graph annotation: a tale of two binary relations
DESCRIPTION
Presentation from Seattle Graph Meetup discussing use of Formal Concept Analysis to annotate graphs. Uses examples from bionformatics/systems biology.TRANSCRIPT
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CRKL
ANK3
CABP1
CACNA2D4
CACNB3
GNB1
PCBD1
RIMS1
PPM1A
PRKACA
RYR2
SRI
CACNA1C
FASFADD
CNTN1
HOOK1
KCNC1 KCNC2
SMAD3
SMAD2
PIK3R1
SPTBN4
SCN1B
SCNN1B
SCN2A
Graph Annotation
Seattle/Bellevue Graphs – Data, Processing, Algorithms Meetup 5 August 2014
A Tale of Two Binary Relations
Benjamin J. Keller linkedin.com/in/bjkeller
Attribution-ShareAlike 3.0 Unported
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Context: Systems story telling
want to help user understand relationships in data so that they can construct stories about biological systems
How do we use biological information and data to go from a list of genes to a story about how symptoms of a genetic disease arise?
[ ]
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Context: Systems Story Telling
Classification Reasoning
Model-based Reasoning
Narrative Reasoning
(based on B. Mirel, Supporting cognition in systems biology analysis; findings on users’ processes and design implications. Journal of Biomedical Discovery and Collaboration 2009; 4:1-17)
what of all this is the right
stuff?
how does it fit together?
how does it do something?
what stories does it tell?
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Context: Systems Story Telling
Classification Reasoning
Model-based Reasoning
Narrative Reasoning
individual components
networks/graphs of
components
system fragments
“whole” systems
roles
contextual classes
Grouping
PatternsComposition
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Two kinds of binary relations
individual components
networks/graphs of
components
roles
contextual classes
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Two kinds of binary relations
component
component
annotation
component
Incidence relation
Graph
,( )
,( )
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Grouping
Start with - a network graph of genes, and - contextual annotations for each
Want to visualize what goes together
[ saw this before in cytoscape.js presentation ]
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Grouping (hypergraph visualization)
MeSH: Calcium
GO BP: Metal Ion TransportGO MF: Gated Channel ActivityGO MF: Cation Channel Activity
GO MF: Voltage-Gated Ion Channel Activity
MeSH: Phosphorylation
MeSH: Signal Transduction
MeSH: Intercellular Signaling Peptides and Proteins
MeSH: Rats
MeSH: Nerve Tissue Proteins
MeSH Ion Channel Gating
CRKL
ANK3
CABP1
CACNA2D4
CACNB3
GNB1
PCBD1
RIMS1
PPM1A
PRKACA
RYR2
SRI
CACNA1C
FASFADD
CNTN1
HOOK1
KCNC1 KCNC2
SMAD3
SMAD2
PIK3R1
SPTBN4
SCN1B
SCNN1B
SCN2A
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Simplified GroupingsMeSH: Calcium
GO MF: Voltage-Gated Ion Channel Activity
MeSH: Phosphorylation
MeSH: Intercellular Signaling Peptides and Proteins
MeSH: Nerve Tissue Proteins
MeSH Ion Channel Gating
CRKL
ANK3
CABP1
CACNA2D4
CACNB3
GNB1
PCBD1
RIMS1
PPM1A
PRKACA
RYR2
SRI
CACNA1C
FASFADD
CNTN1
HOOK1
KCNC1 KCNC2
SMAD3
SMAD2
PIK3R1
SPTBN4
SCN1B
SCNN1B
SCN2A
MeSH: Calcium
GO MF: Voltage-Gated Ion Channel Activity
MeSH: Phosphorylation
MeSH: Intercellular Signaling Peptides and Proteins
MeSH: Rats
MeSH: Nerve Tissue Proteins
CRKL
ANK3
CABP1
CACNA2D4
CACNB3
GNB1
PCBD1
RIMS1
PPM1A
PRKACA
RYR2
SRI
CACNA1C
FASFADD
CNTN1
HOOK1
KCNC1 KCNC2
SMAD3
SMAD2
PIK3R1
SPTBN4
SCN1B
SCNN1B
SCN2A
MeSH: Calcium
GO MF: Voltage-Gated Ion Channel Activity
MeSH: Signal Transduction
MeSH: Nerve Tissue Proteins
MeSH Ion Channel Gating
CRKL
ANK3
CABP1
CACNA2D4
CACNB3
GNB1
PCBD1
RIMS1
PPM1A
PRKACA
RYR2
SRI
CACNA1C
FASFADD
CNTN1
HOOK1
KCNC1 KCNC2
SMAD3
SMAD2
PIK3R1
SPTBN4
SCN1B
SCNN1B
SCN2A
MeSH: Calcium
GO MF: Voltage-Gated Ion Channel Activity
MeSH: Signal Transduction
MeSH: Rats
MeSH: Nerve Tissue Proteins
CRKL
ANK3
CABP1
CACNA2D4
CACNB3
GNB1
PCBD1
RIMS1
PPM1A
PRKACA
RYR2
SRI
CACNA1C
FASFADD
CNTN1
HOOK1
KCNC1 KCNC2
SMAD3
SMAD2
PIK3R1
SPTBN4
SCN1B
SCNN1B
SCN2A
MeSH: Calcium
GO BP: Metal Ion TransportGO MF: Gated Channel ActivityGO MF: Cation Channel Activity
MeSH: Phosphorylation
MeSH: Intercellular Signaling Peptides and Proteins
MeSH: Nerve Tissue Proteins
MeSH Ion Channel Gating
CRKL
ANK3
CABP1
CACNA2D4
CACNB3
GNB1
PCBD1
RIMS1
PPM1A
PRKACA
RYR2
SRI
CACNA1C
FASFADD
CNTN1
HOOK1
KCNC1 KCNC2
SMAD3
SMAD2
PIK3R1
SPTBN4
SCN1B
SCNN1B
SCN2A
MeSH: Calcium
GO BP: Metal Ion TransportGO MF: Gated Channel ActivityGO MF: Cation Channel Activity
MeSH: Phosphorylation
MeSH: Intercellular Signaling Peptides and Proteins
MeSH: Rats
MeSH: Nerve Tissue Proteins
CRKL
ANK3
CABP1
CACNA2D4
CACNB3
GNB1
PCBD1
RIMS1
PPM1A
PRKACA
RYR2
SRI
CACNA1C
FASFADD
CNTN1
HOOK1
KCNC1 KCNC2
SMAD3
SMAD2
PIK3R1
SPTBN4
SCN1B
SCNN1B
SCN2A
MeSH: Calcium
GO BP: Metal Ion TransportGO MF: Gated Channel ActivityGO MF: Cation Channel Activity
MeSH: Signal Transduction
MeSH: Nerve Tissue Proteins
MeSH Ion Channel Gating
CRKL
ANK3
CABP1
CACNA2D4
CACNB3
GNB1
PCBD1
RIMS1
PPM1A
PRKACA
RYR2
SRI
CACNA1C
FASFADD
CNTN1
HOOK1
KCNC1 KCNC2
SMAD3
SMAD2
PIK3R1
SPTBN4
SCN1B
SCNN1B
SCN2A
MeSH: Calcium
GO BP: Metal Ion TransportGO MF: Gated Channel ActivityGO MF: Cation Channel Activity
MeSH: Signal Transduction
MeSH: Rats
MeSH: Nerve Tissue Proteins
CRKL
ANK3
CABP1
CACNA2D4
CACNB3
GNB1
PCBD1
RIMS1
PPM1A
PRKACA
RYR2
SRI
CACNA1C
FASFADD
CNTN1
HOOK1
KCNC1 KCNC2
SMAD3
SMAD2
PIK3R1
SPTBN4
SCN1B
SCNN1B
SCN2A
computed with BLOSOM (Zhao L, Zaki MJ, Ramakrishnan N., KDD 2006, 827-832), support=5
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Human-edited Groupings
MeSH: Calcium
GO BP: Metal Ion TransportGO MF: Gated Channel ActivityGO MF: Cation Channel ActivityORMeSH Ion Channel Gating
MeSH: Phosphorylation
MeSH: Intercellular Signaling Peptides and Proteins
MeSH: Nerve Tissue Proteins
CRKL
ANK3
CABP1
CACNA2D4
CACNB3
GNB1
PCBD1
RIMS1
PPM1A
PRKACA
RYR2
SRI
CACNA1C
FASFADD
CNTN1
HOOK1
KCNC1
KCNC2
SMAD3
SMAD2
PIK3R1
SPTBN4
SCN1B
SCNN1B
SCN2A
MeSH: Calcium
GO BP: Metal Ion TransportGO MF: Gated Channel ActivityGO MF: Cation Channel ActivityORMeSH Ion Channel Gating
MeSH: Signal Transduction
MeSH: Nerve Tissue Proteins
CRKL
ANK3
CABP1
CACNA2D4
CACNB3
GNB1
PCBD1
RIMS1
PPM1A
PRKACA
RYR2
SRI
CACNA1C
FASFADD
CNTN1
HOOK1
KCNC1
KCNC2
SMAD3
SMAD2
PIK3R1
SPTBN4
SCN1B
SCNN1B
SCN2A
“user” merged/deleted annotations
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Formal Concept Analysis
CACNA1C
Ion transport protein
KCNC1
KCNC2
RYR2
SCN2A
Beta1 adrenergic receptor signaling pathway
CACNB3
GNB1
PRKACA
Beta2 adrenergic receptor signaling pathway
cation transport
CACNA2D4
SCN1B
SCNN1B
metal ion transport
channel activity
ion channel activity
gated channel activity
cation channel activity
alkali metal ion binding
calcium channel activity
voltage-gated channel activity
transmembrane transporter activity
voltage-gated ion channel activity
substrate specific channel activity
voltage-gated cation channel activity
ion transmembrane transporter activity
substrate-specific transporter activity
cation transmembrane transporter activity
passive transmembrane transporter activity
metal ion transmembrane transporter activity
substrate-specific transmembrane transporter activity
ANK3
RatsCNTN1
PIK3R1
Animals
SMAD2
SMAD3
CABP1
Calcium
SRI
Ankyrins
SPTBN4
CRKL
Cell Line
FADD
Myocardium
Jurkat CellsFAS
PPM1A Smad2 Protein
Phosphorylation
Ranvier's Nodes
Sodium Channels
Calcium Channels
Precipitin Tests
Protein Subunits
Ion Channel Gating
Signal Transduction
Nerve Tissue ProteinsRIMS1
Patch-Clamp Techniques
Sodium Channel Blockers
Calcium Channels, L-Type
Two-Hybrid System Techniques
Ryanodine Receptor Calcium Release Channel
Intracellular Signaling Peptides and Proteins
• Algebraic approach to studying data as incidence relation b/w objects and attributes
