1.THE SOURCE of our NATURAL WELL-BEINGWORLD PATENTS AND EXCLUSIVENESS

2. 02/03TABLE OF CONTENTSDearFriends..............................................05Our Mission ................................................................................ 06/07 The vision ...................................................................................... 08/09 Story of a man ............................................................................ 10/13 Maintenance of the source of our life is our responsibility .................................................................. 14/15 presents a world exclusivity : Orochronodietology How and why ? ................................................................................ 18 The cell .................................................................................................. 19 The chrono cycle of the cell .................................................... 20 The orogranule .............................................................................. 21 Orality and orobioavailability ........................................................ 22 Conclusion .......................................................................................... 23 RENEW .............................................................. 24/29 FLEX ...................................................................... 30/35 RELAX .................................................................. 36/41 ENERGY ............................................................ 42/47 SLIM ...................................................................... 48/53 NOTOBACKO .............................................. 54/59 TMConclusion..................................................................................60/61 3. 04/05DearThe international structure organized for a rapid and straight enlargement worldwide, the HAPPY.CO software, easy and user friendly, the back office complete and skilled, are all some of our main benefits. The marketing program is very attractive and easy to understand, making it possible for everyone to reach a fast success and offer the opportunity to build a lasting and satisfactory personal improvement through a fantastic mission.FriendsA very important project of new Orochronodietology and dermo dietology products launching is already planned for the next few years.and As Chairman of the Scientific Committee Im very proud and glad to share with you the launch of HAPPY.CO and Orochronodietology worldwide.Orochronodietology : a NEW, BUT ALREADY STRONG AND LASTING HAPPINESS OPPORTUNITY!!! The most innovative and revolutionaryAt the end of 2011, as the chairman of LGZ and responsible for the development and diffusion of Orochronodietology, I was approached by a group of professionals and experts who offered us the exclusivity rights for Orochronodietology in the segment of Network Marketing. We were all really fascinated by the conviction, the motivation and the happiness of these people, which goal was to create a new Company dedicated to Orochronodietology, and to the future development of this fantastic and very promising new natural therapy. With this in mind, It seemed obvious to all of us that we should call this new Company HAPPY.CO, which mission would be to give the opportunity for people to be HAPPY and help them through Orochronodietology, both from a health as well as an ethical development point of view. Starting a new Company with such an innovation in such a turbulent moment is not easy, but our roots are strong and our branches ready to grow quickly.offer in the MLM segment ever proposed for a HAPPY World! A good reason to join us immediately!!! 4. 06/07Our mission Happiness withThe human being can be defined as a complex of intelligent cells with memory, each providing a specific function which work all together in a perfect synergy. A genius of cinema, Woody Allen, defined Health as a state of transition that doesnt promise anything good: just a minimum unbalance can modify our general health status . Even the World Health Organization (WHO) uses this definition in its Constitution preamble of 1946, which hasnt been modified since. Health is a complete state of physical, mental and social wellness, and is not defined as the simple absence of illness or infirmity. It implies that the possibility to satisfy the basic and fundamental needs of the person, whether those needs would be emotional, health related, nutritional, social or cultural, starting from the embryo stage to the elderly ones of our life. Paraphrasing this definition, we can also say that happiness is a transition state that doesnt promise anything good: just a small physical or psychological or even emotional problem makes us face a reality that is no longer the ideal one we were living just a few moments before. And the more time passes without happiness, the harder it is to find it again. HAPPY.CO wanted to look for natural tools that can help us find happiness in our body, our soul and our global life. If we were happy at some point in our life, lets look inside ourselves ! If we did it once, what prevents us from being happy again? lets look inside ourselves ! We ask you this: could we have "unconsciously" locked our way to happiness? Is it because we dont want to make a choice? Our state of mind impacts our health. Lets look inside ourselves ! Be positive! Our little inner voice always speaks to us but we are deaf. We just dont want to listen to it. Yet our cells constantly send us messages that would enable us, if we listened to them, to regain our balance more easily, feel stronger and therefore more willing to take concrete action and believe in our projects and ambitions.Happiness is also to DARE. IF YOU WANT IT, YOU OBTAIN IT, as we were told by our elders when we were children, and how true it was then. BUT now that we definitely have a better control of ourselves, we do not believe in that anymore. Whats stopping us? Our body is a vehicle of happiness. In order to be happy, we need to be in full control of our vehicle. Our body is telling us something constantly using the language of the cells. Orochronodietology helps to rebuild the bridge towards the cells, helping them to reach again their active complexity and their integrity. Following their biological, nutritional and functional cycle, Orochronodietology leads them out of the stress condition where we were putting them through our behaviour and lifestyle. When free from stress, cells can just communicate their happiness and their message will finally be heard by our whole being, for a global happiness.With exclusive concepts and results of Orochronodietology , we cannot set lower goals! REB UI LD YOUR HA P P I N E S S WI TH:I t' a gre a t a mb ition, I TS OUR MI SSI ON 5. 