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TRANSCRIPT
For more information please visit
www.elekta.com/perfexion
Why Leksell Gamma Knife®?Inspired to develop an e!ective yet gentler alternative to intracranial neurosurgery, Professor Lars Leksell conceived the idea of replacing the surgical precision of a scalpel with simultaneous beams of ionizing radiation. Able to deliver a highly accurate therapeutic dose of radiation to the brain with little or no harm to the patient, Leksell Gamma Knife de"ned the "eld of stereotactic radiosurgery (SRS). Over forty years, hundreds of studies, and several evolutions later, Leksell Gamma Knife® Perfexion™ is "ne-tuned to treat the most challenging targets of the head faster and more e#ciently than ever before. The new benchmark upon which all other SRS options are measured, Leksell Gamma Knife Perfexion is rede"ning excellence in stereotactic radiosurgery. Leksell Gamma Knife is manufactured solely by Elekta, the 2nd largest radiation therapy company in the world.
Leksell Gamma Knife uses simultaneously focused radiation to replace the
neurosurgeon’s knife, enable the physician to destroy tumors, and other brain
GLVRUGHUV�ZLWKRXW�RSHQLQJ�XS�WKH�VNXOO��7KH�LPDJH�RQ�SDJH�ÀYH�LOOXVWUDWHV� the principle of Leksell Gamma Knife.
Latest Technology6LQFH�������WKHUH�KDYH�EHHQ�IRXU�QHZ�JHQHUDWLRQV�RI�*DPPD�.QLIH�V\VWHPV�introduced by Elekta, as well as software and hardware upgrades. Today there
DUH�WZR�*DPPD�.QLIH�V\VWHPV�DYDLODEOH��/HNVHOO�*DPPD�.QLIH��&�DQG�/HNVHOO�*DPPD�.QLIH�3HUIH[LRQ��%RWK�PRGHOV�KDYH�D�JXDUDQWHHG�SUHFLVLRQ�IRU�WKH�lifetime of the equipment. The main difference between the models is in
DXWRPDWLRQ��PDNLQJ�WKH�ORZHU�SULFH�PRGHO�PRUH�VXLWHG�IRU�ORZHU�YROXPHV�RU�ORZHU�UHLPEXUVHPHQW�OHYHOV�
Extend™ SystemLeksell Gamma Knife Perfexion is also prepared for fractionated treatment
with a re-locatable frame allowing for a broader range of cases - the Extend
System.
Why Gamma Knife Radiosurgery?
Fully integrated system
Unrivalled accuracy
ShrinkWrap dose conformity
Unparalleled clinical track record
Gamma Knife® Radiosurgery Facts in Short
0
100,000
200,000
300,000
400,000
500,000
600,000
9192
9394
9596
97 9998 00
0102
03 0504
07 0908 1006
Cumulative Number of Patients Treated
2
Leksell GammaPlan - an intuitive treatment planning system with a surgical approach.
900
800
700
600
500
400
300
200
100
0Gamma
Knife
778
AdaptedLinacs
225
Cyberknife
26
Novalis
Note: Across the following indications: acoustic neuroma, meningioma,brain metastases, trigeminal neuralgia, arteriovenous malformation
Source: Elekta Database based on PubMed, 29 February 2012
13
Peer-Reviewed Papers ReportingMore Than 30 Patients Treated With SRS
Patients Treated$V�RI�WRGD\��PRUH�WKDQ���������SDWLHQWV�KDYH�EHHQ� treated with Gamma Knife radiosurgery. The growth is
illustrated below.
The reason for this growth is:1. 3URYHQ�FOLQLFDO�UHVXOWV�²�PRUH�WKDQ�������SXEOLFDWLRQV�
documenting the results.
2. *DPPD�.QLIH�UDGLRVXUJHU\�LV�D�QRQ�LQYDVLYH�technique. This means the patient can usually return
to normal lifestyle the day after treatment.