• Construct formal concepts (biclusters)
• Relate to form formal concept lattice
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Formal Concept
CACNA1C
Ion transport protein
KCNC1
KCNC2
RYR2
SCN2A
Beta1 adrenergic receptor signaling pathway
CACNB3
GNB1
PRKACA
Beta2 adrenergic receptor signaling pathway
cation transport
CACNA2D4
SCN1B
SCNN1B
metal ion transport
channel activity
ion channel activity
gated channel activity
cation channel activity
alkali metal ion binding
calcium channel activity
voltage-gated channel activity
transmembrane transporter activity
voltage-gated ion channel activity
substrate specific channel activity
voltage-gated cation channel activity
ion transmembrane transporter activity
substrate-specific transporter activity
cation transmembrane transporter activity
passive transmembrane transporter activity
metal ion transmembrane transporter activity
substrate-specific transmembrane transporter activity
ANK3
RatsCNTN1
PIK3R1
Animals
SMAD2
SMAD3
CABP1
Calcium
SRI
Ankyrins
SPTBN4
CRKL
Cell Line
FADD
Myocardium
Jurkat CellsFAS
PPM1A Smad2 Protein
Phosphorylation
Ranvier's Nodes
Sodium Channels
Calcium Channels
Precipitin Tests
Protein Subunits
Ion Channel Gating
Signal Transduction
Nerve Tissue ProteinsRIMS1
Patch-Clamp Techniques
Sodium Channel Blockers
Calcium Channels, L-Type
Two-Hybrid System Techniques
Ryanodine Receptor Calcium Release Channel
Intracellular Signaling Peptides and Proteins
• Can view incidence relation as bipartite graph
• A formal concept is a biclique: a pair of vertices (A,B) such that for each object a in A there is an edge (a,b) for every attribute b in B
• Can construct as closure
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Ex: Signal Transduction
Beta1 adrenergic receptor signaling pathway
GNB1
PRKACA
Beta2 adrenergic receptor signaling pathway
Rats
PIK3R1
Animals
SMAD2
SMAD3
Calcium
CRKL
Cell Line
FADD
Myocardium
Jurkat Cells
FAS
PPM1A
Smad2 Protein
Phosphorylation
Calcium Channels
Precipitin Tests
Protein Subunits
Ion Channel Gating
Signal Transduction
Two-Hybrid System Techniques
Ryanodine Receptor Calcium Release Channel
Intracellular Signaling Peptides and Proteins
![Page 14: Graph Annotation: A Tale of Two Binary Relations](https://reader033.vdocument.in/reader033/viewer/2022051613/54c6d7ab4a7959b7618b45a2/html5/thumbnails/14.jpg)
Ex: Signal Transduction
Beta1 adrenergic receptor signaling pathway
GNB1
PRKACA
Beta2 adrenergic receptor signaling pathway
Rats
PIK3R1
Animals
SMAD2
SMAD3
Calcium
CRKL
Cell Line
FADD
Myocardium
Jurkat Cells
FAS
PPM1A
Smad2 Protein
Phosphorylation
Calcium Channels
Precipitin Tests
Protein Subunits
Ion Channel Gating
Signal Transduction
Two-Hybrid System Techniques
Ryanodine Receptor Calcium Release Channel
Intracellular Signaling Peptides and Proteins
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Beta1 adrenergic receptor signaling pathway
GNB1
PRKACA
Beta2 adrenergic receptor signaling pathway
Rats
PIK3R1
Animals
SMAD2
SMAD3
Calcium
CRKL
Cell Line
FADD
Myocardium
Jurkat Cells
FAS
PPM1A
Smad2 Protein
Phosphorylation
Calcium Channels
Precipitin Tests
Protein Subunits
Ion Channel Gating
Signal Transduction
Two-Hybrid System Techniques
Ryanodine Receptor Calcium Release Channel
Intracellular Signaling Peptides and Proteins
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Subconcept
Beta1 adrenergic receptor signaling pathway
GNB1
PRKACA
Beta2 adrenergic receptor signaling pathway
Rats
PIK3R1
Animals
SMAD2
SMAD3
Calcium
CRKL
Cell Line
FADD
Myocardium
Jurkat Cells
FAS
PPM1A
Smad2 Protein
Phosphorylation
Calcium Channels
Precipitin Tests
Protein Subunits
Ion Channel Gating
Signal Transduction
Two-Hybrid System Techniques
Ryanodine Receptor Calcium Release Channel
Intracellular Signaling Peptides and Proteins
Beta1 adrenergic receptor signaling pathway
GNB1
PRKACA
Beta2 adrenergic receptor signaling pathway
Rats
PIK3R1
Animals
SMAD2
SMAD3
Calcium
CRKL
Cell Line
FADD
Myocardium
Jurkat Cells
FAS
PPM1A
Smad2 Protein
Phosphorylation
Calcium Channels
Precipitin Tests
Protein Subunits
Ion Channel Gating
Signal Transduction
Two-Hybrid System Techniques
Ryanodine Receptor Calcium Release Channel
Intracellular Signaling Peptides and Proteins
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Subconcept relationship
Beta1 adrenergic receptor signaling pathway
GNB1
PRKACA
Beta2 adrenergic receptor signaling pathway
Rats
PIK3R1
Animals
SMAD2
SMAD3
Calcium
CRKL
Cell Line
FADD
Myocardium
Jurkat Cells
FAS
PPM1A
Smad2 Protein
Phosphorylation
Calcium Channels
Precipitin Tests
Protein Subunits
Ion Channel Gating
Signal Transduction
Two-Hybrid System Techniques
Ryanodine Receptor Calcium Release Channel
Intracellular Signaling Peptides and Proteins
Beta1 adrenergic receptor signaling pathway
GNB1
PRKACA
Beta2 adrenergic receptor signaling pathway
Rats
PIK3R1
Animals
SMAD2
SMAD3
Calcium
CRKL
Cell Line
FADD
Myocardium
Jurkat Cells
FAS
PPM1A
Smad2 Protein
Phosphorylation
Calcium Channels
Precipitin Tests
Protein Subunits
Ion Channel Gating
Signal Transduction
Two-Hybrid System Techniques
Ryanodine Receptor Calcium Release Channel
Intracellular Signaling Peptides and Proteins
more objects/fewer attributes
fewer objects/more attributes
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Subconcept relationship
Beta1 adrenergic receptor signaling pathway
GNB1
PRKACA
Beta2 adrenergic receptor signaling pathway
Rats
PIK3R1
Animals
SMAD2
SMAD3
Calcium
CRKL
Cell Line
FADD
Myocardium
Jurkat Cells
FAS
PPM1A
Smad2 Protein
Phosphorylation
Calcium Channels
Precipitin Tests
Protein Subunits
Ion Channel Gating
Signal Transduction
Two-Hybrid System Techniques
Ryanodine Receptor Calcium Release Channel
Intracellular Signaling Peptides and Proteins
Beta1 adrenergic receptor signaling pathway
GNB1
PRKACA
Beta2 adrenergic receptor signaling pathway
Rats
PIK3R1
Animals
SMAD2
SMAD3
Calcium
CRKL
Cell Line
FADD
Myocardium
Jurkat Cells
FAS
PPM1A
Smad2 Protein
Phosphorylation
Calcium Channels
Precipitin Tests
Protein Subunits
Ion Channel Gating
Signal Transduction
Two-Hybrid System Techniques
Ryanodine Receptor Calcium Release Channel
Intracellular Signaling Peptides and Proteins
CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175
FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175,
748642
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Concept Lattice
ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1,
KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3,
SPTBN4, SRI;
CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414,
617437
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360,
737390, 737431, 737548
ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA,
SCNN1B; 737748
CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3;
738083
CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118
ANK3, SCN1B, SPTBN4; 738391
ANK3, SCNN1B, SPTBN4; 742325
CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512
CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A,
SCNN1B; 742806
ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A,
SCNN1B; 743584
CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175
CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929
CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B;
745316
CNTN1, SCN2A, SCNN1B; 745760
CABP1, CACNA1C, CACNA2D4, CACNB3;
745845
CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
745845
CABP1, CACNA1C, CACNB3; 742512, 745316, 745845
CNTN1, SCNN1B; 737748, 745760
CNTN1, SCN2A; 744929, 745760
SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316,
745760
CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584,
745316
SCN1B, SPTBN4; 738391, 744929
SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316
CNTN1; 737748, 738083, 744929,
745760
SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316, 745760
GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083,
744175
CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175