08/09VISION: The main target of the company is to help people find their own way to happiness and help them live their life in the right way through the rediscovery of natural health.We want to be: The reference MLM company in the field of natural health in the next 5-10 years; The company that has the trust and the fidelity of all its customers; A constantly forward looking company; An extraordinary team to work and cooperate with. GOALS: We can make this real, together with the HAPPY.CO friends, through the following:1. The development and diffusion, both in scientific and geo graphical terms, of Orochronodietology and HAPPY.CO products starting from Europe and then moving to the rest of the continents.2. The continuous innovation of the HAPPY.CO products as natural tools available to everybody and for everybody.3. The continuous development and maintaining of the ethical, quality and safety value of the HAPPY.CO products and of the entire HAPPY.CO project, already guaranteed by the whole of the company and by every single HAPPY.CO friend.4. The involvement and participationof all the HAPPY.CO friends in the HAPPY.CO children charity programs all over the world, through the financing and/or the realization of CHILD HOSPITALS, SCHOOLS, EDUCATIONAL CENTERS and EDUCATIONAL PROGRAMS.If you share these values, youre already a happy friend !Its time to be happy ! 6. 10/11Story of a Man Nature always expresses itself : you only need to know how to understand it and observe it with humilityBehind my passion for natural medicine there are experiences of my life. Ive always believed that man and nature both possess remedies to the unbalances that manifest in man as diseases. He who knows the sick well, also knows how much talking and giving attention can help resolve many of their problems. He who knows nature also knows how much the study of its language and correct utilization of its fruit can be used to cure the sicknesses of man. All of this is the foundation of my belief and my personal and professional experiences. Venetian, descendant of a dynasty of doctors, chemists and pharmacists for five generations, I had the opportunity, since my youth, to also live both the scientific spirit of the familys chemical pharmaceutical group and the simplicity of another great family tradition : the love of nature, earth and the agricultural world. Actually, I grew up among the grape vines agricultural farm in the hills of Vicenza where my parents brought me to life. Here, since I was a boy, among farmers and farm animals, I was fascinated by the alchemy of vine production and the medicine of simple folk. I tried to understand the secrets of medicinal herbs prepared by old farmers according to the tradition of folk medicine. I have always been sensitive to the stories of the elderly on their use of popular medicine. I was fascinated by their capacity to instinctively individualize, in spite of their diagnostic ignorance and medical therapy, good natural remedies : there was always one available and immediately efficient. Nature always expresses itself : you only need to know how to understand it and observe it with humility as I was told as a medical student, but I was over enthusiastic with a hunger to learn the great scientific theories. These strong memories and this apparent contrast between science and nature, had a lot of importance on my professional life. After graduating in medicine and surgery at the University of Padova in Italy with specialization in General surgery, Anesthesia, Reanimation and clinical pharmacology, I dedicated my first fifteen years of medical profession alternating surgical practice with teaching at the university and research in medicine and pharmacology. The desire for researchand creativity oriented me toward the management of international projects in my family pharmaceutical group created by my grandfather. Within Zambon Laboratories, was a maturation of fundamental experiences of research and pharmaceutical industrial development that lead me to France at Sophia Antipolis in the early 1990s. It was then that I found the meeting point of my experiences and my aspirations: France, in Europe, is a country where phytotherapeutic research is at the avant-garde and the south of France is rich in culture and tradition of the natural world. It was impossible not to find my roots and wings in this environment: my first laboratory of Research and Development is in some way the union of my experience in research, my medical practice and the competence that I developed through the great knowledge of plants and aromatic herbs in this French region. Twenty years as head of a formidable staff of experts in phytoaroma- therapy allowed me to open doors to innovation I found what Id looked for in a long time in my research in this field. Thanks to this innovation, confirmed by worldwide patents obtained today, I was able to transfer my competences, my medical and clinical culture and my experiences of pure research and applied research in a new enterprise reality. I founded Laboratoires Docteur Zannini where nature-sciencecreativity-innovation-efficient and pharmaceutical quality found their realm in offering everybody the benefits that nature made available. In collaboration with international Research Centers, world famous universities, and profiting of medicine and pharmacology researchers skills and experiences, we finally created in 2009 orodietology and in 2010 Orochronodietology, which development and exclusiveness diffusion are from now on ensured by HAPPY.CO international, in perfect synergy and synchrony with Laboratoires Docteur Zannini. 7. 12/13... whichhad its reflectingsIn the research unity, development and production realization. The innovation and ethic, through the respect of nature and environment When I began reflecting on the creation of Laboratoires Docteur Zannini, the syntony between the creation of natural remedies and respect of nature in the entire chain of the fabrication process seemed inevitable to me. My objective has always been to conceive a means of production where the pharmaceutical quality and technology naturally get united with respect to the environment and protection of natural energetic sources. It was in Saint Raphael, south east of the french riviera, that I found the right place. On an old improved refuse site, the technological park Epsilon offered me the opportunity to construct an industrial structure whose composted foundation already respected nature. We then decided to identify and apply to our project the most modern technology in the field of sustainable development, with particular regards to energy.Coherent with this philosophy, our center of production is still today the first industrial establishment in the world to utilize solar energy as a source for all energetic needs, for both air treatment and the nourishing of the industrial process, thanks to a new system that utilizes solar air-conditioning by desiccation. Enough of consuming gas and other energetic sources and make way to a more natural system of production. Sun is sufficient for heating, cooling or climatizing the production cycle to the ideal temperature making it capable of maintaining the best characteristics of our raw plant material and nourishing our whole fabrication process. More than 1800 square meters of high natural technology was built on a terrain of more than 4000 square meters where we wanted to maintain the vegetation that spontaneously grew in this region : lavender, rosemary, thyme, sage, eucalyptus and... grape vines.Innovation, quality and respect for the environment are guaranteed at Laboratoires Docteur Gaetano Zannini who placed at the disposal of HAPPY.COTM International all these wonders of nature ! 