future of pharmaceuticals, healthcare innovation and biotech - conference keynote speaker
DESCRIPTION
http://www.globalchange.com Future of health care, from sickness to performance, disease prevention, health promotion and wellbeing, wellness. Impact of ageing, older people, senior citizens - growing health care demands. Health trends in treatment of genetic disease, inherited medical conditions, HIV, Alzheimers, Parkinsons, Diabetes, Rheumatoid Arthritis etc. How patients, clients, over the counter therapy customers, and consumers of health care products will manage their own treatment. Patrick Dixon is a health care keynote speaker at many public health conferences and forums on future of the pharmaceutical industry. Patient choice and public health policy changes with government budget health cuts, health care rationing, post code lotteries. How doctors and nurses will manage patients who often know more about their own medical condition, have made their own diagnosis, have made decisions about their own treatment (patient autonomy). Impact on over the counter pharmaceutical industry, chemists, drug stores, pharmacies and retail sales of health related products. Wellbeing, disease prevention, health promotion, vitamin and health supplements, dietary supplements are all changing consumer behaviour. How computer aided diagnostics will change clinical management of many medical conditions in hospital, clinics and in community care settings. Health care management and allocation of resources will be influenced by community-based diagnostics. Future of the pharmaceutical industry with non-prescription medicines, remedies, therapies, drugs. Prescribing new treatments using new diagnostic tools, and patient clinical care pathways. Health policy development by governments, and health insurance companies. Patient survival and increase in life expectancy with early diagnosis and treatment using equipment bought by consumers for home use. Future of the NHS and national health service, Medicare in America. Funding of health care in future -- people expected to fund their own health needs.TRANSCRIPT
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Are you fit for tomorrow ?
Dr Patrick DixonChairman Global Change Ltd
Fellow, Centre for Management Development, London Business School
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Patrick Dixon is Chairman of Global Change Ltd, Author of 15 books and has been ranked one of the 20 most influential
business thinkers alive today (Thinkers 50)
Future of Pharmaceuticals, healthcare innovation and biotech for Roche (2011)
500 videos of keynoteswww.youtube.com/pjvdixon
over 4 million views
www.globalchange.com14 million unique visitors
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From Global Crisis to Recovery
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Wild Cards
Low probability, high impact events
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Swine flu boost to E-prescribing
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Future of Health will be shaped by emotion
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Future in developed markets is about performance not wellness
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“Yesterday’s drugs were about need: tomorrow’s will be about living faster and staying young”
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People Want to Look Better• 51% growth in botox treatment• 31% growth laser hair removal• 31% growth in cosmetic surgery enquiries• (UK 2007 2008)
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Sexual Performance
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Brain Faster – and better?
may be
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Remote diagnostics and image reporting Your own personal tech may be better than NHS
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Remote treatment
Remote surgery – hype and reality
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DIY monitoring
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Computer-aided diagnosisWhat kind of training will nurses and doctors really need in future ?
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Reducing Error• 1 in 12 people who died in US hospitals in
2003 were given wrong diagnosis• Dxplain – diagnostic database
– 2500 clinical diseases and 4,900 clinical findings
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Data on drug reactions
• 100,000 deaths a year in US• 2 million significant side effect problems
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Genetic Prophecy – Are We Ready?
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Read Human Genome in an • Fluidics• Biochemistry• Genetics• Mathematics• Immunology• Robotics
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Genes for speech, memory, criminality, depression, obesity and stable relationships
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Huge Unmet Needs
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Innovation in Ageing
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Permanent Hair Colour• Adenovirus • Infected mouse hair cells• Permanent colour change
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Worn out Mitochondria – Energy Boost
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KB-141 Thyroxine Analogue Boosts Metabolism
• KB-141 is a synthetic form of thryroxine that increases metabolic rate, makes the body burn more fat, reduces LDL cholesterol and lipoprotein without stimulating heart rate.