CRKL, FADD, FAS, PIK3R1; 740606,
744175
CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175
FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175,
747193
FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175,
748642
FADD, FAS, PIK3R1; 740606, 744175, 748642
FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642
GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175,
747193
CACNA1C, CACNB3, GNB1; 617414, 617437, 743584
ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584
ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584
CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806,
743584
CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748,
742806
CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584
CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584,
745316
CACNA1C, CACNB3, PRKACA, RYR2; 617414,
617437, 742512
CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512
CABP1, CACNA1C; 738118, 742512, 745316, 745845
CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548, 742512, 743584, 745316, 745845
ANK3, SCN1B; 738391, 742390, 743584
ANK3, SCNN1B; 737748, 742325, 742390, 743584
SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584,
745316
ANK3, SPTBN4; 738391, 742325
CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175
PPM1A, SMAD2, SMAD3; 741302, 742292, 744175
SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193,
748642
CRKL, FADD, PIK3R1; 738855, 740606, 744175
FADD, PIK3R1; 738855, 740606, 744175, 747193,
748642
PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193,
748642
CRKL, PIK3R1; 738855, 740606, 742292, 744175
PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175
PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175,
747193, 748642
SPTBN4; 738391, 742325, 744929
SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390,
742806, 743584, 744929, 745316
ANK3; 737748, 738391, 742325, 742390, 743584
; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760,
745845, 747193, 748541, 748642
CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541
CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541
CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806,
743584, 745316, 745845, 748541
CNTN1, GNB1, PIK3R1, PRKACA;
737748, 738083
GNB1, PIK3R1, PRKACA; 737748, 738083, 742806,
744175
GNB1, PIK3R1; 737748, 738083, 742806, 744175,
747193
PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175
SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584,
745316, 745760
CACNA1C, GNB1, PRKACA; 617414, 617437, 737748,
742806
CACNA1C, GNB1; 617414, 617437, 737748, 742806,
743584
CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316
GNB1, PRKACA; 617414, 617437, 737748, 738083,
742806, 744175
GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193
PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541
CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548, 743584, 745316
CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
742512
KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512,
748541
CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512,
742806, 748541
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ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1,
KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3,
SPTBN4, SRI;
CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414,
617437
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360,
737390, 737431, 737548
ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA,
SCNN1B; 737748
CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3;
738083
CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118
ANK3, SCN1B, SPTBN4; 738391
ANK3, SCNN1B, SPTBN4; 742325
CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512
CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A,
SCNN1B; 742806
ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A,
SCNN1B; 743584
CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175
CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929
CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B;
745316
CNTN1, SCN2A, SCNN1B; 745760
CABP1, CACNA1C, CACNA2D4, CACNB3;
745845
CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
745845
CABP1, CACNA1C, CACNB3; 742512, 745316, 745845
CNTN1, SCNN1B; 737748, 745760
CNTN1, SCN2A; 744929, 745760
SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316,
745760
CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584,
745316
SCN1B, SPTBN4; 738391, 744929
SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316
CNTN1; 737748, 738083, 744929,
745760
SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316, 745760
GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083,
744175
CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175
CRKL, FADD, FAS, PIK3R1; 740606,
744175
CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175
FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175,
747193
FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175,
748642
FADD, FAS, PIK3R1; 740606, 744175, 748642
FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642
GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175,
747193
CACNA1C, CACNB3, GNB1; 617414, 617437, 743584
ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584
ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584
CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806,
743584
CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748,
742806
CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584
CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584,
745316
CACNA1C, CACNB3, PRKACA, RYR2; 617414,
617437, 742512
CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512
CABP1, CACNA1C; 738118, 742512, 745316, 745845
CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548, 742512, 743584, 745316, 745845
ANK3, SCN1B; 738391, 742390, 743584
ANK3, SCNN1B; 737748, 742325, 742390, 743584
SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584,
745316
ANK3, SPTBN4; 738391, 742325
CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175
PPM1A, SMAD2, SMAD3; 741302, 742292, 744175
SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193,
748642
CRKL, FADD, PIK3R1; 738855, 740606, 744175
FADD, PIK3R1; 738855, 740606, 744175, 747193,
748642
PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193,
748642
CRKL, PIK3R1; 738855, 740606, 742292, 744175
PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175
PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175,
747193, 748642
SPTBN4; 738391, 742325, 744929
SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390,
742806, 743584, 744929, 745316
ANK3; 737748, 738391, 742325, 742390, 743584
; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760,
745845, 747193, 748541, 748642
CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541
CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541
CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806,
743584, 745316, 745845, 748541
CNTN1, GNB1, PIK3R1, PRKACA;
737748, 738083
GNB1, PIK3R1, PRKACA; 737748, 738083, 742806,
744175
GNB1, PIK3R1; 737748, 738083, 742806, 744175,
747193
PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175
SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584,
745316, 745760
CACNA1C, GNB1, PRKACA; 617414, 617437, 737748,
742806
CACNA1C, GNB1; 617414, 617437, 737748, 742806,
743584
CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316
GNB1, PRKACA; 617414, 617437, 737748, 738083,
742806, 744175
GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193
PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541
CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548, 743584, 745316
CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
742512
KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512,
748541
CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512,
742806, 748541