8. 14/15Maintenance of the source of our life is our responsibility Nutrition is the source of our lives, since the first cell of the new born is created in the womb of the mother.The new scientific disciplines are more and more interested in the relationship between nutrition and cellular memory. Recent studies (for example of epigenetic) tend to demonstrate that food can interfere with the cells behaviour, even with changes to the chromosomal level. The food supply is supposed to bring to the body all the nutrients necessary for its proper functioning, and therefore to the maintenance of good health. The nutrients are the elementary components contained in the food, or from the ambient nature. They are used by the body to cover its physiological needs, including for growth and development. Water is the main element of our functioning; the carbohydrates, lipids, proteins have a particular energetic function, a function of constitution and of maintenance of tissues; vitamins, essential amino acids, essential fatty acids, the mineral elements (Na, K, Ca, P, Mg, S, Fe, Zn, etc. ), the oligo-elements (I, Cu, Co, Cr, Mn, V, Mo, Ni, Pb, etc. ) have a role in the regulation of metabolism and, finally, the dietary fiber have a function primarily of mechanical type.Nature has created different food, rich in essential nutrients, with a daily and seasonal rhythm, to allow us to be constantly well fed and therefore to be able to respond to the demands of our life and respect what should be our normal life cycle, on daily and in the course of the years basis. However, progressively industrialized, food is paradoxically far from the basic objective and has become poor and toxic. Indeed, the food extracted of intensive practices, whether they are of plant or animal origin, is subject to multiple changes. For reasons of storage, conservation, sustainability, it undergoes aggressive transformation. It is refined, heated to high temperature, irradiated... At equal weight, food contains fewer nutrients than when extracted from traditional agriculture, which has led to an incomplete food supply: - For the food of plant origin: the vitamins and nutrients are affected. 9. 16/17 - For the food of animal origin: the protein content is reduced in favor of water and fat primarily composed of saturated fatty acids. Various substances are incorporated at various stages of production of the modern food, making it less effective for the organism: - The chemical fertilizers and pesticides are an integral part of the intensive agriculture. - confectionery, dairy desserts and many industrial food products contain refined white sugar in large quantities ; - food additives (salts, dextrin, colourings, preservatives, flavour enhancers, flavourings, agents of palatability ...) are used in abundance The food of today is therefore no longer capable of providing us all in good time the nutrients that our body needs. In addition to the defects of the industrialized food impeding the physiological well being, the negative points of the modern way of life of the general population are added, such as stress, smoking, pollution, fatigue ... which are generators of oxidative stress at the cellular level. Our food has therefore become constantly stricken. To maintain a good health, we would ideally need to associate a food supply with an intact natural quality, a perfect mastery of cooking, follow the seasonality of natural foods and of the food as it is known by our cellular memory for centuries and centuries, a regular physical activity, manage daily stress, eliminate tobacco, a good sunprotection all conditions hardly do-able simultaneously. If, years ago, food supplementation was recommended, today, we may well say that it must be mandatory. To fill the existing deficiencies in vitamins and essential nutrients, the use of nutritional supplements capable of providing a true complete cellular Micronutrition becomes inevitable.Orochronodietology is the first cellular nutritional supplement which has proven to be able to supply to the body the essential elements to its proper functioning. In agreement with the needs of the bodys rhythm, it provides nutrition and cellular protection while reviving the impaired functions. Thus properly nourished, protected and supported, the body can perform its vital functions more easily and regain its balance and therefore its ideal functioning.presents a world exclusivity: OROCHRONODIETOLOGY TM 10. 18/19Each new complex resulting from the Orochronodietology is going to be supplied to the cells at the time, depending on their cycle, when they are most capable of profiting.Orochronodietology is the first and only natural scientific discipline that acts : 1.Simultaneously and immediately on all the sources of the imbalance to be treated. 2.At the global cellular level (in active synergy on nutrition, antioxidant protection and functional recovery). 3.Through buccal assimilation, 4.Respecting the natural biological clock.The Happy.co Orochronodietology programs : natural efficacy at its top proven in hours and days and not anymore in weeks and months ! The Cell the cell is the source of our life. Our organism is a complex of intelligent cells, with a memory and each of them having a specific function.- The only ones who are "built" one by one, by the gradual and simultaneous progressive integration of the active ingredients from the center to the periphery. Thanks to this the active ingredients become simultaneously content and container. - The only ones who can integrate in the complex all kind of active ingredients, regardless of their physical and chemical nature (liquid, powder, solid oils, essential oils ...). - The only ones that can so create a new natural complex providing a synergy of multi-target simultaneous and immediate actions. - The only ones where the content is also the container: no need of envelope, of excipient, of capsule, of gelatin, of cellulose, of preservatives. Alcohol and GMO-free.The cell and the wellbeingThe health of the cell depends primarily on its metabolic and nutritional balance, which influence directly effectiveness of its physiological function>I n c r e a s e dN e e dincreased operation increased consumptionThe role of the cells is essential to the life of the organism. However, to ensure their role, the health of cells depends on three key points: - Their Nutrition: the cell must be nourished in order to grow and reproduce. - Their Protection: the cell must be well nourished in order to defend and protect itself - Their Function: the cell must be well nourished and protected in order to exercise its specific physiological function.How and Why ? Thanks to the technology of the orogranules:The cell therefore needs its specific nutrients, that can be found in the blood, that will be used depending on the need within the 24 hours (enzymes, fatty acids, carbohydrates, proteins, trace elements ...).In order to effectively perform their Functions, cells must have a correct Nutritional level and appropriate Protection capabilities. Each disturbance of these levels, whatever the cause, will result in a cellular suffering. During such a disturbance, the cells are forced to temporarily stop their function to be able to find a proper state of nutrition and protection again: the dysfunction is installed. If the cells are no longer able to react, the dysfunction will then be gradually extended to other cells resulting in a state of imbalance in the body, which may gradually evolve into a disease.Nutrition Only well nourished and well protected cells can exercise at their best all the different functions that are vital to the wellbeing of the organism.depletion of the reserves inefficiency of the cellInactive cellreduction in defenses of the cell>Orochronodietology follows in its action the internal biological clock and the rhythmic operation of the various cellular reactions in order to optimize the nutritional and functional effectiveness of the various natural complexes included into the Happyco Programs.