• Obese monkeys lost up to 7% of their body mass in 7 days
• Heart rates were unchanged• KB-141 is only 14 times as active at b receptors than at
a receptors. 100-fold difference would be better• Karo Bio made KB-141 which has been tested by Bristol-
Myers Squib• Global sales of better KB-141 analogue:
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Treatment which restores and maintains the youthful elasticity of
hardened arteries – and helps wrinkled skin. Global sales?
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Twice daily Rx prolongs life by 20% Global sales?
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Caloric Restricted Mice Live LongerStephen Spindler Biomarker Pharmaceuticals
These animals also develop fewer cancers – but prone to infection / other problems
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Metformin – most of the benefit of caloric restriction, none of the pain of diets
Stephen Spindler Biomarker Pharmaceuticals
• Age-onset diabetes Rx for many years (Glucophage / Bristol Myers Squib and many generics)
• Extends lifespan of non-diabetic mice by 20% if started in late middle age
• Few side effects or toxicity when given to non-diabetic humans
• Rapid growth in self-medicated people hoping to extend healthy living – unwilling to wait 20 years for animal studies in monkeys or clinical trials – cost 20 cents a day
• 70% of age-related gene changes in mice are reversed in 2-4 weeks of caloric restriction – sometimes in a day or two
• Similar changes are found when using metformin
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Metformin analogues could be anti-cancer and anti-ageing blockbusters
• Gene expression changes common to metformin and CR are similar
• Changes are consistent with enhanced apoptosis and protein turnover, and reduced tumor incidence and cellular stress
• Results suggest that metformin is potential CR-mimetic.
• Phenformin, a glucoregulatory drug similar to metformin, extends the lifespan of mice by 23%, and reduces cancer as a cause of death from 80% to 20%
• Need for better analogues
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Near-perfect repair of heart or brain damage
following coronary / stroke
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Your
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We can transform cells in a laboratory – but far better would be to transform them where they are in
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Diabetes – New Approaches
• Direct transformation of liver to healthy pancreatic cells using simple injections every three months… a pharma solution
• Achieved in tadpoles and in human liver culture
• Potential sales?
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Transformed cells usually stable
• Transcription factor turns on gene which produces more transcription factor
Add transcription factor
Gene activatedTranscription factor produced in cell
Prime Cell
Transformation
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Switch Liver Cells to Pancreatic
J Slack
• Liver and pancreas develop from embryonic endoderm• Some liver cells are unstable and easily influenced• Biotech trick: make artificial transcription factor which binds to
“liver” promoter gene, but activates “pancreas” genes – PDX1-VP16
DNA recognition Gene activation
Cut molecule and switch gene activator
Liver promoter genes
Transcription factor:
Liver genes Pancreas genes
Silenced Activated
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Liver to Pancreas Next Steps• Mouse studies next year
– Early results in 6 months• Human trials 5 years after
– Prove pancreatic cell groups can be created in liver– Show normal pattern insulin production– Show ectopic pancreatic tissue produces secretions which channel into
bile duct– Develop transport mechanism to deliver PDX1 into liver cells from an
injected precursor (has patentable solution)• Use lisosomes with liver antigens• Use amino acid sequences already present in some transcription factors to
get PDX1 into liver cells• Safer than adenovirus• Short-term protein “blast”• No ethical problems• No new genes
– Previous funding from Wellcome Foundation– Looking for 3 people for 2 years to prove efficacy in mice
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Negligible senescence is a reality
• Rockfish, Turtles, some Whales
• No signs of getting old
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Impact on Budgets and Health Rations
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Future Unmet Needs
NumberAffected
SeverityClinical conditions
Performance / life-enhancement
Trend – line is falling IVF
Female baldness
Male baldness
Sickness
Lifestyle
PublicHealthPolicy
Memory
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Slides: globalchange.com/ppt 12 million different visitors 2.7 million video views
Take Hold of Your Future
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Patrick Dixon is Chairman of Global Change Ltd, Author of 15 books and has been ranked one of the 20 most influential
business thinkers alive today (Thinkers 50)
Future of Pharmaceuticals, healthcare innovation and biotech for Roche (2011)
500 videos of keynoteswww.youtube.com/pjvdixon
over 4 million views
www.globalchange.com14 million unique visitors