formally: concept formed by closure of empty set of attributes alternative: concept with attributes shared by all objects
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formally: concept formed by closure of empty set of objects alternative: concept with objects with all attributes
ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1,
KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3,
SPTBN4, SRI;
CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414,
617437
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360,
737390, 737431, 737548
ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA,
SCNN1B; 737748
CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3;
738083
CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118
ANK3, SCN1B, SPTBN4; 738391
ANK3, SCNN1B, SPTBN4; 742325
CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512
CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A,
SCNN1B; 742806
ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A,
SCNN1B; 743584
CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175
CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929
CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B;
745316
CNTN1, SCN2A, SCNN1B; 745760
CABP1, CACNA1C, CACNA2D4, CACNB3;
745845
CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
745845
CABP1, CACNA1C, CACNB3; 742512, 745316, 745845
CNTN1, SCNN1B; 737748, 745760
CNTN1, SCN2A; 744929, 745760
SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316,
745760
CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584,
745316
SCN1B, SPTBN4; 738391, 744929
SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316
CNTN1; 737748, 738083, 744929,
745760
SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316, 745760
GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083,
744175
CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175
CRKL, FADD, FAS, PIK3R1; 740606,
744175
CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175
FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175,
747193
FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175,
748642
FADD, FAS, PIK3R1; 740606, 744175, 748642
FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642
GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175,
747193
CACNA1C, CACNB3, GNB1; 617414, 617437, 743584
ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584
ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584
CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806,
743584
CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748,
742806
CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584
CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584,
745316
CACNA1C, CACNB3, PRKACA, RYR2; 617414,
617437, 742512
CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512
CABP1, CACNA1C; 738118, 742512, 745316, 745845
CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548, 742512, 743584, 745316, 745845
ANK3, SCN1B; 738391, 742390, 743584
ANK3, SCNN1B; 737748, 742325, 742390, 743584
SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584,
745316
ANK3, SPTBN4; 738391, 742325
CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175
PPM1A, SMAD2, SMAD3; 741302, 742292, 744175
SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193,
748642
CRKL, FADD, PIK3R1; 738855, 740606, 744175
FADD, PIK3R1; 738855, 740606, 744175, 747193,
748642
PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193,
748642
CRKL, PIK3R1; 738855, 740606, 742292, 744175
PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175
PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175,
747193, 748642
SPTBN4; 738391, 742325, 744929
SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390,
742806, 743584, 744929, 745316
ANK3; 737748, 738391, 742325, 742390, 743584
; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760,
745845, 747193, 748541, 748642
CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541
CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541
CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806,
743584, 745316, 745845, 748541
CNTN1, GNB1, PIK3R1, PRKACA;
737748, 738083
GNB1, PIK3R1, PRKACA; 737748, 738083, 742806,
744175
GNB1, PIK3R1; 737748, 738083, 742806, 744175,
747193
PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175
SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584,
745316, 745760
CACNA1C, GNB1, PRKACA; 617414, 617437, 737748,
742806
CACNA1C, GNB1; 617414, 617437, 737748, 742806,
743584
CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316
GNB1, PRKACA; 617414, 617437, 737748, 738083,
742806, 744175
GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193
PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541
CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548, 743584, 745316
CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
742512
KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512,
748541
CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512,
742806, 748541
![Page 22: Graph Annotation: A Tale of Two Binary Relations](https://reader033.vdocument.in/reader033/viewer/2022051613/54c6d7ab4a7959b7618b45a2/html5/thumbnails/22.jpg)
Co-atoms
ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1,
KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3,
SPTBN4, SRI;
CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414,
617437
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360,
737390, 737431, 737548
ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA,
SCNN1B; 737748
CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3;
738083
CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118
ANK3, SCN1B, SPTBN4; 738391
ANK3, SCNN1B, SPTBN4; 742325
CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512
CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A,
SCNN1B; 742806
ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A,
SCNN1B; 743584CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175
CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929
CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B;
745316
CNTN1, SCN2A, SCNN1B; 745760
CABP1, CACNA1C, CACNA2D4, CACNB3;
745845
CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
745845
CABP1, CACNA1C, CACNB3; 742512, 745316, 745845
CNTN1, SCNN1B; 737748, 745760
CNTN1, SCN2A; 744929, 745760
SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316,
745760
CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584,
745316
SCN1B, SPTBN4; 738391, 744929
SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316
CNTN1; 737748, 738083, 744929,
745760
SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316, 745760
GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083,
744175
CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175
CRKL, FADD, FAS, PIK3R1; 740606,
744175
CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175
FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175,
747193
FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175,
748642
FADD, FAS, PIK3R1; 740606, 744175, 748642
FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642
GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175,
747193
CACNA1C, CACNB3, GNB1; 617414, 617437, 743584
ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584
ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584
CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806,
743584
CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748,
742806
CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584
CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584,
745316
CACNA1C, CACNB3, PRKACA, RYR2; 617414,
617437, 742512
CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512
CABP1, CACNA1C; 738118, 742512, 745316, 745845
CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548, 742512, 743584, 745316, 745845
ANK3, SCN1B; 738391, 742390, 743584
ANK3, SCNN1B; 737748, 742325, 742390, 743584
SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584,
745316
ANK3, SPTBN4; 738391, 742325
CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175
PPM1A, SMAD2, SMAD3; 741302, 742292, 744175
SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193,
748642
CRKL, FADD, PIK3R1; 738855, 740606, 744175
FADD, PIK3R1; 738855, 740606, 744175, 747193,
748642
PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193,
748642
CRKL, PIK3R1; 738855, 740606, 742292, 744175
PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175
PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175,
747193, 748642
SPTBN4; 738391, 742325, 744929
SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390,
742806, 743584, 744929, 745316
ANK3; 737748, 738391, 742325, 742390, 743584
; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760,
745845, 747193, 748541, 748642
CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541
CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541
CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806,
743584, 745316, 745845, 748541
CNTN1, GNB1, PIK3R1, PRKACA;
737748, 738083
GNB1, PIK3R1, PRKACA; 737748, 738083, 742806,
744175
GNB1, PIK3R1; 737748, 738083, 742806, 744175,
747193
PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175
SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584,
745316, 745760
CACNA1C, GNB1, PRKACA; 617414, 617437, 737748,
742806
CACNA1C, GNB1; 617414, 617437, 737748, 742806,
743584
CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316
GNB1, PRKACA; 617414, 617437, 737748, 738083,
742806, 744175
GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193
PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541
CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548, 743584, 745316
CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
742512
KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512,
748541
CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512,
742806, 748541
immediate subconcepts of the top concept
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ChainANK3, CABP1, CACNA1C, CACNA2D4, CACNB3,
CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2,
SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI;
CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414,
617437
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360,
737390, 737431, 737548
ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA,
SCNN1B; 737748
CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3;
738083
CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118
ANK3, SCN1B, SPTBN4; 738391
ANK3, SCNN1B, SPTBN4; 742325
CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512
CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A,
SCNN1B; 742806
ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A,
SCNN1B; 743584
CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175
CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929
CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B;
745316
CNTN1, SCN2A, SCNN1B; 745760
CABP1, CACNA1C, CACNA2D4, CACNB3;
745845
CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
745845
CABP1, CACNA1C, CACNB3; 742512, 745316, 745845
CNTN1, SCNN1B; 737748, 745760
CNTN1, SCN2A; 744929, 745760
SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316,
745760
CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584,
745316
SCN1B, SPTBN4; 738391, 744929
SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316
CNTN1; 737748, 738083, 744929,
745760
SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316, 745760
GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083,
744175
CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175
CRKL, FADD, FAS, PIK3R1; 740606,
744175
CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175
FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175,
747193
FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175,
748642
FADD, FAS, PIK3R1; 740606, 744175, 748642
FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642
GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175,
747193
CACNA1C, CACNB3, GNB1; 617414, 617437, 743584
ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584
ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584
CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806,
743584
CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748,
742806
CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584
CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584,
745316
CACNA1C, CACNB3, PRKACA, RYR2; 617414,
617437, 742512
CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512
CABP1, CACNA1C; 738118, 742512, 745316, 745845
CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548, 742512, 743584, 745316, 745845
ANK3, SCN1B; 738391, 742390, 743584
ANK3, SCNN1B; 737748, 742325, 742390, 743584
SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584,
745316
ANK3, SPTBN4; 738391, 742325
CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175
PPM1A, SMAD2, SMAD3; 741302, 742292, 744175
SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193,
748642
CRKL, FADD, PIK3R1; 738855, 740606, 744175
FADD, PIK3R1; 738855, 740606, 744175, 747193,
748642
PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193,
748642
CRKL, PIK3R1; 738855, 740606, 742292, 744175
PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175
PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175,
747193, 748642
SPTBN4; 738391, 742325, 744929
SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390,
742806, 743584, 744929, 745316
ANK3; 737748, 738391, 742325, 742390, 743584
; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760,
745845, 747193, 748541, 748642
CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541
CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541
CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806,
743584, 745316, 745845, 748541
CNTN1, GNB1, PIK3R1, PRKACA;
737748, 738083
GNB1, PIK3R1, PRKACA; 737748, 738083, 742806,
744175
GNB1, PIK3R1; 737748, 738083, 742806, 744175,
747193
PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175
SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584,
745316, 745760
CACNA1C, GNB1, PRKACA; 617414, 617437, 737748,
742806
CACNA1C, GNB1; 617414, 617437, 737748, 742806,
743584
CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316
GNB1, PRKACA; 617414, 617437, 737748, 738083,
742806, 744175
GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193
PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541
CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548, 743584, 745316
CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
742512
KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512,
748541
CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512,
742806, 748541
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Anti-chain
ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1,
KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3,
SPTBN4, SRI;
CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414,
617437
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360,
737390, 737431, 737548
ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA,
SCNN1B; 737748
CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3;
738083
CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118
ANK3, SCN1B, SPTBN4; 738391
ANK3, SCNN1B, SPTBN4; 742325
CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512
CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A,
SCNN1B; 742806
ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A,
SCNN1B; 743584
CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175
CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929
CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B;
745316
CNTN1, SCN2A, SCNN1B; 745760
CABP1, CACNA1C, CACNA2D4, CACNB3;
745845
CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
745845