- POWER: the only one that acts on all sources of the problem thanks to its synergistic multi-target action. - GLOBALITY : the only one that has a complete and simultaneous action on all cells, including the three elements essential to the cell: the nutrition, protection, and its specific function. - RAPIDITY: the only one that is absorbed immediately and directly in the mouth, which allows the direct passage of natural principles in the organism and then into the cells. - BALANCE: the only one respecting the 24 hours cellular biological rhythm. - SAFETY: the only one that has no envelope, no capsule, no excipients, no gelatin, no cellulose, no conservatives, no alcohol and its totally GMO-free.- The only ones that, according to those factors, allow the orobioavailability : direct buccal assimilation ensures 100% absorption of natural active ingredients in the organism, avoiding the classic digestive way, without loss of quality and quantity of the multi-target action.>Orochronodietology is a new science (LOGY) that studies the cellular dietary (DIETO) through mouth assimilation (ORO : from latin Os, oris mouth) respecting the natural daily biorhythm.ITS 5 SOURCES OF WELLBEING:>A new and unique product which acts at the source of our natural wellbeing, 100% of natural origin, and allows to restore, maintain and stabilize very quickly the global balance of the cell with the result of restoring a healthy and happy life.Protection All the metabolic activities of the cell are producing toxins and waste, often in the form of free radicals. When they are produced in excess, they become killers for the cell. Thanks to the nature, the cells have their means to defend themselves, and thus ensure the smooth running of their functions. This is going only to happen, anyway, when in a condition of balance. Unfortunately, the current living conditions, with poor diet, different abuses (tobacco, alcohol ...), lack of exercise, sunlight, stress ... are leading to an increased cellular production of free radicals, and therefore lead to an increased consumption of the antiradical resources of the cell. Nowadays we require to the cells a lot more than that for which they were programmed. The cell specific defense systems are no longer sufficient to ensure a proper protection. A cell inadequately fed and not protected will be subject to the attack of free radicals, depleting its reserves, and not being able to perform its function any longer. This could bring, eventually, to the cell death. Just a single cell becoming inadequate is able to cause a chain reaction leading to a general state of imbalance. 11. 20/21100%100%100%100%0%0%0%0%0% >P < 0.001120 >P < 0.01>110Anti-Oxidation Abilities of Relax Daily (KRL Test)14000 800fluorescence intensity (proportional to oxidant stress) RELAXE Vitaminwitness without productConclusion: Even in low concentration, the action of the Morning program of relax complex on anti- oxidation protection is bigger than action of vitamin E in high concentration.Good for:Life stressDaily also ensures effects of the cell nutrition protection, which allows for maintaining an optimum energy and protection capacity, has a soothing effect against cramps and easy digestion.Anti-Oxidation protector effect[In Press, AJCM)140 Te s t K R LMorning restores the reserves of energy and defensive substancesStudy Conducted with Cell Cultures of Human Keratinocytes (skin cells) after Exposure to Peroxides (induces oxidation stress, i.e. production of free radicals)Daily- supplying the cells with nutrition and defensive substances - preparing the organism for better managing of everyday stressThe nerve cells perform their specific tasks during the day, while they have to respond to everyday mental and physical tasks in order to avoid gradual weakening of the organism.Antioxidation effect (% increase of T1/2 of blood witness)By night :Designed for:Concentration (g/l)TMThe Relax Daily Path has a very significant Anti- Oxidation Effect: it improves resistance to radicals by almost 700% as compared with the reference blood sample700 600 500 400P. Piccerelle, M. Prost, Actes Symposium - New 21st Century Health Challenges and Pre-Medicine, Cassis (France), 21 Mars 2009.300 200 100 0 0125Concentration (by g/l of reaction medium)100 N = 77 Low LowN = 81N = 26 moderate moderateN = 77N = 81N = 26High HighStress impairs the cell ability to defend against radicals P. Piccerelle, M. Prost, Actes Symposium - New 21st Century Health Challenges and Pre-Medicine, Cassis (France), 21 Mars 2009.They need nutrition for their energy demands, for their protection, as well as specific nutrition for their specific tasks.Daily keeps satisfying the needs of the cell nutrition and stamina, but it mainly acts on the nerve cells in imbalance, these need specific nutrition with respect to their function. 21. relax40/41The clinical study conducted for a period of one month in a hospital environment with 20 individuals proved efficient action of Relax on mood and sleep disorders: 3Waking up tired32,52,5221,5Irritation during the day1,51-78%10,50,50-66%Anti-Oxidation Abilities of Relax Evening (KRL Test) Antioxidation effect (% increase of T1/2 of blood witness)TM800 600 500 400 300 200 100 00 Day 0Day 30Day 01 0 2 5 10 Concentration (by g/l of reaction medium)Day 30Relax enables reduction of irritation during the day. P. Piccerelle, M. Prost, Actes Symposium - New 21st Century Health Challenges and Pre-Medicine, Cassis (France), 21 Mars 2009.The Relax Evening has a very significant anti-oxidation effect: it improves resistance to radicals by almost 750% as compared with the reference blood sample.700Effect of Relax evening program on free radicals production after 1 hour of lymphocyte cultureIn the evening, the cell must get ready for correct performance of their night function of restoration, regeneration and detoxification. Stress exhausts the cells designated for defence. These cells of the immune system activate and regenerate during the night.f luorescence intensity2 500 000EveningAntioxidant effect on lymphocytes, in a dosedependant fashion, allowing for the most tested concentrations a decrease of more than 50% of free radicals produced after 1 hour.2 000 000 1 500 000 1 000 000 500 0000=T1237111330Other Supporting Studies - KRL tests conducted with Relax Morning, Daily and Evening, KIRIAL International a company of the Spiral group of laboratories - KRL Patent Michel Prost PCT/FR90/00061, 2009. - Proceedings of Symposium NEW 21ST CENTURY HEALTH CHALLENGES ANDPRE-MEDICINE, Cassis (France), 21 March 2009.Effect of Relax evening program on free radicals production after 24 hours of lymphocyte culture f luorescence intensity- mitigating the impact of stress on organism - strengthening the organism defense - improving resistance of organism to everyday attacks from outside - increasing tolerance to change of seasonsRecommended dosage can be doubled, if required: - 2 Orogranules of Morning in the morning - 4 Orogranules of Daily, two before noon and two eventually at the end of afternoon - 2 Orogranules of Evening before going to sleep.