3. *DPPD�.QLIH�UDGLRVXUJHU\�LV�GHYHORSLQJ�²�QHZ�indications are being researched, and the excellent
UHVXOWV�KDYH�OHG�WR�LQFUHDVLQJ�DFFHSWDQFH�DV�EHWWHU�treated with Leksell Gamma Knife. This leads to
more treatments, and a greater need for Gamma Knife
systems.
��� ,PDJLQJ�LV�JHWWLQJ�EHWWHU�²�05,�LV�ZLGHVSUHDG��DQG�����RI�*DPPD�.QLIH�SURFHGXUHV�DUH�EDVHG�RQ�05,��7KXV��DV�05,�JHWV�EHWWHU��VR�GRHV�*DPPD�.QLIH�radiosurgery.
5. 3DWLHQW�DZDUHQHVV�²�SDWLHQWV�DQG�WKHLU�IDPLOLHV�DUH�PRUH�DZDUH�RI�WKH�EHQHÀWV�RI�*DPPD�.QLIH�radiosurgery compared to other techniques, and more
patients are referred to Gamma Knife treatment. This
includes both doctor and self referrals.
Clinical Evidence7KH�FOLQLFDO�UHVXOWV�RI�*DPPD�.QLIH�UDGLRVXUJHU\�DUH�YHU\�well documented. There are more than 3,000 published
papers on Gamma Knife radiosurgery. The chart shows
the number of published papers document treatments of
30 or more patients, for Leksell Gamma Knife and
VRPH�RWKHU�UDGLRVXUJHU\�WHFKQRORJLHV��5HYLHZLQJ�papers reporting on more than 30 patients, the superior
GRFXPHQWDWLRQ�RI�HYLGHQFH�IRU�*DPPD�.QLIH�UDGLRVXUJHU\�is striking. No other technology can present such rigid
HYLGHQFH�DV�LV�VKRZQ�LQ�WKH�JUDSK�WR�WKH�ULJKW��
Gamma Knife ReliabilityLeksell Gamma Knife® systems
are completely unique in their
design. They are designed to
WUHDW�KLJK�YROXPHV�RI�SDWLHQWV��PRUH�WKDQ�����SHU�\HDU�LV�YHU\�common), with guaranteed
precision and extremely high
reliability. The reliability today is
more than 99% uptime for Leksell
Gamma Knife. Other radiosurgery
WHFKQRORJLHV�KDYH�ORZHU�RU��VLJQLÀFDQWO\�ORZHU�XSWLPH� than a Gamma Knife system.
The reason for this is that Leksell
Gamma Knife is designed with
multiple simultaneous radiation
VRXUFHV�WKDW�GR�QRW�PRYH�GXULQJ�treatment. Thus mechanical
errors and failures from rotating
or translating radiation sources
during treatment are eliminated.
The radiation source for Leksell
*DPPD�.QLIH�LV�WKH�&REDOW����LVRWRSH��SURYLGLQJ�D�UHOLDEOH�DQG�well known intensity, energy and
focus. Elekta is strictly following
the international regulations
regarding transportation and
GLVSRVDO�RI�&REDOW����
Highest Accuracy - 0.15 mmLeksell Gamma Knife® Perfexion™ combines a patented collimator design with a revolutionary new positioning system to e!ectively wrap dose around the most complex shapes while limiting dose to surrounding tissue and critical structures. Dose delivered by each individual beam falls from 80% to 20% in about 1 mm, creating a penumbra that dramatically illustrates how Leksell Gamma Knife Perfexion is able to deliver highly e!ective treatments. "e average accuracy of a Leksell Gamma Knife is 0.15 mm during its lifetime.*
3
Leksell Gamma Knife has the market’s best radiation protection for patients and sta!.
Neurosurgery, volume 61, Sept 07, Christer Lindquist MD and Ian Paddick, MSc, Cromwell Hospital, London, UK.
ShrinkWrap dose conformity. Leksell Gamma Knife has the steepest dose fall o! rate of all radiosurgery devices.
