge Transmission Beam intensity is also
affected by the introduction of beam attenuators that may be used modify the beam’s shape or intensity
Such attenuators may be plastic trays used to support field-shaping blocks, or physical wedges used to modify the beam’s intensity
The transmission of radiation through attenuators is often field-size and depth dependent
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Enhanced Dynamic Wedge (EDW)
Gibbons
The Dynamic Wedge Wedged dose distributions
can be produced without physical attenuators
With “dynamic wedges”, a wedged dose distribution is produced by sweeping a collimator jaw across the field duration irradiation
The position of the jaw as a function of beam irradiation (monitor-unit setting) is given the wedge’s “segmented treatment table (STT)
The STT relates jaw position to fraction of total monitor-unit setting
The determination of dynamic wedge factors is relatively complex
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Off-Axis Quantities To a large degree,
quantities and concepts discussed up to this point have addressed dose along the “central axis” of the beam
It is necessary to characterize beam intensity “off-axis”
Two equivalent quantities are used
Off-Axis Factors (OAF) Off-Center Ratios (OCR)
These two quantities are equivalent
0, ,/),( dxd DDdxOAF where x = distance off-axis
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Off-Axis Factors:Measured Profiles Off-axis factors are extracted from measured profiles
Profiles are smoothed, may be “symmetrized”, and are normalized to the central axis intensity
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Off-Axis Factors: Typical Representations OAFs (OCRs) are
often tabulated and plotted versus depth as a function of distance off axis
Where “distance off axis” means radial distance away from the central axis
Note that, due to beam divergence, this distance varies with distance from the source
Varian 2100C SN 241 6 MV Open-Field Off-Axis Factors
0.95
0.96
0.97
0.98
0.99
1.00
1.01
1.02
1.03
1.04
1.05
0.00 0.02 0.04 0.06 0.08 0.10
Off-Axis "Tangent"
Off
-Axi
s F
acto
r
Depth 1.7
Depth 5.0
Depth 10
Depth 15
Depth 20
Depth 25
Depth 30
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Off-Axis Wedge Corrections
Descriptions vary of off-axis intensity in wedged fields
Measured profiles contain both open-field off-axis intensity as well as differential wedge transmission
We have defined off-axis wedge corrections as corrections to the central axis wedge factor
Open-field off-axis intensity is divided out of the profile
The corrected profile is normalized to the central axis value
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Examples The depth dose for a 6 MV beam at 10 cm
depth for a 10 x 10 field; 100 cm ssd is 0.668. What is the percent depth dose if the ssd is 120 cm.
F=((120 +1.5)/(100+1.5))2 x((100 +10)/(120 +10))2
F= 1.026 dd at 120 ssd = 1.026 x 0.668 = 0.685
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Example Problems
What is the given dose if the dose prescribed is 200 cGy to a depth of 10 cm. 6X, 10 x 10 field, 100 cm SSD.
DD at 10 cm for 10 x 10 is 0.668. Given Dose is 200/0.668 = 299.4
cGy
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Examples
A single anterior 6MV beam is used to deliver 200 cGy to a depth of 5cm. What is the dose to the cord if it lies 12 cm from the anterior surface. Patient is set-up 100 ssd with a 10 x 15 field.
Equivalent square for 10 x 15 = 12cm2
dd for 12 x 12 field at 5cm =.866 dd for 12 x 12 field at 12 cm = .608 Dose to cord = 200/.866 x .608 = 140.4 cGy
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Examples
A patient is treated with parallel opposed fields to midplane. The patient is treated with 6 MV and has a lateral neck thickness of 12cm. The field size used is 6 x 6. The prescription is 200 cGy to midplane. What is the dose per fraction to a node located 3 cm from the right side. The patient is set-up 100 cm SSD.
dd at 6cm=0.810; dd at 9cm=.686 ; dd at 3 cm= 0.945 Dose to node from right= (100/.810) x 0.945 =116.7
cGy Dose to node from left = (100/.810) x .686 = 84.7 cGy Total dose = 116.7 + 84.7 = 201.4 cGy
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Examples
A patient is treated with a single anterior field. Field Size is 8 x 14. Patient is set-up 100 cm SAD. Prescription is 200 cGy to a depth of 6cm. A 6 MV beam is used for treatment. What is the dose to a node that is 3 cm deep? Assume field size is at isocenter.
Equivalent square of field is 10.2 cm2
TMR at 6cm = .8955 TMR at 3 cm = .9761 Dose to node = (200/.8955) x .9761 x (100/97)2 = 231.7
cGy
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Examples
A patient is treated with parallel opposed 6 MV fields. The patient’s separation is 20 cm. Prescription is to deliver 300 cGy to Midplane. Field size is 15 x 20.(100cm SAD) What is the dose to the cord on central axis if the cord lies 6cm from the posterior surface?
Equivalent square is 17.1 TMR at 10 cm = .8063 TMR at 6 cm = .9088 TMR at 14 cm = .7041
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Examples Dose to the Cord from the Anterior (150/.8063) x (100/104)2 x .7041 = 121 cGy Dose to the Cord from the Posterior (150/.8063) x (100/96)2 x .9088 = 183 cGy Total dose to the cord 183 +121 = 304 cGy