CABP1, CACNA1C, CACNB3; 742512, 745316, 745845
CNTN1, SCNN1B; 737748, 745760
CNTN1, SCN2A; 744929, 745760
SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316,
745760
CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584,
745316
SCN1B, SPTBN4; 738391, 744929
SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316
CNTN1; 737748, 738083, 744929,
745760
SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316, 745760
GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083,
744175
CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175
CRKL, FADD, FAS, PIK3R1; 740606,
744175
CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175
FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175,
747193
FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175,
748642
FADD, FAS, PIK3R1; 740606, 744175, 748642
FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642
GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175,
747193
CACNA1C, CACNB3, GNB1; 617414, 617437, 743584
ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584
ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584
CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806,
743584
CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748,
742806
CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584
CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584,
745316
CACNA1C, CACNB3, PRKACA, RYR2; 617414,
617437, 742512
CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512
CABP1, CACNA1C; 738118, 742512, 745316, 745845
CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548, 742512, 743584, 745316, 745845
ANK3, SCN1B; 738391, 742390, 743584
ANK3, SCNN1B; 737748, 742325, 742390, 743584
SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584,
745316
ANK3, SPTBN4; 738391, 742325
CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175
PPM1A, SMAD2, SMAD3; 741302, 742292, 744175
SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193,
748642
CRKL, FADD, PIK3R1; 738855, 740606, 744175
FADD, PIK3R1; 738855, 740606, 744175, 747193,
748642
PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193,
748642
CRKL, PIK3R1; 738855, 740606, 742292, 744175
PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175
PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175,
747193, 748642
SPTBN4; 738391, 742325, 744929
SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390,
742806, 743584, 744929, 745316
ANK3; 737748, 738391, 742325, 742390, 743584
; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760,
745845, 747193, 748541, 748642
CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541
CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541
CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806,
743584, 745316, 745845, 748541
CNTN1, GNB1, PIK3R1, PRKACA;
737748, 738083
GNB1, PIK3R1, PRKACA; 737748, 738083, 742806,
744175
GNB1, PIK3R1; 737748, 738083, 742806, 744175,
747193
PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175
SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584,
745316, 745760
CACNA1C, GNB1, PRKACA; 617414, 617437, 737748,
742806
CACNA1C, GNB1; 617414, 617437, 737748, 742806,
743584
CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316
GNB1, PRKACA; 617414, 617437, 737748, 738083,
742806, 744175
GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193
PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541
CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548, 743584, 745316
CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
742512
KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512,
748541
CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512,
742806, 748541
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Groupings (again)
• A simplified grouping is represented by a minimal anti-chain in the concept lattice that best covers objects (e.g., vertices)
• Heuristic: a. generate concepts for individual annotations b. for each, create chain by selecting subconcept with
most objects c. select from chains such that vertex set is covered
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Ex: Grouping (BLOSOM)
ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3, CNTN1, CRKL, FADD, FAS, GNB1, KCNC1,
KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2, SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3,
SPTBN4, SRI;
CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414,
617437
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360,
737390, 737431, 737548
ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA,
SCNN1B; 737748
CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3;
738083
CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118
ANK3, SCN1B, SPTBN4; 738391
ANK3, SCNN1B, SPTBN4; 742325
CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512
CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A,
SCNN1B; 742806
ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A,
SCNN1B; 743584
CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175
CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929
CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B;
745316
CNTN1, SCN2A, SCNN1B; 745760
CABP1, CACNA1C, CACNA2D4, CACNB3;
745845
CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
745845
CABP1, CACNA1C, CACNB3; 742512, 745316, 745845
CNTN1, SCNN1B; 737748, 745760
CNTN1, SCN2A; 744929, 745760
SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316,
745760
CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584,
745316
SCN1B, SPTBN4; 738391, 744929
SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316
CNTN1; 737748, 738083, 744929,
745760
SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316, 745760
GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083,
744175
CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175
CRKL, FADD, FAS, PIK3R1; 740606,
744175
CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175
FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175,
747193
FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175,
748642
FADD, FAS, PIK3R1; 740606, 744175, 748642
FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642
GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175,
747193
CACNA1C, CACNB3, GNB1; 617414, 617437, 743584
ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584
ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584
CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806,
743584
CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748,
742806
CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584
CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584,
745316
CACNA1C, CACNB3, PRKACA, RYR2; 617414,
617437, 742512
CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512
CABP1, CACNA1C; 738118, 742512, 745316, 745845
CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548, 742512, 743584, 745316, 745845
ANK3, SCN1B; 738391, 742390, 743584
ANK3, SCNN1B; 737748, 742325, 742390, 743584
SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584,
745316
ANK3, SPTBN4; 738391, 742325
CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175
PPM1A, SMAD2, SMAD3; 741302, 742292, 744175
SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193,
748642
CRKL, FADD, PIK3R1; 738855, 740606, 744175
FADD, PIK3R1; 738855, 740606, 744175, 747193,
748642
PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193,
748642
CRKL, PIK3R1; 738855, 740606, 742292, 744175
PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175
PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175,
747193, 748642
SPTBN4; 738391, 742325, 744929
SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390,
742806, 743584, 744929, 745316
ANK3; 737748, 738391, 742325, 742390, 743584
; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760,
745845, 747193, 748541, 748642
CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541
CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541
CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806,
743584, 745316, 745845, 748541
CNTN1, GNB1, PIK3R1, PRKACA;
737748, 738083
GNB1, PIK3R1, PRKACA; 737748, 738083, 742806,
744175
GNB1, PIK3R1; 737748, 738083, 742806, 744175,
747193
PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175
SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584,
745316, 745760
CACNA1C, GNB1, PRKACA; 617414, 617437, 737748,
742806
CACNA1C, GNB1; 617414, 617437, 737748, 742806,
743584
CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316
GNB1, PRKACA; 617414, 617437, 737748, 738083,
742806, 744175
GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193
PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541
CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548, 743584, 745316
CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
742512
KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512,
748541
CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512,
742806, 748541
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Ex: Grouping (BLOSOM)ANK3, CABP1, CACNA1C, CACNA2D4, CACNB3,
CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2,
SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI;
CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414,
617437
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360,
737390, 737431, 737548
ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA,
SCNN1B; 737748
CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3;
738083
CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118
ANK3, SCN1B, SPTBN4; 738391
ANK3, SCNN1B, SPTBN4; 742325
CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512
CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A,
SCNN1B; 742806
ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A,
SCNN1B; 743584
CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175
CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929
CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B;
745316
CNTN1, SCN2A, SCNN1B; 745760
CABP1, CACNA1C, CACNA2D4, CACNB3;
745845
CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
745845
CABP1, CACNA1C, CACNB3; 742512, 745316, 745845
CNTN1, SCNN1B; 737748, 745760
CNTN1, SCN2A; 744929, 745760
SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316,
745760
CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584,
745316
SCN1B, SPTBN4; 738391, 744929
SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316
CNTN1; 737748, 738083, 744929,
745760
SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316, 745760
GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083,
744175
CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175
CRKL, FADD, FAS, PIK3R1; 740606,
744175
CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175
FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175,
747193
FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175,
748642
FADD, FAS, PIK3R1; 740606, 744175, 748642
FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642
GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175,
747193
CACNA1C, CACNB3, GNB1; 617414, 617437, 743584
ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584
ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584
CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806,
743584
CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748,
742806
CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584
CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584,
745316
CACNA1C, CACNB3, PRKACA, RYR2; 617414,
617437, 742512
CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512
CABP1, CACNA1C; 738118, 742512, 745316, 745845
CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548, 742512, 743584, 745316, 745845
ANK3, SCN1B; 738391, 742390, 743584
ANK3, SCNN1B; 737748, 742325, 742390, 743584
SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584,
745316
ANK3, SPTBN4; 738391, 742325
CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175
PPM1A, SMAD2, SMAD3; 741302, 742292, 744175
SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193,
748642
CRKL, FADD, PIK3R1; 738855, 740606, 744175
FADD, PIK3R1; 738855, 740606, 744175, 747193,
748642
PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193,
748642
CRKL, PIK3R1; 738855, 740606, 742292, 744175
PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175
PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175,
747193, 748642
SPTBN4; 738391, 742325, 744929
SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390,
742806, 743584, 744929, 745316
ANK3; 737748, 738391, 742325, 742390, 743584
; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760,
745845, 747193, 748541, 748642
CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541
CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541
CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806,
743584, 745316, 745845, 748541
CNTN1, GNB1, PIK3R1, PRKACA;
737748, 738083
GNB1, PIK3R1, PRKACA; 737748, 738083, 742806,
744175
GNB1, PIK3R1; 737748, 738083, 742806, 744175,
747193
PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175
SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584,
745316, 745760
CACNA1C, GNB1, PRKACA; 617414, 617437, 737748,
742806
CACNA1C, GNB1; 617414, 617437, 737748, 742806,
743584
CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316
GNB1, PRKACA; 617414, 617437, 737748, 738083,
742806, 744175
GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193
PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541
CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548, 743584, 745316
CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
742512
KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512,
748541
CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512,
742806, 748541
MeSH: Calcium
GO BP: Metal Ion TransportGO MF: Gated Channel ActivityGO MF: Cation Channel Activity
MeSH: Signal Transduction
MeSH: Nerve Tissue Proteins
MeSH Ion Channel Gating
CRKL
ANK3
CABP1
CACNA2D4
CACNB3
GNB1
PCBD1
RIMS1
PPM1A
PRKACA
RYR2
SRI
CACNA1C
FASFADD
CNTN1
HOOK1
KCNC1 KCNC2
SMAD3
SMAD2
PIK3R1
SPTBN4
SCN1B
SCNN1B
SCN2A
note: BLOSOM finds minimal generator for a concept: smallest set of attributes with concept as closure
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Graph edges and grouping
RYR2CACNA1C
In what situations does this interaction occur?
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Graph edges
RYR2CACNA1C
CACNA1C
Ion transport protein
RYR2
Beta1 adrenergic receptor signaling pathway
Beta2 adrenergic receptor signaling pathway
cation transport
metal ion transport
channel activity
ion channel activity
gated channel activity
cation channel activity
calcium channel activity
transmembrane transporter activity
substrate specific channel activity
ion transmembrane transporter activity
substrate-specific transporter activity
cation transmembrane transporter activity
passive transmembrane transporter activity
metal ion transmembrane transporter activity
substrate-specific transmembrane transporter activity
Myocardium
Calcium Channels
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Graph edges
CACNA1C
Ion transport protein
RYR2
Beta1 adrenergic receptor signaling pathway
Beta2 adrenergic receptor signaling pathway
cation transport
metal ion transport
channel activity
ion channel activity
gated channel activity
cation channel activity
calcium channel activity
transmembrane transporter activity
substrate specific channel activity
ion transmembrane transporter activity
substrate-specific transporter activity
cation transmembrane transporter activity
passive transmembrane transporter activity
metal ion transmembrane transporter activity
substrate-specific transmembrane transporter activity
Myocardium
Calcium Channels
CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512,
748541