* Based on measurements of 189 individual systems
Cost of Operation and ServiceLeksell Gamma Knife is unique in that it does not require
H[WHQVLYH�VWDIÀQJ��8VXDOO\�RQH�RU�WZR�SK\VLFLDQV��D�physicist and a nurse (all part time) are all the needed
VWDII��6HUYLFH�LV�XVXDOO\�SUHYHQWDWLYH��WKXV�UHGXFLQJ�RU�eliminated any down time or missed patient treatments.
(OHNWD�RIIHUV�D�UDQJH�RI�VHUYLFH�FRQWUDFWV��LQFOXGLQJ�FRPSOHWH�FRYHUDJH��HPHUJHQF\�VHUYLFH�DQG�UHPRWH�GLDJQRVWLFV��6HUYLFH�VWDII�LV�ORFDO�LQ�WKH�UHJLRQ�
Building RequirementsLeksell Gamma Knife is self-shielding, so room
requirements are usually simple. A linac bunker, or other
UDGLDWLRQ�VKLHOGHG�URRP��LV�XVXDOO\�PRUH�WKDQ�VXIÀFLHQW��5DGLDWLRQ�VKLHOGLQJ�OHYHOV�DUH�WKH�PDUNHWV�EHVW��XS�WR�����WLPHV�EHWWHU�WKDQ�DOWHUQDWLYH�WHFKQRORJLHV��VHH�JUDSK�RQ�SDJH�IRXU���+RZHYHU��WKH�*DPPD�.QLIH�XQLW�ZHLJKV��������NJ��VR�WKH�ÁRRU�PXVW�EH�DEOH�WR�ZLWKVWDQG�D�KHDY\�ZHLJKW��JURXQG�ÁRRU�RU�EDVHPHQW�LV�UHFRPPHQGHG��(OHNWD�assists customers with drawings and site planning as part
RI�WKH�VHUYLFH�LQFOXGH�ZKHQ�D�*DPPD�.QLIH�V\VWHP�LV�purchased.
4
Long Lifetime*DPPD�.QLIH�V\VWHPV�KDYH�D�GRFXPHQWHG�OLIHWLPH�RI� at least 10 years. Elekta protects customers with upgrade
and trade in allowances, to ensure those that want the
latest Gamma Knife technology are able to make cost
HIIHFWLYH�LPSURYHPHQWV�WR�WKHLU�V\VWHP��(OHNWD�KDV�D�ORQJ�tradition of rewarding customers for their membership in
WKH�(OHNWD�IDPLO\��7KLV�LV�ZK\�QHDUO\�HYHU\�*DPPD�.QLIH�program started during the last 25 years is still using
Leksell Gamma Knife.
What Else Does Gamma Knife® Bring to a Hospital?Prestige and recognition are two common results of
acquiring Leksell Gamma Knife. Leksell Gamma Knife
is the Gold Standard in radiosurgery, and hospitals that
DFTXLUH�D�*DPPD�.QLIH�V\VWHP�VHH�WKH�EHQHÀW�ERWK�ÀQDQFLDOO\�DQG�LQ�WKHLU�SUHVWLJH�DQG�VWDQGLQJ�LQ�WKH�healthcare and academic community.
In addition, a Gamma Knife program also increases
SDWLHQW�YROXPHV�LQ�RWKHU�GHSDUWPHQWV��$V�DQ�H[DPSOH��ZKHQHYHU�D�SDWLHQW�LV�WUHDWHG�RQ�/HNVHOO�*DPPD�.QLIH��pre-treatment imaging, as well as follow up images at
VL[���������DQG����PRQWKV�DUH�RIWHQ�QHHGHG��GHSHQGLQJ� on the indication treated. All Gamma Knife treatments
DUH�IROORZHG�XS�ZLWK�VRPH�IRUP�RI�LPDJLQJ��7KLV�SURYLGHV�DGGLWLRQDO�VHUYLFHV�IURP�5DGLRORJ\��$QRWKHU�H[DPSOH�LV�the patient who is self-referred, or physician-referred for
Gamma Knife radiosurgery. On occasion, the tumor or
disease is not appropriate for Gamma Knife radiosurgery,
but the hospital is able to offer radiotherapy or surgery as
DQ�DOWHUQDWLYH��,Q�WKLV�PDQQHU��/HNVHOO�*DPPD�.QLIH�KDV�EHHQ�VKRZQ�WR�LQFUHDVH�SDWLHQW�YROXPHV�LQ�WUDGLWLRQDO�RSHQ�neurosurgery, as well as in radiation oncology.
