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GENETICS

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Page 1: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

GENETICS

Page 2: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

Agenda● Review

● Notes

Page 3: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

REVIEW

Page 4: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

What is Genetics?

● Studying heredity and the variation

of inherited characteristics

● Studying heredity and the variation

of inherited characteristics

Page 5: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

Cell Cycle

● Cells reproduce through a

continuous sequence of growth and

division known as the cell cycle● Interphase + Mitosis (+ cytokinesis)

Page 6: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

Cell division/Cell cycle

Page 7: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

CLONING

Page 8: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

What is cloning?

● Process of forming IDENTICAL offspring from a single cell or tissue

● Does not result in the variation of traits that would occur with the combination of male and female sex cells

● Therefore, ASEXUAL REPRODUCTION

Page 9: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

Natural clones

● Identical twins

● Plant cutting○ grafting

Page 10: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

Natural clones

Page 11: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

Artificial clones

● Made in the lab → THANKS to genetic

engineering○ Intentional production of new genetic

material by substituting or altering existing material

● Two ways○ Artificial embryo twinning○ Somatic cell nuclear transfer

Page 12: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

Somatic Cell Nuclear Transfer (SCNT)

● Somatic cell: any cell in the body other

than sperm and egg - has two complete

sets of chromosomes (46 chromosomes)

● Nuclear: nucleus is a compartment that

holds the cell’s DNA

● Transfer: moving an object from one

place to another

Page 13: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

1996 - First mammal created by SCNTSheep (Dolly) - Ian Wilmut and Keith Campbell

Page 14: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning
Page 15: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

Normal Development

● Embryonic cells

differentiation →

different cells

● Shut down genes

they don’t need

for specific

functions

Page 16: GENETICS - Limestone District School Boardschools.limestone.on.ca/locvi/staff/leederp/Classes/SBI...8 cell embryo Blastocyst Pluripotent Blood cells Cardiac muscle Dolly: The Cloning

WHY CLONE?