Group 4:Integrated Fluorescent Probe and RF

Ablator

Rachel Riti

Alex Walsh

What is Radiofrequency Ablation?

Minimally invasive Treats small tumors Radiofrequency Waves1

2

Fluorescence

What is Fluorescence?4

Yield vs. Temperature5-7

8

Fiber Optics

Fiber Optic Probe– Total Internal Reflection– Flexible– Measures Fluorescence

910

Current Technology

Thermocouples

11

Objectives

Design a probe capable of both fluorescence measurements and RFA

Build the designed probe Test the probe

Integration

RF Ablator Fiber Optics

3

References

1"Radiofrequency Ablation." S. Mark Taper Foundation Imaging Center. Cedars Sinai Health System, 2000. <http://www.csmc.edu/10778.html>.

2"Ablation of Liver Tumors." The University of Texas M. D. Anderson Cancer Center. 1999. <http://www.wentek.com/jean/ablation.htm>.

3"Laparoscopic radiofrequency ablation therapy (LRFA) for the treatment of hepatocellular carcinoma." Third Department of Internal Medicine. Niigata University School of Medicine, 9 May 2002. <http://www.med.niigata-u.ac.jp/in3/old/laparo/LMCTandLRFA.html>.

4Lakowicz, Joseph R. Principles of fluorescence spectroscopy. 3rd ed. Baltimore: Springer Science+Business Media, LLC, 2006.

5Menter, Julian M. “Temperature dependence of collagen fluorescence.” Photochemical and Phtotbiological Sciences. 2006 5, 403-410.

6A. Oliver, G. Baker, R. Fugate, F. Tablin, and J. Crowe, "Effects of Temperature on Calcium-Sensitive Fluorescent Probes," Biophysical Journal, vol. 78, pp 2116-2126, 2000.

7E. Bowen, and J. Sahu. "The Effect of Temperature on Fluorescence of Solutions," Journal of Physical Chemisty, vol. 63, pp 4-7, 1959.

8"Fluorescence." Be Seen On a Bike. <http://www.beseenonabike.com/bsoab/beseenonabike_info_fluorescence.htm>.

9"How Fiber Optics Work." Howstuffworks "Electronics.” 09 Nov. 2009. <http://electronics.howstuffworks.com/fiber-optic.htm>.

10"40 Principles of Invention #2: Taking Out [TRIZ]." Paprika Lab. 25 June 2008. <http://paprikalab.com/blog/?p=165>.

11 RITA Medical Systems, “RITA Starburst SDE Electrosurgical Device.” Instructions for Use.