- MILLER AH., Depression and immunity: a role for T cells? Brain Behav Immun. 2010; 24(1):1-8.Concentration (mg/L)2 000 000Good for:Orogranules are to be dissolved mainly in mouth in order to support orobioavailability (instant absorption of active components by buccal way). - 1 Orogranule of Morning in the morning - 2 Orogranules of Daily, one before noon and one at the end of afternoon (or both at one time before noon) - 1 Orogranule of Evening before going to sleep.- DE COTRET LR, Sleep: Period of Intensive Activity. Passeport Sant, 6 October 2008.0Evening continues to support the cell nutrition and stamina, however, it mainly acts on the immune system cells, which need to renew properly to ensure their efficiency during the day, and in particular, to ensure response in stress situations.P. Piccerelle, M. Prost, Actes Symposium - New 21st Century Health Challenges and Pre-Medicine, Cassis (France), 21 Mars 2009.Recommended Use:Antioxidant effect on lymphocytes, in a dose-dependant fashion, for a concentrations of 0,33g/l, Relax Evening program generates a decrease of 37% of free radicals produced within 24 hours.1 500 000 1 000 000 500 000 0 0=T1237Concentration (mg/L)111330RELAX is the only preparation that allows for dealing with various stress situations the organism is exposed to during the day and night, while respecting the daily cell rhythm. 22. 42/43TMHAPPY.COenergy The only preparation thatsuppliestone and energy while respecting the day and night cellular biorythm. 23. TMenergy44/45- cases of decreased energy - cases of insufficient vitality - cases of physical and mental overload - cases of insufficient resistance to load - cases of long and difficult recovery - cases of difficulties with falling asleep and sleeping disordersMorning A strain, whether physical or mental, induces higher production of free radicals.Impact of Physical Exercise on Potential of Defence against Radicals (KRL test)DailyMorningThey need nutrition for their demand for energy and defense, as well as nutrition specific for its tasks.N = Number of studied cases P < 0.01140restores the reserves of energy and defensive substances consumed during the night, and restores the cells, mainly the cells that were exposed to hazard from the external environment the most, to an optimum state so that they can efficiently deal with the load of the entire day and ensure fulfillment of their specific tasks.Good for: - supplying the cells with nutrition and defense - preparing the cells for better functioning during the dayDaily not only makes sure the permanently more intensive cell processes and the level of anti-oxidants, which is impaired by production of free radicals associated with everyday physical and mental strain, are maintained, but it is efficient also at the level of physical and intellectual performance by having adapting effect on the central nervous system, stimulation of adrenal and spermatic glands with stimulation of resistance to tiredness. It also shortens the time required for recovery of strengths and better mastering of physical and mental strain.>120100 N = 46 Non athleteN = 66 Amateur athleteN = 72 Regular athleteAlthough those who train on a regular basis feel more protected, the reduced general potential of defense after strain is always directed against radicals. P. Piccerelle, M. Prost, Actes Symposium - New 21st Century Health Challenges and Pre-Medicine, Cassis (France), 21 Mars 2009.This is why the cells need more to relax after a full day of strain. -58% of free radicals605025At night the cell uses: - nutrition that is available in the blood circulation for its demand for energy, as well as for renewal and detoxification; - its own means of anti-oxidation in order to restrict harmful effects of free radicals produced during the night activities of the cell.> -63% of free radicalsAntioxidation effect (% increase of T1/2 of blood witness)110Concentration (g/l)1,5Reduction of Fatigue and muscular pain6055- improving physical and intellectual vitality - improving resistance to tiredness - shortening of recovery time - helping to manage stressEffet protecteur antioxydant7060Good for:>130The clinical study conducted with 20 sportsmen for a period of 4 months confirmed the efficient action of Energy (Daily) on tone, vitality and sporting performance:The muscle cells perform their specific functions.Study Conducted with Cell Cultures of Human Keratinocytes (skin cells) after Exposure to Peroxides (induces oxidation stress, i.e. production of free radicals)>Time of half haemolysis (in min)150the cells, therefore, have the need to restore their energy reserves and their anti-oxidation defense ability, so that they get to the best possible form to support the specific activities during the day.In the morning,Designed for:T0 T4 Beginning of the study End of the studyRecovery after physical effort Physical fitness 40 35 30 25 20 15 10 5 0Sleep disorder- 78%T0 T4 Beginning of the study End of the studyConcentration 300The Energy Daily Path has a very good anti-oxidation ability: it improves resistance to radicals by almost 270% as compared with the reference blood sample.250 200 150 100 50 0 02510Concentration (by g/l of reaction medium)P. Piccerelle, M. Prost, Actes Symposium - New 21st Century Health Challenges and Pre-Medicine, Cassis (France), 21 Mars 2009.Energy Daily increases the sport and mental performance with the action on speed of strength recovery, quality of sleep, significant improvement of sporting performance. P. Piccerelle, M. Prost, Actes Symposium - New 21st Century Health Challenges and Pre-Medicine, Cassis (France), 21 Mars 2009. 