Goals For This MeetingGoals For This Meeting

Receive input and comment on the recent Receive input and comment on the recent literature regarding the potential adverse literature regarding the potential adverse health effects of dental amalgams (to the health effects of dental amalgams (to the LSRO and the Expert Panel)LSRO and the Expert Panel)

Provide backgroundProvide background to Expert Panelto Expert Panel

Report on the processReport on the process and current and current thinking (to the stakeholder communities)thinking (to the stakeholder communities)

Goals For This ProjectGoals For This Project Identify and evaluateIdentify and evaluate recent recent

literatureliterature ProvideProvide scientific, evidence-based scientific, evidence-based

opinionopinion on the potential adverse on the potential adverse health effects of dental amalgamhealth effects of dental amalgam

NotNot recommending public policyrecommending public policy

General ProceduresGeneral Procedures

Time frame: Summer 2003 – Time frame: Summer 2003 – Spring 2004Spring 2004

Call(s) for public commentCall(s) for public comment Selection of Expert PanelSelection of Expert Panel Transparent processTransparent process Publicly available reportPublicly available report Restricted communicationRestricted communication

Expert PanelExpert Panel

Selection principlesSelection principles Recognized scientific authoritiesRecognized scientific authorities Disciplinary expertiseDisciplinary expertise Un-biased – excluded:Un-biased – excluded:

Dental communityDental community Previously expressed opinionPreviously expressed opinion

Selected and appointed by LSROSelected and appointed by LSRO

Expert PanelExpert Panel

Meryl Karol, PhD (Chair) Meryl Karol, PhD (Chair)

U of PittsburghU of Pittsburgh Stanley Berent, MS, PhDStanley Berent, MS, PhD

U of MichiganU of Michigan Robert Brent, MD, PhDRobert Brent, MD, PhD

Thomas Jefferson UThomas Jefferson U James Bruckner, MS, James Bruckner, MS,

PhDPhD

U of GeorgiaU of Georgia John Doull, MD, PhDJohn Doull, MD, PhD

U of Kansas Med SchoolU of Kansas Med School

M. Eric Gershwin, MDM. Eric Gershwin, MD

U Cal School of MedU Cal School of Med Ronald Hood, MS, PhDRonald Hood, MS, PhD

U of AlabamaU of Alabama Genevieve Matanoski, MD, Genevieve Matanoski, MD,

DrPHDrPH

Johns Hopkins UJohns Hopkins U Raphael Rubin, MDRaphael Rubin, MD

Thomas Jefferson UThomas Jefferson U Bernard Weiss, PhD Bernard Weiss, PhD

(Consultant)(Consultant)

U of RochesterU of Rochester

Panel ExperiencePanel Experience

Past presidents of toxicology societiesPast presidents of toxicology societies Editors of major scientific journalsEditors of major scientific journals Department chairsDepartment chairs Endowed professorshipsEndowed professorships Authors of preeminent textbooksAuthors of preeminent textbooks Authors of thousands of publicationsAuthors of thousands of publications Members of advisory & NAS panelsMembers of advisory & NAS panels Recipient of numerous awardsRecipient of numerous awards

Panel ExpertisePanel Expertise

Toxicology (5)Toxicology (5) Neuro/behavioral Neuro/behavioral

toxicol (2)toxicol (2) Pathology (1)Pathology (1) Allergy (1)Allergy (1) Immunology (2)Immunology (2) Pediatrics (1)Pediatrics (1) Developmental tox Developmental tox

(3)(3)

Reproductive tox (1)Reproductive tox (1) Psychology (1)Psychology (1) Epidemiology (2)Epidemiology (2) Public health (2)Public health (2) Environmental and Environmental and

occupational health occupational health (2)(2)

Toxicokinetics (1)Toxicokinetics (1) Risk assessment (1)Risk assessment (1)

Panel ExperiencePanel Experience

Past presidents of toxicology societiesPast presidents of toxicology societies Editors of major scientific journalsEditors of major scientific journals Department chairsDepartment chairs Endowed professorshipsEndowed professorships Authors of preeminent textbooksAuthors of preeminent textbooks Authors of thousands of publicationsAuthors of thousands of publications Members of government advisory & Members of government advisory &

NAS panelsNAS panels Recipient of numerous awardsRecipient of numerous awards

Restricted Restricted CommunicationCommunication

Communicate with the Panel Communicate with the Panel through LSROthrough LSRO Maintain transparencyMaintain transparency Eliminate biasEliminate bias Ensure the entire panel receives all Ensure the entire panel receives all

inputinput Panel reports any unofficial or Panel reports any unofficial or ex ex

parteparte communication communication

MiscellanyMiscellany

LSRO staff will write the reportLSRO staff will write the report Report will express Expert Panel Report will express Expert Panel

consensus and will not attribute consensus and will not attribute individual opinionsindividual opinions Attempt to reach consensus wordingAttempt to reach consensus wording If necessary include minority If necessary include minority

opinionsopinions Post presentation slides on our web sitePost presentation slides on our web site