3.13.3
1.3
3.7
1.61.0
0.30.80.8
0,0
0,5
1,0
1,5
2,0
2,5
3,0
3,5
4,0
5,0
5,5
6,0
6,5
7,0
7,5
8,0
8,5
9,0
Average incidents Overall satisfaction
AccurayCyberKnife
ElektaInfinity
ElektaLeksell
Gamma KnifePerfexion
SiemensARTISTE*
TomoTherapyHi-Art
VarianClinac iX
VarianNovalis
Tx*
VarianTrilogy
VarianTrueBeam*
User Satisfaction: Leksell Gamma Knife® Perfexion™ had the highest overall rankings by a 10 point margin. The 2011 KLAS Radiation Oncology and TPS report.
80.3
80.7
84.0
84.3
84.4
94.4Leksell Gamma Knife® Perfexion™
Elekta Infinity™
Accuray CyberKnife® System
TomoTherapy® Hi-Art®
Varian Trilogy®
Varian Clinic iX®
Radiation Therapy Vendor / Product Performance Score 1-year trend
1
2
3
4
5
6
Leksell Gamma Knife® PERFEXION™
PERFEXION
Elekta
Leksell Gamma Knife® Perfexion™
Treats brain disorders with a high dose of radiation delivered with surgical precision.
Radiation unit
20ton
With the treatment planning software, Leksell GammaPlan, the shape and amount of radiation is decided to give an optimal treatment.
Leksell Gamma Knife Perfexion is fully automated. The radiation unit is housed inside of the machine itself. The radiation beams are shaped exactly around the tumor. Several tumors can be treated in one session.
The patient can communicate via video camera and an intercom at all times. The treatment time varies between 20 minutes and several hours depending on the complexity of the treatment.
Perfexion is designed to treat patients with di!erent types of brain disorders.
A stereotactic frame is attached to the patients
head and interlocked to the Gamma Knife unit. This to ensure maximum precision.
Ionizing gamma radiation is emitted from
192 cobalt-60 sources whose beams converge on a precise selected area of the brain. The accuracy is about 0.5 mm. There is minimal e!ect on the surrounding healthy tissue.
1
2
21
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Corporate Head O#ce:
www.elekta.com Human Care Makes the Future Possible
Regional Sales, Marketing and Service:
Asia Paci"c
Tel +852 2891 2208 Fax +852 2575 [email protected]
Europe, Middle East, Africa, Eastern Europe, Latin AmericaTel +46 8 587 254 00 Fax +46 8 587 255 [email protected]
North America
Tel +1 770 300 9725 Fax +1 770 448 [email protected]
Elekta AB (publ) Box 7593, SE-103 93 Stockholm, Sweden Tel +46 8 587 254 00 Fax +46 8 587 255 [email protected]
Doc
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2 ©
2012
Ele
kta
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ubl).
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Available Patients(OHNWD�DQG�*DPPD�.QLIH�XVHUV�KDYH�ORRNHG�LQ�GHSWK�DW�WKH�number of cases suitable for Gamma Knife surgery. From
a population of 1,000,000 people, you would expect 376
suitable Gamma Knife cases per year. From this, the number
of cases per year for any population can be easily calculated.
LGK applicable treatable diagnosis
Annual incidence per million
Treatable with LGK
Treatable patients per million
Arteriovenous Malformations 19 70% 13
Meningioma 41 50% 20
Acoustic Neuroma 15 75% 11
Brain metastases: solitary/multiple 621 47% 292
Trigeminal Neuralgia 51 50% 26
Other indications 96 25% 14
Total 376
Table 1. Incidence for the most common Gamma Knife indications.