24. TMenergy46/47 Other Supporting Studies:Clinical study conducted for a period of one month in a hospital environment with 20 subjects:Evening All cells, in particular the muscle and nerve cells, must get ready to perform their night functions of renewal, regeneration and detoxification correctly. The sleeping phase must be efficient and strengthening. The cells need nutrition in order to provide for their demand for energy and defence. The organism must calm down in order to ensure efficiency the recovery phase during the sleep, thus efficiency of specific daily tasks.Evening keeps maintaining the needs of cell nutrition andPeriod of replenishing (in min)6,8 6,620 - 10 mn106,4 6,2 6Day 0Day 30Sleep disorder 2,5 2 1,5- Shortening the required sleeping time - Improving quality of sleep - Ensuring night relax that regenerates - Brings relief and relaxation for better natural ability to respond to impulses+ 40 mn7 300Good for:Total sleep time (in hour) 7,240protection, however, mainly acts on the nervous system cells. Therefore, Evening will ensure the nutrition protection that will enable the immune cells to optimize the energy reserves and defense abilities, it has a soothing effect, sedative effect and anticramp effect with digestion easement.Recommended Use:- 60% 1 0,5 Day 0Day 0Day 30The Energy Evening Path enables to shorten the time of falling asleep, to prolong the sleeping time and to mitigate the sleeping disorders. Subjects sleep better and are less tired in the morning, so they are less stressed during the day: the subjects are quite at night, allowing them to calm down during the day and be more resistant to daily aggressions.Day 30P. Piccerelle, M. Prost, Actes Symposium - New 21st Century Health Challenges and Pre-Medicine, Cassis (France), 21 Mars 2009.Antioxidation effect (% increase of T1/2 of blood witness)Anti-Oxidation Effect of Energy Evening (KRL Test) 800Energy Evening has a very significant anti-oxidation effect: it improves resistance to radicals by almost 700% as compared with the reference blood sample.600 400 200 0 1 0 2 5 Concentration (by g/l of reaction medium)P. Piccerelle, M. Prost, Actes Symposium - New 21st Century Health Challenges and Pre-Medicine, Cassis (France), 21 Mars 2009.ENERGY is the only preparation that brings optimum levels of physical and mental energy in both normal situations and situations of higher demand while respecting the daily rhythm of the cell.Orogranules are to be dissolved mainly in mouth in order to support orobioavailability (instant absorption of active components by buccal way). - 1 Orogranule of Morning in the morning - 2 Orogranules of Daily, one before noon and one at the end of afternoon (or both at one time before noon) - 1 Orogranule of Evening before going to sleep. Recommended dosage can be doubled, if required: - 2 Orogranules of Morning in the morning - 4 Orogranules of Daily, two before noon and two eventually at the end of afternoon - 2 Orogranules of Evening before going to sleep.- KRL tests conducted with Energy Morning, Daily and Evening, KIRIAL International a company of the Spiral group of laboratories - KRL Patent Michel Prost PCT/FR90/00061, 2009. - Proceedings of Symposium NEW 21ST CENTURY HEALTH CHALLENGES ANDPRE-MEDICINE, Cassis (France), 21 March 2009. - DE COTRET LR, Sleep: Period of Intensive Activity. Passeport Sant, 6 October 2008. 25. 48/49TMHAPPY.COslim The only preparation thatenables adjustment of the body shapes while respecting the day and night cellular biorythm 26. slim- cases of body weight increase - cases of swelling feelings - retention - cellulite and incrassation - accumulation of fat, localized masses of fat - unaesthetic swelling - loss of tone of muscles and tissueresistance). These sugars first deposit in the form of muscle and liver glycogen, then in the form of fats. Therefore, it is required to have a sufficient amount of substances supporting degradation of reserves during the morning supply of nutrition during the slimming process.Morning restoresthe reserves of energy and protection of fat cells, acts on heat release, microcirculation activation, dewatering, removal of waste products and detoxification.- supplying nutrition and protection to fat cells - supporting release of fat reserves - supporting fat mass reduction - supporting mitigation of cellulite and incrassation.A failure to cope with eating customs, lack of movement, stress these are at the birth of deregulation of the biological clock of the cells, leading to excessive weight and excessive fat deposition. The fact is that the periods of activity and relaxation within a physiological cycle controlled by the biological clock play the fundamental role in the cell metabolism and for a balance between the fat deposition and consumption.In the weight reduction process, it is important to strengthen removal of the waste from the cell metabolism and restrict the water retention phenomenon, which are two factors impairing the overall functioning of organism, feeling of swelling and gaining weight. During the day the cells take care of dewatering and excretion and perform their specific functions. They need nutrition for their demand for energy and defense, as well as nutrition specific for their functioning. keeps maintaining the cell needs for nutrition and defense, acting mainly on the cells providing for dewatering, which need nutrition specific for their functioning, which results in improved process of detoxification and removal of excessive water.Good for: - reducing overweight - getting slimmertheir energy reserve and ability to defend against oxidants so that they can support the specific activities of the organism during the day in an optimum condition. In presence of excessive fat, the metabolism of fat cells is disturbed, stressed, which leads to excessive production of free radicals. The fat cells thus have an extraordinary need to strengthen the anti-oxidation defence capacity. Unlike the slow sugars, the fast sugars deposit more quickly in the morning and at noon, as certain insulin receptors (supporting utilization of sugars) are less sensitive in the morning (physiological insulin0 -0,2 -0,4 -0,6 -0,8- 1 cm-1 -1,2 - 1,3 cm-1,4 - 1,3 cm-1,6 Day 0The Slim Morning Path has a very significant anti-oxidation effect: it improves resistance to radicals by almost 700% as compared with the reference blood sample.700 600 500 400 300 200 100 0 1 0 2 5 Concentration (by g/l of reaction medium)Day 15Reduction of waist circumference Reduction of thighs circumference Reduction of hip circumferenceDay 30Evolution of the swelling sensation and bulimic impulses with Slim Daily program 2,3 1,8 - 43% 1,3 - 29% 0,8 Day 15800P. Piccerelle, M. Prost, Actes Symposium - New 21st Century Health Challenges and Pre-Medicine, Cassis (France), 21 Mars 2009.The clinical study conducted with 30 women with IMC index between 24 and 30 proved efficient action of Slim (Daily) on reduction of weight, number of measurements and feeling of gaining weight:Efficiency of Slim Daily program in the weight loss 0 -0,4 -0,6 -0,8 -1 -1,2 - 1,5 kg-1,4 -1,6Weight loss Day 0*Day 15IMC = Body weight rate.Day 30Swelling sensation Bulimic impulsesDay 30After 30 days of use, Slim Daily achieved an average reduction of weight by 1,5 kg and reduction in number of measurements, as well as reduced feeling of swelling and bulimia recurrence. P. Piccerelle, M. Prost, Actes Symposium - New 21st Century Health Challenges and Pre-Medicine, Cassis (France), 21 Mars 2009.