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FilterANK3, CABP1, CACNA1C, CACNA2D4, CACNB3,
CNTN1, CRKL, FADD, FAS, GNB1, KCNC1, KCNC2, PIK3R1, PPM1A, PRKACA, RIMS1, RYR2,
SCN1B, SCN2A, SCNN1B, SMAD2, SMAD3, SPTBN4, SRI;
CACNA1C, CACNB3, GNB1, PRKACA, RYR2; 617414,
617437
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, RYR2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360,
737390, 737431, 737548
ANK3, CACNA1C, CNTN1, GNB1, PIK3R1, PRKACA,
SCNN1B; 737748
CNTN1, GNB1, PIK3R1, PRKACA, SMAD2, SMAD3;
738083
CABP1, CACNA1C, PRKACA, RYR2, SRI; 738118
ANK3, SCN1B, SPTBN4; 738391
ANK3, SCNN1B, SPTBN4; 742325
CABP1, CACNA1C, CACNB3, PRKACA, RYR2; 742512
CACNA1C, GNB1, PIK3R1, PRKACA, SCN1B, SCN2A,
SCNN1B; 742806
ANK3, CACNA1C, CACNB3, GNB1, SCN1B, SCN2A,
SCNN1B; 743584
CRKL, FADD, FAS, GNB1, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 744175
CNTN1, RIMS1, SCN1B, SCN2A, SPTBN4; 744929
CABP1, CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B;
745316
CNTN1, SCN2A, SCNN1B; 745760
CABP1, CACNA1C, CACNA2D4, CACNB3;
745845
CACNA1C, CACNA2D4, CACNB3; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
745845
CABP1, CACNA1C, CACNB3; 742512, 745316, 745845
CNTN1, SCNN1B; 737748, 745760
CNTN1, SCN2A; 744929, 745760
SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584, 745316,
745760
CACNA1C, CACNB3, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 743584,
745316
SCN1B, SPTBN4; 738391, 744929
SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316
CNTN1; 737748, 738083, 744929,
745760
SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 742390,
742806, 743584, 744929, 745316, 745760
GNB1, PIK3R1, PRKACA, SMAD2, SMAD3; 738083,
744175
CRKL, FADD, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 744175
CRKL, FADD, FAS, PIK3R1; 740606,
744175
CRKL, PIK3R1, PPM1A, PRKACA, SMAD2, SMAD3; 742292, 744175
FADD, GNB1, PIK3R1, SMAD2, SMAD3; 744175,
747193
FADD, FAS, PIK3R1, SMAD2, SMAD3; 744175,
748642
FADD, FAS, PIK3R1; 740606, 744175, 748642
FADD, PIK3R1, SMAD2, SMAD3; 738855, 744175, 747193, 748642
GNB1, PIK3R1, SMAD2, SMAD3; 738083, 744175,
747193
CACNA1C, CACNB3, GNB1; 617414, 617437, 743584
ANK3, CACNA1C, GNB1, SCNN1B; 737748, 743584
ANK3, SCN1B, SCN2A, SCNN1B; 742390, 743584
CACNA1C, GNB1, SCN1B, SCN2A, SCNN1B; 742806,
743584
CACNA1C, GNB1, PIK3R1, PRKACA, SCNN1B; 737748,
742806
CACNA1C, GNB1, SCNN1B; 737748, 742806, 743584
CACNA1C, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742806, 743584,
745316
CACNA1C, CACNB3, PRKACA, RYR2; 617414,
617437, 742512
CABP1, CACNA1C, PRKACA, RYR2; 738118, 742512
CABP1, CACNA1C; 738118, 742512, 745316, 745845
CACNA1C, CACNB3; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548, 742512, 743584, 745316, 745845
ANK3, SCN1B; 738391, 742390, 743584
ANK3, SCNN1B; 737748, 742325, 742390, 743584
SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 742390, 742806, 743584,
745316
ANK3, SPTBN4; 738391, 742325
CRKL, PIK3R1, PRKACA, SMAD2, SMAD3; 738855, 742292, 744175
PPM1A, SMAD2, SMAD3; 741302, 742292, 744175
SMAD2, SMAD3; 738083, 738855, 741302, 742292, 742793, 744175, 747193,
748642
CRKL, FADD, PIK3R1; 738855, 740606, 744175
FADD, PIK3R1; 738855, 740606, 744175, 747193,
748642
PIK3R1, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175, 747193,
748642
CRKL, PIK3R1; 738855, 740606, 742292, 744175
PIK3R1, PRKACA, SMAD2, SMAD3; 738083, 738855, 742292, 742793, 744175
PIK3R1; 737748, 738083, 738855, 740606, 742292, 742793, 742806, 744175,
747193, 748642
SPTBN4; 738391, 742325, 744929
SCN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 738391, 742390,
742806, 743584, 744929, 745316
ANK3; 737748, 738391, 742325, 742390, 743584
; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738083, 738118, 738391, 738855, 739640, 740606, 741302, 742292, 742325, 742390, 742512, 742793, 742806, 743584, 744175, 744929, 745316, 745760,
745845, 747193, 748541, 748642
CACNA1C, PRKACA, RYR2, SRI; 738118, 739640, 748541
CACNA1C, PRKACA, RYR2; 617414, 617437, 738118, 739640, 742512, 748541
CACNA1C; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 738118, 739640, 742512, 742806,
743584, 745316, 745845, 748541
CNTN1, GNB1, PIK3R1, PRKACA;
737748, 738083
GNB1, PIK3R1, PRKACA; 737748, 738083, 742806,
744175
GNB1, PIK3R1; 737748, 738083, 742806, 744175,
747193
PIK3R1, PRKACA; 737748, 738083, 738855, 742292, 742793, 742806, 744175
SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742325, 742390, 742806, 743584,
745316, 745760
CACNA1C, GNB1, PRKACA; 617414, 617437, 737748,
742806
CACNA1C, GNB1; 617414, 617437, 737748, 742806,
743584
CACNA1C, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 737748, 742806, 743584, 745316
GNB1, PRKACA; 617414, 617437, 737748, 738083,
742806, 744175
GNB1; 617414, 617437, 737748, 738083, 742806, 743584, 744175, 747193
PRKACA; 617414, 617437, 737748, 738083, 738118, 738855, 739640, 742292, 742512, 742793, 742806, 744175, 748541
CACNA1C, KCNC1, KCNC2, RYR2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A, SCNN1B; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737232, 737255,
737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, RYR2; 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548
CACNA1C, CACNA2D4, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, CACNB3, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548, 743584, 745316
CACNA1C, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360,
737390, 737431, 737548
CACNA1C, KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390,
737431, 737548
KCNC1, KCNC2, SCN1B, SCN2A; 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431, 737548,
742806, 743584, 745316
CACNA1C, CACNB3, RYR2; 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548,
742512
KCNC1, KCNC2, SCN2A; 614163, 733740, 733911, 736632, 736738, 736786, 736810, 736836, 737094, 737232, 737234, 737255, 737293, 737304, 737332, 737360, 737390, 737431,
737548
CACNA1C, RYR2; 614163, 617414, 617437, 733740, 733911, 736632, 736738, 736786, 736810, 736839, 737232, 737255, 737304, 737332, 737360, 737390, 737431, 737548, 738118, 739640, 742512,
748541
CACNA1C, PRKACA; 617414, 617437, 737748, 738118, 739640, 742512,
742806, 748541
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Patterns
• Previous examples project annotations onto the graph
• For patterns, project the graph onto the annotations
• Can use lattice to find emergent schema (Banks et al.)
• One heuristic: for each edge (a1,a2) find concepts for a1 and a2, and follow pair of chains upward, adding edges for new objects, until cannot add more
Banks E, Nabieva E, Chazelle B, Singh M (2008) PLoS Comput Biol 4(10): e1000203
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Constructing Schema
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Schema: Moving up chains
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Schema: moving up chains
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Extracting Schema
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Final Schema
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�Recurrent pattern in graph – could be used to match other graphs
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More…
• Could keep going …
• Possible to extract association rules, decision trees and more from concept lattice and use these to annotate functional relationships in graphs (which again is something that has been done other ways)
• Also possible to work with multi-valued incidence relations (e.g., numeric data)
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Inspired and informed by working with Barbara Mirel and NCIBI DBP scientists at U.Michigan
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Resources
B Ganter, R Wille. Formal Concept Analysis: Mathematical Foundations, Springer-Verlag, 1999. !F Kriegel, Visualization of Conceptual Data with Methods of Formal Concept Analysis. Thesis, Technische Universität Dresden, 2012. !http://www.upriss.org.uk/fca/fca.html