-0,2 Weight loss (in kg)In the morning, the cells need nutrition in order to restoreAntio x idation effect (% increase of T1/2 of blood witness)Anti-Oxidation Effect of Slim Morning (KRL Test) At night the cell uses: - nutrition that is available in the blood circulation for its own demand for energy, as well as for its renewal and detoxification activities; - its own means of protection against anti-oxidants in order to mitigate the killing effects of free radicals produced during the night activities of the cell.Reduction of personal measurements with slim daily programThe Daily PathGood for:MorningDailyReduction of measurements (cm)Designed for:50/51Rating evaluationTM 27. slimIn the evening the cells need nutrition for covering their night demands for energy and defense, but also nutrition prioritizing the fat burning, thus inhibition of the fat deposition.Eveningthus complements the daily action of HappyCo Slim by maintaining the activity of cell nutrition and defense, but also by improving the fat mass/non-fat mass ratio thanks to its efficient action on fat burning with full preservation of the muscle tissue, also acting on heat release and supporting excretion.The Slim Evening Path has a very significant anti-oxidation effect: it improves resistance to radicals by almost 35% as compared with the reference blood sample.1 0 2 Concentration (by g/l of reaction medium)A clinical study, lasting 30 days, conducted on a target population of 30 women on hormonal contraception and overweight demonstrated the effectiveness of Slim (Evening) on weight loss and bloating sensation reduction.66- reinforcing the body shapeWeight (kg)65Good for:P. Piccerelle, M. Prost, Actes Symposium - New 21st Century Health Challenges and Pre-Medicine, Cassis (France), 21 Mars 2009.Reduction of waist circumferenceReduction of body weight- reducing the fat mass while prioritizing the muscle mass preservation64 63 - 2,9kg62 61 60- improving the tone of muscles and tissueDay 0Day 2076,5 76 75,5 757498Weight (kg)97,5 97 96,5 - 1,7cm96 95,5 95 Day 0Day 20Day 302- Proceedings of Symposium NEW 21ST CENTURY HEALTH CHALLENGES ANDPRE-MEDICINE, Cassis (France), 21 March 2009.1,5 1 - 95%0,5 0 Day 0Day 20P. Piccerelle, M. Prost, Actes Symposium - New 21st Century Health Challenges and Pre-Medicine, Cassis (France), 21 Mars 2009.Day 30After 30 days of use, Slim Evening gave the result of an average weight loss of about 3 kg and a decrease in all measurements, correlated with a decrease of the bloating sensation.SLIM is the only preparation that can give the organism repeated lessons in proper balance between weight and body line while respecting the daily rhythm of the cell. Recommended Use:73,5 Day 0Reduction of thighs circumference- KRL tests conducted with Slim Morning, Daily and Evening, KIRIAL International a company of the Spiral group of laboratories - KRL Patent Michel Prost PCT/FR90/00061, 20092,5- 1,7cm74,5Day 30Other Supporting StudiesReduction of swelling sensation 3 Measure index35 30 25 20 15 10 5 0Waist circumference (cm)The cells, in particular the fat cells, must get ready for proper performance of their function of renewal, regeneration and detoxification at night. In addition, the evening metabolism differs from the daily metabolism, as secretion to the digestive system occurs, which enables excessive digestion of food. The glycogen synthesis peak (form of sugar deposition) is at night.Anti-Oxidation Effect of Slim Evening Path (KRL Test)Day 20Day 30Reduction of hip circumference Waist circumference (cm)Evening52/53Antio x idation effect (% increase of T1/2 of blood witness)TM58 57,8 57,6 57,4 57,2 57 56,8 56,6 56,4 56,2 56- 1,5cmDay 0Day 20Day 30Orogranules are to be dissolved mainly in mouth in order to support orobioavailability (instant absorption of active components by buccal way). - 2 Orogranules of Morning in the morning - 4 Orogranules of Daily, two before noon and two eventually at the end of afternoon - 2 Orogranules of Evening before going to sleep This dosage can be reduced in the stabilization phase or after the desired results have been obtained - 1 Orogranule of Morning in the morning - 2 Orogranules of Daily, one before noon and one at the end of afternoon (or both at one time before noon) - 1 Orogranule of Evening before going to sleep.- DE COTRET LR, Sleep: Period of Intensive Activity. Passeport Sant, 6 October 2008. - LEUNG A. FOSTER S., Encyclopedia of common natural ingredients used in food, drugs and cosmetics, John Wiley & Son, USA, 1996. - MASON P., Dietary Supplements, Second ed, Pharmaceutical Press, London, 2001. - WICHTL M., Herbs, Tradition, Medical Practice, Science and Therapy, Technique et Documentation, 1999. - HARGRAVE-BARNES KM, AZAIN MJ, MINER JL., Conjugated linoleic acid-induced fat loss dependence on Delta6-desaturase or cyclooxigenase., Obesity (Silver Spring). 2008 Oct;16(10):2245-52. - RAWLINGS AV., Cellulite and its treatment. Int J Cosmet Sci. 2006 Jun; 28(3): 175-90. - WHIGHAM LD, WATRAS AC, SCHOELLER DA. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J Clin Nutr. 2007; 85(5):1203-11. - GAULLIER JM, HALSE J, HYE K, KRISTIANSEN K, FAGERTUN H, VIK H, GUDMUNDSEN O. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J Nutr. 2005; 135(4):778-84. - JIANG ZY, ZHONG WJ, ZHENG CT, LIN YC, YANG L, JIANG SQ. Conjugated linoleic acid differentially regulates fat deposition in back fat and longissimus muscle of finishing pigs. J Anim Sci. 2010. Jan 29. [Epub ahead of print] - NORRIS LE, COLLENE AL, ASP ML, HSU JC, LIU LF, RICHARDSON JR, LI D, BELL D, OSEI K, JACKSON RD, BELURY MA. Comparison of dietary conjugated linoleic acid with safflower oil on body composition in obese postmenopausal women with type 2 diabetes mellitus. Am J Clin Nutr. 2009; 90(3):468-76. 28. 54/55 00/00TMHAPPY.COnotobackoTMCOMINGSOON 29. TMTMnotobacko56/57Each stepDesigned for people who want to stop smoking.Each step is presented in a main box containing 4 little boxes, eachNotobacko was specially designed and created by our researchers to accompany your willingness to defeat the 3 addictions engendered by smoking simultaneously: the physical, psychic and body language addictions. Without imposing the brutal stop of smoking, Notobacko will help you to gradually re-educate your body to the absence of the tobacco. At the same time it will help you to take back completely the control of the functions that the use of cigarettes have modified: stress, memory, concentration, tone, five senses... Based on the exclusive concept of Orochronodietology, Notobacko acts at the heart of the cells according to the time and the progression of the dependencies. Thanks to the Orogranules, that needs to be sucked and dissolved progressively in the mouth, Notobacko will ensure a triple cellular action : nutrition, antioxydant protection and re-launch of the specific cellular function.COMING SOONNotobacko is a program of 100% natural origin, flexible and adapted to everybody, proposed in 3 steps:containing 6 blister packages of 8 Orogranules : each blister package of 8 Orogranules represents the average dosage of a day and contains 3 different Orogranules, each having a specific action on your addictions. The 8 Orogranules need to be sucked throughout the day by following the numbering indicated on the back of the blister package, (as a supplement to a well-balanced diet, as part of a healthy lifestyle. The daily number of Orogranules is adaptable according to your results, but it is important to maintain a minimal quantity of Orogranules to suck during a day in order not to lose the advantage of the control of the oral function. The main features of the program are: - It has a 24-day coverage - Allows to be personally followed by a coach - It contains the direction of use and a questionnaire allowing the program follow-up. The questionnaire needs to be to sent back necessarily one week before the end of the Step, so that the following Step is adapted to the personal results and needs. - It can be used in association with nicotinic substitutes or other antismoking treatments.I Step 1 : Stop Smoking When the consumption of cigarettes is stopped or decreased, the body continues to defend itself from usual attacks caused by the smoke. There is essentially a physical lack and a body language issue. The 3 different Orogranules included in the step 1 help to: - Orogranule A (Positions 2 and 5 on the blister package): Cleanses and purifies the mouth, helps to fight against the acid attacks of bacteria, and to restore the whiteness in teeth. - Orogranule B (Positions 1, 4, 6, 8 on the blister package): Intervenes on the cigarette taste, helps to reduce the need to smoke, calms down the irritation of the mucous membranes and removes the sensation of hunger. - Orogranule C (Positions 3 and 7 on the blister package): Calms down the dependence and relaxes during the day, helps to improve the tiredness and the quality of the sleepIII Step 3 : the detoxification This is the final step of the program. The main need at this stage It is to definitively cleanse your body of all the toxins brought during years of the smoke of cigarette. In this stage, it is thus necessary to begin the phase of final and complete detoxification and to maintain active the fight against the fatal effects of tobacco. The Step 3 will be completely personalized according to the answers which supplied to the second questionnaire. This step will revitalize cells and help to remove gradually the stigmas of tobacco. The Orogranules help the body to naturally take back the control over all the bad habits; at the level of the sleep, of the stress, of the purity of the body as well as the physical and psychic shape. The Step 3 will help to clean the body from all the cumulated toxins, to boost the form and the dynamism, to finally and definitively set FREE from TOBACCO.II Step 2 : the consolidation After the 1st month without smoking, the products of the 2nd Step aim at strengthening your detachment towards the cigarettes by helping your body to fight against the weight gain, the stress and to control your own behavioral addiction (concentration, memory, irritability, fatigue).COMING SOONThe Step 2 will indeed be completely personalized according to the answers supplied to the first questionnaire.TMThe Steps 2 and 3 are totally personalized according to your needs thanks to a questionnaire that needs to be filled one week before the end of each step. NB: According to the results of each, the 3 successive steps are optional.The Step 2 will help not to restart smoking; will prevent the raging hunger, the bulimic drives and will maintain your weight by re-educating your body. It will help to fight against the irritability and to sleep better.First contact With the coach- Step 1: Stop smoking - Step 2: the consolidation - Step 3: the detoxificationStep 1: Stop SmokingStep 2: the consolidationStandard, 24 daysPersonalized, 24 daysPersonalized, 24 days>> questionnaire 1Step 3: the detoxificationquestionnaire 2 CONTINUOUS CONTACT WITH THE PERSONAL CO ACH>Congratulations ! You stopped smoking 30. TMTMnotobacko58/59Step by step, Notobacko progressively acts on all the personal sources of the smoking problemBesides these results, data revealed: Notobacko Clinical Study: A total of 98 patients were included in the study (2/3 women, 1/3 men). All smokers were included, independently of their degree of dependencies and of their daily cigarettes consumption but the sample were finally mainly constituted of moderate and heavy smokers. 100- The ease of use of the treatment: Orogranules of a pleasant taste to be simply sucked and dissolved in the mouth.10080- The importance of orality and of the role of Orogranule in the control of the oral lack80- The importance of a free personalized coaching for the good management of treatment and the intensification of the motivation as witnessed by 87 % of the patients having participated in the study66,7% 60604040%4033,3%2020041,7%- The preservation of the smoking cessation in a long term : About 77,8% of no resumption after 3 months and 6 months 72,2% after 6 months More than 50% after 12 months0 WomenMen11,7% 0 cig/j2/3 of women, 1/3 of men6,7% 1-10 cig/j 10-20 cig/j >20 cig/jPredominance of moderate and heavy smokersDecrease of the smoking consumption throughout NotobackoTM- The absence of annoying side effectsCOMING SOON program100% Diminution rate13%18%80% 60%38%49,30% 41,70%40% 20%30%48% 35%28,40%Step 2Step 3More than 2 patients on 3More than 7 patients on 80% Step 1 Success or 50-90% of decrease( Nearlyon1 patient 2Reduction < 50% 50% < Reduction < 100% 100% Stop before the end because smoking cessationNear 1/3 patient success in the smoking cessation at the end of the program 31. 60/61 These five scientific benefits are made possible thanks to the proprietary exclusive and patented technology of Orogranules: - The only ones who are built one by one gradually from the center to the periphery - The only ones who can integrate into their complex any kind of active ingredient, regardless of their physicochemical nature (liquid, powder, solid, oils, essential oils ...)conclusion- The only ones that create a new complex of multi-target actives ensuring a synergistic action - The only where the active ingredients are simultaneously content and container: no need of shell, excipient, capsule, gelatin, cellulose, conservativesTML'orochronoditologieensures consistency between the function and need of the cells following the cellular biorhythm of the day and night.- The only ones that allow orobioavailability (buccal direct assimilation) to ensure 100% of quality and quantity of natural actives "avoiding" the classic digestive trackOrochronodietology is the base of HAPPYCO Products, all of them being unique and innovative.Its efficiency level, never reached until today, is based on its five strengths:The HAPPY.CO products will also help to restore the natural system in its entirety and at the same time to restore the disrupted function for a more effective, fast and safe action.- POWER: the only one that acts on all sources of the problem to be solved thanks to its multi-target action - SPEED: the only one that is immediately and directly absorbed in the mouth, allowing the direct passage of the actives in the blood - SAFETY: the only one that has no envelope, no capsule, no excipient, no gelatin, no cellulose, no preservatives, no alcohol and is GMOfree - COMPREHENSIVENESS: the only one that has a complete and simultaneous action on the three essential elements for the cell: its nutrition, its protection and its specific function - BALANCE: the only one that respects the cellular biological day / night rhythmEach of the HAPPY.CO products consists of 3 programs to be taken during the day in order to meet the needs of the cells, specific needs at each stage of their daily cycle. Each complex will thus be supplied to the cells at the time, depending on their life cycle, they need it most and are most capable of profiting.Each of the new complexes that are part of the HAPPY.CO natural products is going to be immediately and simultaneously act on all the sources of the problem to be treated, respecting the daily chronobiology of the organism. 32. ITS TIME TO BE HAPPY ! 33. GRAPHO.COM 2012 . PHOTOS : L. LEFEVRE, THINKSTOCK & ISTOCKPHOTOITS TIME TO BE HAPPY !myhappyco.com